TDR Targets

Basic information

Technical information

TDR Targets ID: 131827
Name: (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(4- chloro-2,6-difluorophenyl)methanone
MW: 365.762 | Formula: C17H14ClF2N3O2
H donors: 1 H acceptors: 3 LogP: 3.47 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOc1c(c[nH]c2c1cnn2)C(=O)c1c(F)cc(cc1F)Cl
InChi: 1S/C17H14ClF2N3O2/c1-2-3-4-25-16-10(7-21-17-11(16)8-22-23-17)15(24)14-12(19)5-9(18)6-13(14)20/h5-8H,2-4H2,1H3,(H,21,22,23)
InChiKey: KHLSGMMGWBAAOY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(4-chloro-2,6-difluoro-phenyl)methanone
(4-butoxy-1H-pyrazolo[4,3-e]pyridin-5-yl)-(4-chloro-2,6-difluorophenyl)methanone
(4-butoxy-1H-pyrazolo[4,3-e]pyridin-5-yl)-(4-chloro-2,6-difluoro-phenyl)methanone
SQ-67563 Analog 21i

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin D2	Starlite/ChEMBL	References
Homo sapiens	cyclin B3	Starlite/ChEMBL	References
Homo sapiens	cyclin E2	Starlite/ChEMBL	References
Homo sapiens	cyclin B2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cyclin A, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	cyclin domain-containing protein	Get druggable targets OG5_134175	All targets in OG5_134175
Schistosoma japonicum	ko:K10151 cyclin D2, putative	Get druggable targets OG5_131242	All targets in OG5_131242
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_134175	All targets in OG5_134175
Giardia lamblia	G2/mitotic-specific cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	G1:S specific cyclin D1	Get druggable targets OG5_131242	All targets in OG5_131242
Leishmania infantum	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	IPR002155,Thiolase,domain-containing	Get druggable targets OG5_134175	All targets in OG5_134175
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium hominis	mitotic cyclin-CYC2	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_131242	All targets in OG5_131242
Leishmania braziliensis	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin d	Get druggable targets OG5_131242	All targets in OG5_131242
Leishmania donovani	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Onchocerca volvulus		Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus multilocularis	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus multilocularis	G1:S specific cyclin D1	Get druggable targets OG5_131242	All targets in OG5_131242
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_134175	All targets in OG5_134175
Trypanosoma cruzi	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131242	All targets in OG5_131242
Trypanosoma brucei gambiense	cyclin 6,mitotic cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium parvum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania infantum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	G2:mitotic specific cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Leishmania mexicana	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Entamoeba histolytica	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131242	All targets in OG5_131242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus multilocularis	G2:mitotic specific cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trichomonas vaginalis	cyclin B, putative	cyclin D2	289 aa	246 aa	21.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0078	0.0332	0.0632
Brugia malayi	conserved hypotetical protein	0.0037	0.0016	0.0009
Brugia malayi	beta-lactamase family protein	0.0209	0.134	0.3224
Schistosoma mansoni	agrin	0.0037	0.0018	0.0013
Echinococcus multilocularis	acetylcholinesterase	0.0572	0.4132	0.8142
Echinococcus granulosus	microtubule associated protein 2	0.0694	0.5073	1
Echinococcus granulosus	follistatin	0.0037	0.0018	0.0013
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0016	0.0008
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.0051	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0151	0.0329
Trichomonas vaginalis	cyclin B3, putative	0.0086	0.0392	0.2748
Toxoplasma gondii	ABC1 family protein	0.0209	0.134	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.0667	0.1295
Trypanosoma cruzi	cyclin 6, putative	0.0116	0.0623	0.4512
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0078	0.0332	0.0632
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0051	0.0127	0.0088
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0121	0.0667	0.1295
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0016	0.0008
Trichomonas vaginalis	cyclins, putative	0.0051	0.0123	0.0686
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0078	0.0332	0.0632
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0037	0.0016	0.0008
Echinococcus granulosus	carboxylesterase 5A	0.0572	0.4132	0.8142
Brugia malayi	mbt repeat family protein	0.0111	0.0587	0.1395
Loa Loa (eye worm)	carboxylesterase	0.0199	0.1264	0.3033
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0705	0.1674
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Trichomonas vaginalis	cyclin B, putative	0.0116	0.0623	0.4512
Echinococcus multilocularis	cyclins	0.0086	0.0392	0.0752
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.0051	0.0136
Echinococcus multilocularis	para nitrobenzyl esterase	0.0199	0.1264	0.2475
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0018	0.0016
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0078	0.0332	0.0632
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0054	0.0151	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0623	0.1475
Echinococcus multilocularis	tumor protein p63	0.0329	0.2264	0.4449
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0078	0.0332	0.0632
Brugia malayi	intermediate filament protein	0.0053	0.0144	0.0321
Echinococcus granulosus	cyclins	0.0086	0.0392	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0209	0.134	0.3218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0142	0.0258
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0078	0.0332	0.0768
Onchocerca volvulus		0.0053	0.0144	0.0969
Trichomonas vaginalis	penicillin-binding protein, putative	0.0209	0.134	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0199	0.1264	0.2475
Entamoeba histolytica	cyclin family protein	0.0086	0.0392	0.6229
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0016	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0203	0.1293	0.3104
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0054	0.0151	0.0329
Brugia malayi	steroid hormone receptor	0.0078	0.0332	0.0777
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0051	0.0078
Echinococcus granulosus	cyclin B	0.0116	0.0623	0.1208
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0051	0.0136
Mycobacterium tuberculosis	Conserved protein	0.0209	0.134	0.0721
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0049	0.0092
Echinococcus multilocularis	cyclins	0.0086	0.0392	0.0752
Brugia malayi	mbt repeat family protein	0.0111	0.0587	0.1395
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0209	0.134	0.3224
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0572	0.4132	0.8142
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Echinococcus granulosus	G1:S specific cyclin D1	0.0203	0.1293	0.2532
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1264	0.3033
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Trichomonas vaginalis	penicillin-binding protein, putative	0.0209	0.134	1
Trypanosoma cruzi	cytochrome P450, putative	0.0051	0.0127	0.0714
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0209	0.134	0.2625
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0033	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0049	0.0082
Plasmodium falciparum	cyclin	0.0086	0.0392	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0869	0.6412	0.6156
Schistosoma mansoni	thyroid hormone receptor	0.0078	0.0332	0.0632
Leishmania major	cytochrome p450-like protein	0.0051	0.0127	0.0714
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0199	0.1264	0.2475
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0294	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0151	0.0329
Schistosoma mansoni	lamin	0.0053	0.0144	0.0261
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0051	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1134	0.2717
Loa Loa (eye worm)	cyclin domain-containing protein	0.022	0.1425	0.3425
Brugia malayi	hypothetical protein	0.0041	0.0049	0.0092
Schistosoma mansoni	thyroid hormone receptor	0.0078	0.0332	0.0632
Schistosoma mansoni	follistatin	0.0037	0.0018	0.0013
Mycobacterium leprae	Probable lipase LipE	0.0209	0.134	0.5
Onchocerca volvulus	Putative organic anion transporter	0.0054	0.0151	0.1021
Brugia malayi	secreted modular calcium-binding protein 1	0.0037	0.0018	0.0016
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0078	0.0332	0.0768
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0116	0.0623	0.1484
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0127	0.0279
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.0667	0.1295
Mycobacterium tuberculosis	Probable lipase LipE	0.0209	0.134	0.0721
Entamoeba histolytica	cyclin, putative	0.0116	0.0623	1
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0104	0.0182
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.0016	0.0009
Onchocerca volvulus		0.0078	0.0332	0.2387
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Onchocerca volvulus	Putative organic anion transporter	0.0054	0.0151	0.1021
Mycobacterium tuberculosis	Probable lipase LipD	0.0209	0.134	0.0721
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0037	0.0016	0.0008
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0016	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0623	0.1475
Trichomonas vaginalis	esterase, putative	0.0209	0.134	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0126	0.0705	0.1682
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0078	0.0332	0.0768
Schistosoma mansoni	hypothetical protein	0.0052	0.0133	0.0241
Trichomonas vaginalis	spcc417.12 protein, putative	0.0199	0.1264	0.9419
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0078	0.0332	0.0632
Mycobacterium ulcerans	beta-lactamase	0.0209	0.134	0.1502
Brugia malayi	nuclear receptor RXR	0.0041	0.0049	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0377	0.0877
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0049	0.0075
Toxoplasma gondii	aldehyde dehydrogenase	0.0121	0.0667	0.4906
Brugia malayi	sodium-independent organic anion transporter family protein	0.0054	0.0151	0.0338
Echinococcus multilocularis	G1:S specific cyclin D1	0.0203	0.1293	0.2532
Onchocerca volvulus		0.0199	0.1264	0.9427
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0033	0.0249
Echinococcus granulosus	cyclins	0.0086	0.0392	0.0752
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0078	0.0332	0.0768
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.0016	0.0009
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0084	0.0377	0.0886
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0539	0.3877	0.9379
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0116	0.0623	0.4512
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0033	0.0043
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0016	0.0009
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0051	0.0136
Trypanosoma cruzi	cyclin, putative	0.0116	0.0623	0.4512
Echinococcus multilocularis	cyclins	0.0086	0.0392	0.0752
Leishmania major	hypothetical protein, conserved	0.0209	0.134	1
Schistosoma mansoni	cyclin B3	0.022	0.1425	0.2793
Loa Loa (eye worm)	hypothetical protein	0.0572	0.4132	1
Loa Loa (eye worm)	agrin synaptic family protein	0.0037	0.0018	0.0007
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0054	0.0151	0.0275
Loa Loa (eye worm)	acetylcholinesterase 1	0.0572	0.4132	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0111	0.0587	0.4311
Brugia malayi	sodium-independent organic anion transporter family protein	0.0054	0.0151	0.0338
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Schistosoma mansoni	microtubule-associated protein tau	0.0694	0.5073	1
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0084	0.0377	0.0721
Mycobacterium tuberculosis	Probable esterase LipL	0.0209	0.134	0.0721
Loa Loa (eye worm)	MBCTL1	0.0126	0.0705	0.1674
Echinococcus multilocularis	cyclins	0.0086	0.0392	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0209	0.134	0.3218
Trichomonas vaginalis	cyclin D, putative	0.0086	0.0392	0.2748
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1264	0.3033
Schistosoma mansoni	acetylcholinesterase	0.0199	0.1264	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1264	0.3033
Trypanosoma cruzi	MFS transporter, putative	0.0054	0.0151	0.0899
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0039	0.0033	0.0043
Brugia malayi	nuclear receptor NHR-67	0.0037	0.0016	0.0009
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0078	0.0332	0.0632
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0018	0.0016
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.0016	0.0009
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.0667	0.0718
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0116	0.0623	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0209	0.134	0.3218
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0177	0.1095	0.214
Mycobacterium ulcerans	hypothetical protein	0.0209	0.134	0.1502
Echinococcus granulosus	cyclin b3	0.0086	0.0392	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1264	0.3033
Schistosoma mansoni	RAR-like nuclear receptor	0.0078	0.0332	0.0632
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0049	0.0092
Mycobacterium tuberculosis	Conserved protein	0.0209	0.134	0.0721
Brugia malayi	prostaglandin transporter	0.0054	0.0151	0.0338
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0078	0.0332	0.0632
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0144	0.0312
Onchocerca volvulus	Protein ultraspiracle homolog	0.0078	0.0332	0.2387
Schistosoma mansoni	hypothetical protein	0.0171	0.1044	0.2041
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0078	0.0332	0.0632
Mycobacterium tuberculosis	Probable hydrolase	0.0209	0.134	0.0721
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0203	0.1293	0.311
Schistosoma mansoni	cyclin d	0.0203	0.1293	0.2532
Toxoplasma gondii	transporter, major facilitator family protein	0.0054	0.0151	0.1002
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.022	0.1425	0.2793
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.0294	0.0685
Echinococcus granulosus	geminin	0.0171	0.1044	0.2041
Echinococcus multilocularis	neuroligin	0.0199	0.1264	0.2475
Schistosoma mansoni	sex comb on midleg homolog	0.0111	0.0587	0.1136
Echinococcus granulosus	polycomb protein SCMH1	0.0111	0.0587	0.1136
Trichomonas vaginalis	cyclins, putative	0.0116	0.0623	0.4512
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0078	0.0332	0.0777
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0051	0.0136
Trichomonas vaginalis	cyclins, putative	0.0116	0.0623	0.4512
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0037	0.0016	0.0008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Loa Loa (eye worm)	carboxylesterase	0.0199	0.1264	0.3033
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.0016	0.0009
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0209	0.134	0.0721
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0116	0.0623	0.4512
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0009
Schistosoma mansoni	cyclin B	0.0116	0.0623	0.1208
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0142	0.0258
Onchocerca volvulus	Putative organic anion transporter	0.0054	0.0151	0.1021
Mycobacterium ulcerans	short chain dehydrogenase	0.0869	0.6412	0.7412
Trichomonas vaginalis	cyclins, putative	0.0116	0.0623	0.4512
Echinococcus multilocularis	geminin	0.0171	0.1044	0.2041
Toxoplasma gondii	hypothetical protein	0.0065	0.0233	0.1627
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0084	0.0377	0.0721
Loa Loa (eye worm)	steroid hormone receptor	0.0078	0.0332	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0007
Schistosoma mansoni	sex comb on midleg homolog	0.0111	0.0587	0.1136
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0016	0.0008
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0037	0.0016	0.0008
Echinococcus granulosus	tumor protein p63	0.0329	0.2264	0.4449
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0111	0.0587	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0041	0.0049	0.0075
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0199	0.1264	0.2475
Mycobacterium ulcerans	esterase/lipase LipP	0.0209	0.134	0.1502
Echinococcus multilocularis	agrin	0.0037	0.0018	0.0013
Trichomonas vaginalis	cyclin A, putative	0.0116	0.0623	0.4512
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0199	0.1264	0.2475
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0078	0.0332	0.0777
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0016	0.0008
Onchocerca volvulus		0.0037	0.0018	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0007
Trichomonas vaginalis	cyclin B, putative	0.0116	0.0623	0.4512
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0294	0.0558
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0136	0.0778	0.1515
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0078	0.0332	0.0632
Trypanosoma cruzi	hypothetical protein, conserved	0.0209	0.134	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0136	0.0293
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0051	0.0381
Onchocerca volvulus		0.0209	0.134	1
Brugia malayi	hypothetical protein	0.0199	0.1264	0.304
Schistosoma mansoni	BC026374 protein (S09 family)	0.0199	0.1264	0.2475
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.0801	0.1908
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.022	0.1425	0.2793
Echinococcus granulosus	nuclear receptor nhr 48	0.0037	0.0016	0.0008
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0016	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0049	0.0082
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0041	0.0049	0.0075
Brugia malayi	tailless protein	0.0037	0.0016	0.0009
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0016	0.0008
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0078	0.0332	0.0632
Echinococcus multilocularis	carboxylesterase 5A	0.0572	0.4132	0.8142
Echinococcus multilocularis	cyclins	0.0086	0.0392	0.0752
Brugia malayi	photoreceptor-specific nuclear receptor	0.0078	0.0332	0.0777
Echinococcus granulosus	cyclins	0.0086	0.0392	0.0752
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0078	0.0332	0.0632
Schistosoma mansoni	organic anion transporter	0.0054	0.0151	0.0275
Onchocerca volvulus		0.0199	0.1264	0.9427
Brugia malayi	Cytochrome P450 family protein	0.0063	0.0219	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0587	0.1387
Brugia malayi	MH2 domain containing protein	0.0139	0.0801	0.1916
Echinococcus granulosus	ecdysone induced protein 78C	0.0078	0.0332	0.0632
Brugia malayi	ecdysone receptor	0.0037	0.0016	0.0009
Brugia malayi	SPARC precursor	0.0037	0.0018	0.0016
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0126	0.0705	0.1369
Onchocerca volvulus	Bile acid receptor homolog	0.0078	0.0332	0.2387
Brugia malayi	nuclear hormone receptor	0.0037	0.0016	0.0009
Brugia malayi	Steroid receptor seven-up type 2	0.0078	0.0332	0.0777
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0078	0.0332	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0151	0.0329
Mycobacterium tuberculosis	Carboxylesterase LipT	0.1157	0.8633	0.8536
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0199	0.1264	0.064
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Trichomonas vaginalis	cyclin B, putative	0.0086	0.0392	0.2748
Trypanosoma cruzi	cytochrome P450, putative	0.0051	0.0127	0.0714
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Brugia malayi	Carboxylesterase family protein	0.0572	0.4132	1
Brugia malayi	sodium-independent organic anion transporter family protein	0.0054	0.0151	0.0338
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0078	0.0332	0.0777
Onchocerca volvulus		0.0053	0.0144	0.0969
Schistosoma mansoni	nuclear receptor	0.0037	0.0016	0.0008
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0018	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Schistosoma mansoni	lamin	0.0053	0.0144	0.0261
Echinococcus granulosus	ubiquitin specific protease 41	0.0039	0.0033	0.0043
Echinococcus multilocularis	ubiquitin specific protease 41	0.0039	0.0033	0.0043
Onchocerca volvulus		0.0084	0.0377	0.2725
Mycobacterium ulcerans	carboxylesterase, LipT	0.1157	0.8633	1
Mycobacterium leprae	conserved hypothetical protein	0.0209	0.134	0.5
Onchocerca volvulus		0.0199	0.1264	0.9427
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0392	0.2748
Schistosoma mansoni	zinc finger protein	0.0037	0.0016	0.0008
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0209	0.134	0.2625
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0049	0.0082
Trypanosoma brucei	cytochrome P450, putative	0.0051	0.0127	0.0945
Trypanosoma brucei	hypothetical protein, conserved	0.0209	0.134	1
Onchocerca volvulus		0.0111	0.0587	0.4311
Entamoeba histolytica	cyclin, putative	0.0086	0.0392	0.6229
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0126	0.0705	0.1369
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0078	0.0332	0.0632
Echinococcus granulosus	acetylcholinesterase	0.0572	0.4132	0.8142
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0142	0.0258
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0294	0.0558
Echinococcus granulosus	intermediate filament protein	0.0053	0.0144	0.0261
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0209	0.134	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0151	0.0329
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0127	0.027
Echinococcus granulosus	lamin dm0	0.0053	0.0144	0.0261
Schistosoma mansoni	nuclear hormone receptor	0.0078	0.0332	0.0632
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0437	0.3096	0.6094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Leishmania major	cyclin	0.0116	0.0623	0.4512
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0078	0.0332	0.0768
Brugia malayi	ecdysteroid receptor	0.0078	0.0332	0.0777
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0051	0.0078
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0078	0.0332	0.0777
Brugia malayi	hypothetical protein	0.0054	0.0151	0.0338
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Giardia lamblia	Cyclin A	0.0086	0.0392	0.6091
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.0294	0.0677
Brugia malayi	follicle stimulating hormone receptor	0.0539	0.3877	0.9379
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0007
Brugia malayi	nuclear receptor RXR	0.0037	0.0016	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0078	0.0332	0.0777
Echinococcus granulosus	BC026374 protein S09 family	0.0199	0.1264	0.2475
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0199	0.1264	0.2475
Loa Loa (eye worm)	carboxylesterase	0.0572	0.4132	1
Echinococcus granulosus	cyclins	0.0086	0.0392	0.0752
Echinococcus granulosus	histone acetyltransferase MYST2	0.0126	0.0705	0.1369
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Mycobacterium ulcerans	lipase LipD	0.0209	0.134	0.1502
Echinococcus multilocularis	expressed protein	0.0037	0.0018	0.0013
Onchocerca volvulus		0.0209	0.134	1
Onchocerca volvulus		0.0054	0.0151	0.1021
Loa Loa (eye worm)	RNA binding protein	0.0073	0.0294	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0049	0.0082
Echinococcus granulosus	tar DNA binding protein	0.0073	0.0294	0.0558
Onchocerca volvulus		0.0199	0.1264	0.9427
Mycobacterium tuberculosis	Conserved protein	0.0209	0.134	0.0721
Echinococcus granulosus	L aminoadipate semialdehyde	0.0084	0.0377	0.0721
Trichomonas vaginalis	D-aminoacylase, putative	0.0209	0.134	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0209	0.134	1
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0144	0.0261
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0142	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0078	0.0332	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0104	0.0214
Brugia malayi	hypothetical protein	0.0041	0.0049	0.0092
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0078	0.0332	0.0777
Echinococcus multilocularis	FTZ F1 alpha	0.0078	0.0332	0.0632
Echinococcus multilocularis	acetylcholinesterase	0.0572	0.4132	0.8142
Trichomonas vaginalis	D-aminoacylase, putative	0.0209	0.134	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0199	0.1264	0.9419
Echinococcus granulosus	lamin	0.0053	0.0144	0.0261
Schistosoma mansoni	hypothetical protein	0.0675	0.4921	0.9699
Trypanosoma brucei	mitotic cyclin 6	0.0116	0.0623	0.4648
Trypanosoma cruzi	cyclin, putative	0.0116	0.0623	0.4512
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0151	0.0329
Trichomonas vaginalis	cyclins, putative	0.0086	0.0392	0.2748
Brugia malayi	hypothetical protein	0.0054	0.0151	0.0338
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0037	0.0018	0.0007
Echinococcus multilocularis	follistatin	0.0037	0.0018	0.0013
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0111	0.0587	0.1136
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0294	0.0558
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0049	0.0082
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0078	0.0332	0.0632
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0121	0.0667	0.1295
Echinococcus multilocularis	polycomb protein SCMH1	0.0111	0.0587	0.1136
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0078	0.0332	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1264	0.3033
Giardia lamblia	Hypothetical protein	0.0086	0.0392	0.6091
Loa Loa (eye worm)	CYP4Cod1	0.0051	0.0127	0.027
Onchocerca volvulus		0.0199	0.1264	0.9427
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0126	0.0705	0.1369
Onchocerca volvulus		0.0054	0.0151	0.1021
Schistosoma mansoni	cyclins	0.0086	0.0392	0.0752
Schistosoma mansoni	gliotactin	0.0199	0.1264	0.2475
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0199	0.1264	0.2475
Brugia malayi	Nuclear hormone receptor-like 1	0.0078	0.0332	0.0777
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0033	0.0043
Echinococcus granulosus	FTZ F1 alpha	0.0078	0.0332	0.0632
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0033	0.0043
Brugia malayi	Carboxylesterase family protein	0.0199	0.1264	0.304
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0142	0.0258
Schistosoma mansoni	retinoic acid receptor RXR	0.0177	0.1095	0.214
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0039	0.0033	0.0053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0078	0.0332	0.0768
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0209	0.134	0.0721
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0016	0.0008
Echinococcus granulosus	thyroid hormone receptor alpha	0.0037	0.0016	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0209	0.134	0.3218
Loa Loa (eye worm)	beta-lactamase	0.0209	0.134	0.3218
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0039	0.0033	0.0043
Onchocerca volvulus		0.0116	0.0623	0.4585
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0437	0.3096	0.6094
Echinococcus multilocularis	cyclin b3	0.0086	0.0392	0.0752
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0033	0.0043
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0078	0.0332	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1264	0.3033
Onchocerca volvulus		0.0054	0.0151	0.1021
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0144	0.0312
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0142	0.0308
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0121	0.0667	0.4848
Brugia malayi	RNA binding protein	0.0073	0.0294	0.0685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0078	0.0332	0.0768
Echinococcus multilocularis	musashi	0.0053	0.0144	0.0261
Brugia malayi	Carboxylesterase family protein	0.0199	0.1264	0.304
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0041	0.0049	0.0075
Entamoeba histolytica	cyclin family protein	0.0086	0.0392	0.6229
Loa Loa (eye worm)	hypothetical protein	0.0209	0.134	0.3218
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0078	0.0332	0.0777
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0054	0.0151	0.0275
Trichomonas vaginalis	cyclins, putative	0.0116	0.0623	0.4512
Schistosoma mansoni	nuclear receptor nhr-48	0.0037	0.0016	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.0768
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0078	0.0332	0.0777
Echinococcus multilocularis	lamin	0.0053	0.0144	0.0261
Echinococcus granulosus	cyclin B3 1	0.0086	0.0392	0.0752
Loa Loa (eye worm)	mbt repeat family protein	0.0111	0.0587	0.1387
Brugia malayi	Cyclin, N-terminal domain containing protein	0.022	0.1425	0.3431
Echinococcus granulosus	acetylcholinesterase	0.0572	0.4132	0.8142
Echinococcus multilocularis	microtubule associated protein 2	0.0694	0.5073	1
Giardia lamblia	G2/mitotic-specific cyclin B	0.0116	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0572	0.4132	1
Echinococcus multilocularis	cyclin B3 1	0.0086	0.0392	0.0752
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0209	0.134	0.2625
Echinococcus multilocularis	cyclins	0.0086	0.0392	0.0752
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.0294	0.0558
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0142	0.0258
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0051	0.0381
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0016	0.0009
Echinococcus granulosus	cyclins	0.0086	0.0392	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0078	0.0332	0.0777
Echinococcus granulosus	beta LACTamase domain containing family member	0.0209	0.134	0.2625
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0018	0.0016
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.0667	0.0718
Schistosoma mansoni	hypothetical protein	0.0171	0.1044	0.2041
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0051	0.0381
Trichomonas vaginalis	D-aminoacylase, putative	0.0209	0.134	1
Schistosoma mansoni	coup transcription factor	0.0078	0.0332	0.0632
Brugia malayi	Carboxylesterase family protein	0.0572	0.4132	1
Trichomonas vaginalis	cyclin B, putative	0.0116	0.0623	0.4512
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0078	0.0332	0.2387
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1264	0.3033
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0039	0.0033	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0209	0.134	0.3218
Echinococcus multilocularis	lamin dm0	0.0053	0.0144	0.0261
Echinococcus multilocularis	cyclin B	0.0116	0.0623	0.1208
Brugia malayi	nuclear hormone receptor	0.0078	0.0332	0.0777
Brugia malayi	TAR-binding protein	0.0073	0.0294	0.0685
Brugia malayi	beta-lactamase	0.0209	0.134	0.3224
Schistosoma mansoni	organic anion transporter	0.0054	0.0151	0.0275
Loa Loa (eye worm)	cytochrome P450 family protein	0.0063	0.0219	0.0495
Brugia malayi	beta-lactamase family protein	0.0209	0.134	0.3224
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0199	0.1264	0.064
Echinococcus granulosus	neuroligin	0.0199	0.1264	0.2475
Brugia malayi	nuclear receptor NHR-88	0.0078	0.0332	0.0777
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0078	0.0332	0.0632
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.0294	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0151	0.0329
Echinococcus multilocularis	nuclear receptor nhr 48	0.0037	0.0016	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0144	0.0312
Onchocerca volvulus		0.0054	0.0151	0.1021
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0142	0.0258
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0127	0.0279
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0078	0.0332	0.0777
Trichomonas vaginalis	cyclin D, putative	0.0086	0.0392	0.2748
Brugia malayi	Carboxylesterase family protein	0.0199	0.1264	0.304
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.0667	0.0718
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0126	0.0705	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0007
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0078	0.0332	0.0632
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0127	0.027
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.0801	0.1908
Schistosoma mansoni	nuclear receptor	0.0037	0.0016	0.0008
Echinococcus multilocularis	cyclins	0.0086	0.0392	0.0752
Onchocerca volvulus		0.0209	0.134	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0078	0.0332	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0151	0.0329
Trichomonas vaginalis	cyclin B, putative	0.0116	0.0623	0.4512
Echinococcus granulosus	SAM and MBT domain containing protein	0.0111	0.0587	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0209	0.134	0.3218
Onchocerca volvulus		0.0054	0.0151	0.1021
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0078	0.0332	0.0777
Echinococcus granulosus	agrin	0.0037	0.0018	0.0013
Plasmodium vivax	hypothetical protein, conserved	0.0209	0.134	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0078	0.0332	0.0777
Brugia malayi	Carboxylesterase family protein	0.0199	0.1264	0.304
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0054	0.0151	0.0275
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0041	0.0049	0.0082
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0199	0.1264	0.2475
Onchocerca volvulus		0.0048	0.0104	0.0665
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0199	0.1264	0.2475
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0294	0.0558
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0078	0.0332	0.0777
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0142	0.0317
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0144	0.0321
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0209	0.134	0.1502

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.013 uM	Inhibition of Cyclin-dependent kinase 1-cyclin B	ChEMBL.	12824044
IC50 (binding)	= 0.013 uM	Inhibition of Cyclin-dependent kinase 1-cyclin B	ChEMBL.	12824044
IC50 (binding)	= 0.027 uM	Inhibitory activity against Cyclin-dependent kinase 2-cyclin E	ChEMBL.	12824044
IC50 (binding)	= 0.027 uM	Inhibitory activity against Cyclin-dependent kinase 2-cyclin E	ChEMBL.	12824044
IC50 (binding)	= 0.31 uM	Inhibition of CDK4-Cyclin D	ChEMBL.	12824044
IC50 (binding)	= 0.31 uM	Inhibition of CDK4-Cyclin D	ChEMBL.	12824044

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 5329776

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 131827