Detailed information for compound 1321916

Basic information

Technical information
  • TDR Targets ID: 1321916
  • Name: ethyl 4-[4-(4-ethylphenyl)-6-oxo-3-phenyl-1,4 -dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoate
  • MW: 451.516 | Formula: C28H25N3O3
  • H donors: 1 H acceptors: 3 LogP: 5.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)N1C(=O)c2c(C1c1ccc(cc1)CC)c(n[nH]2)c1ccccc1
  • InChi: 1S/C28H25N3O3/c1-3-18-10-12-20(13-11-18)26-23-24(19-8-6-5-7-9-19)29-30-25(23)27(32)31(26)22-16-14-21(15-17-22)28(33)34-4-2/h5-17,26H,3-4H2,1-2H3,(H,29,30)
  • InChiKey: YITAKHDSVWIGOT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-[4-(4-ethylphenyl)-6-oxo-3-phenyl-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid ethyl ester
  • 4-[4-(4-ethylphenyl)-6-keto-3-phenyl-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid ethyl ester
  • C390-0329
  • NCGC00108493-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0076 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0248 0.3101
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0108 0.0852
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0131 0.1037
Onchocerca volvulus 0.0234 0.0792 0.4903
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0028 0.1563
Mycobacterium ulcerans hypothetical protein 0.0143 0.0461 0.5372
Brugia malayi beta-lactamase 0.0143 0.0461 0.093
Loa Loa (eye worm) hypothetical protein 0.005 0.0127 0.0256
Echinococcus multilocularis GPCR, family 2 0.0038 0.0083 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.012 0.0616
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.0461 0.5767
Schistosoma mansoni zinc finger protein 0.004 0.009 0.009
Echinococcus granulosus peregrin 0.0034 0.0069 0.0069
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0076 0.5
Brugia malayi AMP-binding enzyme family protein 0.0048 0.012 0.0242
Brugia malayi CHD4 protein 0.0027 0.0042 0.0084
Plasmodium vivax SET domain protein, putative 0.003 0.0053 0.0781
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0028 0.0346
Echinococcus multilocularis chromobox protein 1 0.0139 0.0447 0.0447
Schistosoma mansoni chromobox protein 0.0139 0.0447 0.0447
Schistosoma mansoni rotamase 0.0067 0.0187 0.0187
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Loa Loa (eye worm) hypothetical protein 0.0083 0.0246 0.0495
Loa Loa (eye worm) hypothetical protein 0.1387 0.4957 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Toxoplasma gondii hypothetical protein 0.0059 0.0158 0.3153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0413
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0108 0.0852
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0103 0.0103
Onchocerca volvulus 0.0234 0.0792 0.4903
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0051 0.0051
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0083 0.0168
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1263 1
Echinococcus multilocularis expressed protein 0.0067 0.0187 0.0187
Toxoplasma gondii ABC1 family protein 0.0143 0.0461 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0053 0.0781
Onchocerca volvulus 0.0097 0.0298 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0054 0.068
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0234 0.0792 0.2283
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0164 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Brugia malayi Bromodomain containing protein 0.0078 0.0228 0.0459
Echinococcus granulosus Chromobox protein 3 0.0023 0.0028 0.0028
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0108 0.5483
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.02 0.1582
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.021 0.021
Schistosoma mansoni acetylcholinesterase 0.0234 0.0792 0.0792
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0042 0.0084
Echinococcus multilocularis chromobox protein 1 0.0139 0.0447 0.0447
Plasmodium vivax hypothetical protein, conserved 0.0143 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.012 0.0616
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0051 0.0739
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0028 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus multilocularis Chromo domain 0.0023 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0569 0.4506
Mycobacterium leprae Probable lipase LipE 0.0143 0.0461 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0051 0.0636
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Onchocerca volvulus 0.0052 0.0135 0.0738
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0242
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0131 0.1037
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0108 0.0852
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0108 0.0108
Echinococcus multilocularis neuroligin 0.0234 0.0792 0.0792
Echinococcus granulosus carboxylesterase 5A 0.1387 0.4957 0.4957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.0461 0.5767
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0076 0.0153
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0292 0.0292
Brugia malayi jmjC domain containing protein 0.0096 0.0292 0.0589
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0019 0.0019
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0019 0.015
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0075 0.0591
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.0385 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0042 0.0531
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0066 0.1072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.012 0.6258
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0019 0.0038
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1263 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0071 0.0071
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0292 0.0292
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0112 0.0112
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0108 0.5483
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0171 0.1357
Brugia malayi jmjC domain containing protein 0.0039 0.0088 0.0177
Leishmania major cysteine peptidase A (CPA) 0.002 0.0019 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Mycobacterium tuberculosis Conserved protein 0.0143 0.0461 0.1237
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0028 0.0056
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0447 0.5589
Brugia malayi Carboxylesterase family protein 0.1387 0.4957 1
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Schistosoma mansoni hypothetical protein 0.0023 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0083 0.0083
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0104
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0156 0.0315
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0234 0.0792 0.9916
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0028 0.1563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0179 0.0179
Schistosoma mansoni bromodomain containing protein 0.0129 0.0411 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.012 0.6258
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0083 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.0461 0.5767
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0028 0.0346
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0019 0.015
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0028 0.0203
Brugia malayi hypothetical protein 0.0457 0.1597 0.3222
Trichomonas vaginalis rotamase, putative 0.0067 0.0187 0.2334
Loa Loa (eye worm) hypothetical protein 0.0061 0.0166 0.0335
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0143 0.0461 0.093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Echinococcus granulosus chromobox protein 1 0.0139 0.0447 0.0447
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Schistosoma mansoni chromobox protein 0.0023 0.0028 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.012 0.0616
Plasmodium falciparum phd finger protein, putative 0.0029 0.0051 0.5695
Loa Loa (eye worm) hypothetical protein 0.0457 0.1597 0.3222
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0224 0.1773
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Mycobacterium ulcerans hypothetical protein 0.0048 0.012 0.0616
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Onchocerca volvulus 0.0234 0.0792 0.4903
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0088 0.0088
Loa Loa (eye worm) carboxylesterase 0.0234 0.0792 0.1599
Mycobacterium tuberculosis Probable lipase LipD 0.0143 0.0461 0.1237
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0242
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0143 0.0461 0.1237
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0071 0.0071
Brugia malayi MH2 domain containing protein 0.0144 0.0466 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0043 0.0103 0.0103
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0977 0.0977
Echinococcus granulosus GPCR family 2 0.0038 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Mycobacterium ulcerans lipase LipD 0.0143 0.0461 0.5372
Leishmania major hypothetical protein, conserved 0.0143 0.0461 0.3649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Brugia malayi chromobox protein homolog 3 0.0078 0.0227 0.0457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0049 0.0049
Schistosoma mansoni BC026374 protein (S09 family) 0.0234 0.0792 0.0792
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0224 0.1773
Loa Loa (eye worm) beta-lactamase 0.0143 0.0461 0.093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Brugia malayi PHD-finger family protein 0.0051 0.0129 0.026
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0028 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0187 0.2334
Brugia malayi hypothetical protein 0.0286 0.0977 0.1971
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0076 0.1297
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0028 0.0203
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0075 0.0591
Schistosoma mansoni chromobox protein 0.0139 0.0447 0.0447
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0135 0.0135
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0181 0.1432
Mycobacterium ulcerans beta-lactamase 0.0143 0.0461 0.5372
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0553
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0098 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0108 0.1347
Loa Loa (eye worm) hypothetical protein 0.0097 0.0298 0.0601
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.0385 0.0385
Loa Loa (eye worm) cysteine protease 0.002 0.0019 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0519
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0019 0.015
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0227 0.1317
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0112 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0019 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0447 0.5589
Echinococcus multilocularis BC026374 protein (S09 family) 0.0234 0.0792 0.0792
Brugia malayi AMP-binding enzyme family protein 0.0048 0.012 0.0242
Onchocerca volvulus Alhambra homolog 0.0029 0.0051 0.0207
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0234 0.0792 0.0792
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0028 0.1563
Mycobacterium tuberculosis Probable lipase LipE 0.0143 0.0461 0.1237
Loa Loa (eye worm) ctsf protein 0.002 0.0019 0.0038
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0071 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.012 0.0616
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Loa Loa (eye worm) carboxylesterase 0.1387 0.4957 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0042 0.0042
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0019 0.0019
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0799 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Brugia malayi hypothetical protein 0.0043 0.0103 0.0207
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0078 0.0228 0.046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus multilocularis cysteine protease 0.002 0.0019 0.0019
Schistosoma mansoni zinc finger protein 0.0031 0.0058 0.0058
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0108 0.0108
Mycobacterium ulcerans carboxylesterase, LipT 0.0234 0.0792 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.012 0.0952
Echinococcus granulosus chromobox protein 2 0.0023 0.0028 0.0028
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Trichomonas vaginalis spcc417.12 protein, putative 0.0234 0.0792 0.9916
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0553
Echinococcus granulosus acetylcholinesterase 0.1387 0.4957 0.4957
Loa Loa (eye worm) fibroinase 0.002 0.0019 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0234 0.0792 0.2283
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0019 0.015
Onchocerca volvulus 0.0457 0.1597 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0413
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.012 0.0381 0.0768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0042 0.0531
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0242
Leishmania major cathepsin L-like protease 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.0078 0.0227 0.0457
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0028 0.0203
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0.0019 0.5
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0131 0.1037
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Leishmania major cathepsin L-like protease 0.0077 0.0224 0.1773
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0075 0.0591
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Mycobacterium tuberculosis Conserved protein 0.0143 0.0461 0.1237
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Leishmania major hypothetical protein, conserved 0.0031 0.0058 0.0462
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0234 0.0792 0.0792
Echinococcus multilocularis peregrin 0.0034 0.0069 0.0069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0143 0.0461 0.093
Schistosoma mansoni neuroligin 3 (S09 family) 0.0234 0.0792 0.0792
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Brugia malayi Pre-SET motif family protein 0.003 0.0053 0.0107
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0022 0.0176
Echinococcus granulosus cathepsin l1 0.002 0.0019 0.0019
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0067 0.0187 0.0376
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0381 0.0768
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0461 0.3649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0042 0.0531
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.012 0.6258
Brugia malayi Protein cec-1. 0.0023 0.0028 0.0056
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0065 0.0181 0.1432
Brugia malayi hypothetical protein 0.0234 0.0792 0.1599
Echinococcus multilocularis acetylcholinesterase 0.1387 0.4957 0.4957
Echinococcus granulosus tumor protein p63 0.0666 0.2351 0.2351
Loa Loa (eye worm) hypothetical protein 0.0065 0.0179 0.0361
Trypanosoma cruzi ISWI complex protein 0.0031 0.0058 0.0462
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Loa Loa (eye worm) helicase 0.0023 0.0028 0.0056
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0381 0.0768
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.0792 0.0792
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0227 0.2834
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0911 0.3237 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0019 0.0004
Brugia malayi hypothetical protein 0.0023 0.0028 0.0056
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0143 0.0461 0.1237
Onchocerca volvulus 0.0048 0.012 0.0643
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0248 0.1452
Echinococcus granulosus para nitrobenzyl esterase 0.0234 0.0792 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.012 0.0616
Trypanosoma brucei ISWI complex protein 0.0031 0.0058 0.0462
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0083 0.0168
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0028 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.012 0.0952
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Brugia malayi AMP-binding enzyme family protein 0.0048 0.012 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0108 0.1347
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0019 0.0234
Brugia malayi beta-lactamase family protein 0.0143 0.0461 0.093
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0143 0.0461 0.1237
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0164 0.1302
Schistosoma mansoni hypothetical protein 0.0058 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.0461 0.3649
Echinococcus granulosus beta LACTamase domain containing family member 0.0143 0.0461 0.0461
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0569 0.4506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0093 0.0093
Schistosoma mansoni gliotactin 0.0234 0.0792 0.0792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0051 0.0104
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.0792 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Onchocerca volvulus 0.0023 0.0028 0.0057
Brugia malayi Carboxylesterase family protein 0.1387 0.4957 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0065 0.0181 0.1432
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Echinococcus multilocularis zinc finger protein 0.004 0.009 0.009
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0103 0.0103
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0058
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0019 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0028 0.0203
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0131 0.1037
Trichomonas vaginalis hypothetical protein 0.0023 0.0028 0.0346
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0083 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0461 0.3649
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1263 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0181 0.1432
Onchocerca volvulus 0.0234 0.0792 0.4903
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0083 0.0083
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0553
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Brugia malayi PHD-finger family protein 0.0029 0.0051 0.0104
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0553
Echinococcus multilocularis microtubule associated protein 2 0.2784 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Toxoplasma gondii peptidylprolyl isomerase 0.0065 0.0181 0.3666
Echinococcus granulosus BC026374 protein S09 family 0.0234 0.0792 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0519
Echinococcus granulosus neuroligin 0.0234 0.0792 0.0792
Schistosoma mansoni hypothetical protein 0.0029 0.0051 0.0051
Echinococcus multilocularis tumor protein p63 0.0666 0.2351 0.2351
Brugia malayi Bromodomain containing protein 0.0153 0.0498 0.1004
Trypanosoma cruzi ISWI complex protein 0.0031 0.0058 0.0462
Mycobacterium ulcerans esterase/lipase LipP 0.0143 0.0461 0.5372
Echinococcus multilocularis beta LACTamase domain containing family member 0.0143 0.0461 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Onchocerca volvulus 0.0236 0.0799 0.4945
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0088 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.012 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Echinococcus granulosus zinc finger protein 0.004 0.009 0.009
Echinococcus granulosus chromobox protein 1 0.0139 0.0447 0.0447
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.012 0.0952
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0088 0.0088
Mycobacterium tuberculosis Probable hydrolase 0.0143 0.0461 0.1237
Schistosoma mansoni microtubule-associated protein tau 0.2784 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0179 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.012 0.0162
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0028 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.012 0.0616
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0076 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0108 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0145 0.1808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0977 0.0977
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis esterase, putative 0.0143 0.0461 0.5767
Leishmania major cathepsin L-like protease 0.0077 0.0224 0.1773
Mycobacterium tuberculosis Carboxylesterase LipT 0.0234 0.0792 0.2283
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0019 0.0019
Mycobacterium tuberculosis Conserved protein 0.0143 0.0461 0.1237
Echinococcus granulosus Chromo domain 0.0023 0.0028 0.0028
Loa Loa (eye worm) heterochromatin protein 1 0.0139 0.0447 0.0901
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0051 0.0739
Brugia malayi Pre-SET motif family protein 0.0208 0.0696 0.1403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0413
Echinococcus multilocularis chromobox protein 2 0.0023 0.0028 0.0028
Schistosoma mansoni survival motor neuron protein 0.0058 0.0156 0.0156
Onchocerca volvulus 0.0143 0.0461 0.2802
Loa Loa (eye worm) hypothetical protein 0.0144 0.0466 0.094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0108 0.0852
Echinococcus multilocularis para nitrobenzyl esterase 0.0234 0.0792 0.0792
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0466 0.0941
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0013 0.0103
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0224 0.1773
Onchocerca volvulus 0.0023 0.0028 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.0461 0.5767
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0227 0.2834
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0019 0.0148
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.1387 0.4957 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Echinococcus multilocularis cysteine protease 0.002 0.0019 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1263 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0019 0.0038
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0248 0.3101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Mycobacterium ulcerans hypothetical protein 0.0192 0.064 0.7866
Loa Loa (eye worm) hypothetical protein 0.0082 0.0243 0.049
Echinococcus granulosus acetylcholinesterase 0.1387 0.4957 0.4957
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0028 0.0028
Echinococcus multilocularis acetylcholinesterase 0.1387 0.4957 0.4957
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0221 0.0221
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0067 0.0187 0.0376
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0696 0.1403
Echinococcus multilocularis carboxylesterase 5A 0.1387 0.4957 0.4957
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Mycobacterium leprae conserved hypothetical protein 0.0143 0.0461 1
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0028 0.0346
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Schistosoma mansoni hypothetical protein 0.0082 0.0243 0.0243
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0042 0.0042
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0569 0.4506
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Onchocerca volvulus 0.0234 0.0792 0.4903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0088 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.0461 0.0461
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0019 0.0038
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0028 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0145 0.1808
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0019 0.0234
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0298 0.0298
Brugia malayi beta-lactamase family protein 0.0143 0.0461 0.093
Echinococcus granulosus expressed protein 0.0067 0.0187 0.0187
Onchocerca volvulus 0.0143 0.0461 0.2802
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0108 0.0217
Giardia lamblia GTOR 0.0045 0.0108 1
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.0461 0.5767
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0553
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0028 0.0056
Onchocerca volvulus 0.0061 0.0166 0.0932
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0084 0.105
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.012 0.0616
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0051 0.0739
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0108 0.1347
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Loa Loa (eye worm) hypothetical protein 0.0286 0.0977 0.1971
Onchocerca volvulus 0.0058 0.0156 0.087
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Mycobacterium tuberculosis Probable esterase LipL 0.0143 0.0461 0.1237
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0108 0.0108
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0028 0.0028
Trichomonas vaginalis rotamase, putative 0.0065 0.0181 0.2263
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0466 0.0941
Brugia malayi Bromodomain containing protein 0.0034 0.0069 0.0139
Loa Loa (eye worm) hypothetical protein 0.0087 0.026 0.0524
Brugia malayi SET domain containing protein 0.0024 0.0032 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0179 0.0179
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0224 0.1773
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.064 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0108 0.0852
Schistosoma mansoni chromobox protein 0.0023 0.0028 0.0028
Loa Loa (eye worm) acetylcholinesterase 1 0.1387 0.4957 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0181 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0381 0.0768
Loa Loa (eye worm) carboxylesterase 0.0234 0.0792 0.1599
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0243 0.049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Onchocerca volvulus 0.0143 0.0461 0.2802
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1387 0.4957 0.4957
Brugia malayi Heterochromatin protein 1 0.0139 0.0447 0.0901
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0179 0.0179
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0108 0.0217
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0028 0.0203
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0143 0.0461 0.5372

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.2809 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 26.1216 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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