Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0207 | 0.4761 | 0.4549 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.039 | 0.0119 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0274 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0.039 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.039 | 0.0119 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0207 | 0.4761 | 0.4621 |
Schistosoma mansoni | tyrosine kinase | 0.0408 | 0.985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.039 | 0.0119 |
Loa Loa (eye worm) | carboxylesterase | 0.0207 | 0.4761 | 0.4614 |
Brugia malayi | Carboxylesterase family protein | 0.0035 | 0.039 | 0.0665 |
Echinococcus multilocularis | acetylcholinesterase | 0.0207 | 0.4761 | 0.4549 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.4761 | 0.4614 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0035 | 0.039 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0414 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0035 | 0.039 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0274 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.9861 | 0.9856 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.039 | 0.0119 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0251 | 0.5867 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0207 | 0.4761 | 0.4549 |
Brugia malayi | Carboxylesterase family protein | 0.0207 | 0.4761 | 0.8116 |
Echinococcus granulosus | carboxylesterase 5A | 0.0207 | 0.4761 | 0.4549 |
Brugia malayi | Carboxylesterase family protein | 0.0035 | 0.039 | 0.0665 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0274 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0169 | 0.3781 | 0.6445 |
Loa Loa (eye worm) | carboxylesterase | 0.0035 | 0.039 | 0.0119 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.9861 | 0.9856 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.1017 | 0.0663 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.039 | 0.0119 |
Brugia malayi | Carboxylesterase family protein | 0.0035 | 0.039 | 0.0665 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0.039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1017 | 0.0765 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0207 | 0.4761 | 0.4614 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.039 | 0.0119 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0274 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0169 | 0.3781 | 0.3529 |
Brugia malayi | hypothetical protein | 0.003 | 0.0274 | 0.0467 |
Brugia malayi | hypothetical protein | 0.0035 | 0.039 | 0.0665 |
Loa Loa (eye worm) | carboxylesterase | 0.0035 | 0.039 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.039 | 0.0119 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0035 | 0.039 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0207 | 0.4761 | 0.4549 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0414 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.4761 | 0.4614 |
Onchocerca volvulus | 0.006 | 0.1017 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0035 | 0.039 | 0.0665 |
Brugia malayi | Carboxylesterase family protein | 0.0207 | 0.4761 | 0.8116 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.3484 | 0.33 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0035 | 0.039 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0207 | 0.4761 | 0.4549 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0891 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.