Detailed information for compound 1321120

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.434 | Formula: C22H21N5O3
  • H donors: 3 H acceptors: 4 LogP: 3.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)O)c1[nH]nc(c1)C(=O)Nc1c(C)n(n(c1=O)c1ccccc1)C
  • InChi: 1S/C22H21N5O3/c1-13-9-10-16(19(28)11-13)17-12-18(25-24-17)21(29)23-20-14(2)26(3)27(22(20)30)15-7-5-4-6-8-15/h4-12,28H,1-3H3,(H,23,29)(H,24,25)
  • InChiKey: LBFWDYHWPUWYFS-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Schistosoma mansoni smad 0.0057 0.0131 0.0446
Echinococcus multilocularis maspardin 0.0036 0.0062 0.0233
Mycobacterium ulcerans hydrolase 0.0036 0.0062 0.0018
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0022 0.0014 0.0053
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0036 0.0062 0.2094
Mycobacterium ulcerans hydrolase 0.0048 0.0101 0.0058
Echinococcus granulosus tyrosine protein kinase Fyn 0.0022 0.0014 0.0053
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0048 0.0101 0.028
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0048 0.0101 0.0215
Schistosoma mansoni Smad4 0.0025 0.0024 0.0039
Mycobacterium tuberculosis Unknown protein 0.0036 0.0062 0.0026
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0048 0.0101 0.0383
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0098 0.0371
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0098 0.0371
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0345 0.1116 0.4002
Schistosoma mansoni hypothetical protein 0.0146 0.0437 0.161
Toxoplasma gondii hypothetical protein 0.0048 0.0101 0.442
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0096 0.0264 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0022 0.0014 0.0053
Toxoplasma gondii ABC1 family protein 0.0031 0.0044 0.1053
Brugia malayi SRC-1 0.0022 0.0014 0.0025
Trypanosoma cruzi amidase, putative 0.0096 0.0264 0.0888
Brugia malayi MH1 domain containing protein 0.0057 0.0131 0.0448
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0032 0.0047 0.1215
Plasmodium falciparum alpha/beta hydrolase, putative 0.0048 0.0101 0.028
Mycobacterium tuberculosis Possible lysophospholipase 0.0848 0.2835 0.2809
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0196 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Echinococcus multilocularis muscleblind protein 1 0.0129 0.0378 0.143
Echinococcus multilocularis inositol monophosphatase 1 0.0032 0.0047 0.0177
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0098 0.0371
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0022 0.0014 0.0053
Onchocerca volvulus Alpha\/beta hydrolase2 homolog 0.0036 0.0062 1
Brugia malayi MH2 domain containing protein 0.0831 0.2778 1
Treponema pallidum carboxylesterase (est) 0.0036 0.0062 0.1467
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0199 0.0616 0.0583
Toxoplasma gondii hypothetical protein 0.0026 0.0027 0.0049
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0345 0.1116 0.4002
Schistosoma mansoni smad1 5 8 and 0.0057 0.0131 0.0446
Plasmodium vivax unspecified product 0.0048 0.0101 0.028
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0048 0.0101 0.028
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0096 0.0264 0.0888
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0044 0.0133
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0048 0.0101 0.0215
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0047 0.001
Toxoplasma gondii hypothetical protein 0.0036 0.0062 0.2094
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0196 0.0693
Brugia malayi MH2 domain containing protein 0.0057 0.0131 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Mycobacterium ulcerans hypothetical protein 0.0036 0.0062 0.0018
Leishmania major hypothetical protein, conserved 0.0048 0.0101 0.028
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0044 0.0067
Onchocerca volvulus 0.0031 0.0044 0.5258
Brugia malayi beta-lactamase family protein 0.0031 0.0044 0.0133
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0022 0.0014 0.0053
Schistosoma mansoni smad 0.0025 0.0024 0.0039
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0096 0.0264 1
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0044 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0098 0.0371
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0022 0.0014 0.0053
Mycobacterium ulcerans hydrolase 0.0036 0.0062 0.0018
Echinococcus granulosus fatty acid amide hydrolase 1 0.0792 0.2645 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0022 0.0014 0.0053
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0048 0.0101 0.0332
Echinococcus granulosus tyrosine protein kinase Lyn 0.0022 0.0014 0.0053
Brugia malayi hypothetical protein 0.0026 0.0026 0.0068
Loa Loa (eye worm) amidase 0.0096 0.0264 0.0928
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0044 0.0067
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0022 0.0014 0.0053
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0098 0.032
Schistosoma mansoni fatty-acid amide hydrolase 0.0096 0.0264 0.0952
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.2945 1 1
Toxoplasma gondii hypothetical protein 0.0048 0.0101 0.442
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0062 0.0026
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0107 0.0072
Trypanosoma cruzi amidase, putative 0.0096 0.0264 0.0888
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0044 0.0061
Mycobacterium ulcerans hypothetical protein 0.0036 0.0062 0.0018
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0048 0.0101 0.028
Loa Loa (eye worm) hypothetical protein 0.0129 0.0378 0.1339
Toxoplasma gondii phospholipase 0.0048 0.0101 0.442
Leishmania major hypothetical protein, conserved 0.0036 0.0062 0.0133
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0048 0.0101 0.0332
Plasmodium falciparum esterase, putative 0.0048 0.0101 0.028
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0044 0.0166
Brugia malayi beta-lactamase 0.0031 0.0044 0.0133
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Plasmodium vivax PST-A protein 0.0048 0.0101 0.028
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0098 0.0268
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0098 0.0371
Trypanosoma brucei monoglyceride lipase, putative 0.0812 0.2711 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0196 0.5827
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0048 0.0101 0.0215
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0057 0.0131 0.0446
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0159 0.0553
Brugia malayi Smad1 0.0057 0.0131 0.0448
Leishmania major hypothetical protein, conserved 0.0036 0.0062 0.0133
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0159 0.055
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0048 0.0101 0.0215
Echinococcus granulosus maspardin 0.0036 0.0062 0.0233
Brugia malayi MH2 domain containing protein 0.0057 0.0131 0.0448
Toxoplasma gondii hypothetical protein 0.0048 0.0101 0.442
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0098 0.0268
Schistosoma mansoni smad1 5 8 and 0.0057 0.0131 0.0446
Mycobacterium tuberculosis Probable epoxide hydrolase EphC (epoxide hydratase) 0.0036 0.0062 0.0026
Loa Loa (eye worm) inositol-1 0.0032 0.0047 0.0143
Brugia malayi Probable ClpP-like protease 0.0076 0.0196 0.0683
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0048 0.0101 0.0215
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0047 0.001
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0022 0.0014 0.0053
Plasmodium falciparum epoxide hydrolase 2 0.0048 0.0101 0.028
Plasmodium falciparum BEM46-like protein, putative 0.0048 0.0101 0.028
Echinococcus granulosus tyrosine protein kinase Fyn 0.0022 0.0014 0.0053
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0096 0.0264 0.0846
Loa Loa (eye worm) hypothetical protein 0.0236 0.0743 0.2657
Entamoeba histolytica ;Alias 0.0048 0.0101 0.0205
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0098 0.0268
Plasmodium vivax alpha/beta hydrolase, putative 0.0048 0.0101 0.028
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0098 0.0063
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0107 0.0405
Brugia malayi MH1 domain containing protein 0.0031 0.0045 0.0136
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0048 0.0101 0.0205
Trypanosoma brucei Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0044 0.0009
Mycobacterium tuberculosis Probable oxidoreductase 0.0036 0.0062 0.0026
Echinococcus granulosus TGF beta signal transducer SmadC 0.0057 0.0131 0.0497
Entamoeba histolytica hypothetical protein 0.0048 0.0101 0.0205
Echinococcus multilocularis geminin 0.0146 0.0437 0.1654
Mycobacterium tuberculosis Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap) 0.0036 0.0062 0.0026
Loa Loa (eye worm) RNA binding protein 0.0065 0.0159 0.055
Echinococcus granulosus abhydrolase domain containing protein 13 0.0048 0.0101 0.0383
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0044 0.0067
Toxoplasma gondii hypothetical protein 0.0036 0.0062 0.2094
Plasmodium falciparum lysophospholipase, putative 0.0048 0.0101 0.028
Schistosoma mansoni inositol monophosphatase 0.0032 0.0047 0.0124
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0133
Loa Loa (eye worm) Smad1 0.0057 0.0131 0.0448
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0044 0.0114
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0133
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0109 0.0311 0.1175
Plasmodium falciparum lysophospholipase, putative 0.0048 0.0101 0.028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0047 0.0077
Schistosoma mansoni hypothetical protein 0.0109 0.0311 0.1128
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0196 0.0153
Brugia malayi MH1 domain containing protein 0.0031 0.0045 0.0136
Brugia malayi CCG1-interacting factor B 0.0036 0.0062 0.0197
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0048 0.0101 0.028
Brugia malayi Latrophilin receptor protein 2 0.0109 0.0311 0.1095
Echinococcus granulosus tar DNA binding protein 0.0065 0.0159 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.2711 1
Brugia malayi RNA binding protein 0.0065 0.0159 0.055
Echinococcus granulosus abhydrolase domain containing protein 8 0.0036 0.0062 0.0233
Trypanosoma cruzi monoglyceride lipase, putative 0.0812 0.2711 1
Mycobacterium ulcerans oxidoreductase 0.0036 0.0062 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Mycobacterium ulcerans hypothetical protein 0.0048 0.0101 0.0058
Mycobacterium ulcerans amidase 0.0096 0.0264 0.0221
Mycobacterium ulcerans hydrolase 0.0036 0.0062 0.0018
Mycobacterium tuberculosis Conserved protein 0.0036 0.0062 0.0026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0027 0.0003
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0096 0.0264 0.023
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0096 0.0264 0.0888
Loa Loa (eye worm) MH2 domain-containing protein 0.0057 0.0131 0.0448
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0159 0.0553
Echinococcus granulosus fatty acid amide hydrolase 1 0.0096 0.0264 0.0999
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0044 0.0009
Echinococcus granulosus protein phosphatase methylesterase 1 0.0036 0.0062 0.0233
Mycobacterium tuberculosis Possible hydrolase 0.0036 0.0062 0.0026
Brugia malayi Muscleblind-like protein 0.0129 0.0378 0.1339
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0044 0.0166
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Schistosoma mansoni hypothetical protein 0.0109 0.0311 0.1128
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0159 0.0553
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0062 0.0133
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0098 0.0268
Plasmodium falciparum alpha/beta hydrolase, putative 0.0048 0.0101 0.028
Echinococcus granulosus fatty acid amide hydrolase 1 0.0792 0.2645 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0098 0.0328
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0062 0.0026
Leishmania major monoglyceride lipase, putative 0.0812 0.2711 1
Onchocerca volvulus Putative protein phosphatase methylesterase 1 0.0036 0.0062 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0101 0.0066
Schistosoma mansoni hypothetical protein 0.0236 0.0743 0.2772
Loa Loa (eye worm) amidase 0.0096 0.0264 0.0928
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0136
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0159 0.055
Plasmodium falciparum alpha/beta hydrolase, putative 0.0048 0.0101 0.028
Echinococcus granulosus mothers against decapentaplegic 5 0.0057 0.0131 0.0497
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0096 0.0264 0.0999
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0048 0.0101 0.028
Echinococcus multilocularis mothers against decapentaplegic 2 0.0025 0.0024 0.0092
Loa Loa (eye worm) hypothetical protein 0.0129 0.0378 0.1339
Echinococcus granulosus GPCR family 2 0.0109 0.0311 0.1175
Plasmodium vivax PST-A protein 0.0048 0.0101 0.028
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0792 0.2645 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0107 0.0072
Mycobacterium ulcerans peptide amidase, GatA 0.0096 0.0264 0.0221
Mycobacterium tuberculosis Probable lipase/esterase LipG 0.0036 0.0062 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0044 0.0067
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0057 0.0131 0.0497
Echinococcus multilocularis mothers against decapentaplegic 6 0.0025 0.0024 0.0092
Echinococcus multilocularis smad 0.0057 0.0131 0.0497
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0007 0.0027
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0048 0.0101 0.442
Mycobacterium ulcerans hydrolase 0.0036 0.0062 0.0018
Toxoplasma gondii hypothetical protein 0.0048 0.0101 0.442
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0096 0.0264 0.023
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.034
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0062 0.0133
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0098 0.423
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0133
Brugia malayi mothers against decapentaplegic homolog 3 0.0025 0.0024 0.0062
Loa Loa (eye worm) transcription factor SMAD2 0.0831 0.2778 1
Echinococcus granulosus tyrosine protein kinase Blk 0.002 0.0007 0.0027
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0048 0.0101 0.028
Echinococcus granulosus smad 0.0057 0.0131 0.0497
Mycobacterium tuberculosis Conserved protein 0.0036 0.0062 0.0026
Schistosoma mansoni fatty-acid amide hydrolase 0.0792 0.2645 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0062 0.0018
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0047 0.0077
Plasmodium falciparum esterase, putative 0.0048 0.0101 0.028
Brugia malayi MGC79044 protein 0.0048 0.0101 0.034
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0101 0.028
Plasmodium falciparum esterase, putative 0.0812 0.2711 1
Schistosoma mansoni amidase 0.0792 0.2645 1
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0812 0.2711 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0311 0.1095
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0096 0.0264 0.0952
Mycobacterium tuberculosis Unknown protein 0.0036 0.0062 0.0026
Echinococcus granulosus mothers against decapentaplegic 6 0.0025 0.0024 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0096 0.0264 0.0999
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0036 0.0062 0.2094
Loa Loa (eye worm) nuclear factor I 0.0031 0.0045 0.0136
Brugia malayi hydrolase, alpha/beta fold family protein 0.0036 0.0062 0.0197
Plasmodium vivax alpha/beta hydrolase, putative 0.0048 0.0101 0.028
Onchocerca volvulus 0.0036 0.0062 1
Mycobacterium ulcerans epoxide hydrolase EphC 0.0036 0.0062 0.0018
Echinococcus granulosus tyrosine protein kinase Src42A 0.0022 0.0014 0.0053
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0022 0.0014 0.0053
Echinococcus multilocularis abhydrolase domain containing protein 13 0.0036 0.0062 0.0233
Brugia malayi Calcitonin receptor-like protein seb-1 0.0345 0.1116 0.4002
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0024 0.0062
Echinococcus granulosus tyrosine kinase 0.002 0.0007 0.0027
Mycobacterium ulcerans thioesterase 0.0036 0.0062 0.0018
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Plasmodium vivax PST-A protein 0.0048 0.0101 0.028
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0196 0.0603
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0048 0.0101 0.442
Mycobacterium ulcerans amidase 0.0096 0.0264 0.0221
Trypanosoma brucei monoglyceride lipase, putative 0.0812 0.2711 1
Mycobacterium tuberculosis Possible hydrolase 0.0036 0.0062 0.0026
Brugia malayi beta-lactamase family protein 0.0031 0.0044 0.0133
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0159 0.055
Leishmania major hypothetical protein, conserved 0.0048 0.0101 0.028
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0196 0.0634
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0062 0.0124
Mycobacterium tuberculosis Possible lipase LipV 0.0036 0.0062 0.0026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0068
Echinococcus multilocularis Smad4 0.0057 0.0131 0.0497
Brugia malayi MH2 domain containing protein 0.0025 0.0024 0.0062
Toxoplasma gondii peptidase S15, putative 0.0048 0.0101 0.442
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0812 0.2711 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0133
Schistosoma mansoni hypothetical protein 0.0109 0.0311 0.1128
Mycobacterium ulcerans amidase 0.0096 0.0264 0.0221
Brugia malayi Amidase family protein 0.0096 0.0264 0.0928
Toxoplasma gondii hypothetical protein 0.0036 0.0062 0.2094
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0027 0.0003
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0848 0.2835 1
Mycobacterium tuberculosis Conserved protein 0.0031 0.0044 0.0009
Mycobacterium tuberculosis Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase) 0.0036 0.0062 0.0026
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0096 0.0264 0.0999
Mycobacterium ulcerans amidase 0.0096 0.0264 0.0221
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0196 1
Entamoeba histolytica hypothetical protein 0.0048 0.0101 0.0205
Brugia malayi MH1 domain containing protein 0.0057 0.0131 0.0448
Mycobacterium ulcerans lysophospholipase 0.0036 0.0062 0.0018
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0032 0.0047 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0062 0.0026
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0098 0.0268
Echinococcus granulosus inositol monophosphatase 1 0.0032 0.0047 0.0177
Trichomonas vaginalis inositol monophosphatase, putative 0.0032 0.0047 0.001
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0096 0.0264 0.023
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0048 0.0101 0.442
Echinococcus granulosus geminin 0.0146 0.0437 0.1654
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0792 0.2645 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0062 0.0018
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0048 0.0101 0.028
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.002 0.0007 0.0027
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0029 0.0035 0.003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0196 0.0153
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0036 0.0062 0.0026
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0098 0.0328
Toxoplasma gondii protein c14orf29, putative 0.0048 0.0101 0.442
Onchocerca volvulus Valacyclovir hydrolase homolog 0.0036 0.0062 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0812 0.2711 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0062
Echinococcus multilocularis protein phosphatase methylesterase 1 0.0036 0.0062 0.0233
Schistosoma mansoni hypothetical protein 0.0146 0.0437 0.161
Echinococcus multilocularis abhydrolase domain containing 3 0.0048 0.0101 0.0383
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0107 0.0405
Loa Loa (eye worm) latrophilin receptor protein 2 0.0109 0.0311 0.1095
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0048 0.0101 0.028
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0196 0.0742
Echinococcus granulosus muscleblind protein 0.0129 0.0378 0.143
Brugia malayi protein phosphatase methylesterase 1 0.0036 0.0062 0.0197
Brugia malayi putative amidase 0.0096 0.0264 0.0928
Trypanosoma cruzi serine peptidase, putative 0.0048 0.0101 0.028
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0101 0.028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0098 0.0371
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0048 0.0101 0.028
Schistosoma mansoni Smad4 0.0057 0.0131 0.0446
Schistosoma mansoni Smad4 0.0025 0.0024 0.0039
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0812 0.2711 1
Mycobacterium ulcerans lipase LipV 0.0036 0.0062 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0101 0.028
Loa Loa (eye worm) SRC-1 0.0022 0.0014 0.0025
Brugia malayi amidase 0.0792 0.2645 0.9517
Plasmodium falciparum lysophospholipase, putative 0.0812 0.2711 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0022 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0196 0.0683
Brugia malayi Protein C20orf22 0.0048 0.0101 0.034
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0048 0.0101 0.0215
Plasmodium vivax PST-A protein 0.0812 0.2711 1
Onchocerca volvulus 0.0031 0.0044 0.5258
Mycobacterium leprae Possible membrane protein 0.0036 0.0062 0.0124
Loa Loa (eye worm) protein phosphatase methylesterase 1 0.0036 0.0062 0.0197
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0044 0.0009
Mycobacterium tuberculosis Possible hydrolase 0.0036 0.0062 0.0026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0109 0.0311 0.1175
Echinococcus multilocularis muscleblind protein 0.0129 0.0378 0.143
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0812 0.2711 1
Leishmania major hypothetical protein, conserved 0.0096 0.0264 0.0888
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0098 0.423
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0107 0.0286
Leishmania major hypothetical protein, conserved 0.0036 0.0062 0.0133
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.034
Echinococcus granulosus Phospholipase carboxylesterase 0.0048 0.0101 0.0383
Brugia malayi Amidase family protein 0.0096 0.0264 0.0928
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0109 0.0311 0.1175
Plasmodium falciparum lysophospholipase, putative 0.0812 0.2711 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0048 0.0101 0.028
Loa Loa (eye worm) MH2 domain-containing protein 0.0831 0.2778 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0098 0.0268
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0047 0.0077
Plasmodium vivax lysophospholipase, putative 0.0048 0.0101 0.028
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0812 0.2711 1
Echinococcus granulosus Smad4 0.0057 0.0131 0.0497
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0096 0.0264 0.023
Mycobacterium ulcerans hydrolase 0.0036 0.0062 0.0018
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0096 0.0264 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0109 0.0311 0.1175
Brugia malayi latrophilin 2 splice variant baaae 0.0236 0.0743 0.2657
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0044 0.0009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0044 0.0009
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0048 0.0101 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0159 0.0553
Mycobacterium ulcerans hypothetical protein 0.0812 0.2711 0.2679
Brugia malayi isocitrate dehydrogenase 0.0047 0.0098 0.0328
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0036 0.0062 0.0026
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0159 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0159 0.0553
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0044 0.0133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0062 0.0026
Plasmodium vivax unspecified product 0.0048 0.0101 0.028
Brugia malayi Inositol-1 0.0032 0.0047 0.0143
Brugia malayi MGC83647 protein 0.0048 0.0101 0.034
Plasmodium vivax PST-A protein 0.0048 0.0101 0.028
Toxoplasma gondii chain a, pp2a-specific methylesterase apo form (pme), putative 0.0036 0.0062 0.2094
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0096 0.0264 0.0221
Mycobacterium ulcerans lysophospholipase 0.0812 0.2711 0.2679
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0048 0.0101 0.028
Mycobacterium leprae POSSIBLE HYDROLASE 0.0036 0.0062 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Mycobacterium tuberculosis Probable lignin peroxidase LipJ 0.0036 0.0062 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0109 0.0311 0.1095
Plasmodium vivax PST-A protein 0.0048 0.0101 0.028
Loa Loa (eye worm) CCG1-interacting factor B 0.0036 0.0062 0.0197
Mycobacterium leprae Possible hydrolase 0.0036 0.0062 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0048 0.0101 0.0215
Loa Loa (eye worm) hypothetical protein 0.0345 0.1116 0.4002
Echinococcus multilocularis tyrosine protein kinase Blk 0.002 0.0007 0.0027
Plasmodium vivax lysophospholipase, putative 0.0048 0.0101 0.028
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0048 0.0101 1
Schistosoma mansoni hypothetical protein 0.0109 0.0311 0.1128
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0048 0.0101 0.0215
Mycobacterium ulcerans hypothetical protein 0.0048 0.0101 0.0058
Loa Loa (eye worm) beta-lactamase 0.0031 0.0044 0.0133
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0048 0.0101 0.0383
Mycobacterium ulcerans hydrolase 0.0036 0.0062 0.0018
Echinococcus multilocularis Phospholipase carboxylesterase 0.0048 0.0101 0.0383
Plasmodium falciparum lysophospholipase, putative 0.0812 0.2711 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0196 0.5827
Echinococcus granulosus tyrosine protein kinase Fyn 0.0022 0.0014 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.2711 1
Mycobacterium leprae Probable lipase LipE 0.0031 0.0044 0.0061
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0096 0.0264 0.0846
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0096 0.0264 0.023
Mycobacterium tuberculosis Conserved protein 0.0031 0.0044 0.0009
Loa Loa (eye worm) hypothetical protein 0.0792 0.2645 0.9517
Mycobacterium ulcerans hypothetical protein 0.0036 0.0062 0.0018
Mycobacterium leprae PROBABLE LIPASE/ESTERASE LIPG 0.0036 0.0062 0.0124
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0098 0.0268
Toxoplasma gondii phospholipase/carboxylesterase 0.0048 0.0101 0.442
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0812 0.2711 1
Mycobacterium tuberculosis Probable epoxide hydrolase EphB (epoxide hydratase) 0.0036 0.0062 0.0026
Loa Loa (eye worm) MH1 domain-containing protein 0.0057 0.0131 0.0448
Plasmodium vivax lysophospholipase, putative 0.0048 0.0101 0.028
Schistosoma mansoni smad1 5 8 and 0.0057 0.0131 0.0446
Plasmodium falciparum exported lipase 1 0.0048 0.0101 0.028
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0036 0.0062 0.0133
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0024 0.0062
Schistosoma mansoni inositol monophosphatase 0.0032 0.0047 0.0124
Echinococcus multilocularis GPCR, family 2 0.0109 0.0311 0.1175
Echinococcus granulosus mothers against decapentaplegic 2 0.0025 0.0024 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0044 0.0114
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0036 0.0062 0.0026
Plasmodium falciparum prodrug activation and resistance esterase 0.0048 0.0101 0.028
Echinococcus multilocularis tyrosine protein kinase Srms 0.002 0.0007 0.0027
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0048 0.0101 0.028
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0196 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.0215
Echinococcus multilocularis abhydrolase domain containing protein 8 0.0036 0.0062 0.0233
Plasmodium falciparum alpha/beta hydrolase, putative 0.0048 0.0101 0.028
Onchocerca volvulus 0.0031 0.0044 0.5258
Mycobacterium ulcerans amidase 0.0096 0.0264 0.0221
Mycobacterium tuberculosis Unknown protein 0.0036 0.0062 0.0026
Leishmania major hypothetical protein, conserved 0.0031 0.0044 0.0067
Schistosoma mansoni protein phosphatase methylesterase 1 (S33 family) 0.0036 0.0062 0.0181
Onchocerca volvulus 0.0036 0.0062 1
Mycobacterium tuberculosis Conserved protein 0.0031 0.0044 0.0009
Echinococcus granulosus abhydrolase domain containing 3 0.0048 0.0101 0.0383
Plasmodium falciparum exported lipase 2 0.0048 0.0101 0.028
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0036 0.0062 0.0066
Schistosoma mansoni peptidase 0.0048 0.0101 0.0332
Trypanosoma cruzi serine peptidase, putative 0.0048 0.0101 0.028
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0812 0.2711 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0044 0.0009
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0196 0.6873
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0096 0.0264 0.0888
Brugia malayi TAR-binding protein 0.0065 0.0159 0.055
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0022 0.0014 0.0053
Echinococcus multilocularis mothers against decapentaplegic 5 0.0057 0.0131 0.0497
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0133
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0196 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0022 0.0014 0.0053
Leishmania major hypothetical protein, conserved 0.0036 0.0062 0.0133
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0196 0.7134

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.1042 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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