Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth factor, augmenter of liver regeneration | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0078 | 1 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0078 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0078 | 1 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0041 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0041 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0078 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0078 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0041 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | 0.0078 | 1 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0078 | 1 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0078 | 1 | 0.5 |
Onchocerca volvulus | 0.0078 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 3.9 uM | PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.