Detailed information for compound 1323965

Basic information

Technical information
  • TDR Targets ID: 1323965
  • Name: SMR000221781
  • MW: 312.234 | Formula: C16H19Cl2NO
  • H donors: 1 H acceptors: 1 LogP: 4.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1(CC1(Cl)Cl)c1ccccc1)NC1CCCCC1
  • InChi: 1S/C16H19Cl2NO/c17-16(18)11-15(16,12-7-3-1-4-8-12)14(20)19-13-9-5-2-6-10-13/h1,3-4,7-8,13H,2,5-6,9-11H2,(H,19,20)
  • InChiKey: LVUNTUIYDNZMTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STOCK2S-45669
  • 2,2-Dichloro-1-phenyl-cyclopropanecarboxylic acid cyclohexylamide
  • MLS000332535

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus allatostatin A receptor 0.0032 0.0265 0.0265
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0501 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0501 1 1
Onchocerca volvulus 0.0032 0.0265 0.5
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0265 0.0265
Echinococcus multilocularis serotonin receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0265 0.0265
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Schistosoma mansoni histamine h1 receptor 0.0032 0.0265 0.0265
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi G-protein coupled receptor 0.0032 0.0265 0.0265
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0789 0.0775
Plasmodium falciparum thioredoxin reductase 0.0057 0.0789 1
Onchocerca volvulus 0.0032 0.0265 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Brugia malayi neuropeptide F receptor 0.0032 0.0265 0.0265
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Treponema pallidum NADH oxidase 0.002 0.0015 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0265 0.0265
Echinococcus multilocularis somatostatin receptor 0.0032 0.0265 0.0265
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0265 0.0265
Trypanosoma brucei trypanothione reductase 0.0057 0.0789 0.0775
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0789 0.0789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0015 0.0015
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0265 0.0265
Brugia malayi G-protein coupled receptor 0.0032 0.0265 0.0265
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0265 0.0265
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0265 0.0265
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0015 0.5
Onchocerca volvulus 0.0032 0.0265 0.5
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Schistosoma mansoni amine GPCR 0.0032 0.0265 0.0265
Schistosoma mansoni neuropeptide receptor 0.0032 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Toxoplasma gondii fructose-bisphospatase I 0.0186 0.3471 0.3461
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0265 0.0265
Echinococcus granulosus hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0265 0.0265
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0265 0.0265
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0041 0.0459 0.0459
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptide receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0265 0.0265
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0501 1 1
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0015 0.5
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0789 0.0789
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0265 0.0265
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptide receptor 0.0032 0.0265 0.0265
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0265 0.0265
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0265 0.0265
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0789 0.2985
Onchocerca volvulus 0.0032 0.0265 0.5
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0015 0.5
Schistosoma mansoni amine GPCR 0.0032 0.0265 0.0265
Schistosoma mansoni opsin-like receptor 0.0032 0.0265 0.0265
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0265 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1065 0.1065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine receptor 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Onchocerca volvulus 0.0032 0.0265 0.5
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2609 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis sex peptide receptor 0.0032 0.0265 0.0265
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0265 0.0265
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0265 0.0265
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni opsin-like receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Echinococcus granulosus g protein coupled receptor 0.0032 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0265 0.0265
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0265 0.0265
Plasmodium falciparum glutathione reductase 0.0057 0.0789 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0265 0.0265
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0789 1
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0265 0.0265
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0265 0.0265
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Echinococcus granulosus somatostatin receptor 0.0032 0.0265 0.0265
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0265 0.0265
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0265 0.0265
Echinococcus granulosus orexin receptor type 2 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0265 0.0265
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0265 0.0265
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0265 0.0265
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus granulosus sex peptide receptor 0.0032 0.0265 0.0265
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine receptor 0.0032 0.0265 0.0265
Brugia malayi neuropeptide F receptor 0.0032 0.0265 0.0265
Brugia malayi ORL1-like opioid receptor 0.0032 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0789 0.0789
Echinococcus granulosus serotonin receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) glutathione reductase 0.0057 0.0789 0.0789
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0265 0.0265
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2609 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0015 0.5
Onchocerca volvulus 0.0032 0.0265 0.5
Schistosoma mansoni adenoreceptor 0.0032 0.0265 0.0265
Echinococcus granulosus g protein coupled receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0265 0.0265
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0501 1 1
Echinococcus granulosus fmrfamide receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0015 0.0015
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0032 0.0265 0.0265
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0186 0.3471 0.3461
Onchocerca volvulus 0.0032 0.0265 0.5
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0265 0.0265
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0265 0.0265
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0265 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0265 0.0265
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0015 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0265 0.0265
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0265 0.0265
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0265 0.0265
Schistosoma mansoni opsin-like receptor 0.0032 0.0265 0.0265
Toxoplasma gondii fructose-bisphospatase II 0.0501 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2307 0.8837
Brugia malayi Dopamine receptor protein 2 0.0032 0.0265 0.0265
Brugia malayi Thioredoxin reductase 0.0057 0.0789 0.0789
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0186 0.3471 0.3461
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0015 0.0015
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0265 0.0265
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0265 0.0265
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0265 0.0265
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0501 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0265 0.0265
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0265 0.0265
Plasmodium vivax glutathione reductase, putative 0.0057 0.0789 1
Leishmania major trypanothione reductase 0.0057 0.0789 0.0775
Echinococcus granulosus g protein coupled receptor 0.0032 0.0265 0.0265
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0015 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0265 0.0265
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2307 0.8837
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0265 0.0265
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0015 0.0015
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0854 0.0854
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0501 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi AKH receptor 0.0032 0.0265 0.0265
Mycobacterium tuberculosis Probable reductase 0.013 0.2307 0.8837
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0265 0.0265
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0459 0.0459
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0854 0.0854
Schistosoma mansoni amine GPCR 0.0032 0.0265 0.0265
Schistosoma mansoni neuropeptide receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0265 0.0265
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0501 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0265 0.0265
Brugia malayi Dopamine receptor 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0265 0.0265
Schistosoma mansoni neuropeptide receptor 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0041 0.0459 0.0459
Schistosoma mansoni myosin xvIII 0.0032 0.0265 0.0265
Echinococcus multilocularis serotonin receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2307 0.8837
Schistosoma mansoni amine GPCR 0.0032 0.0265 0.0265
Brugia malayi GnHR receptor homolog 0.0032 0.0265 0.0265
Brugia malayi sulfakinin receptor protein 0.0032 0.0265 0.0265
Brugia malayi larval opioid receptor 0.0032 0.0265 0.0265
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0265 0.0265
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0265 0.0265
Schistosoma mansoni neuropeptide receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Toxoplasma gondii thioredoxin reductase 0.0057 0.0789 0.0775
Brugia malayi Dopamine receptor protein 1 0.0032 0.0265 0.0265
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0015 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi G protein-coupled receptor 0.0032 0.0265 0.0265
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0265 0.0265
Brugia malayi Melatonin receptor type 1A 0.0032 0.0265 0.0265
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0265 0.0265
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0186 0.3471 0.3461
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Leishmania major 0.0501 1 1
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi hypothetical protein 0.0166 0.3055 0.3055
Onchocerca volvulus 0.0032 0.0265 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Onchocerca volvulus 0.0032 0.0265 0.5
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2307 0.8837
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Brugia malayi glutathione reductase 0.0057 0.0789 0.0789
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Schistosoma mansoni amine GPCR 0.0032 0.0265 0.0265
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0015 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0265 0.0265
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0265 0.0265
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0265 0.0265
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0186 0.3471 0.3461
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0265 0.0265
Brugia malayi Serotonin receptor 0.0032 0.0265 0.0265
Brugia malayi putative neuropeptide receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.006 0.0854 0.0854
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0265 0.0265
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2307 0.8837
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0265 0.0265
Brugia malayi Serotonin receptor 0.0032 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0032 0.0265 0.0265
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2609 1
Brugia malayi hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0265
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0265 0.0265
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0265 0.0265
Brugia malayi RE15519p 0.0032 0.0265 0.0265
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0265 0.0265
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2609 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0015 0.5
Onchocerca volvulus 0.0032 0.0265 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5805 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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