Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1782 | 0.4161 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1782 | 0.1782 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.0198 | 0.0529 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 0.8747 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0198 | 0.0463 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1782 | 0.4161 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3747 | 0.3747 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1782 | 0.4161 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0198 | 0.0529 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3747 | 0.3747 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0198 | 0.0463 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1782 | 0.1782 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0198 | 0.0463 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.7804 | 0.7804 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.0198 | 0.0529 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.0198 | 0.0198 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3747 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3747 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1782 | 0.4757 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3747 | 0.3747 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0198 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0198 | 0.0198 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0198 | 0.0529 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 0.8747 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.7804 | 0.7804 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1782 | 0.4757 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0076 | 0.3747 | 0.3747 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 0.8747 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3747 | 0.3747 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 0.8747 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0198 | 0.0463 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1782 | 0.4757 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1782 | 0.4757 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.0198 | 0.0198 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3747 | 0.3747 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.7804 | 0.7804 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.7804 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4283 | 0.4283 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.4283 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.4283 | 0.4283 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0198 | 0.0529 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 0.8747 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.