Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0146 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.047 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.047 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0146 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0146 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.003 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.047 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.047 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0146 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.047 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.047 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.047 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2993 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.