Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0028 | 0.1087 | 0.1087 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0058 | 0.3694 | 0.3701 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.013 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0058 | 0.3694 | 0.3694 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.998 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0994 | 0.0996 |
Echinococcus granulosus | intermediate filament protein | 0.0058 | 0.3694 | 0.3694 |
Echinococcus multilocularis | musashi | 0.0058 | 0.3694 | 0.3694 |
Loa Loa (eye worm) | intermediate filament protein | 0.0058 | 0.3694 | 0.3701 |
Schistosoma mansoni | lamin | 0.0058 | 0.3694 | 0.3694 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3601 | 0.3609 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1561 | 0.1564 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2906 | 0.2912 |
Brugia malayi | intermediate filament protein | 0.0058 | 0.3694 | 0.3701 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.998 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0028 | 0.1087 | 0.1087 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.013 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1561 | 0.1561 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0058 | 0.3694 | 0.3701 |
Schistosoma mansoni | intermediate filament proteins | 0.0058 | 0.3694 | 0.3694 |
Onchocerca volvulus | 0.0058 | 0.3694 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.2912 |
Schistosoma mansoni | lamin | 0.0058 | 0.3694 | 0.3694 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.013 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0058 | 0.3694 | 0.3694 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.013 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.013 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.013 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0031 | 0.1354 | 0.1357 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2906 | 0.2912 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.998 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0058 | 0.3694 | 0.3694 |
Echinococcus multilocularis | lamin | 0.0058 | 0.3694 | 0.3694 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.013 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2906 | 0.2912 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.013 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0994 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1561 | 0.1564 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0031 | 0.1354 | 0.1357 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.013 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1087 | 0.1089 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3694 | 0.3701 |
Onchocerca volvulus | 0.0058 | 0.3694 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0032 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.