Detailed information for compound 1323706

Basic information

Technical information
  • TDR Targets ID: 1323706
  • Name: ethyl 2-[2-(4-methoxyphenyl)-6,8-dimethyl-5,7 -dioxopyrimido[6,5-d]pyrimidin-4-yl]sulfanylb utanoate
  • MW: 444.504 | Formula: C21H24N4O5S
  • H donors: 0 H acceptors: 5 LogP: 3.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(Sc1nc(nc2c1c(=O)n(c(=O)n2C)C)c1ccc(cc1)OC)CC
  • InChi: 1S/C21H24N4O5S/c1-6-14(20(27)30-7-2)31-18-15-17(24(3)21(28)25(4)19(15)26)22-16(23-18)12-8-10-13(29-5)11-9-12/h8-11,14H,6-7H2,1-5H3
  • InChiKey: CFAGKETWUDHBQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[2-(4-methoxyphenyl)-6,8-dimethyl-5,7-dioxo-pyrimido[6,5-d]pyrimidin-4-yl]sulfanylbutanoate
  • 2-[[2-(4-methoxyphenyl)-6,8-dimethyl-5,7-dioxo-4-pyrimido[6,5-d]pyrimidinyl]thio]butanoic acid ethyl ester
  • 2-[[5,7-diketo-2-(4-methoxyphenyl)-6,8-dimethyl-pyrimido[6,5-d]pyrimidin-4-yl]thio]butyric acid ethyl ester
  • SMR000016610
  • EU-0060305
  • MLS000102286
  • MLS000092618

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0042 0.0145 0.0171
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Schistosoma mansoni hypothetical protein 0.0032 0.0032 0.0048
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0635 0.6671 1
Brugia malayi protein kinase C II. 0.0313 0.3123 0.3123
Loa Loa (eye worm) hypothetical protein 0.0313 0.3123 0.3101
Brugia malayi Variant SH3 domain containing protein 0.0045 0.0174 0.0174
Brugia malayi Cytohesin 3 0.0032 0.0032 0.0032
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0313 0.3123 0.4682
Entamoeba histolytica hypothetical protein 0.0042 0.0145 0.0114
Echinococcus multilocularis Pleckstrin y 0.0032 0.0032 0.0048
Echinococcus granulosus serine threonine protein kinase nrc 0.0603 0.632 0.9474
Echinococcus granulosus oxysterol binding protein 1 0.0032 0.0032 0.0048
Entamoeba histolytica protein kinase domain containing protein 0.0384 0.3906 0.3886
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Leishmania major folate/biopterin transporter, putative 0.0042 0.0145 0.0292
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0042 0.0145 0.018
Echinococcus granulosus tyrosine protein kinase Lyn 0.0139 0.1207 0.181
Echinococcus granulosus Pleckstrin y 0.0032 0.0032 0.0048
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0032 0.0032 0.0048
Echinococcus multilocularis protein kinase shaggy 0.0384 0.3906 0.5855
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Schistosoma mansoni serine/threonine-protein kinase 0.0635 0.6671 1
Entamoeba histolytica hypothetical protein 0.0042 0.0145 0.0114
Echinococcus granulosus tyrosine kinase 0.0116 0.0956 0.1434
Toxoplasma gondii protein kinase domain-containing protein 0.0042 0.0145 0.0118
Echinococcus multilocularis Rho GTPase activating protein 24 0.0032 0.0032 0.0048
Echinococcus multilocularis oxysterol binding protein 1 0.0032 0.0032 0.0048
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0045 0.0174 0.0142
Entamoeba histolytica protein kinase, putative 0.0042 0.0145 0.0114
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0032 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Echinococcus granulosus NDR protein kinase 0.0313 0.3123 0.4682
Echinococcus granulosus nervana 2 0.0593 0.6207 0.9304
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Schistosoma mansoni dynamin 0.0032 0.0032 0.0048
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0384 0.3906 0.3886
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0032 0.0032 0.0048
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0032 0.0032 0.0048
Echinococcus granulosus tyrosine protein kinase Src42A 0.0112 0.0917 0.1374
Echinococcus granulosus GRB2 associated binding protein 3 0.0032 0.0032 0.0048
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0032 0.0032
Trypanosoma brucei rac serine-threonine kinase, putative 0.0937 1 1
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0032 0.0032 0.0032
Echinococcus multilocularis pdz domain containing protein 0.0032 0.0032 0.0048
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0128 0.1094 0.164
Schistosoma mansoni hypothetical protein 0.0032 0.0032 0.0048
Schistosoma mansoni oxysterol-binding protein 1 0.0032 0.0032 0.0048
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0042 0.0145 0.0171
Schistosoma mansoni rho gtpase activating protein 0.0032 0.0032 0.0048
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0112 0.0917 0.1374
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0313 0.3123 0.3101
Echinococcus multilocularis Glutaredoxin protein 5 0.0593 0.6207 0.9304
Echinococcus granulosus Oxysterol binding protein 11 0.0032 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0345 0.3474 0.3453
Brugia malayi Uncoordinated protein 104 0.0032 0.0032 0.0032
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0032 0.0032 0.0048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0128 0.1094 0.164
Echinococcus granulosus tyrosine protein kinase Src64B 0.0128 0.1094 0.164
Entamoeba histolytica protein kinase, putative 0.0906 0.9649 0.9648
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0384 0.3906 1
Echinococcus multilocularis actin binding protein anillin 0.0032 0.0032 0.0048
Echinococcus multilocularis Pleckstrin y 0.0032 0.0032 0.0048
Brugia malayi hypothetical protein 0.0032 0.0032 0.0032
Schistosoma mansoni syntrophin 0.0032 0.0032 0.0048
Echinococcus granulosus DCC interacting protein 13 beta 0.0032 0.0032 0.0048
Schistosoma mansoni zinc finger protein 0.0032 0.0032 0.0048
Brugia malayi Dynamin 0.0032 0.0032 0.0032
Echinococcus granulosus protein kinase C gamma type 0.0313 0.3123 0.4682
Brugia malayi intracellular kinase 0.0384 0.3906 0.3906
Brugia malayi Hr1 repeat family protein 0.0313 0.3123 0.3123
Echinococcus multilocularis serine:threonine protein kinase N2 0.0313 0.3123 0.4682
Echinococcus granulosus Glutaredoxin protein 5 0.0593 0.6207 0.9304
Loa Loa (eye worm) AGC/NDR protein kinase 0.0313 0.3123 0.3101
Brugia malayi probable spectrin beta chain 0.0032 0.0032 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0313 0.3123 0.3101
Plasmodium falciparum calcium-dependent protein kinase 7 0.0042 0.0145 0.018
Echinococcus multilocularis oxysterol binding protein 3 0.0032 0.0032 0.0048
Echinococcus granulosus tyrosine protein kinase Blk 0.0116 0.0956 0.1434
Trichomonas vaginalis AGC family protein kinase 0.0313 0.3123 0.3101
Entamoeba histolytica PH domain containing protein kinase, putative 0.0635 0.6671 0.666
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0042 0.0145 0.0171
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0313 0.3123 0.4682
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.276 0.2737
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0032 0.0032 0.0048
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0313 0.3123 0.4682
Trichomonas vaginalis AGC family protein kinase 0.0937 1 1
Echinococcus multilocularis Pleckstrin y 0.0032 0.0032 0.0048
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0603 0.632 1
Echinococcus multilocularis nervana 2 0.0593 0.6207 0.9304
Entamoeba histolytica PH domain containing protein kinase, putative 0.0635 0.6671 0.666
Leishmania major serine/threonine-protein kinase a, putative 0.0042 0.0145 0.0292
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0384 0.3906 0.5835
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Echinococcus granulosus calcium dependent secretion activator 1 0.0032 0.0032 0.0048
Brugia malayi Cadps2 protein 0.0032 0.0032 0.0032
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0032 0.0032 0.0032
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0042 0.0145 0.0114
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0313 0.3123 0.3101
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0032 0.0032 0.0048
Entamoeba histolytica PH domain containing protein kinase, putative 0.0042 0.0145 0.0114
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0128 0.1094 0.164
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0593 0.6207 0.9304
Echinococcus multilocularis myotubularin protein 13 0.0032 0.0032 0.0048
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0384 0.3906 0.5855
Echinococcus granulosus Protein kinase C brain isozyme 0.0313 0.3123 0.4682
Echinococcus multilocularis tyrosine protein kinase HCK 0.0103 0.0815 0.1222
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Schistosoma mansoni hypothetical protein 0.0032 0.0032 0.0048
Schistosoma mansoni goodpasture antigen-binding protein 0.0032 0.0032 0.0048
Echinococcus granulosus oxysterol binding protein 9 0.0032 0.0032 0.0048
Echinococcus granulosus beta 1 syntrophin 0.0032 0.0032 0.0048
Schistosoma mansoni centaurin alpha 0.0032 0.0032 0.0048
Echinococcus granulosus tyrosine protein kinase HCK 0.0103 0.0815 0.1222
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0032 0.0032 0.0048
Echinococcus granulosus Rho GTPase activating protein 24 0.0032 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0937 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0906 0.9649 0.9648
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0032 0.0032 0.0048
Echinococcus granulosus Pleckstrin y 0.0032 0.0032 0.0048
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0032 0.0032 0.0048
Entamoeba histolytica hypothetical protein 0.0044 0.017 0.0138
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0128 0.1094 0.164
Brugia malayi Pleckstrin Homology Domain 0.0032 0.0032 0.0032
Onchocerca volvulus 0.0384 0.3906 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0313 0.3123 0.4682
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0042 0.0145 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.3123 0.4682
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Brugia malayi Plekhf2 protein 0.0032 0.0032 0.0032
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0313 0.3123 0.3123
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0603 0.632 0.9474
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0313 0.3123 0.4682
Loa Loa (eye worm) AGC/PKN protein kinase 0.0313 0.3123 0.3101
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Brugia malayi Oxysterol-binding protein 0.0032 0.0032 0.0032
Echinococcus multilocularis protein kinase c epsilon type 0.0313 0.3123 0.4682
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0032 0.0032 0.0048
Echinococcus multilocularis tyrosine protein kinase Srms 0.0116 0.0956 0.1434
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0032 0.0032 0.0048
Brugia malayi Oxysterol binding protein 0.0032 0.0032 0.0032
Plasmodium vivax glycogen synthase kinase 3, putative 0.0384 0.3906 0.616
Schistosoma mansoni hypothetical protein 0.0032 0.0032 0.0048
Schistosoma mansoni goodpasture antigen-binding protein 0.0032 0.0032 0.0048
Trypanosoma brucei protein kinase, putative 0.0384 0.3906 0.3886
Echinococcus multilocularis Ras associated and pleckstrin y 0.0032 0.0032 0.0048
Echinococcus granulosus Pleckstrin y 0.0032 0.0032 0.0048
Schistosoma mansoni serine/threonine kinase 0.0313 0.3123 0.4682
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0042 0.0145 0.0114
Schistosoma mansoni serine/threonine-protein kinase 0.0635 0.6671 1
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.3123 0.4682
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0593 0.6207 0.9304
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0042 0.0145 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.3123 0.4682
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0042 0.0145 0.0292
Entamoeba histolytica protein kinase, putative 0.0937 1 1
Echinococcus multilocularis serine threonine protein kinase 0.0313 0.3123 0.4682
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.3123 0.4682
Loa Loa (eye worm) TK protein kinase 0.0116 0.0956 0.0927
Schistosoma mansoni dynamin 0.0032 0.0032 0.0048
Echinococcus multilocularis pleckstrin y domain containing family A 0.0032 0.0032 0.0048
Schistosoma mansoni vav2 0.0045 0.0174 0.026
Echinococcus granulosus dynamin 1 0.0032 0.0032 0.0048
Echinococcus granulosus serine/threonine protein kinase 0.0635 0.6671 1
Brugia malayi TBC domain containing protein 0.0032 0.0032 0.0032
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0042 0.0145 0.0171
Loa Loa (eye worm) AGC/AKT protein kinase 0.0937 1 1
Brugia malayi follicle stimulating hormone receptor 0.028 0.276 0.276
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0313 0.3123 0.4682
Giardia lamblia Kinase, AGC PKA 0.0603 0.632 1
Entamoeba histolytica p21-activated kinase 0.0042 0.0145 0.0114
Toxoplasma gondii AGC kinase 0.0906 0.9649 1
Schistosoma mansoni hypothetical protein 0.0032 0.0032 0.0048
Entamoeba histolytica protein kinase, putative 0.0042 0.0145 0.0114
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0042 0.0145 0.0118
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0044 0.017 0.0255
Echinococcus granulosus tyrosine protein kinase Fyn 0.0128 0.1094 0.164
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Plasmodium falciparum glycogen synthase kinase 3 0.0384 0.3906 0.616
Echinococcus multilocularis tyrosine protein kinase Blk 0.0116 0.0956 0.1434
Echinococcus multilocularis serine:threonine protein kinase 38 0.0313 0.3123 0.4682
Echinococcus multilocularis serine:threonine protein kinase N2 0.0313 0.3123 0.4682
Brugia malayi p70 ribosomal S6 kinase beta 0.0906 0.9649 0.9649
Trichomonas vaginalis AGC family protein kinase 0.0937 1 1
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0937 1 1
Brugia malayi SRC-1 0.0128 0.1094 0.1094
Entamoeba histolytica PH domain containing protein kinase, putative 0.0042 0.0145 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.3123 0.4682
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0128 0.1094 0.164
Trypanosoma cruzi NIMA-related kinase, putative 0.0042 0.0145 0.0171
Schistosoma mansoni atypical protein kinase C 0.0313 0.3123 0.4682
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0032 0.0032 0.0048
Entamoeba histolytica protein kinase, putative 0.0042 0.0145 0.0114
Echinococcus multilocularis calcium dependent secretion activator 1 0.0032 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0603 0.632 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.3123 0.3123
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0032 0.0032 0.0048
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0042 0.0145 0.0171
Leishmania major protein kinase, putative 0.0042 0.0145 0.0292
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0032 0.0032 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0384 0.3906 0.3886
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0032 0.0032 0.0048
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0313 0.3123 0.3101
Echinococcus granulosus myotubularin protein 13 0.0032 0.0032 0.0048
Entamoeba histolytica PH domain containing protein kinase, putative 0.0042 0.0145 0.0114
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0128 0.1094 0.164
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Trichomonas vaginalis AGC family protein kinase 0.0937 1 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0042 0.0145 0.0171
Echinococcus multilocularis rac serine:threonine kinase 0.0635 0.6671 1
Echinococcus granulosus protein kinase c epsilon type 0.0313 0.3123 0.4682
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Entamoeba histolytica PH domain containing protein kinase, putative 0.0042 0.0145 0.0114
Echinococcus multilocularis GRB2 associated binding protein 3 0.0032 0.0032 0.0048
Schistosoma mansoni oxysterol-binding protein 1 0.0032 0.0032 0.0048
Schistosoma mansoni growth factor receptor-bound protein 0.0032 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0937 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0128 0.1094 0.164
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0042 0.0145 0.0114
Loa Loa (eye worm) SRC-1 0.0128 0.1094 0.1065
Echinococcus granulosus tyrosine protein kinase Src42A 0.0128 0.1094 0.164
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0128 0.1094 0.164
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0032 0.0032 0.0048
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0042 0.0145 0.0114
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0384 0.3906 0.3886
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0042 0.0145 0.0114
Echinococcus multilocularis DCC interacting protein 13 beta 0.0032 0.0032 0.0048
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0603 0.632 0.9471
Schistosoma mansoni zinc finger protein 0.0032 0.0032 0.0048
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0384 0.3906 0.5855
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0384 0.3906 0.4028
Brugia malayi protein-tyrosine kinase 0.0116 0.0956 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.3123 0.4682
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0128 0.1094 0.164
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0603 0.632 0.9474
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Echinococcus granulosus pleckstrin y domain containing family A 0.0032 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0045 0.0174 0.0142
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0128 0.1094 0.164
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0042 0.0145 0.0171
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0313 0.3123 0.3101
Loa Loa (eye worm) TK protein kinase 0.0103 0.0815 0.0785
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.3123 0.4682
Trypanosoma cruzi Protein kinase B 0.0635 0.6671 1
Echinococcus multilocularis Oxysterol binding protein 11 0.0032 0.0032 0.0048
Echinococcus granulosus cytohesin 1 0.0032 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0313 0.3123 0.3101
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Echinococcus multilocularis dynamin 1 0.0032 0.0032 0.0048
Echinococcus granulosus protein kinase shaggy 0.0384 0.3906 0.5855
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Echinococcus granulosus tyrosine protein kinase Fyn 0.0128 0.1094 0.164
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0116 0.0956 0.1434
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0128 0.1094 0.164
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0313 0.3123 0.4682
Echinococcus multilocularis oxysterol binding protein 9 0.0032 0.0032 0.0048
Schistosoma mansoni myotubularin-related protein 0.0032 0.0032 0.0048
Brugia malayi Dynamin 0.0032 0.0032 0.0032
Echinococcus multilocularis beta 1 syntrophin 0.0032 0.0032 0.0048
Brugia malayi PH domain containing protein 0.0032 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0103 0.0815 0.0785
Entamoeba histolytica protein kinase, putative 0.0042 0.0145 0.0114
Brugia malayi MAX-1A 0.0032 0.0032 0.0032
Echinococcus multilocularis cytohesin 1 0.0032 0.0032 0.0048
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0384 0.3906 0.3886
Entamoeba histolytica protein kinase 2, putative 0.0603 0.632 0.6308
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0302 0.301 0.2988
Schistosoma mansoni tyrosine kinase 0.0128 0.1094 0.164
Entamoeba histolytica protein kinase, putative 0.0313 0.3123 0.3101
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0384 0.3906 0.5855
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0128 0.1094 0.164
Trichomonas vaginalis CMGC family protein kinase 0.0384 0.3906 0.3886
Entamoeba histolytica protein kinase, putative 0.0042 0.0145 0.0114
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0042 0.0145 0.0114
Brugia malayi Syntrophin-1 0.0032 0.0032 0.0032
Echinococcus multilocularis protein kinase c iota type 0.0313 0.3123 0.4682
Trichomonas vaginalis CMGC family protein kinase 0.0384 0.3906 0.3886
Echinococcus granulosus serine:threonine protein kinase N2 0.0313 0.3123 0.4682
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0044 0.017 0.0255
Echinococcus multilocularis nervana 2 0.0593 0.6207 0.9304
Trichomonas vaginalis AGC family protein kinase 0.0937 1 1
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0044 0.017 0.0255
Trypanosoma brucei protein kinase, putative 0.0042 0.0145 0.0114
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0116 0.0956 0.1434
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0032 0.0032 0.0048
Schistosoma mansoni tyrosine kinase 0.0128 0.1094 0.164
Echinococcus granulosus pdz domain containing protein 0.0032 0.0032 0.0048
Echinococcus granulosus nervana 2 0.0593 0.6207 0.9304
Leishmania major protein kinase, putative 0.0042 0.0145 0.0292
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Echinococcus granulosus oxysterol binding protein 3 0.0032 0.0032 0.0048
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0042 0.0145 0.0292
Echinococcus granulosus protein kinase c iota type 0.0313 0.3123 0.4682
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0145 0.0114
Entamoeba histolytica protein kinase, putative 0.0937 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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