Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0665 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0665 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0351 | 0.1071 | 0.1071 |
Brugia malayi | nuclear hormone receptor | 0.0665 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0665 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0665 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0665 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0351 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0665 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0351 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0665 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0665 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0351 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0351 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0351 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1071 | 0.1071 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1071 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0665 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0351 | 0.1071 | 0.1071 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0351 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0665 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0665 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0665 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0665 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0665 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0665 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0665 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0665 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0665 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0665 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0665 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0665 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0351 | 0.1071 | 0.1071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0665 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0665 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0665 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0665 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0351 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0665 | 1 | 1 |
Onchocerca volvulus | 0.0665 | 1 | 1 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0665 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0665 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0665 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0665 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0665 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0665 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0665 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0665 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 36.738 um | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] | ChEMBL. | No reference |
EC50 (binding) | = 64.251 um | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] | ChEMBL. | No reference |
Max_Activity_Concent (functional) | 0.8 uM | PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.