Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.2356 | 0.6942 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1311 | 0.3628 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0282 | 0.0363 | 0.0086 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0282 | 0.0363 | 0.3969 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0282 | 0.0363 | 0.3969 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0356 | 0.0597 | 0.8734 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.1311 | 0.3628 | 0.3519 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0273 | 0.0335 | 0.0169 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0306 | 0.0439 | 0.5522 |
Trichomonas vaginalis | cyclins, putative | 0.0375 | 0.0659 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0356 | 0.0597 | 0.8734 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.2356 | 0.6942 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.3321 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0273 | 0.0335 | 0.3907 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0306 | 0.0439 | 0.5522 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.0659 | 0.0498 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0282 | 0.0363 | 0.0086 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0375 | 0.0659 | 0.0498 |
Trypanosoma cruzi | cyclin, putative | 0.0375 | 0.0659 | 0.0983 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.3321 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0221 | 0.0169 | 0.078 |
Trichomonas vaginalis | AGC family protein kinase | 0.0356 | 0.0597 | 0.8833 |
Trichomonas vaginalis | cyclin B, putative | 0.0375 | 0.0659 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0356 | 0.0597 | 0.0795 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0273 | 0.0335 | 0.0169 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.2356 | 0.6942 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0356 | 0.0597 | 0.0435 |
Echinococcus granulosus | prolyl endopeptidase | 0.0282 | 0.0363 | 0.0198 |
Giardia lamblia | Kinase, CMGC CDK | 0.0273 | 0.0335 | 0.3391 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0311 | 0.0144 |
Trypanosoma cruzi | cyclin, putative | 0.0375 | 0.0659 | 0.0983 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0282 | 0.0363 | 0.4439 |
Trichomonas vaginalis | cyclin D, putative | 0.0221 | 0.0169 | 0.078 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0375 | 0.0659 | 0.0983 |
Brugia malayi | serine/threonine kinase 12 | 0.0356 | 0.0597 | 0.0435 |
Trypanosoma cruzi | cyclin 6, putative | 0.0375 | 0.0659 | 0.0983 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0306 | 0.0439 | 0.5522 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0356 | 0.0597 | 0.0435 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0375 | 0.0659 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0282 | 0.0363 | 0.0086 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0356 | 0.0597 | 0.0435 |
Schistosoma mansoni | protein kinase | 0.0356 | 0.0597 | 0.0435 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1311 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.0659 | 0.0498 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0375 | 0.0659 | 0.0498 |
Entamoeba histolytica | protein kinase, putative | 0.0356 | 0.0597 | 0.8734 |
Plasmodium falciparum | protein kinase 5 | 0.0273 | 0.0335 | 0.0245 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0221 | 0.0169 | 0.078 |
Leishmania major | protein kinase, putative | 0.0356 | 0.0597 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0363 | 0.0198 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.2356 | 0.6942 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0356 | 0.0597 | 0.8734 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0273 | 0.0335 | 0.0169 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0282 | 0.0363 | 0.0198 |
Loa Loa (eye worm) | AUR protein kinase | 0.0356 | 0.0597 | 0.0435 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0356 | 0.0597 | 0.0435 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0282 | 0.0363 | 0.3969 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0282 | 0.0363 | 0.3969 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0282 | 0.0363 | 0.0086 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1311 | 0.3628 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0282 | 0.0363 | 0.0198 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0282 | 0.0363 | 0.0086 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0356 | 0.0597 | 0.0795 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.3321 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2356 | 0.6942 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2356 | 0.6942 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.2356 | 0.6942 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0375 | 0.0659 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0273 | 0.0335 | 0.0169 |
Brugia malayi | hypothetical protein | 0.0914 | 0.2369 | 0.2237 |
Trichomonas vaginalis | cyclin B3, putative | 0.0221 | 0.0169 | 0.078 |
Entamoeba histolytica | protein kinase , putative | 0.0356 | 0.0597 | 0.8734 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0282 | 0.0363 | 0.0198 |
Brugia malayi | Protein kinase domain containing protein | 0.0273 | 0.0335 | 0.0169 |
Trichomonas vaginalis | AGC family protein kinase | 0.0356 | 0.0597 | 0.8833 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0273 | 0.0335 | 0.0169 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0273 | 0.0335 | 0.1027 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0356 | 0.0597 | 0.0632 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0282 | 0.0363 | 0.0086 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.1311 | 0.3628 | 0.3519 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0282 | 0.0363 | 0.0086 |
Schistosoma mansoni | cyclin B | 0.0375 | 0.0659 | 0.0498 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1311 | 0.3628 | 1 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0282 | 0.0363 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 0.0728 | 0.0569 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0273 | 0.0335 | 0.3907 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0356 | 0.0597 | 0.0396 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0356 | 0.0597 | 0.0435 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0375 | 0.0659 | 0.0983 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0282 | 0.0363 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0375 | 0.0659 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0282 | 0.0363 | 0.0198 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0282 | 0.0363 | 0.0198 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0356 | 0.0597 | 0.8734 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0306 | 0.0439 | 0.5522 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0363 | 0.0198 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.3321 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0356 | 0.0597 | 0.8734 |
Echinococcus multilocularis | cyclin B | 0.0375 | 0.0659 | 0.0498 |
Plasmodium vivax | hypothetical protein, conserved | 0.0282 | 0.0363 | 0.0043 |
Toxoplasma gondii | hypothetical protein | 0.0282 | 0.0363 | 0.1113 |
Trichomonas vaginalis | cyclins, putative | 0.0375 | 0.0659 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0273 | 0.0335 | 0.3391 |
Trichomonas vaginalis | cyclins, putative | 0.0375 | 0.0659 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0273 | 0.0335 | 0.0169 |
Trichomonas vaginalis | cyclins, putative | 0.0375 | 0.0659 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0273 | 0.0335 | 0.3391 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.1196 | 0.3263 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0221 | 0.0169 | 0.078 |
Trypanosoma cruzi | oligopeptidase b | 0.0282 | 0.0363 | 0.0086 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0282 | 0.0363 | 0.4439 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.2369 | 0.2237 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0282 | 0.0363 | 0.0086 |
Echinococcus multilocularis | aurora kinase A | 0.0356 | 0.0597 | 0.0435 |
Trichomonas vaginalis | cyclin B, putative | 0.0375 | 0.0659 | 1 |
Onchocerca volvulus | 0.0375 | 0.0659 | 0.0306 | |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0273 | 0.0335 | 0.0169 |
Leishmania major | oligopeptidase b | 0.0282 | 0.0363 | 0.0086 |
Brugia malayi | cell division control protein 2 homolog | 0.0273 | 0.0335 | 0.0169 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0282 | 0.0363 | 0.3969 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0282 | 0.0363 | 0.0198 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0273 | 0.0335 | 0.0169 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0356 | 0.0597 | 0.0435 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1311 | 0.3628 | 0.3519 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0273 | 0.0335 | 0.0169 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0282 | 0.0363 | 0.0198 |
Echinococcus granulosus | cyclin B | 0.0375 | 0.0659 | 0.0498 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0273 | 0.0335 | 0.0169 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0282 | 0.0363 | 0.3969 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0282 | 0.0363 | 0.0086 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0375 | 0.0659 | 0.0983 |
Echinococcus granulosus | aurora kinase A | 0.0356 | 0.0597 | 0.0435 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0273 | 0.0335 | 0.0169 |
Plasmodium falciparum | peptidase, putative | 0.0282 | 0.0363 | 0.0287 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0306 | 0.0439 | 0.5522 |
Trichomonas vaginalis | cyclin B, putative | 0.0375 | 0.0659 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0273 | 0.0335 | 0.0169 |
Trichomonas vaginalis | AGC family protein kinase | 0.0356 | 0.0597 | 0.8833 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0282 | 0.0363 | 0.0198 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.2356 | 0.6942 | 1 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0282 | 0.0363 | 0.0086 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0282 | 0.0363 | 0.0086 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0273 | 0.0335 | 0.0169 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0273 | 0.0335 | 0.3391 |
Trypanosoma brucei | prolyl endopeptidase | 0.0282 | 0.0363 | 0.0086 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0282 | 0.0363 | 0.3969 |
Trypanosoma cruzi | oligopeptidase b | 0.0282 | 0.0363 | 0.0086 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0282 | 0.0363 | 0.0198 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0282 | 0.0363 | 0.4439 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0282 | 0.0363 | 0.0198 |
Toxoplasma gondii | prolyl endopeptidase | 0.0282 | 0.0363 | 0.1113 |
Trichomonas vaginalis | cyclins, putative | 0.0221 | 0.0169 | 0.078 |
Trichomonas vaginalis | AGC family protein kinase | 0.0356 | 0.0597 | 0.8833 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1311 | 0.3628 | 1 |
Giardia lamblia | Aurora kinase | 0.0356 | 0.0597 | 0.8734 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.1311 | 0.3628 | 0.3519 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0282 | 0.0363 | 0.3969 |
Leishmania major | cyclin | 0.0375 | 0.0659 | 0.0983 |
Entamoeba histolytica | cyclin, putative | 0.0375 | 0.0659 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0273 | 0.0335 | 0.3907 |
Loa Loa (eye worm) | AUR protein kinase | 0.0356 | 0.0597 | 0.0435 |
Toxoplasma gondii | aurora kinase | 0.0356 | 0.0597 | 0.1829 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0282 | 0.0363 | 0.0198 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.3321 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.