Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1904 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.577 | 0.4775 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.1904 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.1904 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1904 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.577 | 0.4775 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.577 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1904 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.1904 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Echinococcus multilocularis | dna polymerase eta | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.1904 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.1904 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1904 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.1904 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.