Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0794 | 0.0794 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0676 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0046 | 0.0046 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0676 | 0.0676 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0046 | 0.0046 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0794 | 0.1195 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0046 | 0.007 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0046 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3312 | 0.3312 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0794 | 0.1195 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3312 | 0.3312 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0046 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0046 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 0.3312 | 0.4981 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0046 | 0.0046 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0676 | 0.0676 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 0.3312 | 0.4981 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0254 | 0.665 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 0.3312 | 0.4981 |
Brugia malayi | MH2 domain containing protein | 0.0254 | 0.665 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 0.3312 | 0.3312 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0676 | 0.1016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0794 | 0.0794 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0046 | 0.007 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0794 | 0.0794 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0046 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0676 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3312 | 0.3312 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0676 | 0.0676 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0046 | 0.007 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0046 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0046 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0794 | 0.0794 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 0.3312 | 0.3312 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0794 | 0.0794 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0046 | 0.0046 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0046 | 0.0046 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0046 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3312 | 0.3312 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0046 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0046 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0676 | 0.0676 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0676 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0676 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0046 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0046 | 0.0046 |
Echinococcus multilocularis | geminin | 0.0373 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0794 | 0.0794 |
Brugia malayi | RNA binding protein | 0.0135 | 0.3312 | 0.4981 |
Brugia malayi | TAR-binding protein | 0.0135 | 0.3312 | 0.4981 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0794 | 0.0794 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 0.3312 | 0.4981 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3312 | 0.3312 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0046 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0046 | 0.007 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0046 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0046 | 0.0046 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0046 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0046 | 0.0046 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0046 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0254 | 0.665 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.