Detailed information for compound 132137

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 382.496 | Formula: C23H30N2O3
  • H donors: 2 H acceptors: 1 LogP: 4.9 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC1(CCCC)Oc2c(O1)c(ccc2)NC(=O)c1ccc(cc1)CN
  • InChi: 1S/C23H30N2O3/c1-3-5-14-23(15-6-4-2)27-20-9-7-8-19(21(20)28-23)25-22(26)18-12-10-17(16-24)11-13-18/h7-13H,3-6,14-16,24H2,1-2H3,(H,25,26)
  • InChiKey: YCZAAGOVUKXJFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bradykinin receptor B2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor bradykinin receptor B2 391 aa 354 aa 19.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Onchocerca volvulus 0.0091 0.0138 0.7973
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0011 0.009
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0011 0.0001 0.0006
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.023 1
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0108 0.0108
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0016 0.0009 0.0075
Plasmodium falciparum glutathione reductase 0.0023 0.0021 0.0934
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0019 0.0812
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0014 0.0118
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0108 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.001 0.0082
Echinococcus granulosus G protein coupled receptor 139 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0025 0.0025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.006 0.0611
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0042 0.0351
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0001 0.0026
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0011 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.1143
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0009 0.0389
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0006 0.0053
Echinococcus multilocularis neuropeptide s receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus granulosus orexin receptor type 2 0.0091 0.0138 0.1164
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.0023 0.0191
Brugia malayi Tachykinin-like peptides receptor 99D 0.0091 0.0138 0.1404
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0044 0.037
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0021 0.1683
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0091 0.0138 0.1164
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0091 0.0138 0.1164
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0044 0.1858
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0022 0.0976
Plasmodium vivax thioredoxin reductase, putative 0.0067 0.0097 0.4208
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0021 0.0471
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) CYP4Cod1 0.0087 0.0132 0.1345
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0021 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0108 0.11
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0098 0.1001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0108 0.0911
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0016 0.0009 0.0091
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Schistosoma mansoni organic anion transporter 0.0111 0.0173 0.146
Loa Loa (eye worm) hypothetical protein 0.0104 0.0161 0.1644
Chlamydia trachomatis cysteine--tRNA ligase 0.0085 0.0128 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0001 0.0026
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0011 0.0011
Brugia malayi hypothetical protein 0.0111 0.0173 0.1761
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0132 0.1345
Schistosoma mansoni hypothetical protein 0.0014 0.0006 0.0053
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0111 0.0173 0.146
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0014 0.012
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0071 0.2793
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0091 0.0138 0.1404
Schistosoma mansoni neuropeptide receptor 0.0091 0.0138 0.1164
Brugia malayi sulfakinin receptor protein 0.0091 0.0138 0.1404
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0016 0.001 0.0424
Onchocerca volvulus 0.0091 0.0138 0.7973
Schistosoma mansoni opsin-like receptor 0.0091 0.0138 0.1164
Plasmodium vivax importin-beta 2, putative 0.0029 0.0032 0.1391
Toxoplasma gondii exonuclease III APE 0.002 0.0016 0.0706
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0138 0.1404
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0014 0.0118
Brugia malayi beta-lactamase family protein 0.0073 0.0108 0.11
Onchocerca volvulus Putative organic anion transporter 0.0111 0.0173 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0021 0.0567
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0044 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.5804 1 1
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0108 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0014 0.0143
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0006 0.0053
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Brugia malayi G protein-coupled receptor F59B2.13 0.0091 0.0138 0.1404
Schistosoma mansoni cytochrome P450 0.0025 0.0025 0.021
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0091 0.0138 0.1404
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0085 0.0128 0.0119
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.0648
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0138 0.1164
Schistosoma mansoni amine GPCR 0.0091 0.0138 0.1164
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0001 0.0026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0128 0.1303
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0005
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0091 0.0138 0.1404
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0044 0.1908
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0108 0.4697
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0111 0.0173 0.1761
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0016 0.0009 0.0075
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0011 0.0001 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0208 0.1754
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0091 0.0138 0.7973
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0091 0.0138 0.1404
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Leishmania major trypanothione reductase 0.0067 0.0097 0.4208
Echinococcus multilocularis neuropeptide FF receptor 2 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0108 0.0108
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0044 0.037
Plasmodium vivax cysteine--tRNA ligase, putative 0.0085 0.0128 0.5553
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Loa Loa (eye worm) glutathione reductase 0.0067 0.0097 0.0985
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0024 0.0023 0.0191
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0132 0.1345
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0025 0.0025
Echinococcus multilocularis g-protein coupled receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0073 0.0108 0.11
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0016 0.0009 0.0389
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0021 0.0878
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0016 0.0137
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0025 0.1082
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0755
Trypanosoma brucei Flagellar Member 6 0.0016 0.0009 0.0329
Echinococcus granulosus dro:myosuppressin receptor 0.0091 0.0138 0.1164
Brugia malayi Death domain containing protein 0.0014 0.0006 0.0064
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.009
Echinococcus multilocularis serotonin receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0091 0.0138 0.1404
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0016 0.0009 0.0075
Toxoplasma gondii protease inhibitor PI2 0.0076 0.0112 0.4883
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0014 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0071 0.3073
Echinococcus granulosus GPCR family 2 0.0017 0.0011 0.009
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0025 0.0016
Echinococcus granulosus follistatin 0.0076 0.0112 0.0947
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0009 0.0008
Schistosoma mansoni growth hormone secretagogue receptor 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0025 0.0025
Echinococcus granulosus allatostatin A receptor 0.0091 0.0138 0.1164
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0016 0.001 0.0082
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0138 0.1164
Schistosoma mansoni hypothetical protein 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0108 0.0108
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0108 0.0913
Brugia malayi Serotonin receptor 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0091 0.0138 0.1164
Brugia malayi Serotonin receptor 0.0091 0.0138 0.1404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0567
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0138 0.1164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0014 0.0118
Echinococcus multilocularis expressed conserved protein 0.0016 0.001 0.0082
Echinococcus multilocularis sex peptide receptor 0.0091 0.0138 0.1164
Onchocerca volvulus 0.0016 0.0009 0.0517
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0014 0.0118
Echinococcus multilocularis expressed protein 0.0076 0.0112 0.0947
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.1143
Brugia malayi Dopamine receptor protein 2 0.0091 0.0138 0.1404
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0044 0.037
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0016 0.0009 0.0075
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0023 0.0191
Leishmania major protein kinase, putative 0.0016 0.001 0.0424
Brugia malayi beta-NAC-like protein 0.0144 0.023 0.2341
Onchocerca volvulus 0.0091 0.0138 0.7973
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.0009 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0326
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.0112 0.4883
Plasmodium falciparum cysteine--tRNA ligase 0.0085 0.0128 0.5553
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.0023 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0108 0.4697
Loa Loa (eye worm) hypothetical protein 0.0085 0.0128 0.1303
Echinococcus granulosus Ankyrin 0.0014 0.0006 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0108 0.4697
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni lamin 0.0085 0.0128 0.108
Mycobacterium tuberculosis Conserved protein 0.0073 0.0108 0.0108
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0016 0.0706
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0021 0.0878
Echinococcus granulosus lamin 0.0085 0.0128 0.108
Loa Loa (eye worm) AGC/PKG protein kinase 0.0016 0.001 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0044 0.1908
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0016 0.0009 0.0075
Entamoeba histolytica transcription factor BTF3, putative 0.0144 0.023 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0019 0.0158
Onchocerca volvulus Putative organic anion transporter 0.0111 0.0173 1
Echinococcus granulosus lamin dm0 0.0085 0.0128 0.108
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0085 0.0128 0.1077
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0138 0.1164
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Leishmania major cyclic nucleotide-binding protein-like protein 0.0016 0.0009 0.0389
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0021 0.0181
Echinococcus granulosus neuropeptide s receptor 0.0091 0.0138 0.1164
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0138 0.1164
Echinococcus granulosus neuropeptide receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) cytochrome P450 0.0025 0.0025 0.0253
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0189 0.1923
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0025 0.0016
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus granulosus patatin phospholipase domain containing protein 0.0016 0.0009 0.0075
Echinococcus multilocularis geminin 0.0697 0.1185 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0091 0.0138 0.1164
Onchocerca volvulus 0.0085 0.0128 0.7379
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0067 0.0097 0.0816
Trypanosoma brucei transcription factor BTF3, putative 0.0144 0.023 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0071 0.3073
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0011 0.0465
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0044 0.037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.023
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0091 0.0138 0.1404
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0138 0.1164
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0025 0.0025
Schistosoma mansoni neuropeptide f receptor 76f 0.0091 0.0138 0.1164
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0014 0.0809
Loa Loa (eye worm) agrin synaptic family protein 0.0076 0.0112 0.1143
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni hypothetical protein 0.0091 0.0138 0.1164
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0014 0.0143
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0085 0.0128 0.5525
Echinococcus granulosus g-protein coupled receptor 0.0091 0.0138 0.1164
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0016 0.0009 0.0329
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0406
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus granulosus agrin 0.0076 0.0112 0.0947
Mycobacterium leprae Probable lipase LipE 0.0073 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0091
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0001 0.0026
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0014 0.0143
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0138 0.1164
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0044 0.1908
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0014 0.0118
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0138 0.1164
Echinococcus granulosus snurportin 1 0.0312 0.052 0.4385
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0091 0.0138 0.1164
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0016 0.0009 0.0389
Schistosoma mansoni hypothetical protein 0.0091 0.0138 0.1164
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Schistosoma mansoni alpha-1 adrenergic receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0073 0.0108 0.11
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0044 0.2941
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0016 0.0009 0.0075
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.0112 0.1143
Brugia malayi Egg laying defective protein 4 0.0016 0.001 0.0099
Mycobacterium ulcerans hypothetical protein 0.0073 0.0108 0.0099
Leishmania major hypothetical protein, conserved 0.0016 0.0009 0.0389
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0044 0.1908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0021 0.0181
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0011 0.009
Brugia malayi secreted modular calcium-binding protein 1 0.0076 0.0112 0.1143
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Onchocerca volvulus 0.0111 0.0173 1
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0014 0.0118
Onchocerca volvulus 0.0091 0.0138 0.7973
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0189 0.1923
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.0023 0.0191
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0567
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0108 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.044
Schistosoma mansoni netrin receptor unc5 0.0014 0.0006 0.0053
Brugia malayi GnHR receptor homolog 0.0091 0.0138 0.1404
Schistosoma mansoni opsin-like receptor 0.0091 0.0138 0.1164
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.009
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0021 0.0934
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Onchocerca volvulus 0.0073 0.0108 0.6242
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0819
Echinococcus multilocularis lamin dm0 0.0085 0.0128 0.108
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0021 0.0934
Schistosoma mansoni hypothetical protein 0.0697 0.1185 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0011 0.0108
Echinococcus granulosus sex peptide receptor 0.0091 0.0138 0.1164
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0011 0.0108
Schistosoma mansoni hypothetical protein 0.0697 0.1185 1
Brugia malayi putative neuropeptide receptor NPR1 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0016 0.0009 0.0075
Echinococcus granulosus Solute carrier organic anion transporter family 0.0111 0.0173 0.146
Onchocerca volvulus 0.0111 0.0173 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.0112 0.4883
Echinococcus granulosus importin subunit beta 1 0.0029 0.0032 0.027
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0014 0.0118
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0025 0.0016
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.0023 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0025 0.0025
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0016 0.0009 0.0075
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0025 0.0025
Brugia malayi sodium-independent organic anion transporter family protein 0.0111 0.0173 0.1761
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0071 0.2793
Schistosoma mansoni neuropeptide receptor 0.0091 0.0138 0.1164
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0138 0.1164
Echinococcus multilocularis agrin 0.0076 0.0112 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0025 0.0025
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0085 0.0128 0.1077
Treponema pallidum cysteinyl-tRNA synthetase 0.0085 0.0128 1
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0001 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0025 0.0025
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0016 0.0009 0.0517
Echinococcus multilocularis neuropeptide receptor A26 0.0091 0.0138 0.1164
Brugia malayi steroid hormone receptor 0.0019 0.0014 0.0143
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0014 0.0118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0014 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0014 0.0143
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0023 0.0191
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0091 0.0138 0.1164
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0011 0.0108
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0021 0.0219
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0073 0.0748
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0001 0.0026
Echinococcus granulosus g protein coupled receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0073 0.0108 0.11
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0009 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0014 0.0143
Schistosoma mansoni importin beta-1 0.0029 0.0032 0.027
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0016 0.0009 0.0091
Brugia malayi sodium-independent organic anion transporter family protein 0.0111 0.0173 0.1761
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0091 0.0138 0.1404
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0016 0.0706
Brugia malayi G protein-coupled receptor 0.0091 0.0138 0.1404
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0138 0.1404
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0098 0.083
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Conserved protein 0.0073 0.0108 0.0108
Schistosoma mansoni amine GPCR 0.0091 0.0138 0.1164
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0006 0.0055
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0025 0.0016
Trypanosoma brucei cytochrome P450, putative 0.0087 0.0132 0.5719
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0021 0.0021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus multilocularis orexin receptor type 2 0.0091 0.0138 0.1164
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0024 0.0023 0.0191
Plasmodium falciparum cGMP-dependent protein kinase 0.0016 0.001 0.0424
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0011 0.0109
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0014 0.0118
Schistosoma mansoni biogenic amine receptor 0.0091 0.0138 0.1164
Schistosoma mansoni follistatin 0.0076 0.0112 0.0947
Trichomonas vaginalis esterase, putative 0.0073 0.0108 0.4697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Echinococcus granulosus tar DNA binding protein 0.0068 0.0098 0.083
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0021 0.0934
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.006 0.0611
Brugia malayi Uncoordinated protein 44 0.0014 0.0006 0.0064
Trichomonas vaginalis adenylate cyclase type, putative 0.0011 0.0001 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0014 0.0143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0014 0.0143
Echinococcus multilocularis somatostatin receptor 0.0091 0.0138 0.1164
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0025 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0025 0.0025
Brugia malayi neuropeptide F receptor 0.0091 0.0138 0.1404
Echinococcus granulosus g protein coupled receptor 0.0091 0.0138 0.1164
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0812
Echinococcus granulosus neuropeptide receptor A26 0.0091 0.0138 0.1164
Brugia malayi Dopamine receptor 0.0091 0.0138 0.1404
Schistosoma mansoni myosin xvIII 0.0091 0.0138 0.1164
Trypanosoma brucei protein kinase A regulatory subunit 0.0016 0.0009 0.0329
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0014 0.0143
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.1143
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0091 0.0138 0.1404
Leishmania major hypothetical protein, conserved 0.0016 0.0009 0.0389
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0009 0.0389
Loa Loa (eye worm) thioredoxin reductase 0.0067 0.0097 0.0985
Brugia malayi MAP kinase sur-1 0.0052 0.0071 0.0719
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0091 0.0138 0.1164
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0006 0.0053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0016 0.0007
Brugia malayi cytochrome P450 0.0025 0.0025 0.0253
Onchocerca volvulus 0.0091 0.0138 0.7973
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0079
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0044 0.158
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0021 0.0013
Brugia malayi beta-lactamase 0.0073 0.0108 0.11
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0138 0.1164
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0009 0.0389
Brugia malayi hypothetical protein 0.0111 0.0173 0.1761
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0108 0.4664
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0016 0.0009 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.001 0.0082
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0138 0.1164
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0032 0.1338
Schistosoma mansoni biogenic amine receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0085 0.0128 0.13
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0108 0.11
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0071 0.0596
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0025 0.0025
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0032 0.027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0064
Schistosoma mansoni hypothetical protein 0.0036 0.0044 0.0374
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0071 0.0596
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0071 0.5198
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.0023 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0108 0.4483
Loa Loa (eye worm) hypothetical protein 0.0111 0.0173 0.1761
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0021 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0014 0.0143
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0016 0.0009 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0108 0.4483
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0138 0.1164
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.019
Onchocerca volvulus 0.0111 0.0173 1
Trypanosoma cruzi transcription factor btf3, putative 0.0144 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0138 0.1164
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0091 0.0138 0.1164
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0023 0.0191
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0021 0.0021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0014 0.0118
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0016 0.0009 0.0389
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0108 0.0911
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0011 0.0111
Brugia malayi AKH receptor 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0091
Schistosoma mansoni coup transcription factor 0.0019 0.0014 0.0118
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0934
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0567
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0066
Echinococcus granulosus cGMP dependent protein kinase 0.0016 0.001 0.0082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0006 0.0064
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0175 0.7621
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0091 0.0138 0.1164
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0011 0.009
Mycobacterium ulcerans lipase LipD 0.0073 0.0108 0.0099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.009
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0091 0.0138 0.1164
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0011 0.009
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0044 0.1908
Echinococcus multilocularis dro:myosuppressin receptor 0.0091 0.0138 0.1164
Plasmodium vivax glutathione reductase, putative 0.0067 0.0097 0.4208
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.0023 0.0191
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0006 0.0053
Brugia malayi glutathione reductase 0.0067 0.0097 0.0985
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0014 0.0118
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.0789 0.0789
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0014 0.0143
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0025 0.0025
Brugia malayi nuclear receptor NHR-88 0.0019 0.0014 0.0143
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0014 0.0809
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0505
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0567
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0025 0.021
Toxoplasma gondii NAC domain-containing protein 0.0144 0.023 1
Mycobacterium leprae putative cytochrome p450 0.0025 0.0025 0.0024
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.0112 0.4883
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0016 0.0009 0.07
Brugia malayi Melatonin receptor type 1A 0.0091 0.0138 0.1404
Toxoplasma gondii thioredoxin reductase 0.0067 0.0097 0.4208
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0014 0.0143
Plasmodium falciparum thioredoxin reductase 0.0023 0.0021 0.0934
Loa Loa (eye worm) hypothetical protein 0.0111 0.0173 0.1761
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0087 0.0132 0.0123
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0111 0.0173 0.146
Loa Loa (eye worm) hypothetical protein 0.0062 0.0089 0.0904
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0021 0.0181
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0085 0.0128 0.13
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0014 0.0118
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Entamoeba histolytica hypothetical protein 0.0024 0.0022 0.0976
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0085 0.0128 0.5553
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0016 0.001 0.0082
Echinococcus multilocularis Ankyrin 0.0014 0.0006 0.0055
Schistosoma mansoni histamine h1 receptor 0.0091 0.0138 0.1164
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0091 0.0138 0.1404
Entamoeba histolytica hypothetical protein 0.0144 0.023 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.044
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0071 0.2793
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0016 0.0706
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0091 0.0138 0.1164
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0025 0.0016
Brugia malayi sodium-independent organic anion transporter family protein 0.0111 0.0173 0.1761
Echinococcus multilocularis transcription factor btf3 0.0144 0.023 0.194
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Trypanosoma brucei protein kinase, putative 0.0052 0.0071 0.303
Brugia malayi SPARC precursor 0.0076 0.0112 0.1143
Onchocerca volvulus 0.0085 0.0128 0.74
Loa Loa (eye worm) TYRA-2 protein 0.0091 0.0138 0.1404
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.0023 0.0191
Plasmodium falciparum thioredoxin reductase 0.0067 0.0097 0.4208
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0052 0.0441
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0706
Leishmania major cysteinyl-tRNA synthetase, putative 0.0085 0.0128 0.5553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0014 0.0143
Mycobacterium tuberculosis Conserved protein 0.0016 0.0009 0.0009
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0019 0.0812
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0014 0.0143
Schistosoma mansoni neuropeptide receptor 0.0091 0.0138 0.1164
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0044 0.037
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0465
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.001 0.0082
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0009 0.0389
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni amine GPCR 0.0091 0.0138 0.1164
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0025 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0014 0.0143
Loa Loa (eye worm) hypothetical protein 0.0073 0.0108 0.11
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.0023 0.0191
Brugia malayi Cytochrome P450 family protein 0.0025 0.0025 0.0253
Brugia malayi follicle stimulating hormone receptor 0.058 0.0982 1
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0138 0.1164
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Echinococcus granulosus g protein coupled receptor 0.0091 0.0138 0.1164
Plasmodium falciparum glutathione reductase 0.0067 0.0097 0.4208
Plasmodium falciparum basic transcription factor 3b, putative 0.0144 0.023 1
Schistosoma mansoni biogenic amine receptor 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0108 0.0108
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0025 0.0024
Echinococcus granulosus neuropeptide FF receptor 2 0.0091 0.0138 0.1164
Trichomonas vaginalis hypothetical protein 0.0011 0.0001 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0143
Echinococcus granulosus 7tm_1 domain containing protein 0.0091 0.0138 0.1164
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis adenylate cyclase type, putative 0.0011 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0073 0.0108 0.11
Loa Loa (eye worm) follicle stimulating hormone receptor 0.058 0.0982 1
Loa Loa (eye worm) RNA binding protein 0.0068 0.0098 0.1001
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.009
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0023 0.0191
Echinococcus granulosus death domain containing protein 0.0014 0.0006 0.0053
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0021 0.0934
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0016 0.0016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0128 0.1303
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0447
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0044 0.0447
Trypanosoma brucei cAMP response protein 1, putative 0.0016 0.0009 0.0329
Onchocerca volvulus 0.0091 0.0138 0.7973
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0108 0.4697
Schistosoma mansoni amine GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0085 0.0128 0.1077
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0021 0.0934
Brugia malayi intermediate filament protein 0.0085 0.0128 0.1303
Schistosoma mansoni agrin 0.0076 0.0112 0.0947
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0025 0.0721
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0025 0.0025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0052 0.0441
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0071 0.3073
Onchocerca volvulus 0.0091 0.0138 0.7973
Treponema pallidum NADH oxidase 0.0023 0.0021 0.1056
Leishmania major cytochrome p450-like protein 0.0025 0.0025 0.1082
Echinococcus granulosus neuropeptide receptor 0.0091 0.0138 0.1164
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0025 0.0016
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0035 0.0042 0.0424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0021 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0025 0.0016
Plasmodium falciparum importin beta, putative 0.0029 0.0032 0.1391
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0016 0.0009 0.0075
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0011 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0098 0.083
Echinococcus granulosus geminin 0.0697 0.1185 1
Schistosoma mansoni amine GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0208 0.1754
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0085 0.0128 0.5373
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0009 0.0389
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0011 0.0406
Brugia malayi RE15519p 0.0091 0.0138 0.1404
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0006 0.0053
Schistosoma mansoni transcription factor btf3 0.0144 0.023 0.194
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0025 0.0025
Echinococcus multilocularis snurportin 1 0.0312 0.052 0.4385
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0098 0.083
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0016 0.0009 0.0075
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0021 0.0471
Schistosoma mansoni lamin 0.0085 0.0128 0.108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0073 0.0748
Onchocerca volvulus 0.0091 0.0138 0.7973
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0009 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0071 0.3073
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.019
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0016 0.0009 0.0075
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0044 0.158
Brugia malayi Cytochrome P450 family protein 0.0087 0.0132 0.1345
Brugia malayi RNA binding protein 0.0068 0.0098 0.1001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0014 0.0143
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0114 0.0179 0.1507
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0098 0.083
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0044 0.037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0098 0.1001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Echinococcus granulosus intermediate filament protein 0.0085 0.0128 0.108
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0108 0.4697
Onchocerca volvulus Neuropeptide F receptor homolog 0.0091 0.0138 0.7973
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0016 0.0009 0.0329
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0021 0.0934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0014 0.0143
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0025 0.0016
Brugia malayi neuropeptide F receptor 0.0091 0.0138 0.1404
Onchocerca volvulus 0.0091 0.0138 0.7973
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0071 0.3073
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0452
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.052 0.5292
Trichomonas vaginalis adenylate cyclase type III, putative 0.0011 0.0001 0.0026
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.0112 0.1143
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0108
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0014 0.0143
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0025 0.0025
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0016 0.0009 0.0091
Giardia lamblia Cysteinyl-tRNA synthetase 0.0085 0.0128 1
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0108 0.0108
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0016 0.0137
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0016 0.0165
Brugia malayi larval opioid receptor 0.0091 0.0138 0.1404
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0025 0.0016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0073 0.0748
Trypanosoma cruzi trypanothione reductase, putative 0.0067 0.0097 0.3974
Brugia malayi TAR-binding protein 0.0068 0.0098 0.1001
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0137
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0016 0.0009 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0011 0.009
Toxoplasma gondii ABC1 family protein 0.0073 0.0108 0.4697
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0014 0.0809
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0706
Trypanosoma cruzi transcription factor btf3, putative 0.0144 0.023 1
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0021 0.0567
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) ICD-1 protein 0.0144 0.023 0.2341
Leishmania major cytochrome p450-like protein 0.0087 0.0132 0.5745
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0138 0.1164
Echinococcus granulosus transcription factor btf3 0.0144 0.023 0.194
Onchocerca volvulus 0.0111 0.0173 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0021 0.0878
Schistosoma mansoni 60S ribosomal protein L21 0.0019 0.0014 0.012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0014 0.0118
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.0023 0.023
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0132 0.5573
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0011 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Trypanosoma brucei trypanothione reductase 0.0067 0.0097 0.4172
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0111 0.0173 0.146
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0024 0.0023 0.0191
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0071 0.303
Onchocerca volvulus 0.0091 0.0138 0.7973
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0014 0.0118
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0083 0.0125 0.1276
Echinococcus granulosus alpha 1A adrenergic receptor 0.0091 0.0138 0.1164
Brugia malayi Thioredoxin reductase 0.0067 0.0097 0.0985
Echinococcus granulosus single minded 2 0.0011 0.0001 0.0005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0021 0.0934
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0016 0.0165
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0934
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0006 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0011 0.0109
Onchocerca volvulus 0.0091 0.0138 0.7973
Echinococcus granulosus cGMP dependent protein kinase 1 0.0016 0.001 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0073 0.0748
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0025 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0111 0.0173 0.1761
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0098 0.083
Brugia malayi Cytochrome P450 family protein 0.0087 0.0132 0.1345
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0025 0.0253
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0021 0.1056
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0111 0.0173 0.1761
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0014 0.0143
Schistosoma mansoni hypothetical protein 0.0312 0.052 0.4385
Brugia malayi G-protein coupled receptor 0.0091 0.0138 0.1404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0567
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0022 0.0611
Echinococcus granulosus serotonin receptor 0.0091 0.0138 0.1164
Plasmodium vivax basic transcription factor 3b, putative 0.0144 0.023 1
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0138 0.1164
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0023 0.0982
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0175 0.7621
Onchocerca volvulus 0.0111 0.0173 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0025 0.0016
Leishmania major hypothetical protein, unknown function 0.0016 0.0009 0.0389
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0025 0.0025
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.0112 0.1143
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0025 0.1026
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0025 0.0025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0014 0.0118
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0019 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0025 0.0025
Brugia malayi Importin beta-1 subunit 0.0029 0.0032 0.0326
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0014 0.0118
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.009
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0138 0.1164
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus granulosus thioredoxin glutathione reductase 0.0067 0.0097 0.0816
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0071 0.0596
Brugia malayi Cytochrome P450 family protein 0.0025 0.0025 0.0253
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0011 0.009
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0001 0.0026
Trichomonas vaginalis ran, putative 0.0021 0.0019 0.0812
Leishmania major importin beta-1 subunit, putative 0.0024 0.0022 0.0976
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0025 0.0016
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0042 0.0351
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0138 0.1164
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0025 0.0721
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0138 0.1164
Brugia malayi Protein kinase domain containing protein 0.0015 0.0007 0.0072
Schistosoma mansoni ran 0.0021 0.0019 0.0158
Trichomonas vaginalis adenylate cyclase type, putative 0.0011 0.0001 0.0026
Onchocerca volvulus 0.0091 0.0138 0.7973
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0011 0.0001 0.0026
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0085 0.0128 0.5553
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0021 0.0934
Brugia malayi Cyclic-nucleotide gated cation channel 0.0024 0.0023 0.023
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0071 0.0719
Leishmania major protein kinase A regulatory subunit, putative 0.0016 0.0009 0.0389
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni hypothetical protein 0.0091 0.0138 0.1164
Onchocerca volvulus 0.0016 0.0009 0.0517
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0044 0.037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0108 0.0108
Mycobacterium tuberculosis Conserved protein 0.0073 0.0108 0.0108
Echinococcus multilocularis allatostatin A receptor 0.0091 0.0138 0.1164
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.0465
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0137
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0011 0.0465
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.0042 0.0351
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0098 0.083
Leishmania major hypothetical protein, conserved 0.0073 0.0108 0.4697
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0138 0.1164
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0014 0.0118
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0025 0.0721
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5804 1 1
Mycobacterium ulcerans beta-lactamase 0.0073 0.0108 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0108 0.0911
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0138 0.1164
Leishmania major regulatory subunit of protein kinase a-like protein 0.0016 0.0009 0.0389
Onchocerca volvulus 0.0076 0.0112 0.649
Echinococcus multilocularis G protein coupled receptor 139 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Brugia malayi prostaglandin transporter 0.0111 0.0173 0.1761
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0025 0.0016
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0032 0.1338
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0132 0.5573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Onchocerca volvulus 0.0073 0.0108 0.6242
Echinococcus granulosus voltage gated potassium channel 0.0035 0.0042 0.0351
Brugia malayi beta-lactamase family protein 0.0073 0.0108 0.11
Onchocerca volvulus Putative organic anion transporter 0.0111 0.0173 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0025 0.0016
Leishmania major cytochrome p450-like protein 0.0025 0.0025 0.1082
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0098 0.1001
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0128 0.1303
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0016 0.0009 0.0389
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0085 0.0128 0.5553
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0025 0.0025
Echinococcus multilocularis lamin 0.0085 0.0128 0.108
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0044 0.0452
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0016 0.0009 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0014 0.0143
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0189 0.1594
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0014 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0108 0.4697
Echinococcus granulosus peptide allatostatin:somatostatin 0.0091 0.0138 0.1164
Echinococcus granulosus 7TM GPCR rhodopsin 0.0091 0.0138 0.1164
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0138 0.1164
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0138 0.1164
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0022 0.0976
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0138 0.1164
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0024 0.0023 0.0191
Schistosoma mansoni hypothetical protein 0.0055 0.0076 0.0642
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0016 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0014 0.0118
Brugia malayi hypothetical protein 0.0091 0.0138 0.1404
Trypanosoma brucei cAMP binding protein, putative 0.0016 0.0009 0.0329
Echinococcus multilocularis G-protein coupled receptor, putative 0.0091 0.0138 0.1164
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0006 0.0363
Onchocerca volvulus 0.0073 0.0108 0.6242
Leishmania major hypothetical protein, conserved 0.0016 0.0009 0.0389
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0014 0.0118
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0042 0.0351
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0016 0.0009 0.0075
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0009 0.0389
Echinococcus multilocularis GPCR, family 2 0.0017 0.0011 0.009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0014 0.0118
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0001 0.0026
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0021 0.0934
Brugia malayi isocitrate dehydrogenase 0.0017 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0067 0.0097 0.0097
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0091 0.0138 0.1164
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0108 0.0099
Echinococcus granulosus leucyl tRNA synthetase 0.0085 0.0128 0.1077
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0016 0.0614
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0014 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0014 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0021 0.0567
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0085 0.0128 0.5373
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0071 0.2793
Echinococcus granulosus cGMP dependent protein kinase 1 0.0016 0.001 0.0082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.033
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0071 0.3073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0143
Brugia malayi nuclear hormone receptor 0.0019 0.0014 0.0143
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0189 0.1594
Echinococcus granulosus somatostatin receptor 0.0091 0.0138 0.1164
Brugia malayi Dopamine receptor protein 1 0.0091 0.0138 0.1404
Echinococcus granulosus hypothetical protein 0.0091 0.0138 0.1164
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0016 0.0009 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0108 0.11
Brugia malayi ecdysteroid receptor 0.0019 0.0014 0.0143
Schistosoma mansoni organic anion transporter 0.0111 0.0173 0.146
Entamoeba histolytica Ran family GTPase 0.0021 0.0019 0.0812
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0042 0.0351
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0016 0.0614
Schistosoma mansoni retinoic acid receptor RXR 0.0124 0.0196 0.1651
Schistosoma mansoni opsin-like receptor 0.0091 0.0138 0.1164
Brugia malayi putative neuropeptide receptor 0.0091 0.0138 0.1404
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0071 0.3073
Loa Loa (eye worm) hypothetical protein 0.0111 0.0173 0.1761
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0138 0.1404
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0016 0.0009 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0025 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0424
Loa Loa (eye worm) beta-lactamase 0.0073 0.0108 0.11
Brugia malayi N-terminal motif family protein 0.0016 0.0009 0.0091
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0108 0.0107
Echinococcus multilocularis 0.0025 0.0025 0.021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.0023 0.0191
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni ran 0.0021 0.0019 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0014 0.0143
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0022 0.0976
Onchocerca volvulus 0.0091 0.0138 0.7973
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0108 0.0913
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0071 0.0596
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0138 0.1164
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0016 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0014 0.0143
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0009 0.0389
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0505
Echinococcus multilocularis serotonin receptor 0.0091 0.0138 0.1164
Schistosoma mansoni intermediate filament proteins 0.0085 0.0128 0.108
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.1143
Toxoplasma gondii transporter, major facilitator family protein 0.0111 0.0173 0.7525
Loa Loa (eye worm) hypothetical protein 0.0111 0.0173 0.1761
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0091 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Brugia malayi G-protein coupled receptor 0.0091 0.0138 0.1404
Trypanosoma cruzi MFS transporter, putative 0.0111 0.0173 0.7424
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0014 0.0143
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0124 0.0196 0.1651
Leishmania major basic transcription factor 3a, putative 0.0144 0.023 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0023 0.0021 0.0021
Onchocerca volvulus 0.0091 0.0138 0.7973
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0014 0.0118
Onchocerca volvulus 0.0091 0.0138 0.7973
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0011 0.009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0138 0.1164
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0025 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Onchocerca volvulus 0.0091 0.0138 0.7973
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0011 0.0001 0.0026
Echinococcus granulosus fmrfamide receptor 0.0091 0.0138 0.1164
Leishmania major GTP-binding protein, putative 0.0021 0.0019 0.0812
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0016 0.0009 0.0075
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0014 0.0118
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0085 0.0128 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0071 0.0596
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.0112 0.4883
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0021 0.0021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0021 0.0567
Loa Loa (eye worm) hypothetical protein 0.0085 0.0128 0.13
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0032 0.1391
Onchocerca volvulus 0.0085 0.0128 0.74
Loa Loa (eye worm) hypothetical protein 0.0111 0.0173 0.1761
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0138 0.1164
Schistosoma mansoni adenoreceptor 0.0091 0.0138 0.1164
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0076 0.0112 0.1143
Loa Loa (eye worm) hypothetical protein 0.0091 0.0138 0.1404
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0023 0.0982
Echinococcus multilocularis musashi 0.0085 0.0128 0.108
Leishmania major protein kinase, putative 0.0016 0.001 0.0424
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0025 0.1082
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.023 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0091 0.0138 0.1164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0014 0.0118
Onchocerca volvulus 0.0019 0.0014 0.0809
Echinococcus granulosus cysteinyl tRNA synthetase 0.0085 0.0128 0.1077
Schistosoma mansoni hypothetical protein 0.0025 0.0025 0.021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.009
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0138 0.1164
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0091 0.0138 0.1164
Plasmodium falciparum cysteine--tRNA ligase 0.0085 0.0128 0.5553
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0021 0.0013
Trichomonas vaginalis adenylate cyclase type III, putative 0.0011 0.0001 0.0026
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.0112 0.1143
Onchocerca volvulus 0.0091 0.0138 0.7973
Schistosoma mansoni neuropeptide receptor 0.0091 0.0138 0.1164
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0011 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0014 0.0143
Brugia malayi RNA, U transporter 1 0.0083 0.0125 0.1272
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0016 0.0009 0.0389
Loa Loa (eye worm) melatonin receptor type 1A 0.0091 0.0138 0.1404
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0138 0.1164
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0025 0.0016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0532
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0025 0.0016
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0016 0.0009 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0026
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0138 0.1164
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.0023 0.0191
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0016 0.0009 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0138 0.1164
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0025 0.0025
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0016 0.033
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0138 0.1404
Brugia malayi ORL1-like opioid receptor 0.0091 0.0138 0.1404
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0016 0.0009 0.0009
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0001 0.0026
Echinococcus multilocularis follistatin 0.0076 0.0112 0.0947
Echinococcus granulosus tachykinin peptides receptor 99D 0.0091 0.0138 0.1164
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0016 0.0009 0.0075

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 13 uM Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cells ChEMBL. 11078192
Kd (binding) = 13 uM Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cells ChEMBL. 11078192

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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