TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 230.266 | Formula: C12H14N4O
H donors: 1 H acceptors: 1 LogP: 2.76 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N=Nc1c(C)n[nH]c1C
InChi: 1S/C12H14N4O/c1-8-12(9(2)14-13-8)16-15-10-6-4-5-7-11(10)17-3/h4-7H,1-3H3,(H,13,14)
InChiKey: QCGISKLKAPGJMY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Loa Loa (eye worm)	fibroinase	0.0141	0.2155	0.2155
Trichomonas vaginalis	aldo/keto reductase, putative	0.0226	0.407	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Trypanosoma cruzi	cysteine protease, putative	0.0079	0.0763	0.0331
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0226	0.407	1
Trypanosoma cruzi	aldo-keto reductase	0.0226	0.407	0.3793
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0177	0.2965	0.2635
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.2155	0.1787
Echinococcus multilocularis	cysteine protease	0.0141	0.2155	0.1787
Schistosoma mansoni	cathepsin F (C01 family)	0.0141	0.2155	0.1787
Trypanosoma brucei	aldo-keto reductase, putative	0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0226	0.407	0.407
Echinococcus multilocularis	aldo keto reductase	0.0226	0.407	0.3793
Echinococcus granulosus	cathepsin l1	0.0141	0.2155	0.1787
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.2155	0.2155
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.2155	0.1787
Loa Loa (eye worm)	oxidoreductase	0.0226	0.407	0.407
Echinococcus granulosus	cathepsin l1	0.0099	0.1206	0.0794
Loa Loa (eye worm)	cathepsin B	0.0177	0.2965	0.2965
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0177	0.2965	0.2635
Brugia malayi	Cathepsin L-like precursor	0.0099	0.1206	0.1206
Echinococcus multilocularis	cysteine protease	0.0141	0.2155	0.1787
Leishmania major	cysteine peptidase A (CPA)	0.0141	0.2155	0.4713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0763	0.0872
Mycobacterium ulcerans	oxidoreductase	0.0226	0.407	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Loa Loa (eye worm)	hypothetical protein	0.0488	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0079	0.0763	0.0872
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Schistosoma mansoni	cathepsin F (C01 family)	0.0099	0.1206	0.0794
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0177	0.2965	0.6948
Entamoeba histolytica	cysteine proteinase 1, putative	0.0079	0.0763	0.0872
Trypanosoma cruzi	cruzipain precursor, putative	0.0141	0.2155	0.1787
Brugia malayi	Cathepsin L-like precursor	0.0141	0.2155	0.2155
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Onchocerca volvulus		0.0226	0.407	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Onchocerca volvulus		0.0099	0.1206	0.2094
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0488	1	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0099	0.1206	0.2094
Plasmodium vivax	vivapain-3	0.0079	0.0763	0.1851
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Mycobacterium leprae	Conserved hypothetical protein	0.016	0.2593	0.5922
Echinococcus granulosus	aldo keto reductase	0.0226	0.407	0.3793
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Onchocerca volvulus		0.0141	0.2155	0.4713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0141	0.2155	0.1787
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Schistosoma mansoni	pol-related	0.0226	0.407	0.3793
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0141	0.2155	1
Onchocerca volvulus	Cathepsin L homolog	0.0141	0.2155	0.4713
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1206	0.1206
Brugia malayi	Cathepsin L-like precursor	0.0141	0.2155	0.2155
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.0763	0.0331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Brugia malayi	Cathepsin L-like precursor	0.0141	0.2155	0.2155
Echinococcus granulosus	cysteine protease	0.0079	0.0763	0.0331
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.2155	0.1787
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Onchocerca volvulus		0.0141	0.2155	0.4713
Echinococcus multilocularis	cathepsin L cysteine protease	0.0141	0.2155	0.1787
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Echinococcus multilocularis	cathepsin L cysteine protease	0.0141	0.2155	0.1787
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0141	0.2155	0.1787
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0226	0.407	0.407
Trypanosoma brucei	prostaglandin f synthase	0.0226	0.407	1
Entamoeba histolytica	aldose reductase, putative	0.0226	0.407	1
Echinococcus multilocularis	aldehyde reductase	0.016	0.2593	0.2246
Onchocerca volvulus		0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0099	0.1206	0.2094
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Leishmania major	prostaglandin f synthase, putative	0.0226	0.407	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Mycobacterium tuberculosis	Probable oxidoreductase	0.0226	0.407	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0226	0.407	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0065	0.0447	0.0447
Echinococcus granulosus	cathepsin L	0.0079	0.0763	0.0331
Plasmodium vivax	vivapain-2	0.0141	0.2155	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0141	0.2155	0.1787
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0226	0.407	0.407
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.2155	0.4713
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Trichomonas vaginalis	aldo/keto reductase, putative	0.0226	0.407	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Onchocerca volvulus	Cathepsin L homolog	0.0141	0.2155	0.4713
Brugia malayi	NADH-dependent xylose reductase	0.0065	0.0447	0.0447
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Echinococcus multilocularis	aldo keto reductase	0.0226	0.407	0.3793
Onchocerca volvulus		0.0141	0.2155	0.4713
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0763	0.0872
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Echinococcus granulosus	cathepsin b	0.0488	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Giardia lamblia	Aldose reductase	0.0226	0.407	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Brugia malayi	Cathepsin L-like precursor	0.0141	0.2155	0.2155
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0099	0.1206	0.1206
Entamoeba histolytica	aldose reductase, putative	0.0226	0.407	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0177	0.2965	0.6948
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Schistosoma mansoni	aldo-keto reductase	0.0226	0.407	0.3793
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Toxoplasma gondii	cathepsin B	0.0177	0.2965	0.6948
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0226	0.407	0.3793
Schistosoma mansoni	aldo-keto reductase	0.0226	0.407	0.3793
Echinococcus granulosus	cathepsin b	0.0488	1	1
Onchocerca volvulus		0.0226	0.407	1
Echinococcus granulosus	aldo keto reductase	0.0226	0.407	0.3793
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0141	0.2155	1
Loa Loa (eye worm)	oxidoreductase	0.0226	0.407	0.407
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0141	0.2155	0.4713
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0226	0.407	0.407
Entamoeba histolytica	cysteine proteinase, putative	0.0099	0.1206	0.2094
Plasmodium vivax	vivapain-2	0.0141	0.2155	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0141	0.2155	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0763	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1206	0.1206
Echinococcus multilocularis	aldo keto reductase	0.0226	0.407	0.3793
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Entamoeba histolytica	aldose reductase, putative	0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0763	0.0872
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0079	0.0763	0.0331
Loa Loa (eye worm)	ctsf protein	0.0141	0.2155	0.2155
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Onchocerca volvulus	Cathepsin F homolog	0.0141	0.2155	0.4713
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.0763	0.0331
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0099	0.1206	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0141	0.2155	0.1787
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Brugia malayi	Cathepsin L-like precursor	0.0141	0.2155	0.2155
Plasmodium vivax	vivapain-1	0.0079	0.0763	0.1851
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.2155	0.4713
Echinococcus granulosus	cathepsin L cysteine protease	0.0079	0.0763	0.0331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0763	0.0872
Trypanosoma cruzi	cysteine proteinase, putative	0.0079	0.0763	0.0331
Trypanosoma cruzi	aldo/keto reductase, putative	0.0226	0.407	0.3793
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0177	0.2965	0.6948
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Leishmania major	aldo-keto reductase-like protein	0.0226	0.407	1
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Loa Loa (eye worm)	oxidoreductase	0.0226	0.407	0.407
Toxoplasma gondii	cathepsin CPL	0.0141	0.2155	0.4713
Onchocerca volvulus		0.0141	0.2155	0.4713
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Plasmodium vivax	unspecified product	0.0079	0.0763	0.1851
Trypanosoma cruzi	cysteine proteinase, putative	0.0079	0.0763	0.0331
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0763	0.0872
Trichomonas vaginalis	aldo/keto reductase, putative	0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Echinococcus multilocularis	aldo keto reductase	0.0226	0.407	0.3793
Echinococcus granulosus	hypothetical protein	0.0226	0.407	0.3793
Toxoplasma gondii	aldose reductase, putative	0.0226	0.407	1
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0763	0.0872
Onchocerca volvulus		0.0226	0.407	1
Onchocerca volvulus		0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Loa Loa (eye worm)	hypothetical protein	0.0226	0.407	0.407
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Brugia malayi	Cathepsin L-like precursor	0.0099	0.1206	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1206	0.1206
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0141	0.2155	0.4713
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0763	0.0872
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Loa Loa (eye worm)	cysteine protease	0.0141	0.2155	0.2155
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0079	0.0763	0.1851
Onchocerca volvulus		0.0226	0.407	1
Echinococcus granulosus	aldehyde reductase	0.016	0.2593	0.2246
Loa Loa (eye worm)	oxidoreductase	0.0226	0.407	0.407
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0226	0.407	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.2155	0.4713
Giardia lamblia	Aldose reductase	0.0226	0.407	1
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	1	1
Brugia malayi	Cathepsin L-like precursor	0.0141	0.2155	0.2155
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0226	0.407	0.3793
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Echinococcus multilocularis	cathepsin b	0.0488	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0763	0.0872
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	1	1
Echinococcus multilocularis	cathepsin L	0.0079	0.0763	0.0331
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.0763	0.0763
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0488	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0141	0.2155	0.2155
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0226	0.407	1
Echinococcus multilocularis	cathepsin b	0.0488	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0141	0.2155	0.1787
Entamoeba histolytica	cysteine protease, putative	0.0141	0.2155	0.4713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.2155	0.4713
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0141	0.2155	0.2155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.0763	0.0763
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.2155	0.1787
Echinococcus granulosus	aldo keto reductase	0.0226	0.407	0.3793
Onchocerca volvulus		0.0141	0.2155	0.4713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.2155	0.4713
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0065	0.0447	0.0447
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0763	0.0872
Leishmania major	cathepsin L-like protease	0.0141	0.2155	0.4713
Brugia malayi	cathepsin L-like precursor	0.0099	0.1206	0.1206
Trichomonas vaginalis	aldo-keto reductase, putative	0.0226	0.407	1
Onchocerca volvulus		0.0141	0.2155	0.4713
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.0763	0.0331
Onchocerca volvulus		0.0141	0.2155	0.4713
Loa Loa (eye worm)	oxidoreductase	0.0226	0.407	0.407
Loa Loa (eye worm)	hypothetical protein	0.0141	0.2155	0.2155

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	199.5262 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1455519

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1323067