Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.1248 | 0.1248 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0033 | 0.1295 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.1248 | 0.2362 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0033 | 0.1295 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0033 | 0.1295 | 0.2451 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1248 | 0.2097 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0033 | 0.1295 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.5283 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.2451 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5283 | 0.888 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1248 | 0.1248 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.2451 |
Brugia malayi | RNA binding protein | 0.0066 | 0.5283 | 0.5283 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0033 | 0.1295 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0033 | 0.1295 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.5949 | 0.5949 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.2451 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5283 | 0.888 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0033 | 0.1295 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5283 | 0.888 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.2451 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1248 | 0.2097 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.5283 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0033 | 0.1295 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1248 | 0.2097 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1248 | 0.2362 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1248 | 0.2362 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1248 | 0.2362 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.5283 | 0.5283 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.1295 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5283 | 0.888 |
Brugia malayi | isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.1295 |
Brugia malayi | Isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.1295 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0033 | 0.1295 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.5283 | 0.5283 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1248 | 0.2097 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.5283 | 0.5283 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.1248 | 0.1248 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.2176 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0033 | 0.1295 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0033 | 0.1295 | 0.2451 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0033 | 0.1295 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.5283 | 0.5283 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5283 | 0.888 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.5949 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.5949 | 0.5949 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.5283 | 0.5283 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.1248 | 0.1248 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1248 | 0.2362 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.1248 | 0.2362 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2512 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.