Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.046 | 0.1596 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0422 | 0.0422 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0048 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.046 | 0.1596 | 0.1596 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.046 | 0.1596 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.046 | 0.1596 | 0.1555 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0422 | 0.0422 |
Onchocerca volvulus | 0.046 | 0.1596 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.046 | 0.1596 | 0.1555 |
Echinococcus granulosus | BC026374 protein S09 family | 0.046 | 0.1596 | 0.1555 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0422 | 0.0422 |
Onchocerca volvulus | 0.046 | 0.1596 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.046 | 0.1596 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Brugia malayi | Carboxylesterase family protein | 0.046 | 0.1596 | 0.1596 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.046 | 0.1596 | 0.1555 |
Brugia malayi | Carboxylesterase family protein | 0.2724 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0048 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.046 | 0.1596 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.0647 | 0.0601 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.046 | 0.1596 | 0.1555 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0647 | 0.0601 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.046 | 0.1596 | 0.1555 |
Brugia malayi | Carboxylesterase family protein | 0.046 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2724 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.046 | 0.1596 | 0.1555 |
Onchocerca volvulus | 0.046 | 0.1596 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0043 | 0.0048 | 0.0048 |
Brugia malayi | Carboxylesterase family protein | 0.046 | 0.1596 | 0.1596 |
Echinococcus multilocularis | acetylcholinesterase | 0.2724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2724 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.046 | 0.1596 | 0.1555 |
Echinococcus multilocularis | acetylcholinesterase | 0.2724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.046 | 0.1596 | 0.1555 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.046 | 0.1596 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.046 | 0.1596 | 0.1555 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.046 | 0.1596 | 0.1555 |
Brugia malayi | Carboxylesterase family protein | 0.046 | 0.1596 | 0.1596 |
Schistosoma mansoni | gliotactin | 0.046 | 0.1596 | 0.1555 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2724 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0048 | 0.5 |
Onchocerca volvulus | 0.046 | 0.1596 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.046 | 0.1596 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.046 | 0.1596 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.046 | 0.1596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0647 | 0.0601 |
Echinococcus granulosus | acetylcholinesterase | 0.2724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2724 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2724 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2724 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2724 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.046 | 0.1596 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.1596 | 0.1596 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2724 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.046 | 0.1596 | 0.1555 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0048 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0647 | 0.0601 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.046 | 0.1596 | 0.1596 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.