TDR Targets

Basic information

Technical information

TDR Targets ID: 1322757
Name: STK203095
MW: 420.891 | Formula: C23H21ClN4O2
H donors: 2 H acceptors: 2 LogP: 4.16 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CC(C)(C)CC2=C1C(N=C(N2)Nc1nc2c(o1)cccc2)c1ccccc1Cl
InChi: 1S/C23H21ClN4O2/c1-23(2)11-16-19(17(29)12-23)20(13-7-3-4-8-14(13)24)27-21(25-16)28-22-26-15-9-5-6-10-18(15)30-22/h3-10,20H,11-12H2,1-2H3,(H2,25,26,27,28)
InChiKey: MBMNAAZTSJKXFK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	galactokinase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	galactokinase, putative	Get druggable targets OG5_129789	All targets in OG5_129789
Treponema pallidum	galactokinase	Get druggable targets OG5_129789	All targets in OG5_129789
Trypanosoma cruzi	galactokinase, putative	Get druggable targets OG5_129789	All targets in OG5_129789
Trypanosoma brucei gambiense	galactokinase, putative	Get druggable targets OG5_129789	All targets in OG5_129789
Trypanosoma cruzi	galactokinase, putative	Get druggable targets OG5_129789	All targets in OG5_129789
Leishmania infantum	galactokinase-like protein	Get druggable targets OG5_129789	All targets in OG5_129789
Echinococcus multilocularis	galactokinase	Get druggable targets OG5_129789	All targets in OG5_129789
Mycobacterium ulcerans	galactokinase	Get druggable targets OG5_129789	All targets in OG5_129789
Trypanosoma cruzi	galactokinase-like protein, putative	Get druggable targets OG5_129789	All targets in OG5_129789
Leishmania major	galactokinase-like protein	Get druggable targets OG5_129789	All targets in OG5_129789
Leishmania braziliensis	galactokinase-like protein	Get druggable targets OG5_129789	All targets in OG5_129789
Leishmania donovani	galactokinase-like protein	Get druggable targets OG5_129789	All targets in OG5_129789
Entamoeba histolytica	galactokinase, putative	Get druggable targets OG5_129789	All targets in OG5_129789
Leishmania mexicana	galactokinase-like protein	Get druggable targets OG5_129789	All targets in OG5_129789
Trypanosoma brucei	galactokinase-like protein, putative	Get druggable targets OG5_129789	All targets in OG5_129789
Mycobacterium tuberculosis	Probable galactokinase GalK (galactose kinase)	Get druggable targets OG5_129789	All targets in OG5_129789
Echinococcus granulosus	galactokinase	Get druggable targets OG5_129789	All targets in OG5_129789

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	galactokinase family protein	galactokinase 1	392 aa	405 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cAMP binding protein, putative	0.0067	0.0078	0.194
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0067	0.0078	0.0065
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.01	0.0185	0.0172
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0067	0.0078	0.0144
Trypanosoma brucei	Aminopeptidase M1, putative	0.0168	0.0403	1
Loa Loa (eye worm)	hypothetical protein	0.0439	0.127	0.1201
Brugia malayi	Peptidase family M1 containing protein	0.0168	0.0403	0.0864
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0168	0.0403	1
Trypanosoma cruzi	Flagellar Member 6	0.0067	0.0078	0.1
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0067	0.0078	0.0286
Treponema pallidum	cyclic nucleotide binding protein	0.0067	0.0078	1
Brugia malayi	N-terminal motif family protein	0.0067	0.0078	0.0144
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0168	0.0403	0.0337
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0473	0.1377	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0168	0.0403	0.039
Trypanosoma cruzi	galactokinase, putative	0.0064	0.0069	0.0735
Echinococcus granulosus	aminopeptidase N	0.0168	0.0403	0.039
Mycobacterium ulcerans	transcriptional regulatory protein	0.0067	0.0078	0.0286
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0067	0.0078	0.0065
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0168	0.0403	0.0337
Schistosoma mansoni	voltage-gated potassium channel	0.0147	0.0333	0.0321
Mycobacterium ulcerans	aminopeptidase N PepN	0.0168	0.0403	1
Brugia malayi	Egg laying defective protein 4	0.0067	0.0078	0.0144
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0168	0.0403	0.2858
Treponema pallidum	catabolite gene activator (Crp)	0.0067	0.0078	1
Echinococcus multilocularis	expressed conserved protein	0.0067	0.0078	0.001
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0168	0.0403	0.039
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0067	0.0078	1
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0067	0.0078	0.0065
Trypanosoma cruzi	aminopeptidase, putative	0.0168	0.0403	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0168	0.0403	1
Leishmania major	hypothetical protein, unknown function	0.0067	0.0078	0.0286
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0168	0.0403	0.0337
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0067	0.0078	0.001
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.01	0.0185	0.0172
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0168	0.0403	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0168	0.0403	0.0327
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0067	0.0078	0.0065
Trypanosoma cruzi	cAMP binding protein, putative	0.0067	0.0078	0.1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0168	0.0403	0.0337
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0078	0.0065
Mycobacterium ulcerans	transmembrane transport protein	0.0067	0.0078	0.0286
Brugia malayi	hypothetical protein	0.0168	0.0403	0.0864
Toxoplasma gondii	aminopeptidase n, putative	0.0168	0.0403	1
Toxoplasma gondii	aminopeptidase N, putative	0.0168	0.0403	1
Leishmania major	hypothetical protein, conserved	0.0067	0.0078	0.0286
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0147	0.0333	0.0321
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0067	0.0078	0.0065
Trypanosoma brucei	Flagellar Member 6	0.0067	0.0078	0.194
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0067	0.0078	0.0065
Entamoeba histolytica	aminopeptidase, putative	0.0168	0.0403	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0168	0.0403	0.039
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0067	0.0078	0.1
Brugia malayi	Peptidase family M1 containing protein	0.0168	0.0403	0.0864
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0067	0.0078	0.0477
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0067	0.0078	0.001
Echinococcus multilocularis	voltage gated potassium channel	0.0147	0.0333	0.0267
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.01	0.0185	0.1258
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0506	0.1483	0.3259
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0067	0.0078	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.0078	0.1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0168	0.0403	0.2858
Mycobacterium ulcerans	hypothetical protein	0.0067	0.0078	0.0286
Echinococcus granulosus	hyperpolarization activated cyclic	0.01	0.0185	0.0172
Trypanosoma brucei	aminopeptidase, putative	0.0168	0.0403	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0168	0.0403	0.0337
Trypanosoma cruzi	cAMP response protein 1, putative	0.0067	0.0078	0.1
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0403	0.0327
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0067	0.0078	0.0144
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0067	0.0078	0.5
Leishmania major	protein kinase, putative	0.0067	0.0078	0.0286
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0067	0.0078	0.0065
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0506	0.1483	0.1425
Trypanosoma brucei	cAMP response protein 1, putative	0.0067	0.0078	0.194
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0067	0.0078	0.5
Brugia malayi	hypothetical protein	0.0168	0.0403	0.0864
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0168	0.0403	0.039
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0168	0.0403	0.039
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0067	0.0078	0.0065
Toxoplasma gondii	aminopeptidase N protein	0.0168	0.0403	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0168	0.0403	0.0337
Schistosoma mansoni	hypothetical protein	0.0067	0.0078	0.0065
Leishmania major	hypothetical protein, conserved	0.0067	0.0078	0.0286
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0168	0.0403	1
Trypanosoma cruzi	cAMP response protein 1	0.0067	0.0078	0.1
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0078	0.0065
Echinococcus granulosus	voltage gated potassium channel	0.0147	0.0333	0.0321
Echinococcus multilocularis	hyperpolarization activated cyclic	0.01	0.0185	0.0117
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.01	0.0185	0.0172
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0067	0.0078	0.0065
Echinococcus granulosus	galactokinase	0.0064	0.0069	0.0056
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0067	0.0078	0.0065
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0147	0.0333	0.071
Echinococcus multilocularis	hyperpolarization activated cyclic	0.01	0.0185	0.0117
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.01	0.0185	0.0117
Schistosoma mansoni	voltage-gated potassium channel	0.01	0.0185	0.0172
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0168	0.0403	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0067	0.0078	1
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0067	0.0078	0.0477
Mycobacterium ulcerans	aminopeptidase N PepN	0.0168	0.0403	1
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0067	0.0078	1
Schistosoma mansoni	voltage-gated potassium channel	0.008	0.012	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0333	0.0257
Mycobacterium ulcerans	regulatory protein	0.0067	0.0078	0.0286
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0067	0.0078	0.0477
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0067	0.0078	0.0065
Schistosoma mansoni	voltage-gated potassium channel	0.0552	0.1632	0.1621
Onchocerca volvulus		0.0168	0.0403	1
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0067	0.0078	0.0286
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0147	0.0333	0.0267
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0067	0.0078	1
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0078	0.0065
Mycobacterium leprae	Conserved hypothetical protein	0.0067	0.0078	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.01	0.0185	0.0172
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0067	0.0078	0.001
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0168	0.0403	0.039
Schistosoma mansoni	voltage-gated potassium channel	0.0147	0.0333	0.0321
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.3167	1	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0168	0.0403	0.039
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0067	0.0078	0.0065
Schistosoma mansoni	60S ribosomal protein L21	0.008	0.012	0.0107
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0067	0.0078	0.0065
Mycobacterium ulcerans	hypothetical protein	0.0067	0.0078	0.0286
Leishmania major	protein kinase A regulatory subunit, putative	0.0067	0.0078	0.0286
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0168	0.0403	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0506	0.1483	0.1472
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.01	0.0185	0.0117
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0067	0.0078	0.001
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.01	0.0185	0.0172
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0506	0.1483	0.1416
Mycobacterium tuberculosis	Conserved protein	0.0067	0.0078	1
Onchocerca volvulus		0.0168	0.0403	1
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0078	0.0477
Brugia malayi	TATA binding protein associated factor	0.0168	0.0403	0.0864
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0067	0.0078	0.001
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0067	0.0078	0.0065
Trypanosoma cruzi	galactokinase, putative	0.0064	0.0069	0.0735
Trypanosoma brucei	protein kinase A regulatory subunit	0.0067	0.0078	0.194
Trypanosoma brucei	Aminopeptidase M1, putative	0.0168	0.0403	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.01	0.0185	0.0107
Trypanosoma cruzi	aminopeptidase, putative	0.0168	0.0403	1
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0168	0.0403	1
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0168	0.0403	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0185	0.0107
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.01	0.0185	0.0172
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.3167	1	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.01	0.0185	0.0117
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0067	0.0078	0.0065
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0168	0.0403	0.2858
Loa Loa (eye worm)	aminopeptidase N	0.0168	0.0403	0.0327
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0473	0.1377	1
Leishmania major	protein kinase, putative	0.0067	0.0078	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0403	0.0327
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0067	0.0078	0.0144
Leishmania major	hypothetical protein, conserved	0.0067	0.0078	0.0286
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0168	0.0403	1
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0067	0.0078	0.001
Brugia malayi	hypothetical protein	0.1456	0.4524	1
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0168	0.0403	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.01	0.0185	0.0172
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0067	0.0078	0.0065
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0067	0.0078	0.1
Treponema pallidum	cyclic nucleotide binding protein	0.0067	0.0078	1
Mycobacterium ulcerans	hypothetical protein	0.0067	0.0078	0.0286
Brugia malayi	Cyclic-nucleotide gated cation channel	0.01	0.0185	0.038
Schistosoma mansoni	voltage-gated potassium channel	0.0552	0.1632	0.1621
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0168	0.0403	1
Echinococcus multilocularis	aminopeptidase N	0.0168	0.0403	0.0337
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0168	0.0403	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0168	0.0403	1
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0067	0.0078	0.0065
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0168	0.0403	0.039
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.01	0.0185	0.0107
Echinococcus granulosus	cGMP dependent protein kinase	0.0067	0.0078	0.0065
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.3167	1	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0067	0.0078	0.194
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0067	0.0078	0.001
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0403	0.0327
Mycobacterium ulcerans	hypothetical protein	0.0067	0.0078	0.0286
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0067	0.0078	0.1
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0067	0.0078	0.001
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0067	0.0078	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0067	0.0078	0.0477
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0168	0.0403	0.039
Brugia malayi	Peptidase family M1 containing protein	0.0168	0.0403	0.0864
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.01	0.0185	0.1258
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0067	0.0078	0.0065
Echinococcus granulosus	hyperpolarization activated cyclic	0.01	0.0185	0.0172
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0046	0.0013	0.0324
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0168	0.0403	0.039
Onchocerca volvulus		0.0168	0.0403	1
Treponema pallidum	catabolite gene activator	0.0067	0.0078	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.01	0.0185	0.0172
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0168	0.0403	1
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0168	0.0403	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0067	0.0078	0.194
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0067	0.0078	0.1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.01	0.0185	0.0172
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0067	0.0078	0.0065
Loa Loa (eye worm)	TATA binding protein associated factor	0.0168	0.0403	0.0327

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1122 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 8.4057 um	PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Human Galactosidase (GALK): probe SAR. (Class of assay: confirmatory) [Related pubchem assays: 1868, 2114, 1379 ]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1434176

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1322757