Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0319 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0319 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0319 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0319 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0319 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0319 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0319 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0319 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0319 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0319 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0319 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0283 | 0.7743 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0319 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0197 | 0.2407 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0319 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0197 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0319 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0283 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0158 | 0 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0161 | 0.0151 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0319 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0319 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0319 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0319 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0319 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0319 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0158 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0319 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.