Detailed information for compound 1321338

Basic information

Technical information
  • TDR Targets ID: 1321338
  • Name: ethyl 2-[2-[(4-oxo-1,2,3-benzotriazin-3-yl)me thylsulfanyl]-1,3-thiazol-4-yl]acetate
  • MW: 362.427 | Formula: C15H14N4O3S2
  • H donors: 0 H acceptors: 3 LogP: 3.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cc1csc(n1)SCn1nnc2c(c1=O)cccc2
  • InChi: 1S/C15H14N4O3S2/c1-2-22-13(20)7-10-8-23-15(16-10)24-9-19-14(21)11-5-3-4-6-12(11)17-18-19/h3-6,8H,2,7,9H2,1H3
  • InChiKey: CINKKNJHTHOYAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[2-[(4-oxo-1,2,3-benzotriazin-3-yl)methylsulfanyl]thiazol-4-yl]acetate
  • 2-[2-[(4-oxo-1,2,3-benzotriazin-3-yl)methylthio]-4-thiazolyl]acetic acid ethyl ester
  • 2-[2-[(4-keto-1,2,3-benzotriazin-3-yl)methylthio]thiazol-4-yl]acetic acid ethyl ester
  • ethyl 2-[2-[(4-oxo-1,2,3-benzotriazin-3-yl)methylsulfanyl]-1,3-thiazol-4-yl]ethanoate
  • T5238181
  • ZINC02643431
  • MLS000055773
  • SMR000066634

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.008 0.034
Toxoplasma gondii thioredoxin reductase 0.0057 0.2361 1
Brugia malayi RNA binding protein 0.0076 0.3546 0.8012
Plasmodium falciparum glutathione reductase 0.0057 0.2361 1
Schistosoma mansoni lamin 0.0033 0.0861 0.0861
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0129 0.0129
Onchocerca volvulus 0.0033 0.0861 0.5
Brugia malayi Bromodomain containing protein 0.0046 0.1697 0.3739
Echinococcus multilocularis musashi 0.0033 0.0861 0.2253
Trichomonas vaginalis mercuric reductase, putative 0.002 0.008 0.5
Brugia malayi intermediate filament protein 0.0033 0.0861 0.1805
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.008 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3546 0.8626
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3546 0.8012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0129 0.0142
Onchocerca volvulus 0.0033 0.0861 0.5
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.008 0.5
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.008 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.3277 0.9224
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0129 0.0142
Loa Loa (eye worm) hypothetical protein 0.0032 0.0825 0.1755
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.2361 0.2985
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0129 0.0129
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1523 0.4162
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.6831 0.8837
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0535 0.0535
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0535 0.1311
Loa Loa (eye worm) hypothetical protein 0.0049 0.1877 0.4413
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3546 0.8626
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.6831 0.8837
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1523 0.4162
Brugia malayi PHD-finger family protein 0.003 0.0709 0.1454
Loa Loa (eye worm) hypothetical protein 0.0046 0.1703 0.3972
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0861 0.1847
Echinococcus granulosus lamin dm0 0.0033 0.0861 0.2253
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.008 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.2361 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.008 0.034
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.2361 0.658
Brugia malayi Bromodomain containing protein 0.0091 0.4406 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0535 0.1311
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.008 0.034
Echinococcus multilocularis zinc finger protein 0.0024 0.0316 0.0679
Plasmodium vivax glutathione reductase, putative 0.0057 0.2361 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.3546 0.8626
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0129 0.0129
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0129 0.0142
Brugia malayi glutathione reductase 0.0057 0.2361 0.5272
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0394 0.0667
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.008 0.5
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.6831 0.8837
Echinococcus granulosus lamin 0.0033 0.0861 0.2253
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0129 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3546 0.3546
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.772 1
Echinococcus granulosus zinc finger protein 0.0024 0.0316 0.0679
Schistosoma mansoni zinc finger protein 0.0024 0.0316 0.0316
Schistosoma mansoni lamin 0.0033 0.0861 0.0861
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.008 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.008 0.008
Schistosoma mansoni bromodomain containing protein 0.0076 0.3541 0.3541
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3546 0.3546
Echinococcus granulosus intermediate filament protein 0.0033 0.0861 0.2253
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3546 0.3546
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.2361 0.5633
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.6831 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034
Trypanosoma brucei trypanothione reductase 0.0057 0.2361 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.772 1
Schistosoma mansoni hypothetical protein 0.0025 0.0394 0.0394
Schistosoma mansoni intermediate filament proteins 0.0033 0.0861 0.0861
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.3277 0.9224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034
Trichomonas vaginalis glutathione reductase, putative 0.002 0.008 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3546 0.3546
Leishmania major trypanothione reductase 0.0057 0.2361 1
Brugia malayi Thioredoxin reductase 0.0057 0.2361 0.5272
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3546 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034
Loa Loa (eye worm) hypothetical protein 0.0085 0.409 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.2361 1
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0175 0.0114
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0861 0.1847
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0129 0.0129
Treponema pallidum NADH oxidase 0.002 0.008 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3546 0.3546
Echinococcus multilocularis lamin dm0 0.0033 0.0861 0.2253
Echinococcus granulosus tar DNA binding protein 0.0076 0.3546 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.008 0.034
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.008 0.034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0861 0.1847
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.2361 0.658
Loa Loa (eye worm) hypothetical protein 0.0052 0.2018 0.4769
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0861 0.1805
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.008 0.034
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.008 0.5
Brugia malayi TAR-binding protein 0.0076 0.3546 0.8012
Mycobacterium tuberculosis Probable reductase 0.013 0.6831 0.8837
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.008 0.034
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034
Plasmodium falciparum thioredoxin reductase 0.0057 0.2361 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.008 0.5
Loa Loa (eye worm) glutathione reductase 0.0057 0.2361 0.5633
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.008 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.772 1
Echinococcus multilocularis lamin 0.0033 0.0861 0.2253
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.772 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.6831 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.034

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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