TDR Targets

Basic information

Technical information

TDR Targets ID: 1321284
Name: N-[2-[1-[(2-hydroxy-5-methoxyphenyl)methyl]pi peridin-4-yl]pyrazol-3-yl]-3-(phenoxy)propana mide
MW: 450.53 | Formula: C25H30N4O4
H donors: 2 H acceptors: 3 LogP: 2.95 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)CN1CCC(CC1)n1nccc1NC(=O)CCOc1ccccc1)O
InChi: 1S/C25H30N4O4/c1-32-22-7-8-23(30)19(17-22)18-28-14-10-20(11-15-28)29-24(9-13-26-29)27-25(31)12-16-33-21-5-3-2-4-6-21/h2-9,13,17,20,30H,10-12,14-16,18H2,1H3,(H,27,31)
InChiKey: BJNJSIYQXLOOPE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[2-[1-[(2-hydroxy-5-methoxy-phenyl)methyl]-4-piperidyl]pyrazol-3-yl]-3-(phenoxy)propanamide
N-[2-[1-[(2-hydroxy-5-methoxyphenyl)methyl]-4-piperidinyl]-3-pyrazolyl]-3-(phenoxy)propanamide
N-[2-[1-(2-hydroxy-5-methoxy-benzyl)-4-piperidyl]pyrazol-3-yl]-3-(phenoxy)propionamide
N-[2-[1-[(2-hydroxy-5-methoxy-phenyl)methyl]piperidin-4-yl]pyrazol-3-yl]-3-(phenoxy)propanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0047	0.0126	0.0124
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0026
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0015	0.0027	0.0026
Echinococcus granulosus	geminin	0.0205	0.0608	0.0606
Echinococcus multilocularis	orexin receptor type 2	0.0047	0.0126	0.0124
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.0126	0.0124
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0015	0.0027	0.0026
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0028	0.0026
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0015	0.0027	0.0026
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	neuropeptide receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0007	0.0003	0.0001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0047	0.0126	0.0123
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0088	0.0086
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0047	0.0126	0.0124
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0082	0.0079
Onchocerca volvulus		0.0047	0.0126	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0335	0.0333
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0005	0.0003
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0007	0.0003	0.0001
Echinococcus multilocularis	serotonin receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Onchocerca volvulus		0.0047	0.0126	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0082	0.008
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0015	0.0027	0.0025
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0015	0.0027	0.0026
Schistosoma mansoni	hypothetical protein	0.0047	0.0126	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	ecdysone induced protein 78C	0.0015	0.0027	0.0026
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0015	0.0027	0.0026
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0007	0.0003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	biogenic amine receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	7tm_1 domain containing protein	0.0047	0.0126	0.0124
Brugia malayi	Nuclear hormone receptor-like 1	0.0015	0.0027	0.0025
Echinococcus granulosus	fmrfamide receptor	0.0047	0.0126	0.0124
Entamoeba histolytica	hypothetical protein	0.0035	0.0088	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0047	0.0126	0.0124
Onchocerca volvulus		0.0047	0.0124	0.9861
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.0126	0.0124
Brugia malayi	G protein-coupled receptor F59B2.13	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	FTZ F1 alpha	0.0015	0.0027	0.0026
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0008	0.0005	0.0003
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	protein patched	0.1346	0.4106	0.4104
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.0126	0.0123
Echinococcus granulosus	g protein coupled receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0015	0.0027	0.0025
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0335	0.0333
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0005	0.0003
Echinococcus multilocularis	neuropeptide s receptor	0.0047	0.0126	0.0124
Onchocerca volvulus		0.0047	0.0126	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.0126	0.0124
Brugia malayi	G protein-coupled receptor	0.0047	0.0126	0.0123
Schistosoma mansoni	neuropeptide receptor	0.0047	0.0126	0.0124
Brugia malayi	nuclear hormone receptor	0.0015	0.0027	0.0025
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0015	0.0027	0.0026
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.0126	0.0124
Brugia malayi	hypothetical protein	0.0008	0.0005	0.0003
Echinococcus granulosus	Niemann Pick C1 protein	0.1346	0.4106	0.4104
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.327	1	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.1534	0.4681	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0162	0.016
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.0126	0.0124
Brugia malayi	Serotonin receptor	0.0047	0.0126	0.0123
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.0683	0.0681
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.0126	0.0124
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0015	0.0027	0.2006
Echinococcus multilocularis	dro:myosuppressin receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0007	0.0003	0.0001
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.0126	0.0123
Brugia malayi	GnHR receptor homolog	0.0047	0.0126	0.0123
Brugia malayi	AKH receptor	0.0047	0.0126	0.0123
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0015	0.0027	0.0026
Brugia malayi	ORL1-like opioid receptor	0.0047	0.0126	0.0123
Onchocerca volvulus		0.0015	0.0027	0.2006
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0015	0.0027	0.0025
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	growth hormone secretagogue receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Onchocerca volvulus		0.0047	0.0126	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0015	0.0027	0.0026
Echinococcus granulosus	neuropeptide receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Onchocerca volvulus		0.0028	0.0066	0.5147
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0027	0.0025
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.0126	0.0124
Echinococcus multilocularis	Niemann Pick C1 protein	0.1346	0.4106	0.4104
Echinococcus granulosus	smad	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	orexin receptor type 2	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0005	0.0003
Schistosoma mansoni	nuclear receptor nhr-48	0.0007	0.0003	0.0001
Echinococcus multilocularis	Smad4	0.0008	0.0005	0.0003
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	g-protein coupled receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.0126	0.0124
Brugia malayi	hypothetical protein	0.0008	0.0005	0.0003
Brugia malayi	Smad1	0.0008	0.0005	0.0002
Schistosoma mansoni	opsin-like receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Onchocerca volvulus	Bile acid receptor homolog	0.0015	0.0027	0.2006
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0047	0.0126	0.0123
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0005	0.0003
Echinococcus multilocularis	neuropeptide receptor A26	0.0047	0.0126	0.0124
Schistosoma mansoni	cpg binding protein	0.0029	0.0071	0.0069
Loa Loa (eye worm)	melatonin receptor type 1A	0.0047	0.0126	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	neuropeptide receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0028	0.0025
Onchocerca volvulus		0.0047	0.0126	1
Echinococcus granulosus	neuropeptide s receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Schistosoma mansoni	hypothetical protein	0.0035	0.0088	0.0086
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.0126	0.0124
Brugia malayi	nuclear receptor RXR	0.0008	0.0005	0.0003
Brugia malayi	MH2 domain containing protein	0.0008	0.0005	0.0002
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0088	0.0086
Schistosoma mansoni	nuclear receptor	0.0007	0.0003	0.0001
Schistosoma mansoni	smad	0.0008	0.0005	0.0003
Echinococcus granulosus	neuropeptide receptor A26	0.0047	0.0126	0.0124
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0028	0.0025
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.327	1	0.5
Onchocerca volvulus		0.0047	0.0126	1
Onchocerca volvulus		0.0047	0.0126	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0015	0.0027	0.0025
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.1534	0.4681	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0129	0.0126
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0015	0.0027	0.0026
Brugia malayi	Dopamine receptor	0.0047	0.0126	0.0123
Brugia malayi	larval opioid receptor	0.0047	0.0126	0.0123
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	neuropeptide receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0026
Echinococcus granulosus	allatostatin A receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0047	0.0126	0.0123
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0129	0.0126
Brugia malayi	photoreceptor-specific nuclear receptor	0.0015	0.0027	0.0025
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0015	0.0027	0.0026
Schistosoma mansoni	hypothetical protein	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Schistosoma mansoni	histamine h1 receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	thyroid hormone receptor alpha	0.0007	0.0003	0.0001
Schistosoma mansoni	hypothetical protein	0.0205	0.0608	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0066	0.0063
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.1534	0.4681	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.0126	0.0124
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0007	0.0004
Echinococcus multilocularis	serotonin receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.1346	0.4106	0.4104
Brugia malayi	MH1 domain containing protein	0.0008	0.0005	0.0002
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	sex peptide receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0047	0.0126	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Schistosoma mansoni	opsin-like receptor	0.0047	0.0126	0.0124
Onchocerca volvulus		0.0047	0.0126	1
Brugia malayi	Steroid receptor seven-up type 2	0.0015	0.0027	0.0025
Brugia malayi	G-protein coupled receptor	0.0047	0.0126	0.0123
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0028	0.0026
Schistosoma mansoni	biogenic amine receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	RAR-like nuclear receptor	0.0015	0.0027	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0015	0.0027	0.0025
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0047	0.0126	0.0124
Brugia malayi	CHE-14 protein	0.1346	0.4106	0.4104
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	ecdysone induced protein 78C	0.0015	0.0027	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.1346	0.4106	0.4104
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0027	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0129	0.0126
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0028	0.0026
Brugia malayi	ecdysteroid receptor	0.0015	0.0027	0.0025
Echinococcus granulosus	g protein coupled receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0047	0.0126	0.0124
Schistosoma mansoni	neuropeptide f receptor 76f	0.0047	0.0126	0.0124
Onchocerca volvulus		0.0047	0.0126	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.327	1	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0005	0.0003
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0003	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0015	0.0027	0.0025
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0007	0.0003	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0027	0.0025
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0027	0.0026
Echinococcus multilocularis	sterol regulatory element binding protein	0.1346	0.4106	0.4104
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0082	0.0079
Brugia malayi	follicle stimulating hormone receptor	0.0047	0.0126	0.0123
Brugia malayi	sulfakinin receptor protein	0.0047	0.0126	0.0123
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0066	0.0063
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	G protein coupled receptor 139	0.0047	0.0126	0.0124
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.327	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0027	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0015	0.0027	0.0025
Onchocerca volvulus		0.0047	0.0126	1
Schistosoma mansoni	amine GPCR	0.0047	0.0126	0.0124
Brugia malayi	RE15519p	0.0047	0.0126	0.0123
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0005	0.0002
Entamoeba histolytica	hypothetical protein	0.0035	0.0088	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	nuclear receptor nhr 48	0.0007	0.0003	0.0001
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	7TM GPCR rhodopsin	0.0047	0.0126	0.0124
Brugia malayi	steroid hormone receptor	0.0015	0.0027	0.0025
Schistosoma mansoni	amine GPCR	0.0047	0.0126	0.0124
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	Smad4	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0007	0.0003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	sterol regulatory element binding protein	0.1346	0.4106	0.4104
Echinococcus multilocularis	allatostatin A receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.0683	0.0681
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0047	0.0126	0.0124
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0005	0.0003
Schistosoma mansoni	zinc finger protein	0.0007	0.0003	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0015	0.0027	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.0126	0.0124
Brugia malayi	MH1 domain containing protein	0.0008	0.0005	0.0002
Echinococcus granulosus	Smad4	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.0005	0.0003
Brugia malayi	G-protein coupled receptor	0.0047	0.0126	0.0123
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0683	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0005	0.0003
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	nuclear receptor	0.0007	0.0003	0.0001
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0026
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.2981	0.2979
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0047	0.0126	0.0123
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.0126	0.0124
Entamoeba histolytica	hypothetical protein	0.0035	0.0088	0.5
Schistosoma mansoni	amine GPCR	0.0047	0.0126	0.0124
Brugia malayi	Dopamine receptor protein 1	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0015	0.0027	0.0026
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0027	0.0026
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.0126	0.0124
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.327	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	smad	0.0008	0.0005	0.0003
Loa Loa (eye worm)	steroid hormone receptor	0.0015	0.0027	0.0025
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.0126	0.0124
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	sex peptide receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0015	0.0027	0.0026
Echinococcus multilocularis	dnaJ subfamily B	0.0397	0.1196	0.1194
Schistosoma mansoni	hypothetical protein	0.0047	0.0126	0.0124
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0047	0.0126	0.0124
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0047	0.0126	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Schistosoma mansoni	adenoreceptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Brugia malayi	Dopamine receptor protein 2	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0047	0.0126	0.0124
Onchocerca volvulus	Protein ultraspiracle homolog	0.0015	0.0027	0.2006
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0124	0.0121
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0027	0.0025
Echinococcus multilocularis	geminin	0.0205	0.0608	0.0606
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0047	0.0126	0.0124
Brugia malayi	hypothetical protein	0.0229	0.0683	0.0681
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	myosin xvIII	0.0047	0.0126	0.0124
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0007	0.0005
Schistosoma mansoni	biogenic amine receptor	0.0047	0.0126	0.0124
Onchocerca volvulus		0.0047	0.0126	1
Brugia malayi	MH2 domain containing protein	0.0008	0.0005	0.0002
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0047	0.0126	0.0123
Brugia malayi	Melatonin receptor type 1A	0.0047	0.0126	0.0123
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0005	0.0002
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0005	0.0003
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0124	0.0122
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	cpg binding protein	0.0029	0.0071	0.0069
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.327	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	somatostatin receptor	0.0047	0.0126	0.0124
Onchocerca volvulus		0.0047	0.0126	1
Echinococcus granulosus	serotonin receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.1346	0.4106	0.4104
Entamoeba histolytica	hypothetical protein	0.0035	0.0088	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0015	0.0027	0.0025
Brugia malayi	hypothetical protein	0.0035	0.0088	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0047	0.0126	0.0124
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	hypothetical protein	0.0397	0.1196	0.1194
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0005	0.0003
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.1534	0.4681	0.5
Echinococcus granulosus	Protein patched homolog 1	0.1346	0.4106	0.4104
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0047	0.0126	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0005	0.0003
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0027	0.0026
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0008	0.0005	0.0003
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.0126	0.0124
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0047	0.0126	0.0123
Onchocerca volvulus		0.0047	0.0126	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0007	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0015	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	neuropeptide receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	hypothetical protein	0.0205	0.0608	0.0606
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0015	0.0027	0.0026
Schistosoma mansoni	hypothetical protein	0.0047	0.0124	0.0122
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Onchocerca volvulus		0.0047	0.0126	1
Brugia malayi	MH2 domain containing protein	0.0116	0.0335	0.0333
Echinococcus granulosus	FTZ F1 alpha	0.0015	0.0027	0.0026
Schistosoma mansoni	cpg binding protein	0.0029	0.0071	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	Smad1	0.0008	0.0005	0.0002
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0007	0.0003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	GPCR family 2	0.0015	0.0028	0.0026
Schistosoma mansoni	amine GPCR	0.0047	0.0126	0.0124
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0047	0.0126	0.0123
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.0027	0.0026
Onchocerca volvulus		0.0047	0.0126	1
Echinococcus granulosus	hypothetical protein	0.0047	0.0126	0.0124
Loa Loa (eye worm)	TYRA-2 protein	0.0047	0.0126	0.0123
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0005	0.0003
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.0126	0.0124
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0027	0.0026
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0003	0.0001
Echinococcus granulosus	cpg binding protein	0.0029	0.0071	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0027	0.0026
Schistosoma mansoni	cpg binding protein	0.0028	0.0066	0.0064
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0015	0.0027	0.0025
Echinococcus granulosus	dnaJ subfamily B	0.0397	0.1196	0.1194
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.0126	0.0124
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.327	1	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	g protein coupled receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0015	0.0027	0.0025
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0088	0.0086
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0025
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0047	0.0126	0.0124
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0142	0.5
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0027	0.0025
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.0126	0.0123
Brugia malayi	putative neuropeptide receptor NPR1	0.0047	0.0126	0.0123
Echinococcus granulosus	neuropeptide FF receptor 2	0.0047	0.0126	0.0124
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.0126	0.0123
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.327	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.0126	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0015	0.0027	0.0025
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0047	0.0126	0.0124
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0007	0.0005
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0015	0.0027	0.0026
Onchocerca volvulus		0.0047	0.0126	1
Echinococcus granulosus	somatostatin receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	coup transcription factor	0.0015	0.0027	0.0026
Brugia malayi	neuropeptide F receptor	0.0047	0.0126	0.0123
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0015	0.0027	0.0026
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	g-protein coupled receptor	0.0047	0.0126	0.0124
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0129	0.0126
Schistosoma mansoni	amine GPCR	0.0047	0.0126	0.0124
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0007	0.0003	0.0001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.0126	0.0124
Schistosoma mansoni	opsin-like receptor	0.0047	0.0126	0.0124
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0028	0.0026
Brugia malayi	neuropeptide F receptor	0.0047	0.0126	0.0123
Schistosoma mansoni	patched 1	0.1346	0.4106	0.4104
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0027	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0015	0.0027	0.0025
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0047	0.0126	0.0123
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0005	0.0003
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0027	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0047	0.0126	0.0124
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.0126	0.0124
Echinococcus granulosus	dro:myosuppressin receptor	0.0047	0.0126	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.1346	0.4106	0.877
Echinococcus multilocularis	nuclear receptor nhr 48	0.0007	0.0003	0.0001
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0047	0.0126	0.0124
Onchocerca volvulus		0.0047	0.0126	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0015	0.0027	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0028	0.0025
Brugia malayi	Serotonin receptor	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0047	0.0126	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Brugia malayi	putative neuropeptide receptor	0.0047	0.0126	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0027	0.0025
Schistosoma mansoni	hypothetical protein	0.0047	0.0126	0.0124
Echinococcus multilocularis	protein dispatched 1	0.1346	0.4106	0.4104
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.327	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0015	0.0027	0.0026
Brugia malayi	hypothetical protein	0.0047	0.0126	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0126	0.0123
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0007	0.0003	0.0001

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 150 um	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)]	ChEMBL.	No reference
EC50 (functional)	> 150 um	PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.3489 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1453391

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1321284