Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0033 | 0.0183 | 0.5 | |
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | 0.0842 | 1 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0019 | 0.0375 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0518 | 1 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) | 0.0842 | 1 | 0.5 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta | 0.0842 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0183 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0183 | 0.3537 |
Schistosoma mansoni | lamin | 0.0033 | 0.0183 | 0.6116 |
Echinococcus granulosus | lamin | 0.0033 | 0.0183 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0287 | 0.5545 |
Onchocerca volvulus | 0.0033 | 0.0183 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0518 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0183 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0019 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0176 | 0.3397 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0518 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0183 | 0.3537 |
Schistosoma mansoni | lamin | 0.0033 | 0.0183 | 0.6116 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0019 | 0.0375 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0183 | 1 |
Plasmodium falciparum | DNA-directed RNA polymerase subunit beta, putative | 0.0842 | 1 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0019 | 0.0375 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0287 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0183 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0183 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0183 | 0.6116 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.0842 | 1 | 0.5 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta | 0.0842 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0518 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0183 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0183 | 0.3537 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0183 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0287 | 0.5545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.8913 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.