Detailed information for compound 1323075

Basic information

Technical information
  • TDR Targets ID: 1323075
  • Name: N-[[3-(2,5-dimethylphenyl)sulfonyl-1,3-oxazin an-2-yl]methyl]-N'-(pyridin-3-ylmethyl)oxamid e
  • MW: 446.52 | Formula: C21H26N4O5S
  • H donors: 2 H acceptors: 5 LogP: 1.39 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)S(=O)(=O)N1CCCOC1CNC(=O)C(=O)NCc1cccnc1)C
  • InChi: 1S/C21H26N4O5S/c1-15-6-7-16(2)18(11-15)31(28,29)25-9-4-10-30-19(25)14-24-21(27)20(26)23-13-17-5-3-8-22-12-17/h3,5-8,11-12,19H,4,9-10,13-14H2,1-2H3,(H,23,26)(H,24,27)
  • InChiKey: UEZSJKVUHZWZDG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[3-(2,5-dimethylphenyl)sulfonyl-1,3-oxazinan-2-yl]methyl]-N'-(3-pyridylmethyl)oxamide
  • N-[[3-(2,5-dimethylphenyl)sulfonyl-1,3-oxazinan-2-yl]methyl]-N'-(pyridin-3-ylmethyl)ethanediamide
  • MLS000684933
  • SMR000324880

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0025 0.3141 0.0612
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0025 0.3141 0.0612
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0055 1 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0055 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Brugia malayi hypothetical protein 0.0025 0.3141 0.0612
Schistosoma mansoni acetylcholine receptor subunit beta 0.0025 0.3141 0.3141
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0025 0.3141 0.0612
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.284 0.02
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.284 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Onchocerca volvulus 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.2694 0.5
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0055 1 1
Trypanosoma brucei unspecified product 0.0023 0.2694 0.9201
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0055 1 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0055 1 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0055 1 1
Onchocerca volvulus 0.0029 0.4127 0.1438
Echinococcus multilocularis glycine receptor subunit beta 0.0055 1 1
Onchocerca volvulus 0.0055 1 1
Schistosoma mansoni DNA polymerase eta 0.0023 0.2694 0.2694
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.284 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.3141 0.0612
Schistosoma mansoni DNA helicase recq1 0.0024 0.284 0.284
Loa Loa (eye worm) hypothetical protein 0.0023 0.2694 0.2614
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0108 0.0262
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0055 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2694 0.9465
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.3141 0.0612
Brugia malayi Cation transporter family protein 0.0055 1 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 1 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0025 0.3141 0.3141
Schistosoma mansoni nAChR subunit 0.0055 1 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.284 0.02
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.284 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Schistosoma mansoni nAChR subunit 0.0055 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.284 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.3141 0.0612
Onchocerca volvulus 0.0055 1 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0055 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0055 1 1
Schistosoma mansoni nAChR subunit 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Schistosoma mansoni nAChR subunit 0.0025 0.3141 0.3141
Brugia malayi hypothetical protein 0.0025 0.3141 0.0612
Schistosoma mansoni nAChR subunit 0.0055 1 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0055 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0055 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 1 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.284 0.02
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0055 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.284 0.2762
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.284 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.2694 0.2614
Schistosoma mansoni neurotransmitter gated ion channel 0.0025 0.3141 0.3141
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.3141 0.0612
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.284 0.02
Loa Loa (eye worm) RecQ helicase 0.0024 0.284 0.2762
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.2694 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0029 0.4127 0.1962
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.2694 0.9465
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.284 1
Brugia malayi Cation transporter family protein 0.0055 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.2694 0.9201
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0055 1 1
Schistosoma mansoni nAChR subunit 0.0055 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 1 1
Schistosoma mansoni nAChR subunit 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.284 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0055 1 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.4127 0.1962
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.2694 0.2694
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0055 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.284 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Brugia malayi Cation transporter family protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Echinococcus multilocularis nAChR subunit 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Schistosoma mansoni DNA helicase recq5 0.0024 0.284 0.284
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0108 0.0381
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0055 1 1
Loa Loa (eye worm) LGC-31 protein 0.0055 1 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0055 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Onchocerca volvulus Putative nachr subunit 0.0055 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Schistosoma mansoni nAChR subunit 0.0055 1 1
Echinococcus multilocularis glycine receptor subunit beta 0.0055 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Loa Loa (eye worm) acetylcholine receptor protein 0.0025 0.3141 0.3066
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.4127 0.4127
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0055 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2694 0.9465
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0108 0.0108
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.2694 0.2694
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.2694 0.6527
Echinococcus multilocularis bloom syndrome protein 0.0024 0.284 0.02
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0029 0.4127 0.4127
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0055 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0055 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2694 0.9465
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0025 0.3141 0.0612
Brugia malayi hypothetical protein 0.0025 0.3141 0.0612
Onchocerca volvulus 0.0055 1 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 1 1
Loa Loa (eye worm) ACC-1 protein 0.0055 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.284 0.5
Onchocerca volvulus 0.0055 1 1
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0108 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.2694 0.9201
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0029 0.4127 0.4127
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 1 1
Entamoeba histolytica hypothetical protein 0.0029 0.4127 1
Loa Loa (eye worm) ACC-1 protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Echinococcus granulosus nAChR subunit 0.0029 0.4127 0.1962
Echinococcus granulosus bloom syndrome protein 0.0024 0.284 0.02
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.2694 0.5
Schistosoma mansoni acetylcholine receptor-related 0.0025 0.3141 0.3141
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0029 0.4127 0.1962
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0000000023226
Echinococcus granulosus nAChR subunit 0.0055 1 1
Entamoeba histolytica recQ family helicase, putative 0.0024 0.284 0.6881
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0055 1 1
Onchocerca volvulus 0.0029 0.4127 0.1438
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.3141 0.3066
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4127 0.4063
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.3141 0.0612
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0108 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0055 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0055 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.284 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.2694 0.9201
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Loa Loa (eye worm) GABA receptor subunit 0.0029 0.4127 0.4063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2694 0.9465
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.2694 0.9201
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0025 0.3141 0.0612
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Brugia malayi hypothetical protein 0.0025 0.3141 0.0612
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0055 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0025 0.3141 0.0612
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 1 1
Brugia malayi hypothetical protein 0.0025 0.3141 0.0612
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 1 1
Echinococcus multilocularis nAChR subunit 0.0029 0.4127 0.1962
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.284 0.02
Loa Loa (eye worm) hypothetical protein 0.0024 0.284 0.2762
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.284 0.02
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0029 0.4127 0.1962
Loa Loa (eye worm) hypothetical protein 0.0025 0.3141 0.3066
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0055 1 1
Onchocerca volvulus 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Schistosoma mansoni nAChR subunit 0.0025 0.3141 0.3141
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0055 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.2694 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 1 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0025 0.3141 0.3066
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.284 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2694 0.9201
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.284 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0055 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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