Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1068 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0073 | 0.0476 | 0.0468 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0024 | 0.0013 | 0.0048 |
Brugia malayi | MH1 domain containing protein | 0.004 | 0.0164 | 0.0157 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0024 | 0.0013 | 0.0048 |
Brugia malayi | Latrophilin receptor protein 2 | 0.014 | 0.1123 | 0.1116 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0932 | 0.0925 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.0008 | 0.0028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.2786 | 1 |
Echinococcus granulosus | smad | 0.0073 | 0.0476 | 0.1075 |
Echinococcus granulosus | tar DNA binding protein | 0.0314 | 0.2786 | 0.6385 |
Echinococcus granulosus | Smad4 | 0.0073 | 0.0476 | 0.1075 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0032 | 0.0088 | 0.0289 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0032 | 0.0088 | 0.0289 |
Schistosoma mansoni | Smad4 | 0.0033 | 0.009 | 0.0324 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0033 | 0.009 | 0.0083 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.0251 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0033 | 0.009 | 0.0083 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0031 | 0.0078 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0013 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0088 | 0.008 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0024 | 0.0013 | 0.002 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0.0078 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0367 | 0.3286 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0024 | 0.0013 | 0.002 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0087 | 0.0612 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0024 | 0.0013 | 0.0013 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.014 | 0.1123 | 0.2563 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0033 | 0.009 | 0.019 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.0088 | 0.0316 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0024 | 0.0013 | 0.0006 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0093 | 0.0666 | 0.0659 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.012 | 0.0932 | 0.3345 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0024 | 0.0013 | 0.0048 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0078 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0033 | 0.009 | 0.0297 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.1123 | 0.4031 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0031 | 0.0078 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.0008 | 0.0028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.2786 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0073 | 0.0476 | 0.1707 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0024 | 0.0013 | 0.0048 |
Schistosoma mansoni | Smad4 | 0.0033 | 0.009 | 0.0324 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0024 | 0.0013 | 0.0013 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0024 | 0.0013 | 0.0013 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.0008 | 0.0028 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.0279 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0093 | 0.0666 | 0.1512 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.014 | 0.1123 | 0.1116 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0073 | 0.0476 | 0.1707 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0303 | 0.2683 | 0.2677 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0031 | 0.0078 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0033 | 0.009 | 0.019 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0024 | 0.0013 | 0.0013 |
Brugia malayi | RNA binding protein | 0.0314 | 0.2786 | 0.278 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.0008 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0703 | 0.2524 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0008 | 0.0028 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.014 | 0.1123 | 0.2563 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.014 | 0.1123 | 0.1116 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0024 | 0.0013 | 0.002 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0024 | 0.0013 | 0.002 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.0251 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0073 | 0.0476 | 0.1683 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.012 | 0.0932 | 0.0925 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1068 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0032 | 0.0088 | 0.008 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0073 | 0.0476 | 0.1075 |
Loa Loa (eye worm) | nuclear factor I | 0.004 | 0.0164 | 0.0157 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0078 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.0032 | 0.0088 | 0.0185 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.012 | 0.0932 | 0.0925 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.0088 | 0.0316 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.012 | 0.0932 | 0.2124 |
Schistosoma mansoni | Smad4 | 0.0073 | 0.0476 | 0.1707 |
Brugia malayi | MH1 domain containing protein | 0.0073 | 0.0476 | 0.0468 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.0008 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.2683 | 0.2677 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0031 | 0.0078 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0314 | 0.2786 | 1 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.1123 | 0.4031 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.016 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.2786 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.0251 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0073 | 0.0476 | 0.0468 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.0008 | 0.0028 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0024 | 0.0013 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0164 | 0.0157 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0024 | 0.0013 | 0.0048 |
Brugia malayi | isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.007 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0073 | 0.0476 | 0.1075 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.2683 | 0.9629 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.0008 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.1123 | 0.4031 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.3286 | 0.3281 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0444 | 0.4027 | 0.4022 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.4027 | 0.4022 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0444 | 0.4027 | 0.4022 |
Echinococcus multilocularis | Smad4 | 0.0073 | 0.0476 | 0.1683 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.009 | 0.0083 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0078 | 0.0251 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0314 | 0.2786 | 0.278 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.0008 | 0.0028 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0024 | 0.0013 | 0.0013 |
Brugia malayi | MH2 domain containing protein | 0.0073 | 0.0476 | 0.0468 |
Schistosoma mansoni | smad1 5 8 and | 0.0073 | 0.0476 | 0.1707 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0032 | 0.0088 | 0.0185 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.0008 | 0.0028 |
Echinococcus multilocularis | smad | 0.0073 | 0.0476 | 0.1683 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0314 | 0.2786 | 0.278 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0033 | 0.009 | 0.0297 |
Brugia malayi | MH1 domain containing protein | 0.004 | 0.0164 | 0.0157 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0024 | 0.0013 | 0.0048 |
Loa Loa (eye worm) | Smad1 | 0.0073 | 0.0476 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1123 | 0.1116 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.014 | 0.1123 | 0.4014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.2786 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0073 | 0.0476 | 0.1707 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0485 | 0.0478 |
Echinococcus multilocularis | GPCR, family 2 | 0.014 | 0.1123 | 0.4014 |
Brugia malayi | Smad1 | 0.0073 | 0.0476 | 0.0468 |
Schistosoma mansoni | smad | 0.0033 | 0.009 | 0.0324 |
Schistosoma mansoni | voltage-gated potassium channel | 0.01 | 0.0741 | 0.2658 |
Schistosoma mansoni | smad | 0.0073 | 0.0476 | 0.1707 |
Schistosoma mansoni | voltage-gated potassium channel | 0.01 | 0.0741 | 0.2658 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.009 | 0.0083 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.012 | 0.0932 | 0.3326 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.0008 | 0.0028 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0024 | 0.0013 | 0.0013 |
Brugia malayi | MH2 domain containing protein | 0.0073 | 0.0476 | 0.0468 |
Brugia malayi | TAR-binding protein | 0.0314 | 0.2786 | 0.278 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0024 | 0.0013 | 0.0006 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0087 | 0.0612 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.014 | 0.1123 | 0.4014 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0093 | 0.0666 | 0.0659 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0444 | 0.4027 | 0.4022 |
Echinococcus multilocularis | FTZ F1 alpha | 0.012 | 0.0932 | 0.3326 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0093 | 0.0666 | 0.2368 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0078 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.014 | 0.1123 | 0.2563 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0033 | 0.009 | 0.0252 |
Echinococcus granulosus | FTZ F1 alpha | 0.0479 | 0.4359 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.0008 | 0.0028 |
Brugia malayi | N-terminal motif family protein | 0.0367 | 0.3286 | 0.3281 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0073 | 0.0476 | 0.1683 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.1123 | 0.4031 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0033 | 0.009 | 0.0083 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0024 | 0.0013 | 0.0006 |
Loa Loa (eye worm) | TAR-binding protein | 0.0314 | 0.2786 | 0.278 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0073 | 0.0476 | 0.0468 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.007 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0078 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0314 | 0.2786 | 0.278 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.2786 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay | ChEMBL. | 22003428 |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2469, AID2475, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2335, AID2466, AID2469, AID2505, AID2798, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2469, AID2483, AID2485, AID2800, AID2801] | ChEMBL. | No reference |
IC50 (binding) | > 20 uM | Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay | ChEMBL. | 22003428 |
IC50 (binding) | > 20 uM | Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay | ChEMBL. | 22003428 |
IC50 (functional) | > 25 uM | PUBCHEM_BIOASSAY: SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2333] | ChEMBL. | No reference |
IC50 (functional) | > 25 uM | PUBCHEM_BIOASSAY: SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID2250, AID2260] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.