TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 294.391 | Formula: C19H22N2O
H donors: 1 H acceptors: 0 LogP: 4.49 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(N/N=C/1\CC(Oc2c1cccc2)c1ccccc1)(C)C
InChi: 1S/C19H22N2O/c1-19(2,3)21-20-16-13-18(14-9-5-4-6-10-14)22-17-12-8-7-11-15(16)17/h4-12,18,21H,13H2,1-3H3/b20-16+
InChiKey: VHROBQTXHXDELU-CAPFRKAQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Streptococcus pyogenes serotype M1	Streptokinase A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania braziliensis	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium vivax	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus granulosus	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Theileria parva	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	ko:K01527 nascent polypeptide-associated complex subunit beta, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Entamoeba histolytica	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Cryptosporidium parvum	BTF domain, basal transcription factor	Get druggable targets OG5_127333	All targets in OG5_127333
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania major	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	beta-NAC-like protein	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania mexicana	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma brucei	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus multilocularis	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Neospora caninum	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium knowlesi	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Toxoplasma gondii	NAC domain-containing protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma brucei gambiense	nascent polypeptide associated complex alpha subunit, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium berghei	transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Cryptosporidium hominis	NAC domain protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania donovani	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	ICD-1 protein	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania infantum	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium yoelii	basic transcription factor 3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium falciparum	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Babesia bovis	NAC domain containing protein	Get druggable targets OG5_127333	All targets in OG5_127333

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0068	0.0101	0.0212
Schistosoma mansoni	hypothetical protein	0.0113	0.0361	0.0998
Echinococcus granulosus	FTZ F1 alpha	0.0812	0.4375	1
Brugia malayi	Latrophilin receptor protein 2	0.0113	0.0361	0.0339
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0413	0.0391
Echinococcus granulosus	Smad4	0.0122	0.0413	0.0891
Brugia malayi	RNA recognition motif domain containing protein	0.068	0.3616	0.3602
Echinococcus granulosus	GPCR family 2	0.0113	0.0361	0.0772
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0099	0.0279	1
Echinococcus granulosus	tar DNA binding protein	0.068	0.3616	0.8255
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0355	0.1748	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0357	0.1763	0.1745
Brugia malayi	Probable ClpP-like protease	0.0355	0.1748	0.173
Loa Loa (eye worm)	hypothetical protein	0.0355	0.1748	0.173
Loa Loa (eye worm)	MH1 domain-containing protein	0.0055	0.0025	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0109	0.0339	0.0317
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0279	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0279	0.5
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0355	0.1748	0.3962
Schistosoma mansoni	Smad4	0.0055	0.0025	0.007
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0068	0.0101	0.3084
Brugia malayi	isocitrate dehydrogenase	0.0068	0.0101	0.0079
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0068	0.0101	0.0212
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0068	0.0101	0.0212
Loa Loa (eye worm)	Smad1	0.0122	0.0413	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0361	0.0339
Brugia malayi	MH1 domain containing protein	0.0122	0.0413	0.0391
Schistosoma mansoni	hypothetical protein	0.0113	0.0361	0.0998
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0113	0.0361	0.0339
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0068	0.0101	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0244	0.1114	0.1094
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.068	0.3616	0.3602
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0355	0.1748	0.5
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0355	0.1748	1
Brugia malayi	hypothetical protein	0.0851	0.4595	0.4583
Loa Loa (eye worm)	RNA binding protein	0.068	0.3616	0.3602
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0279	0.5
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0122	0.0413	0.108
Brugia malayi	MH1 domain containing protein	0.0068	0.01	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0851	0.4595	0.4583
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0122	0.0413	0.108
Echinococcus granulosus	smad	0.0122	0.0413	0.0891
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0099	0.0279	0.0257
Brugia malayi	serine/threonine-protein kinase plk-2	0.0099	0.0279	0.0257
Schistosoma mansoni	tar DNA-binding protein	0.068	0.3616	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0244	0.1114	0.1094
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0355	0.1748	0.4799
Schistosoma mansoni	hypothetical protein	0.0077	0.0156	0.0431
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0099	0.0279	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0355	0.1748	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0339	0.0317
Schistosoma mansoni	smad1 5 8 and	0.0122	0.0413	0.1142
Brugia malayi	MH1 domain containing protein	0.0122	0.0413	0.0391
Brugia malayi	MH2 domain containing protein	0.0122	0.0413	0.0391
Echinococcus multilocularis	smad	0.0122	0.0413	0.108
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0068	0.0101	0.0281
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0068	0.0101	0.0458
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0068	0.0101	0.0079
Brugia malayi	MH2 domain containing protein	0.0055	0.0025	0.0003
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0156	0.0431
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0279	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0357	0.1763	0.1745
Trypanosoma brucei	polo-like protein kinase	0.0099	0.0279	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0068	0.0101	0.0458
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0355	0.1748	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0355	0.1748	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0068	0.0101	0.0175
Brugia malayi	TAR-binding protein	0.068	0.3616	0.3602
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0355	0.1748	0.5
Echinococcus multilocularis	isocitrate dehydrogenase	0.0068	0.0101	0.0212
Loa Loa (eye worm)	transcription factor SMAD2	0.1792	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0156	0.0364
Toxoplasma gondii	isocitrate dehydrogenase	0.0068	0.0101	0.0458
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.0279	1
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0279	0.5
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0122	0.0414	0.2267
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0156	0.03
Loa Loa (eye worm)	nuclear factor I	0.0068	0.01	0.0077
Brugia malayi	mothers against decapentaplegic homolog 3	0.0055	0.0025	0.0003
Schistosoma mansoni	smad1 5 8 and	0.0122	0.0413	0.1142
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0109	0.0339	0.0721
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0122	0.0413	0.0891
Loa Loa (eye worm)	MH2 domain-containing protein	0.1792	1	1
Brugia malayi	RNA binding protein	0.068	0.3616	0.3602
Loa Loa (eye worm)	hypothetical protein	0.0357	0.1763	0.1745
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0122	0.0413	0.1142
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0109	0.0339	0.0873
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0113	0.0361	0.0935
Echinococcus multilocularis	tar DNA binding protein	0.068	0.3616	1
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0279	0.0771
Schistosoma mansoni	tar DNA-binding protein	0.068	0.3616	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0068	0.0101	0.0458
Brugia malayi	Smad1	0.0122	0.0413	0.0391
Schistosoma mansoni	smad	0.0055	0.0025	0.007
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0233	0.1047	0.4744
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0025	0.0003
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0233	0.1047	0.2845
Brugia malayi	hypothetical protein	0.0077	0.0156	0.0134
Loa Loa (eye worm)	MH1 domain-containing protein	0.0122	0.0413	0.0391
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0355	0.1748	0.5
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0355	0.1748	1
Schistosoma mansoni	tar DNA-binding protein	0.068	0.3616	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0113	0.0361	0.0772
Echinococcus multilocularis	Smad4	0.0122	0.0413	0.108
Schistosoma mansoni	peptidase Clp (S14 family)	0.0355	0.1748	0.4836
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0122	0.0414	0.2267
Loa Loa (eye worm)	hypothetical protein	0.0068	0.01	0.0077
Schistosoma mansoni	tar DNA-binding protein	0.068	0.3616	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0068	0.0101	0.3084
Schistosoma mansoni	hypothetical protein	0.0113	0.0361	0.0998
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0357	0.1763	0.1745
Giardia lamblia	Kinase, PLK	0.0099	0.0279	0.5
Onchocerca volvulus		0.0851	0.4595	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0233	0.1047	1
Schistosoma mansoni	tar DNA-binding protein	0.068	0.3616	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0109	0.0339	0.0937
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0279	0.5
Toxoplasma gondii	hypothetical protein	0.0122	0.0414	0.2267
Echinococcus granulosus	peptidase Clp S14 family	0.0233	0.1047	0.2349
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0113	0.0361	0.0772
Schistosoma mansoni	hypothetical protein	0.0113	0.0361	0.0998
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0279	0.5
Schistosoma mansoni	smad1 5 8 and	0.0122	0.0413	0.1142
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0233	0.1047	1
Schistosoma mansoni	Smad4	0.0055	0.0025	0.007
Schistosoma mansoni	Smad4	0.0122	0.0413	0.1142
Loa Loa (eye worm)	TAR-binding protein	0.068	0.3616	0.3602
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0109	0.0339	0.0317
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0355	0.1748	0.5
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0068	0.0101	0.3084
Brugia malayi	MH2 domain containing protein	0.0122	0.0413	0.0391
Echinococcus multilocularis	FTZ F1 alpha	0.0109	0.0339	0.0873
Schistosoma mansoni	hypothetical protein	0.0079	0.0165	0.0456
Loa Loa (eye worm)	MH2 domain-containing protein	0.0055	0.0025	0.0003
Brugia malayi	Isocitrate dehydrogenase	0.0068	0.0101	0.0079
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.0279	1
Echinococcus multilocularis	GPCR, family 2	0.0113	0.0361	0.0935
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0068	0.0101	0.3084
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0099	0.0279	0.0582
Schistosoma mansoni	smad	0.0122	0.0413	0.1142
Echinococcus granulosus	mothers against decapentaplegic 5	0.0122	0.0413	0.0891
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0099	0.0279	0.0554
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0113	0.0361	0.0339
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0099	0.0279	0.0705
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0355	0.1748	0.5
Schistosoma mansoni	hypothetical protein	0.0244	0.1114	0.3081
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0068	0.0101	0.3084
Brugia malayi	MH1 domain containing protein	0.0068	0.01	0.0077
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0113	0.0361	0.0935

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 7.953 um	PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response Follow up to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1915, 1914, 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1435608

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1321144