Detailed information for compound 1320079

Basic information

Technical information
  • TDR Targets ID: 1320079
  • Name: N-(2-oxochromen-6-yl)pyridine-3-carboxamide
  • MW: 266.252 | Formula: C15H10N2O3
  • H donors: 1 H acceptors: 3 LogP: 1.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc2c(o1)ccc(c2)NC(=O)c1cccnc1
  • InChi: 1S/C15H10N2O3/c18-14-6-3-10-8-12(4-5-13(10)20-14)17-15(19)11-2-1-7-16-9-11/h1-9H,(H,17,19)
  • InChiKey: PNPGPGOQDGBLDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-oxo-6-chromenyl)-3-pyridinecarboxamide
  • N-(2-ketochromen-6-yl)nicotinamide
  • ST061716
  • ZINC00578578
  • MLS000075075
  • N-(2-Oxo-2H-chromen-6-yl)-nicotinamide
  • SMR000014853
  • BAS 08208013

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0147 0.0893 0.1381
Schistosoma mansoni hypothetical protein 0.0129 0.0771 0.0764
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0025 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0462 0.3102 0.3135
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0241 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0025 0.0027
Mycobacterium ulcerans hypothetical protein 0.0027 0.0054 0.0536
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0079 0.006
Echinococcus granulosus intermediate filament protein 0.0028 0.006 0.0036
Brugia malayi Pre-SET motif family protein 0.0829 0.5675 0.6244
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0528 0.0516
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.05 0.5597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0338 0.0521
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0144 0.012
Brugia malayi MH2 domain containing protein 0.006 0.0286 0.0288
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0528 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0208 0.0322
Loa Loa (eye worm) hypothetical protein 0.0147 0.0893 0.0984
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0035 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0286 0.0315
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.065 0.064
Loa Loa (eye worm) trypsin family protein 0.0112 0.065 0.0716
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.002 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0338 0.0521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0054 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0245 0.0378
Echinococcus granulosus GPCR family 2 0.0065 0.0321 0.0298
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.05 0.2356
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0137 0.0827 0.0804
Echinococcus multilocularis tumor protein p63 0.1447 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0338 0.0521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0188 0.0164
Echinococcus granulosus lamin dm0 0.0028 0.006 0.0036
Brugia malayi MH1 domain containing protein 0.0033 0.0098 0.0081
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0829 0.5675 0.6254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0338 0.0521
Schistosoma mansoni survival motor neuron protein 0.0047 0.0195 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0208 0.0321
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.03 0.0457
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0431 0.8341
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0577 0.0555
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0035 0.001
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0084 0.0867
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0528 0.5915
Brugia malayi RNA recognition motif domain containing protein 0.0462 0.3102 0.3401
Schistosoma mansoni hypothetical protein 0.0065 0.0321 0.0306
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0025 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0137 0.0827 0.082
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.065 0.064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0025 0.0004
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0301 0.1977 0.1957
Loa Loa (eye worm) hypothetical protein 0.014 0.0849 0.0936
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0054 0.0033
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0321 0.0298
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0027 0.0054 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.006
Loa Loa (eye worm) hypothetical protein 0.005 0.0218 0.024
Onchocerca volvulus 0.0112 0.065 0.0691
Onchocerca volvulus 0.0112 0.065 0.0691
Brugia malayi MH1 domain containing protein 0.0033 0.0098 0.0081
Loa Loa (eye worm) hypothetical protein 0.0147 0.0893 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0245 0.0378
Loa Loa (eye worm) beta-lactamase 0.0147 0.0893 0.0984
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0079 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.07 0.0691
Schistosoma mansoni tar DNA-binding protein 0.0462 0.3102 0.3135
Loa Loa (eye worm) acetyltransferase 0.0301 0.1977 0.2179
Echinococcus granulosus lamin 0.0028 0.006 0.0036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0363 0.0339
Onchocerca volvulus 0.0147 0.0893 0.0959
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.05 0.5172
Loa Loa (eye worm) hypothetical protein 0.0147 0.0893 0.0984
Loa Loa (eye worm) hypothetical protein 0.0041 0.0153 0.0168
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0129 0.0105
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0286 0.0315
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0286 0.0262
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0119 0.07 0.0677
Mycobacterium ulcerans beta-lactamase 0.0147 0.0893 1
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.0893 0.1381
Schistosoma mansoni smad 0.006 0.0286 0.027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0893 0.0887
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0218 0.4054
Echinococcus granulosus tar DNA binding protein 0.0462 0.3102 0.3085
Brugia malayi jmjC domain containing protein 0.004 0.0144 0.0131
Onchocerca volvulus 0.0119 0.07 0.0746
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0528 0.0505
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0577 0.0555
Echinococcus granulosus Smad4 0.006 0.0286 0.0262
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0079 0.0087
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0079 0.0122
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0035 0.001
Schistosoma mansoni smad 0.0027 0.0054 0.0034
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.0893 0.1381
Loa Loa (eye worm) hypothetical protein 0.0033 0.0098 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0008
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.065 0.064
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0893 0.1378
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0112 0.065 0.0691
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0025 0.0027
Echinococcus multilocularis microtubule associated protein 2 0.1425 0.985 0.9849
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.065 0.064
Loa Loa (eye worm) hypothetical protein 0.0112 0.065 0.0716
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0188 0.0207
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.0059
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0462 0.3102 0.3419
Echinococcus multilocularis transmembrane protease serine 3 0.0112 0.065 0.0627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0407 0.0629
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Trichomonas vaginalis esterase, putative 0.0147 0.0893 0.1378
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0528 1
Schistosoma mansoni hypothetical protein 0.0112 0.065 0.064
Onchocerca volvulus 0.1203 0.829 0.9134
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0054 0.003
Schistosoma mansoni tar DNA-binding protein 0.0462 0.3102 0.3135
Onchocerca volvulus 0.0944 0.6477 0.7131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0208 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0079 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0208 0.0322
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0528 0.5883
Onchocerca volvulus 0.0112 0.065 0.0691
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0528 1
Brugia malayi Trypsin family protein 0.1315 0.9073 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0431 0.8133
Mycobacterium leprae Probable lipase LipE 0.0147 0.0893 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.05 0.0477
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1478 0.1458
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0849 0.0911
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.0893 0.0871
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.0893 0.1381
Schistosoma mansoni hypothetical protein 0.0047 0.0195 0.0178
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0054 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0056
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0054 0.0536
Echinococcus granulosus smad 0.006 0.0286 0.0262
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0315 0.0347
Brugia malayi Trypsin family protein 0.0112 0.065 0.0691
Echinococcus granulosus glycoprotein Antigen 5 0.0112 0.065 0.0627
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0054 0.0536
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Echinococcus multilocularis glycoprotein Antigen 5 0.0112 0.065 0.0627
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0084 0.0937
Toxoplasma gondii ABC1 family protein 0.0147 0.0893 1
Brugia malayi hypothetical protein 0.0112 0.065 0.0691
Schistosoma mansoni smad1 5 8 and 0.006 0.0286 0.027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0025 0.0027
Schistosoma mansoni hypothetical protein 0.0065 0.0321 0.0306
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.0893 0.0959
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0188 0.0181
Brugia malayi Trypsin family protein 0.0112 0.065 0.0691
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.005 0.0055
Echinococcus multilocularis GPCR, family 2 0.0065 0.0321 0.0298
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.065 0.064
Brugia malayi hypothetical protein 0.0297 0.1945 0.2122
Toxoplasma gondii hypothetical protein 0.0033 0.0094 0.1058
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0893 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0239 0.0263
Echinococcus granulosus zinc finger protein 0.0028 0.0064 0.004
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0431 0.0418
Brugia malayi acetyltransferase, GNAT family protein 0.0301 0.1977 0.2158
Echinococcus multilocularis enteropeptidase 0.0112 0.065 0.0627
Echinococcus multilocularis musashi 0.0028 0.006 0.0036
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.0893 0.0984
Brugia malayi beta-lactamase 0.0147 0.0893 0.0959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0188 0.0171
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0321 0.0354
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0054 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.05 0.0771
Schistosoma mansoni coup transcription factor 0.0023 0.0025 0.0004
Mycobacterium ulcerans hypothetical protein 0.0147 0.0893 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0321 0.0298
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.03 0.0457
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.0893 0.1381
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.0893 0.0871
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0094 0.0989
Entamoeba histolytica hypothetical protein 0.0297 0.1945 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0066
Schistosoma mansoni zinc finger protein 0.0028 0.0064 0.0044
Echinococcus granulosus microtubule associated protein 2 0.1425 0.985 0.9849
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.05 0.0477
Brugia malayi hypothetical protein 0.0032 0.0094 0.0076
Leishmania major hypothetical protein, conserved 0.0147 0.0893 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0218 0.1711
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0371 0.3586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0188 0.0171
Schistosoma mansoni apoferritin-2 0.0035 0.0112 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0462 0.3102 0.3135
Plasmodium vivax SET domain protein, putative 0.0119 0.07 0.7821
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0079 0.0293
Brugia malayi MH1 domain containing protein 0.006 0.0286 0.0288
Onchocerca volvulus 0.0028 0.006 0.0039
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1478 0.1458
Onchocerca volvulus 0.0047 0.0195 0.0189
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0025 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0321 0.0298
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0054 0.0059
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0144 0.0125
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Schistosoma mansoni ferritin 0.0035 0.0112 0.0093
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0286 0.0262
Loa Loa (eye worm) RNA binding protein 0.0462 0.3102 0.3419
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.05 0.0551
Loa Loa (eye worm) hypothetical protein 0.0212 0.135 0.1488
Schistosoma mansoni apoferritin-2 0.0035 0.0112 0.0093
Entamoeba histolytica hypothetical protein 0.0297 0.1945 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0827 0.0911
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0134 0.011
Schistosoma mansoni hypothetical protein 0.0065 0.0321 0.0306
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0025 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.05 0.0772
Brugia malayi beta-lactamase family protein 0.0147 0.0893 0.0959
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0321 0.0328
Echinococcus granulosus peregrin 0.0041 0.0153 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0079 0.0122
Onchocerca volvulus 0.0112 0.065 0.0691
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0929 0.0925
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0084 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.05 0.0772
Brugia malayi intermediate filament protein 0.0028 0.006 0.0039
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0528 0.565
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1315 0.9073 0.921
Mycobacterium leprae conserved hypothetical protein 0.0147 0.0893 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0286 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0025 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0025 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.1304 0.1414
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0054 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0025 0.0027
Onchocerca volvulus 0.1315 0.9073 1
Echinococcus multilocularis tar DNA binding protein 0.0462 0.3102 0.3085
Onchocerca volvulus Alhambra homolog 0.0031 0.0084 0.0065
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0166 0.107
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.05 0.5563
Echinococcus multilocularis Mastin 0.0112 0.065 0.0627
Loa Loa (eye worm) hypothetical protein 0.023 0.1478 0.1629
Brugia malayi MH2 domain containing protein 0.006 0.0286 0.0288
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0094 0.0479
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Onchocerca volvulus 0.0112 0.065 0.0691
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0338 0.3781
Loa Loa (eye worm) nuclear factor I 0.0033 0.0098 0.0108
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0025 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.0893 0.1381
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0528 0.0505
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0936 0.6422 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Brugia malayi Trypsin family protein 0.0112 0.065 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.05 0.0772
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0079 0.0055
Onchocerca volvulus 0.0027 0.0054 0.0033
Schistosoma mansoni smad1 5 8 and 0.006 0.0286 0.027
Echinococcus multilocularis zinc finger protein 0.0028 0.0064 0.004
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.0893 0.1381
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0195 0.0189
Loa Loa (eye worm) hypothetical protein 0.0075 0.0394 0.0434
Brugia malayi jmjC domain containing protein 0.0101 0.0577 0.0611
Entamoeba histolytica hypothetical protein 0.0297 0.1945 1
Echinococcus granulosus transmembrane protease serine 3 0.0112 0.065 0.0627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0208 0.0321
Schistosoma mansoni smad1 5 8 and 0.006 0.0286 0.027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.037 0.0572
Brugia malayi hypothetical protein 0.023 0.1478 0.1607
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0771 0.0749
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0169 0.0145
Schistosoma mansoni lamin 0.0028 0.006 0.004
Plasmodium falciparum phd finger protein, putative 0.0031 0.0084 0.1473
Schistosoma mansoni hypothetical protein 0.014 0.0849 0.0843
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0119 0.07 0.0691
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0218 0.2385
Schistosoma mansoni ferritin 0.0035 0.0112 0.0093
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.0112 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.037 0.0572
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0301 0.1977 0.1991
Brugia malayi Bromodomain containing protein 0.0041 0.0153 0.0141
Onchocerca volvulus 0.0147 0.0893 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0208 0.0322
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0893 0.1378
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0371 0.3586
Loa Loa (eye worm) hypothetical protein 0.0147 0.0893 0.0984
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0286 0.0262
Loa Loa (eye worm) hypothetical protein 0.0051 0.0221 0.0244
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0025 0.0004
Echinococcus multilocularis expressed protein 0.0035 0.0112 0.0088
Echinococcus multilocularis peregrin 0.0041 0.0153 0.0129
Brugia malayi Bromodomain containing protein 0.0048 0.0203 0.0197
Brugia malayi PHD-finger family protein 0.0031 0.0084 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.037 0.0572
Schistosoma mansoni ferritin light chain 0.0035 0.0112 0.0093
Brugia malayi Probable ClpP-like protease 0.0094 0.0528 0.0556
Echinococcus granulosus enteropeptidase 0.0112 0.065 0.0627
Echinococcus granulosus histone lysine methyltransferase setb 0.0137 0.0827 0.0804
Loa Loa (eye worm) hypothetical protein 0.0112 0.065 0.0716
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0054 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0338 0.0521
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0084 0.0937
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0004
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.05 0.2356
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0929 0.0925
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6725 0.6717
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0297 0.1945 0.1926
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.05 0.5172
Schistosoma mansoni hypothetical protein 0.0112 0.065 0.064
Loa Loa (eye worm) hypothetical protein 0.1315 0.9073 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0878 0.6016 0.663
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.05 0.5172
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0134 0.011
Brugia malayi hypothetical protein 0.005 0.0218 0.0214
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.05 0.0488
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0054 0.0059
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0084 0.0092
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.03 0.0277
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.0929 0.0907
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0054 0.0536
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0008
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0112 0.065 0.0627
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.0669 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0079 0.0122
Schistosoma mansoni hypothetical protein 0.0297 0.1945 0.1958
Loa Loa (eye worm) Smad1 0.006 0.0286 0.0315
Schistosoma mansoni Smad4 0.006 0.0286 0.027
Brugia malayi Trypsin-like protease protein 5 0.0112 0.065 0.0691
Loa Loa (eye worm) transcription factor SMAD2 0.0878 0.6016 0.663
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0054 0.0536
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.1304 0.1414
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0035 0.0112 0.0691
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.0893 0.1381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0338 0.0521
Loa Loa (eye worm) hypothetical protein 0.0053 0.0236 0.026
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0112 0.065 0.064
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0893 1
Schistosoma mansoni Smad4 0.0027 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0094 0.0528 0.0582
Loa Loa (eye worm) TAR-binding protein 0.0462 0.3102 0.3419
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0188 0.0164
Mycobacterium ulcerans lipase LipD 0.0147 0.0893 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.037 0.0572
Schistosoma mansoni ferritin 0.0035 0.0112 0.0093
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.0112 0.0164
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0112 0.065 0.0627
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0218 0.1711
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.006 0.0066
Mycobacterium tuberculosis Conserved protein 0.0147 0.0893 0.1381
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0321 0.0328
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.0112 0.1189
Onchocerca volvulus 0.0212 0.135 0.1464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.05 0.0525
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0144 0.0158
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0321 0.0298
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0025 0.0004
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.03 0.2932
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.03 0.0277
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0528 0.5883
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.0112 0.1189
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0528 0.5883
Schistosoma mansoni tar DNA-binding protein 0.0462 0.3102 0.3135
Brugia malayi Pre-SET motif family protein 0.0119 0.07 0.0746
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0064
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.0893 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.05 0.5597
Loa Loa (eye worm) hypothetical protein 0.0112 0.065 0.0716
Loa Loa (eye worm) hypothetical protein 0.0147 0.0893 0.0984
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.05 0.5313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0188 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0137 0.0827 0.082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0062
Loa Loa (eye worm) hypothetical protein 0.0065 0.0321 0.0354
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0054 0.0074
Echinococcus multilocularis smad 0.006 0.0286 0.0262
Schistosoma mansoni ferritin 0.0035 0.0112 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.0893 1
Brugia malayi MH2 domain containing protein 0.0027 0.0054 0.0032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0119 0.07 0.7838
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0054 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0893 0.0887
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0286 0.0262
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Schistosoma mansoni cellular tumor antigen P53 0.0212 0.135 0.1353
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.065 0.064
Schistosoma mansoni Smad4 0.0027 0.0054 0.0034
Loa Loa (eye worm) hypothetical protein 0.0205 0.1304 0.1438
Loa Loa (eye worm) hypothetical protein 0.0147 0.0893 0.0984
Onchocerca volvulus 0.0147 0.0893 0.0959
Schistosoma mansoni ferritin light chain 0.0035 0.0112 0.0093
Echinococcus multilocularis ferritin 0.0035 0.0112 0.0088
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0297 0.1945 0.1926
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0431 0.1991
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0893 0.1378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0338 0.0521
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0084 0.006
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0371 0.3774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0291 0.045
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.006 0.0039
Echinococcus multilocularis Smad4 0.006 0.0286 0.0262
Schistosoma mansoni transcription factor LCR-F1 0.0297 0.1945 0.1958
Loa Loa (eye worm) hypothetical protein 0.1315 0.9073 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.013 0.0622
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1315 0.9073 0.921
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0893 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0188 0.0171
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0112 0.065 0.0627
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0112 0.065 0.0627
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.05 0.0771
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0025 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0208 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0054 0.0536
Schistosoma mansoni lamin 0.0028 0.006 0.004
Leishmania major hypothetical protein, conserved 0.005 0.0218 0.1954
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0528 0.5915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0278 0.0429
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0528 1
Brugia malayi MH1 domain containing protein 0.006 0.0286 0.0288
Loa Loa (eye worm) hypothetical protein 0.0112 0.065 0.0716
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0084 0.006
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0144 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.037 0.0572
Trichomonas vaginalis ferritin, putative 0.0035 0.0112 0.0173
Brugia malayi RNA binding protein 0.0462 0.3102 0.3401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0079 0.006
Schistosoma mansoni bromodomain containing protein 0.0075 0.0389 0.0376
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0169 0.0145
Brugia malayi Smad1 0.006 0.0286 0.0288
Onchocerca volvulus 0.0028 0.006 0.0039
Echinococcus granulosus Mastin 0.0112 0.065 0.0627
Schistosoma mansoni hypothetical protein 0.0065 0.0321 0.0306
Schistosoma mansoni intermediate filament proteins 0.0028 0.006 0.004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.05 0.5172
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0218 0.4054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0245 0.0378
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0771 0.0749
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0054 0.003
Brugia malayi TAR-binding protein 0.0462 0.3102 0.3401
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.0893 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.065 0.0716
Loa Loa (eye worm) intermediate filament protein 0.0028 0.006 0.0066
Trichomonas vaginalis set domain proteins, putative 0.0944 0.6477 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.05 0.5313
Entamoeba histolytica hypothetical protein 0.0297 0.1945 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0025 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0188 0.0164
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0893 0.1378
Echinococcus multilocularis lamin 0.0028 0.006 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0241 0.0372
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0218 0.2444
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0025 0.0004
Echinococcus granulosus expressed protein 0.0035 0.0112 0.0088
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0025 0.0004
Brugia malayi PHD-finger family protein 0.0034 0.0104 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0079 0.0122
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.0054 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0054 0.0536
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.1304 0.1438
Schistosoma mansoni microtubule-associated protein tau 0.1425 0.985 1
Brugia malayi Bromodomain containing protein 0.0087 0.0477 0.05
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0027
Giardia lamblia GTOR 0.009 0.05 1
Mycobacterium tuberculosis Conserved protein 0.0147 0.0893 0.1381
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0893 0.1378
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0094 0.1681
Echinococcus multilocularis lamin dm0 0.0028 0.006 0.0036
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.1901 0.1881
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.05 0.0477
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0008
Mycobacterium ulcerans hypothetical protein 0.0112 0.065 0.7258
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0528 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0363 0.0339
Brugia malayi MH2 domain containing protein 0.0878 0.6016 0.6621
Treponema pallidum bacterioferrin (TpF1) 0.0035 0.0112 0.041
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0218 0.1711
Brugia malayi beta-lactamase family protein 0.0147 0.0893 0.0959
Echinococcus granulosus ferritin 0.0035 0.0112 0.0088

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1836 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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