Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1513 | 0.1299 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1513 | 0.1513 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0246 | 0.0246 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1513 | 0.1513 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2046 | 0.2046 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0246 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.2189 | 0.1992 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 1 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.2189 | 0.2189 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.2189 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1513 | 0.1299 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1513 | 0.1299 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0246 | 0.0246 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2189 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.2189 | 0.1992 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.2189 | 0.1992 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.2189 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.2189 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.2189 | 0.2189 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1513 | 0.1513 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2046 | 0.2046 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1513 | 0.1513 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1513 | 0.1299 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.2189 | 0.1992 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2189 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.2189 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0246 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2189 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2046 | 0.2046 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.2189 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.2189 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2189 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0246 | 0.0246 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.2189 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0246 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1513 | 0.1513 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0246 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2046 | 0.2046 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.2189 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.2189 | 0.2189 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.2189 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.2189 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.1735 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3048 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.