Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0131 | 0.0131 |
Onchocerca volvulus | 0.0058 | 0.0131 | 0.5 | |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0131 | 0.0283 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0131 | 0.0283 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0162 | 0.4622 | 0.4622 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.4622 | 0.4622 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0162 | 0.4622 | 0.4622 |
Loa Loa (eye worm) | carboxylesterase | 0.0162 | 0.4622 | 0.4622 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0162 | 0.4622 | 0.4622 |
Echinococcus granulosus | acetylcholinesterase | 0.0162 | 0.4622 | 0.4622 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.4622 | 0.4622 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0162 | 0.4622 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0162 | 0.4622 | 0.4622 |
Echinococcus multilocularis | acetylcholinesterase | 0.0162 | 0.4622 | 0.4622 |
Echinococcus multilocularis | acetylcholinesterase | 0.0162 | 0.4622 | 0.4622 |
Echinococcus granulosus | acetylcholinesterase | 0.0162 | 0.4622 | 0.4622 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0162 | 0.4622 | 0.4622 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.