Detailed information for compound 1320254

Basic information

Technical information
  • TDR Targets ID: 1320254
  • Name: N-(4-fluorophenyl)-2-[7-(4-methylphenyl)sulfo nyl-8-oxo-[1,3]dioxolo[4,5-g]quinolin-5-yl]ac etamide
  • MW: 494.492 | Formula: C25H19FN2O6S
  • H donors: 1 H acceptors: 4 LogP: 3.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)c1cn(CC(=O)Nc2ccc(cc2)F)c2c(c1=O)cc1c(c2)OCO1
  • InChi: 1S/C25H19FN2O6S/c1-15-2-8-18(9-3-15)35(31,32)23-12-28(13-24(29)27-17-6-4-16(26)5-7-17)20-11-22-21(33-14-34-22)10-19(20)25(23)30/h2-12H,13-14H2,1H3,(H,27,29)
  • InChiKey: QMPVZMMYSFOQQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-fluorophenyl)-2-[8-keto-7-(4-methylphenyl)sulfonyl-[1,3]dioxolo[4,5-g]quinolin-5-yl]acetamide
  • N-(4-fluorophenyl)-2-[7-(4-methylphenyl)sulfonyl-8-oxo-[1,3]dioxolo[4,5-g]quinolin-5-yl]ethanamide
  • NCGC00111165-01
  • C655-0108

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia DNA damage repair protein 0.0083 0.0457 0.2225
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0002 0.0042
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.1905 0.384
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0032 0.0032
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0215 0.0434
Echinococcus granulosus expressed protein 0.0384 0.2953 0.2953
Trypanosoma brucei hypothetical protein, conserved 0.0083 0.0457 0.23
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0215 0.0215
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0267 0.1988 0.1988
Echinococcus granulosus dna polymerase eta 0.0267 0.1988 0.1988
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0032 0.0706
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0075 0.0389 0.0784
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Brugia malayi hypothetical protein 0.0028 0.0005 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0072 0.0145
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Brugia malayi PHD-finger family protein 0.003 0.0019 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0444 0.0444
Echinococcus multilocularis dna polymerase kappa 0.0267 0.1988 0.1988
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0215 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0215 0.0215
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0215 0.0215
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0072 0.0072
Trypanosoma brucei chrX additional, unordered contigs 0.0083 0.0457 0.23
Trypanosoma cruzi DNA polymerase eta, putative 0.0267 0.1988 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0626 0.496 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0267 0.1988 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Trypanosoma brucei DNA polymerase IV, putative 0.0267 0.1988 1
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0215 0.0434
Mycobacterium tuberculosis Conserved hypothetical protein 0.0267 0.1988 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0005 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0215 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0457 0.23
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0032 0.0162
Mycobacterium ulcerans DNA polymerase IV 0.0267 0.1988 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0215 0.0434
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0457 0.2293
Schistosoma mansoni hypothetical protein 0.0081 0.0444 0.0444
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0005 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0215 0.0434
Echinococcus multilocularis thyroid hormone receptor alpha 0.0054 0.0215 0.0215
Plasmodium falciparum DNA repair protein REV1, putative 0.0083 0.0457 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0215 0.0434
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0005 0.0005
Trypanosoma brucei unspecified product 0.0184 0.1299 0.6535
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0215 0.0215
Brugia malayi ImpB/MucB/SamB family protein 0.0267 0.1988 0.4008
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0318 0.064
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0267 0.1988 1
Brugia malayi nuclear receptor RXR 0.0028 0.0005 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0457 0.2293
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0005 0.0005
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0005 0.0005
Trypanosoma brucei DNA damage repair protein, putative 0.0083 0.0457 0.23
Trypanosoma brucei DNA polymerase kappa, putative 0.0184 0.1299 0.6535
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0626 0.496 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0457 0.2293
Echinococcus granulosus peregrin 0.003 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0215 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0215 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0215 0.0434
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0215 0.0434
Trypanosoma cruzi DNA damage repair protein, putative 0.0083 0.0457 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0215 0.0434
Brugia malayi steroid hormone receptor 0.0054 0.0215 0.0434
Schistosoma mansoni hypothetical protein 0.0176 0.1229 0.1229
Echinococcus multilocularis geminin 0.1233 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0215 0.0215
Loa Loa (eye worm) RNA binding protein 0.0066 0.0318 0.064
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0318 0.0318
Mycobacterium ulcerans DNA polymerase IV 0.0267 0.1988 1
Giardia lamblia DINP protein human, muc B family 0.0267 0.1988 1
Plasmodium falciparum phd finger protein, putative 0.003 0.0019 0.0419
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0444 0.0444
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0032 0.0032
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0083 0.0457 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0318 0.0318
Schistosoma mansoni DNA polymerase IV / kappa 0.0083 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0257 0.1905 0.384
Trypanosoma brucei hypothetical protein, conserved 0.0083 0.0457 0.23
Loa Loa (eye worm) hypothetical protein 0.0267 0.1988 0.4008
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0318 0.0318
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0318 0.064
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0444 0.0896
Leishmania major DNA polymerase kappa, putative 0.0083 0.0457 0.2293
Trypanosoma brucei DNA damage repair protein, putative 0.0083 0.0457 0.23
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0215 0.0434
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0054 0.0215 0.0215
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0215 0.0215
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0032 0.0162
Trypanosoma brucei DNA polymerase IV, putative 0.0267 0.1988 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0083 0.0457 1
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0215 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0215 0.0434
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.224 0.4518
Trypanosoma brucei unspecified product 0.0267 0.1988 1
Echinococcus multilocularis snurportin 1 0.0298 0.224 0.224
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0215 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0215 0.0215
Brugia malayi ecdysteroid receptor 0.0054 0.0215 0.0434
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.059 0.059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0626 0.496 0.496
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0032 0.0706
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0215 0.0215
Leishmania major DNA polymerase eta, putative 0.0267 0.1988 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0215 0.0434
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0444 0.0896
Brugia malayi TAR-binding protein 0.0066 0.0318 0.064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0215 1
Brugia malayi hypothetical protein 0.0028 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0052 0.0198 0.04
Schistosoma mansoni hypothetical protein 0.1233 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0009
Echinococcus multilocularis sentrin specific protease 8 0.0075 0.0389 0.0389
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0019 0.0019
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0267 0.1988 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0002 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0444 0.0444
Loa Loa (eye worm) Ulp1 protease 0.0075 0.0389 0.0784
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0267 0.1988 0.1988
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0318 0.0318
Echinococcus granulosus dna polymerase kappa 0.0267 0.1988 0.1988
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0215 0.0215
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0039
Echinococcus granulosus GPCR family 2 0.0081 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0028 0.0002 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0215 0.0215
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0215 0.0215
Trypanosoma brucei unspecified product 0.0184 0.1299 0.6535
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.059 0.059
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0005 0.0009
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0032 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0215 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0215 0.0434
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0009
Echinococcus granulosus sentrin specific protease 8 0.0075 0.0389 0.0389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0215 0.0434
Schistosoma mansoni terminal deoxycytidyl transferase 0.0267 0.1988 0.1988
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0318 0.0318
Trichomonas vaginalis DNA polymerase eta, putative 0.0267 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0444 0.0896
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Echinococcus granulosus snurportin 1 0.0298 0.224 0.224
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0215 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.1229 0.2477
Plasmodium vivax hypothetical protein, conserved 0.003 0.0019 0.0419
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0267 0.1988 0.4008
Brugia malayi isocitrate dehydrogenase 0.0032 0.0032 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0215 0.0434
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0184 0.1299 0.6535
Trypanosoma brucei DNA polymerase IV, putative 0.0267 0.1988 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0215 0.0215
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0117 0.0117
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0215 0.0434
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0019 0.0419
Trypanosoma cruzi DNA polymerase kappa, putative 0.0267 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0457 0.0922
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0032 0.0065
Schistosoma mansoni hypothetical protein 0.1233 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0267 0.1988 1
Leishmania major DNA damage repair protein, putative 0.0083 0.0457 0.2293
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0072 0.0072
Brugia malayi RNA binding protein 0.0066 0.0318 0.064
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0083 0.0457 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0267 0.1988 1
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0215 0.0215
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0267 0.1988 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0318 0.064
Echinococcus multilocularis GPCR, family 2 0.0081 0.0444 0.0444
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0032 0.0032
Onchocerca volvulus 0.0054 0.0215 1
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0032 0.0706
Schistosoma mansoni hypothetical protein 0.0081 0.0444 0.0444
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0421 0.0421
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0002 0.0042
Leishmania major DNA polymerase eta, putative 0.0083 0.0457 0.2293
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0597 0.4723 0.4723
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0457 0.23
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0117 0.0117
Schistosoma mansoni retinoic acid receptor RXR 0.0054 0.0215 0.0215
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0215 0.0434
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0215 1
Plasmodium vivax DNA repair protein REV1, putative 0.0083 0.0457 1
Schistosoma mansoni hypothetical protein 0.0081 0.0444 0.0444
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0184 0.1299 0.6535
Brugia malayi hypothetical protein 0.0028 0.0005 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0032 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Echinococcus multilocularis expressed protein 0.0384 0.2953 0.2953
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0215 0.0434
Echinococcus multilocularis dna polymerase eta 0.0267 0.1988 0.1988
Leishmania major DNA polymerase kappa, putative 0.0267 0.1988 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0444 0.0444
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.1229 0.2477
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Schistosoma mansoni hypothetical protein 0.0298 0.224 0.224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0215 0.0215
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0215 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0626 0.496 0.496
Brugia malayi jmjC domain containing protein 0.0037 0.0072 0.0145
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0032 0.0706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.1905 0.384
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0005 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0215 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0318 0.0318
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0002 0.0042
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0215 0.0215
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0002 0.0042
Brugia malayi nuclear hormone receptor 0.0054 0.0215 0.0434
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0215 0.0215
Brugia malayi ImpB/MucB/SamB family protein 0.0267 0.1988 0.4008
Schistosoma mansoni DNA polymerase eta 0.0267 0.1988 0.1988
Schistosoma mansoni coup transcription factor 0.0054 0.0215 0.0215
Echinococcus multilocularis peregrin 0.003 0.0019 0.0019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0444 0.0896
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0215 0.0434
Trypanosoma cruzi DNA damage repair protein, putative 0.0083 0.0457 0.2293
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0267 0.1988 0.1988
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0032 0.0153
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0019 0.0419
Trypanosoma brucei DNA polymerase eta, putative 0.0267 0.1988 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0075 0.0389 0.0389
Brugia malayi RNA, U transporter 1 0.0079 0.0427 0.0861
Echinococcus granulosus tar DNA binding protein 0.0066 0.0318 0.0318
Schistosoma mansoni hypothetical protein 0.003 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0267 0.1988 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0032 0.0153
Entamoeba histolytica deoxycytidyl transferase, putative 0.0267 0.1988 1
Brugia malayi nuclear receptor NHR-88 0.0054 0.0215 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0215 0.0434
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0019 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0434
Trypanosoma cruzi hypothetical protein 0.0075 0.0389 0.1948
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0286 0.0577
Brugia malayi Bromodomain containing protein 0.003 0.0019 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0215 1
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0072 0.0072
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.1905 0.384
Brugia malayi polk-prov protein 0.0083 0.0457 0.0922
Brugia malayi jmjC domain containing protein 0.0099 0.059 0.1189
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0081 0.0444 0.0444

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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