Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0204 | 0.0896 | 0.0885 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.0163 | 0.0294 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0072 | 0.0203 | 0.0192 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0097 | 0.0333 | 0.1499 |
Echinococcus multilocularis | tumor protein p63 | 0.1092 | 0.5552 | 0.6709 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0045 | 0.0063 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0199 | 0.0188 |
Echinococcus multilocularis | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0079 | 0.024 | 0.029 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0378 | 0.1806 | 0.1806 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0063 | 0.0154 | 0.0143 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0071 | 0.0199 | 0.0814 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0099 | 0.0087 |
Mycobacterium ulcerans | pyruvate kinase | 0.0065 | 0.0166 | 0.0124 |
Onchocerca volvulus | 0.0095 | 0.0323 | 0.0433 | |
Schistosoma mansoni | hypothetical protein | 0.0223 | 0.0994 | 0.0994 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0058 | 0.0128 | 0.0117 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0199 | 0.0188 |
Onchocerca volvulus | 0.016 | 0.0663 | 0.1373 | |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0024 | 0.0708 |
Loa Loa (eye worm) | pyruvate kinase | 0.0065 | 0.0166 | 0.0156 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0095 | 0.0323 | 0.0323 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0058 | 0.0128 | 0.0117 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.0324 | 0.0584 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.0542 | 0.0977 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0072 | 0.0203 | 0.0192 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0163 | 0.0294 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.0666 | 0.1199 |
Brugia malayi | RNA recognition motif domain containing protein | 0.071 | 0.3548 | 0.3541 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0077 | 0.0229 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | TAR-binding protein | 0.071 | 0.3548 | 0.3541 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0065 | 0.0166 | 0.5152 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0065 | 0.0166 | 0.0724 |
Giardia lamblia | Pyruvate kinase | 0.0065 | 0.0166 | 0.5003 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0114 | 0.042 | 0.0757 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.0561 | 0.0561 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.0666 | 0.0655 |
Echinococcus multilocularis | pyruvate kinase | 0.0051 | 0.0094 | 0.0114 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.0561 | 0.0551 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.0561 | 0.0561 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0087 | 0.0352 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0079 | 0.024 | 0.0229 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0071 | 0.0199 | 0.0814 |
Entamoeba histolytica | hypothetical protein | 0.0223 | 0.0994 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0097 | 0.0333 | 0.1499 |
Trichomonas vaginalis | glutaminase, putative | 0.194 | 1 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0071 | 0.0199 | 0.0157 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0199 | 0.0188 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0072 | 0.0203 | 0.0192 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0043 | 0.0149 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.0549 | 0.0549 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0057 | 0.0125 | 0.0114 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0196 | 0.0853 | 0.1031 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.016 | 0.0663 | 0.0663 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0291 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | pyruvate kinase | 0.0065 | 0.0166 | 0.0156 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.0561 | 0.0678 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0045 | 0.0063 | 0.0052 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0178 | 0.0757 | 0.0746 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0161 | 0.0669 | 0.1205 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0042 | 0.0043 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0072 | 0.0203 | 0.0192 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0042 | 0.0043 | 0.0078 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0095 | 0.0323 | 0.0323 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.024 | 0.024 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.0163 | 0.0152 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0097 | 0.0333 | 0.1499 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.2157 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0011 | 0.0013 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.0042 | 0.1289 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0024 | 0.0126 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0077 | 0.0229 | 0.0218 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0097 | 0.0333 | 0.0333 |
Trichomonas vaginalis | esterase, putative | 0.0071 | 0.0199 | 0.0188 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.0043 | 0.0032 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.0324 | 0.0392 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0042 | 0.0043 | 0.0325 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.2157 | 0.2148 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0099 | 0.0088 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0043 | 0.0149 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0199 | 0.0188 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0199 | 0.0814 |
Onchocerca volvulus | 0.0754 | 0.3782 | 1 | |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0011 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0163 | 0.0152 |
Echinococcus granulosus | tumor protein p63 | 0.1092 | 0.5552 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0095 | 0.0323 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0071 | 0.0199 | 0.0188 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0024 | 0.0982 |
Brugia malayi | RNA binding protein | 0.071 | 0.3548 | 0.3541 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0114 | 0.042 | 0.0508 |
Leishmania major | pyruvate kinase | 0.0065 | 0.0166 | 0.0724 |
Schistosoma mansoni | glutamate receptor kainate | 0.0178 | 0.0757 | 0.0757 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0071 | 0.0199 | 0.0814 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0083 | 0.0258 | 0.0248 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0087 | 0.361 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0163 | 0.0163 |
Schistosoma mansoni | tar DNA-binding protein | 0.071 | 0.3548 | 0.3548 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0178 | 0.0757 | 0.0746 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0163 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0557 | 0.0546 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0161 | 0.0669 | 0.0808 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.0563 | 0.0553 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.0042 | 0.0031 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0065 | 0.0166 | 0.0724 |
Loa Loa (eye worm) | RNA binding protein | 0.071 | 0.3548 | 0.3541 |
Echinococcus multilocularis | geminin | 0.0363 | 0.1726 | 0.2086 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0065 | 0.0166 | 0.0665 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0066 | 0.0169 | 0.0205 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0079 | 0.024 | 0.0229 |
Echinococcus multilocularis | glutamate receptor 2 | 0.013 | 0.0508 | 0.0614 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0065 | 0.0166 | 0.0156 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.0666 | 0.0805 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0071 | 0.0199 | 0.0359 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0095 | 0.0323 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0077 | 0.0229 | 0.1016 |
Brugia malayi | Pre-SET motif family protein | 0.0663 | 0.3302 | 0.3294 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0456 | 0.2218 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0178 | 0.0757 | 0.0914 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0199 | 0.0814 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0066 | 0.0169 | 0.0205 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.004 | 0.0036 | 0.0114 |
Echinococcus granulosus | geminin | 0.0363 | 0.1726 | 0.3109 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0097 | 0.0333 | 0.3272 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0223 | 0.0994 | 0.1791 |
Loa Loa (eye worm) | glutaminase | 0.194 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.0163 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0663 | 0.0652 |
Mycobacterium ulcerans | glutaminase | 0.194 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.2302 | 0.2294 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.0666 | 0.0655 |
Trichomonas vaginalis | set domain proteins, putative | 0.0754 | 0.3782 | 0.3775 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0057 | 0.0125 | 0.0114 |
Echinococcus granulosus | tar DNA binding protein | 0.071 | 0.3548 | 0.639 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0087 | 0.268 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.071 | 0.3548 | 0.3541 |
Echinococcus multilocularis | tar DNA binding protein | 0.071 | 0.3548 | 0.4288 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0097 | 0.0333 | 0.0322 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0196 | 0.0853 | 0.1031 |
Schistosoma mansoni | hypothetical protein | 0.0363 | 0.1726 | 0.1726 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.0042 | 0.0031 |
Leishmania major | pyruvate kinase | 0.0065 | 0.0166 | 0.0724 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0046 | 0.0065 | 0.025 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0199 | 0.0199 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0099 | 0.0088 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.0853 | 0.1031 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0042 | 0.0043 | 0.1335 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.0666 | 0.0805 |
Schistosoma mansoni | glutamate receptor kainate | 0.0178 | 0.0757 | 0.0757 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.0163 | 0.0152 |
Entamoeba histolytica | hypothetical protein | 0.0223 | 0.0994 | 1 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0097 | 0.0333 | 0.0599 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0472 | 0.2302 | 0.2782 |
Plasmodium vivax | hypothetical protein, conserved | 0.0071 | 0.0199 | 0.6161 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0099 | 0.0088 |
Loa Loa (eye worm) | inositol-1 | 0.0042 | 0.0043 | 0.0032 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0043 | 0.0149 |
Schistosoma mansoni | tar DNA-binding protein | 0.071 | 0.3548 | 0.3548 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0065 | 0.0166 | 0.8176 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0071 | 0.0199 | 0.0814 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0071 | 0.0199 | 0.0814 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0079 | 0.024 | 0.7425 |
Schistosoma mansoni | hypothetical protein | 0.0363 | 0.1726 | 0.1726 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0077 | 0.0229 | 0.0218 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0178 | 0.0757 | 0.0757 |
Leishmania major | hypothetical protein, conserved | 0.0071 | 0.0199 | 0.0876 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0077 | 0.0229 | 0.0218 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0097 | 0.0333 | 0.0322 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0072 | 0.0203 | 0.0192 |
Mycobacterium ulcerans | beta-lactamase | 0.0071 | 0.0199 | 0.0157 |
Brugia malayi | beta-lactamase | 0.0071 | 0.0199 | 0.0188 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0199 | 0.0157 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0099 | 0.0087 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0204 | 0.0896 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0087 | 0.0076 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.0561 | 0.1011 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0063 | 0.0052 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0065 | 0.0166 | 0.0724 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0199 | 0.0188 |
Toxoplasma gondii | ABC1 family protein | 0.0071 | 0.0199 | 0.6161 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0042 | 0.0043 | 0.0052 |
Brugia malayi | hypothetical protein | 0.005 | 0.0087 | 0.0076 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0087 | 0.361 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.2157 | 0.2148 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0097 | 0.0333 | 0.1499 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.0563 | 0.0563 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0378 | 0.1806 | 0.3252 |
Brugia malayi | Pre-SET motif family protein | 0.0095 | 0.0323 | 0.0312 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0096 | 0.033 | 0.0319 |
Entamoeba histolytica | hypothetical protein | 0.0223 | 0.0994 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0065 | 0.0166 | 0.0201 |
Schistosoma mansoni | glutaminase | 0.194 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.033 | 0.0452 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0071 | 0.0199 | 0.0876 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0178 | 0.0757 | 0.0746 |
Onchocerca volvulus | 0.0071 | 0.0199 | 0.009 | |
Brugia malayi | Glutamate receptor 1 precursor | 0.0178 | 0.0757 | 0.0746 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.0853 | 0.1031 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.0561 | 0.0551 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0071 | 0.0199 | 0.0241 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0043 | 0.0149 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0163 | 0.0197 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0097 | 0.0333 | 0.0322 |
Brugia malayi | hypothetical protein | 0.0072 | 0.02 | 0.0189 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.0561 | 0.0678 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0095 | 0.0323 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0199 | 0.0188 |
Echinococcus granulosus | glutamate receptor 2 | 0.0196 | 0.0853 | 0.1537 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.0549 | 0.0549 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.0561 | 0.0561 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0066 | 0.0169 | 0.0305 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0071 | 0.0199 | 0.0814 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0065 | 0.0166 | 0.0156 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0071 | 0.0199 | 0.0814 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0043 | 0.0043 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.0042 | 0.1289 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0071 | 0.0199 | 0.0157 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.0557 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1017 | 0.1007 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0087 | 0.0352 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0472 | 0.2302 | 0.4146 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0042 | 0.0043 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0323 | 0.0312 |
Schistosoma mansoni | pyruvate kinase | 0.0065 | 0.0166 | 0.0166 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0099 | 0.0088 |
Mycobacterium leprae | Probable lipase LipE | 0.0071 | 0.0199 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.0853 | 0.1537 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0095 | 0.0323 | 0.0323 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0097 | 0.0333 | 0.3272 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.033 | 0.033 |
Onchocerca volvulus | 0.0071 | 0.0199 | 0.009 | |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.0563 | 0.068 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0099 | 0.0087 |
Loa Loa (eye worm) | pyruvate kinase | 0.0065 | 0.0166 | 0.0156 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0199 | 0.0188 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0071 | 0.0199 | 0.0188 |
Schistosoma mansoni | tar DNA-binding protein | 0.071 | 0.3548 | 0.3548 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.014 | 0.0557 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0199 | 0.0188 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0663 | 0.3302 | 0.3294 |
Echinococcus multilocularis | NMDA receptor | 0.0066 | 0.0169 | 0.0205 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0223 | 0.0994 | 0.1201 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0011 | 0.0345 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.0853 | 0.1537 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.0043 | 0.0032 |
Schistosoma mansoni | tar DNA-binding protein | 0.071 | 0.3548 | 0.3548 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0095 | 0.0323 | 0.0323 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0087 | 0.0352 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.0199 | 0.0188 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.2157 | 1 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0066 | 0.0169 | 0.0205 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0095 | 0.0323 | 0.0391 |
Mycobacterium leprae | conserved hypothetical protein | 0.0071 | 0.0199 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0065 | 0.0166 | 0.5152 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0223 | 0.0994 | 0.0994 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0072 | 0.0203 | 0.6267 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0169 | 0.0169 |
Brugia malayi | glutaminase DH11.1 | 0.194 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1611 | 0.8275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0199 | 0.0188 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0097 | 0.0333 | 0.0402 |
Echinococcus granulosus | glutamate receptor 2 | 0.013 | 0.0508 | 0.0915 |
Schistosoma mansoni | pyruvate kinase | 0.0065 | 0.0166 | 0.0166 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.0561 | 0.1011 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0065 | 0.0166 | 0.0156 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0196 | 0.0853 | 0.1537 |
Brugia malayi | Inositol-1 | 0.0042 | 0.0043 | 0.0032 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.0199 | 0.0876 |
Plasmodium falciparum | pyruvate kinase | 0.0065 | 0.0166 | 0.6938 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0065 | 0.0166 | 0.0724 |
Schistosoma mansoni | glutamate receptor kainate | 0.0178 | 0.0757 | 0.0757 |
Echinococcus multilocularis | pyruvate kinase | 0.0065 | 0.0166 | 0.0201 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0087 | 0.0352 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0077 | 0.0229 | 0.1016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0072 | 0.0203 | 0.0192 |
Loa Loa (eye worm) | beta-lactamase | 0.0071 | 0.0199 | 0.0188 |
Giardia lamblia | GTOR | 0.0097 | 0.0333 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0065 | 0.0166 | 0.0156 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0097 | 0.0333 | 0.0322 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.0163 | 0.0197 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.0853 | 0.1031 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0097 | 0.0333 | 0.1499 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0095 | 0.0323 | 0.0391 |
Echinococcus granulosus | pyruvate kinase | 0.0065 | 0.0166 | 0.03 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0079 | 0.024 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.071 | 0.3548 | 0.3548 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0163 | 0.0163 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0011 | 0.0011 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0199 | 0.0188 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0071 | 0.0199 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0199 | 0.0188 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0199 | 0.0814 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0087 | 0.268 |
Onchocerca volvulus | 0.0071 | 0.0199 | 0.009 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.0042 | 0.0075 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.0042 | 0.1289 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0077 | 0.0229 | 0.0218 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0077 | 0.0229 | 0.1016 |
Brugia malayi | hypothetical protein | 0.0223 | 0.0994 | 0.0984 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0043 | 0.0043 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.0165 | 0.0154 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0204 | 0.0896 | 0.0885 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0058 | 0.0128 | 0.0117 |
Chlamydia trachomatis | pyruvate kinase | 0.0065 | 0.0166 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0378 | 0.1806 | 0.2182 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0166 | 0.0156 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.2157 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.0853 | 0.1537 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.024 | 0.0229 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0097 | 0.0333 | 0.0322 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0097 | 0.0333 | 0.1499 |
Onchocerca volvulus | 0.0093 | 0.0311 | 0.04 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0163 | 0.0197 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0066 | 0.0169 | 0.0305 |
Brugia malayi | hypothetical protein | 0.0472 | 0.2302 | 0.2294 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0072 | 0.0203 | 0.0192 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0066 | 0.0169 | 0.0205 |
Toxoplasma gondii | mitochondrial inner membrane translocase subunit TIM17, putative | 0.0079 | 0.024 | 0.7425 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0199 | 0.0199 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0178 | 0.0757 | 0.0757 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0896 | 0.0885 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0178 | 0.0757 | 0.0757 |
Brugia malayi | TAR-binding protein | 0.071 | 0.3548 | 0.3541 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.0199 | 0.0876 |
Entamoeba histolytica | hypothetical protein | 0.0223 | 0.0994 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.0199 | 0.0188 |
Brugia malayi | hypothetical protein | 0.0072 | 0.02 | 0.0189 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0066 | 0.0169 | 0.0305 |
Echinococcus granulosus | pyruvate kinase | 0.0065 | 0.0166 | 0.03 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0066 | 0.0169 | 0.0305 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0079 | 0.024 | 0.0229 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0092 | 0.0305 | 0.0549 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.0563 | 0.0553 |
Schistosoma mansoni | survival motor neuron protein | 0.0096 | 0.033 | 0.033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 33 nM | In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates | ChEMBL. | 1975275 |
IC50 (binding) | = 90 nM | In vitro inhibitory activity against [3H]-DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates | ChEMBL. | 1975275 |
IC50 (binding) | = 6800 nM | In vitro inhibitory activity against [3H]-TCP binding to PCP receptor in guinea pig brain membrane homogenates | ChEMBL. | 1975275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.