Detailed information for compound 1322006

Basic information

Technical information
  • TDR Targets ID: 1322006
  • Name: 3-(2,4-dimethoxyphenyl)-1-(3-methylbutyl)-1-( 1-pyridin-2-ylethyl)urea
  • MW: 371.473 | Formula: C21H29N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.6 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=O)N(C(c1ccccn1)C)CCC(C)C
  • InChi: 1S/C21H29N3O3/c1-15(2)11-13-24(16(3)18-8-6-7-12-22-18)21(25)23-19-10-9-17(26-4)14-20(19)27-5/h6-10,12,14-16H,11,13H2,1-5H3,(H,23,25)
  • InChiKey: GCEOXMRDLSVMCS-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-(2,4-dimethoxyphenyl)-1-isopentyl-1-[1-(2-pyridyl)ethyl]urea
  • 3-(2,4-dimethoxyphenyl)-1-isoamyl-1-[1-(2-pyridyl)ethyl]urea
  • MLS000120180
  • SMR000097097

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Onchocerca volvulus Chorion peroxidase homolog 0.0057 0.0339 0.1395
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Brugia malayi conserved hypotetical protein 0.002 0.0054 0.0197
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Mycobacterium ulcerans polyketide synthase Pks13 0.0041 0.0212 0.0188
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0039 0.0137
Echinococcus granulosus microtubule associated protein 2 0.0735 0.5608 1
Onchocerca volvulus 0.0058 0.0349 0.1438
Schistosoma mansoni notch 0.0018 0.0039 0.0058
Onchocerca volvulus 0.0018 0.0039 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Brugia malayi nuclear hormone receptor 0.0043 0.023 0.0938
Onchocerca volvulus 0.002 0.0054 0.0197
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.023 0.0963
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0041 0.0212 0.0263
Brugia malayi nuclear receptor RXR 0.002 0.0054 0.0197
Brugia malayi EGF-like domain containing protein 0.0018 0.0039 0.0137
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0054 0.0197
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.1071 0.1049
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0105 0.0414
Echinococcus granulosus protein jagged 2 0.0018 0.0039 0.0058
Brugia malayi nuclear receptor NHR-88 0.0043 0.023 0.0938
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.2301 1
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) hypothetical protein 0.0107 0.0726 0.3041
Schistosoma mansoni hypothetical protein 0.0058 0.0349 0.0611
Brugia malayi Muscle positioning protein 4 0.0018 0.0039 0.0137
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.023 0.0938
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0243 0.0995
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0101 0.0107
Schistosoma mansoni hypothetical protein 0.0034 0.0159 0.0272
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2115 0.3763
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0101 0.0107
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.023 0.0938
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0105 0.0415
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0105 0.6197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Onchocerca volvulus 0.0018 0.0039 0.0137
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0056 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.023 0.0938
Echinococcus granulosus slit 2 protein 0.0018 0.0039 0.0058
Onchocerca volvulus 0.0259 0.1907 0.7988
Onchocerca volvulus 0.0018 0.0039 0.0137
Echinococcus multilocularis notch 0.0018 0.0039 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0054 0.0197
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0105 0.0359
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.023 0.0398
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0058 0.0047
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0111 0.0438
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.2301 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0105 0.6197
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0367 0.2745 0.2727
Schistosoma mansoni notch 0.0018 0.0039 0.0058
Schistosoma mansoni peroxidasin 0.0057 0.0339 0.0593
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.1032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0054 0.0197
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0058
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0111 0.0186
Schistosoma mansoni hypothetical protein 0.0307 0.2281 0.406
Onchocerca volvulus 0.0053 0.031 0.1273
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0339 0.1419
Brugia malayi Endoplasmin precursor 0.0035 0.0165 0.0667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.023 0.0398
Brugia malayi EGF-like domain containing protein 0.0018 0.0039 0.0137
Schistosoma mansoni cell polarity protein 0.0018 0.0039 0.0058
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0056 0.0208
Echinococcus granulosus protein jagged 2 0.0018 0.0039 0.0058
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0055 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Toxoplasma gondii EGF family domain-containing protein 0.0018 0.0039 0.0119
Loa Loa (eye worm) hypothetical protein 0.0055 0.0325 0.1361
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0061 0.0239
Echinococcus multilocularis fibropellin Ia 0.0018 0.0039 0.0049
Brugia malayi EGF-like domain containing protein 0.0018 0.0039 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.023 0.0938
Schistosoma mansoni thyroid hormone receptor 0.0043 0.023 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.1071 0.1468
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0159 0.0272
Brugia malayi ecdysteroid receptor 0.0043 0.023 0.0938
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0235
Onchocerca volvulus 0.0057 0.0339 0.1395
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Schistosoma mansoni notch 0.0018 0.0039 0.0058
Schistosoma mansoni hypothetical protein 0.0073 0.0463 0.0815
Schistosoma mansoni endoplasmin 0.0035 0.0165 0.0283
Mycobacterium leprae Polyketide synthase Pks13 0.0041 0.0212 0.0263
Onchocerca volvulus 0.0018 0.0039 0.0137
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0339 0.1419
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0072 0.0277
Brugia malayi Delta serrate ligand family protein 0.0018 0.0039 0.0137
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1072 0.4488
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.023 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.023 0.0938
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0466 0.082
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0115 0.0127
Onchocerca volvulus 0.032 0.2386 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0243 0.103
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0243 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.023 0.0938
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0159 0.0557
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.023 0.0398
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0054 0.0071
Echinococcus multilocularis protein patched 0.0045 0.0246 0.0363
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0057 0.0045
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0339 0.1395
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.023 0.0338
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0864 0.6608 1
Loa Loa (eye worm) notch protein 0.0018 0.0039 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0107 0.0421
Onchocerca volvulus Peroxidase homolog 0.0057 0.0339 0.1395
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0041 0.0212 0.0263
Schistosoma mansoni zinc finger protein 0.002 0.0054 0.0084
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0056 0.0075
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0115 0.0127
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0711 0.3072
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0466 0.082
Schistosoma mansoni hypothetical protein 0.0034 0.0159 0.0272
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0054 0.0084
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0054 0.0084
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0052 0.0302 0.1243
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.023 0.0338
Brugia malayi nuclear receptor NHR-67 0.002 0.0054 0.0197
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0039 0.0058
Onchocerca volvulus Fatty acid synthase homolog 0.0052 0.0302 0.1243
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.023 0.0963
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.023 0.0398
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0115 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0111 0.0316
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1301 1 1
Onchocerca volvulus 0.002 0.0054 0.0197
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0101 0.0107
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.023 0.0963
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0711 0.1258
Brugia malayi EGF-like domain containing protein 0.0018 0.0039 0.0137
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2115 0.3193
Onchocerca volvulus Slit protein homolog 0.0018 0.0039 0.0137
Echinococcus multilocularis neural cadherin 0.0018 0.0039 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Giardia lamblia DINP protein human, muc B family 0.0021 0.0056 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0466 0.0443
Echinococcus granulosus notch 0.0018 0.0039 0.0058
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0115 0.0127
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0207 0.0256
Schistosoma mansoni notch 0.0018 0.0039 0.0058
Brugia malayi hypothetical protein 0.0023 0.0072 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0339 0.1395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0726 0.3021
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0934 0.7152 1
Onchocerca volvulus Peroxidase homolog 0.0057 0.0339 0.1395
Echinococcus multilocularis dna polymerase eta 0.0021 0.0056 0.0075
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.023 0.0338
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.023 0.0398
Brugia malayi steroid hormone receptor 0.0043 0.023 0.0938
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0058
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0165 0.0692
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.023 0.0398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0726 0.3041
Schistosoma mansoni nuclear hormone receptor 0.002 0.0054 0.0084
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Echinococcus multilocularis fat cadherin tumor suppressor 0.0018 0.0039 0.0049
Onchocerca volvulus Dual oxidase homolog 0.0057 0.0339 0.1395
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.023 0.0938
Brugia malayi ecdysone receptor 0.002 0.0054 0.0197
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0111 0.0438
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Brugia malayi notch-like transmembrane receptor 0.0018 0.0039 0.0137
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0159 0.0231
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.1061 0.1882
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.023 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.023 0.0963
Schistosoma mansoni hypothetical protein 0.0358 0.2675 0.4764
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0304
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1301 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0466 0.062
Echinococcus multilocularis heat shock protein 90 0.0028 0.0111 0.0158
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0056 0.0216
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0039 0.0137
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0072 0.01
Loa Loa (eye worm) DR-78 0.002 0.0054 0.0225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.006 0.0049
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0039 0.0137
Leishmania major DNA polymerase eta, putative 0.0021 0.0056 0.0209
Echinococcus granulosus delta-like protein 1 0.0018 0.0039 0.0058
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0057 0.0032
Brugia malayi Cadherin domain containing protein 0.0018 0.0039 0.0137
Echinococcus granulosus X box binding protein 1 0.0307 0.2281 0.406
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0056 0.0075
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0159 0.0665
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0034 0.0159 0.0665
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.023 0.0398
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.1061 0.1597
Onchocerca volvulus Huntingtin homolog 0.0131 0.091 0.3799
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0246 0.1007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Mycobacterium ulcerans polyketide synthase 0.0026 0.0101 0.0076
Echinococcus granulosus neural cadherin 0.0018 0.0039 0.0058
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0339 0.1419
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0159 0.0642
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0007 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.023 0.0938
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.023 0.0938
Echinococcus multilocularis protein dispatched 1 0.0051 0.0296 0.0438
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0207 0.0256
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0246 0.0428
Schistosoma mansoni coup transcription factor 0.0043 0.023 0.0398
Brugia malayi Nuclear hormone receptor E75 0.002 0.0054 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.023 0.0938
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0466 0.1935
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Echinococcus granulosus protein jagged 1 0.0018 0.0039 0.0058
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0057 0.0183
Echinococcus multilocularis protein jagged 2 0.0018 0.0039 0.0049
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0243 0.0995
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0243 0.0134
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0159 0.0641
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0111 0.0121
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0726 0.3021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.1205 0.1656
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0165 0.0692
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0349 0.1438
Echinococcus granulosus FTZ F1 alpha 0.0043 0.023 0.0398
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0165 0.0669
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0466 0.0696
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.2381 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0165 0.0669
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Leishmania major hypothetical protein, conserved 0.0027 0.0105 0.0414
Mycobacterium ulcerans polyketide synthase 0.0028 0.0115 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0056 0.0216
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0054 0.0084
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.031 0.0541
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0165 0.058
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0165 1
Mycobacterium ulcerans thioesterase 0.0024 0.0084 0.006
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0165 0.0669
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0111 0.0453
Loa Loa (eye worm) hypothetical protein 0.0286 0.2115 0.8863
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0111 0.0438
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0724 0.128
Onchocerca volvulus Neurogenic locus notch homolog 0.0018 0.0039 0.0137
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0322 0.1329
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.023 0.0338
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Brugia malayi EGF-like domain containing protein 0.0018 0.0039 0.0137
Brugia malayi nuclear hormone receptor 0.002 0.0054 0.0197
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0159 0.0231
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.023 0.0398
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0159 0.0272
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.023 0.0938
Schistosoma mansoni inositol monophosphatase 0.0045 0.0243 0.0422
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0367 0.2745 0.3817
Echinococcus multilocularis geminin 0.0358 0.2675 0.4042
Loa Loa (eye worm) Notch2 0.0018 0.0039 0.0165
Onchocerca volvulus 0.0057 0.0339 0.1395
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0159 0.023
Brugia malayi Peroxidasin 0.0057 0.0339 0.1395
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0885 0.3707
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0159 0.0639
Brugia malayi nuclear receptor RXR 0.0023 0.0072 0.0277
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0243 0.103
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0058
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0165 0.0669
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0159 0.0189
Schistosoma mansoni hypothetical protein 0.0034 0.0159 0.0272
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.023 0.0398
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0934 0.7152 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.023 0.0938
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0246 0.1007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0159 0.0642
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0304
Loa Loa (eye worm) inositol-1 0.0045 0.0243 0.1018
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0111 0.0121
Brugia malayi Pax transcription factor protein 2 0.0259 0.1907 0.7988
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0885 0.3707
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0056 0.0209
Echinococcus granulosus tumor protein p63 0.0363 0.2719 0.4843
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0243 0.0863
Giardia lamblia Grp94/Hsp90 0.0028 0.0111 0.0316
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0043 0.0131
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0101 0.0396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0056 0.0044
Loa Loa (eye worm) hypothetical protein 0.0131 0.091 0.3816
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.023 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0115 0.0127
Echinococcus granulosus neurogenic locus notch protein 4 0.0018 0.0039 0.0058
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0056 0.0088
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0084 0.0084
Schistosoma mansoni laminin gamma-3 chain 0.0018 0.0039 0.0058
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.023 0.0938
Brugia malayi Blistered cuticle protein 3 0.0057 0.0339 0.1395
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Loa Loa (eye worm) hypothetical protein 0.0053 0.031 0.1298
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Echinococcus granulosus expressed conserved protein 0.0099 0.0662 0.117
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.023 0.0338
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.023 0.0398
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0039 0.0058
Echinococcus multilocularis neurogenic locus notch protein 4 0.0018 0.0039 0.0049
Plasmodium falciparum heat shock protein 90 0.0035 0.0165 1
Schistosoma mansoni hypothetical protein 0.0043 0.0234 0.0405
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Plasmodium vivax endoplasmin, putative 0.0035 0.0165 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0711 0.2962
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0339 0.1395
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0165 0.0669
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0243 0.103
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0054 0.0084
Toxoplasma gondii hypothetical protein 0.0052 0.0297 0.1061
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0243 0.0358
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.023 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.023 0.0398
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0054 0.0225
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Schistosoma mansoni microtubule-associated protein tau 0.0735 0.5608 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0054 0.0071
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Loa Loa (eye worm) hypothetical protein 0.0046 0.0254 0.1064
Echinococcus granulosus heat shock protein 90 0.0028 0.0111 0.0186
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.023 0.0938
Echinococcus granulosus endoplasmin 0.0028 0.0111 0.0186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0054 0.0084
Onchocerca volvulus 0.005 0.0288 0.1185
Schistosoma mansoni nuclear receptor 0.002 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0105 0.0711 0.2981
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0072 0.0304
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0159 0.9606
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0159 0.0643
Echinococcus multilocularis heat shock protein 0.0035 0.0165 0.0241
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0243 0.0995
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0165 0.0669
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0111 0.0453
Schistosoma mansoni survival motor neuron protein 0.0058 0.0349 0.0611
Echinococcus granulosus GPCR family 2 0.0034 0.0159 0.0272
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0711 0.1067
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0159 0.0557
Brugia malayi hypothetical protein 0.0057 0.0339 0.1395
Schistosoma mansoni hypothetical protein 0.0043 0.0234 0.0405
Schistosoma mansoni heat shock protein 0.0035 0.0165 0.0283
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0339 0.1419
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.023 0.0398
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.044
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0115 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.023 0.0938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.023 0.0963
Schistosoma mansoni endoplasmin 0.0035 0.0165 0.0283
Schistosoma mansoni inositol monophosphatase 0.0045 0.0243 0.0422
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.023 0.0963
Loa Loa (eye worm) hypothetical protein 0.0131 0.091 0.3816
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0339 0.1395
Echinococcus granulosus geminin 0.0358 0.2675 0.4764
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0054 0.0197
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0466 0.082
Brugia malayi nuclear receptor NHR-88 0.002 0.0054 0.0197
Brugia malayi Nuclear hormone receptor E75 0.002 0.0054 0.0197
Loa Loa (eye worm) hypothetical protein 0.032 0.2386 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0243 0.103
Echinococcus multilocularis tumor protein p63 0.0363 0.2719 0.4109
Brugia malayi Cadherin domain containing protein 0.0018 0.0039 0.0137
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0054 0.0225
Onchocerca volvulus Huntingtin homolog 0.0131 0.091 0.3799
Onchocerca volvulus 0.0043 0.023 0.0938
Echinococcus granulosus fibropellin Ia 0.0018 0.0039 0.0058
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0246 0.0363
Brugia malayi hypothetical protein 0.032 0.2386 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0056 0.0216
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.0039 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.023 0.0938
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Brugia malayi CHE-14 protein 0.0045 0.0246 0.1006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.023 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0072 0.0118
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.023 0.0938
Echinococcus multilocularis peroxidasin 0.0057 0.0339 0.0503
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0165 0.058
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0367 0.2745 1
Brugia malayi hypothetical protein 0.002 0.0054 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0072 0.0118
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.0107 0.0116
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0115 0.0127
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0039 0.0049
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0115 0.0127
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.2381 1
Onchocerca volvulus 0.0018 0.0039 0.0137
Brugia malayi follicle stimulating hormone receptor 0.028 0.2069 0.8668
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0165 0.0669
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.023 0.0398
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0056 0.0088
Onchocerca volvulus Peroxidasin homolog 0.0057 0.0339 0.1395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Brugia malayi EGF-like domain containing protein 0.0018 0.0039 0.0137
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0056 0.0209
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0056 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0105 0.0414
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Schistosoma mansoni nuclear hormone receptor 0.0043 0.023 0.0398
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0159 0.0272
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.1071 0.1468
Schistosoma mansoni slit 0.0018 0.0039 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0105 0.6197
Echinococcus multilocularis X box binding protein 1 0.0307 0.2281 0.3445
Echinococcus multilocularis expressed conserved protein 0.0099 0.0662 0.0993
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0243 0.0422
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0076
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0107
Onchocerca volvulus Putative cubilin 0.0018 0.0039 0.0137
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0054 0.0197
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0159 0.023
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0246 0.1007
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0056 0.0209
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Schistosoma mansoni peroxidasin 0.0057 0.0339 0.0593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.023 0.0963
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0159 0.0643
Echinococcus multilocularis microtubule associated protein 2 0.0735 0.5608 0.8485
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0039 0.0049
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0159 0.0667
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0246 0.0428
Trypanosoma brucei unspecified product 0.0021 0.0056 0.0209
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Echinococcus multilocularis GPCR, family 2 0.0034 0.0159 0.023
Brugia malayi hypothetical protein 0.0131 0.091 0.3799
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0039 0.0049
Leishmania major mitochondrial DNA polymerase beta 0.032 0.2381 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0463 0.1919
Schistosoma mansoni hypothetical protein 0.0358 0.2675 0.4764
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0018 0.0039 0.0058
Schistosoma mansoni notch 0.0018 0.0039 0.0058
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1072 0.4488
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2069 0.8672
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0054 0.0071
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.001 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.023 0.0963
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0111 0.0453
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0165 0.0669
Echinococcus multilocularis heat shock protein 90 0.0035 0.0165 0.0241
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0246 0.1032
Plasmodium falciparum endoplasmin, putative 0.0021 0.0061 0.345
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0061 0.0239
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0243 0.0995
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.2301 0.2215
Schistosoma mansoni hypothetical protein 0.0043 0.0234 0.0405
Onchocerca volvulus 0.0027 0.0107 0.0421
Schistosoma mansoni hypothetical protein 0.0043 0.0234 0.0405
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Brugia malayi heat shock protein 90 0.0035 0.0165 0.0667
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0159 0.0642
Schistosoma mansoni septate junction protein 0.0018 0.0039 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Echinococcus granulosus protein jagged 1 0.0018 0.0039 0.0058
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0054 0.0197
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0056 0.0235
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0225
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0339 0.1395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0165 0.0669
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0165 0.0558
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0072 0.0118
Echinococcus granulosus dna polymerase eta 0.0021 0.0056 0.0088
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1301 1 1
Echinococcus granulosus heat shock protein 90 0.0035 0.0165 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.023 0.0938
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0159 0.0231
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0056 0.0032
Leishmania major DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Echinococcus multilocularis protein jagged 1 0.0018 0.0039 0.0049
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0054 0.0084
Onchocerca volvulus Peroxidasin homolog 0.0057 0.0339 0.1395
Brugia malayi Inositol-1 0.0045 0.0243 0.0993
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0466 0.0443
Loa Loa (eye worm) hypothetical protein 0.0073 0.0463 0.1941
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.1072 0.4488
Loa Loa (eye worm) pax transcription factor protein 2 0.0259 0.1907 0.7993
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0466 0.1678
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0054 0.0225
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0039 0.0137
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0115 0.0395
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0072 0.0277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Loa Loa (eye worm) blistered cuticle protein 3 0.0057 0.0339 0.1419
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0084 0.006
Loa Loa (eye worm) endoplasmin 0.0035 0.0165 0.0693
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0115 0.0091
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0056 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Brugia malayi hypothetical protein 0.0017 0.0031 0.0103
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0056 0.0209
Echinococcus granulosus neurogenic locus protein delta 0.0018 0.0039 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0246 0.1007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0304
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0054 0.0084
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0056 0.0088
Brugia malayi hypothetical protein 0.0023 0.0072 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0246 0.1044
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0159 0.9606
Brugia malayi hypothetical protein 0.0286 0.2115 0.886
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0058
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0054 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.023 0.0398
Echinococcus multilocularis protein jagged 1 0.0018 0.0039 0.0049
Brugia malayi hypothetical protein 0.0027 0.0105 0.0414
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Brugia malayi tailless protein 0.002 0.0054 0.0197
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0101 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Brugia malayi hypothetical protein 0.002 0.0054 0.0197
Brugia malayi EGF-like domain containing protein 0.0018 0.0039 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.2301 1
Brugia malayi isocitrate dehydrogenase 0.0034 0.0159 0.0641
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0159 0.0231
Schistosoma mansoni patched 1 0.0045 0.0246 0.0428
Schistosoma mansoni thyroid hormone receptor 0.0043 0.023 0.0398
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0165 0.0692
Schistosoma mansoni nuclear hormone receptor 0.002 0.0054 0.0084
Echinococcus multilocularis endoplasmin 0.0028 0.0111 0.0158
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0056 0.0209
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.023 0.0938
Echinococcus multilocularis slit 2 protein 0.0018 0.0039 0.0049
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0111 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0054 0.0071
Schistosoma mansoni DNA polymerase eta 0.0021 0.0056 0.0088
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0107 0.0448
Echinococcus granulosus peroxidasin 0.0057 0.0339 0.0593
Loa Loa (eye worm) fatty acid synthase 0.0029 0.0119 0.0497
Echinococcus granulosus dna polymerase kappa 0.0021 0.0056 0.0088
Schistosoma mansoni heat shock protein 0.0035 0.0165 0.0283
Schistosoma mansoni nuclear receptor 0.002 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Mycobacterium ulcerans hypothetical protein 0.0168 0.1205 0.1183
Loa Loa (eye worm) hypothetical protein 0.0043 0.023 0.0963
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0054 0.0084
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0159 0.0231
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0039 0.0049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0054 0.0071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0159 0.0639
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0209
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0018 0.0039 0.0137
Brugia malayi MH2 domain containing protein 0.0127 0.0885 0.369
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0056 0.0044
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0115 0.0127
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0165 0.0693
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0057 0.0032
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.1419
Leishmania major heat shock protein 83-1 0.0035 0.0165 0.0669
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0304
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.2381 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0159 0.0272
Schistosoma mansoni hypothetical protein 0.0034 0.0159 0.0272
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.2301 1
Schistosoma mansoni notch 0.0018 0.0039 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0304
Echinococcus granulosus heat shock protein 0.0035 0.0165 0.0283
Onchocerca volvulus 0.0057 0.0339 0.1395
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.023 0.0338
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.023 0.0398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0466 0.0443

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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