Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.2419 | 0.1303 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | plexin A | 0.0043 | 0.6571 | 0.6066 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2419 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.5306 | 0.4615 |
Onchocerca volvulus | 0.0037 | 0.5306 | 1 | |
Brugia malayi | plexin A | 0.0043 | 0.6571 | 0.6066 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.8813 | 0.8638 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.8813 | 0.8638 |
Echinococcus multilocularis | plexin a4 | 0.0043 | 0.6571 | 0.6066 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.8813 | 0.8638 |
Echinococcus granulosus | plexin a4 | 0.0043 | 0.6571 | 0.6066 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.8813 | 0.8638 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | plexin | 0.0021 | 0.2419 | 0.1303 |
Schistosoma mansoni | plexin | 0.0037 | 0.5306 | 0.4615 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.8813 | 0.8638 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 1 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.8813 | 0.8638 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.8813 | 0.8638 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.8813 | 0.8638 |
Brugia malayi | Plexin repeat family protein | 0.0037 | 0.5306 | 0.4615 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 1 | 1 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.8813 | 0.8638 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.