Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0161 | 0.1358 | 0.0303 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0161 | 0.1358 | 0.1336 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0161 | 0.1358 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0147 | 0.1183 | 0.0107 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0314 | 0.3297 | 0.3297 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0118 | 0.0816 | 0.0793 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0057 | 0.0053 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1358 | 0.1336 |
Brugia malayi | CHE-14 protein | 0.0057 | 0.0053 | 0.0027 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0065 | 0.0154 | 0.0774 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.031 | 0.3248 | 0.2424 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0161 | 0.1358 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0057 | 0.0053 | 0.0027 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0161 | 0.1358 | 0.0303 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0139 | 0.1088 | 0.1088 |
Leishmania major | mitochondrial DNA polymerase beta | 0.031 | 0.3248 | 0.2424 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0161 | 0.1358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0053 | 0.0027 |
Echinococcus multilocularis | protein patched | 0.0057 | 0.0053 | 0.0027 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0163 | 0.1393 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0065 | 0.0154 | 0.0774 |
Mycobacterium ulcerans | hypothetical protein | 0.0161 | 0.1358 | 0.8858 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0139 | 0.1088 | 0.1065 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0161 | 0.1358 | 0.1358 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0139 | 0.1088 | 0.1088 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0139 | 0.1088 | 0.1065 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0057 | 0.0053 | 0.0027 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.031 | 0.3248 | 0.3248 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0845 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0314 | 0.3297 | 0.2243 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0161 | 0.1358 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0314 | 0.3297 | 0.3297 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.031 | 0.3248 | 0.3248 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0147 | 0.1183 | 0.0107 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0065 | 0.0154 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0118 | 0.0816 | 0.0793 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0314 | 0.3297 | 0.2479 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0057 | 0.0053 | 0.0027 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0147 | 0.1183 | 0.1183 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0108 | 0.0697 | 0.0673 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0057 | 0.0053 | 0.0027 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0314 | 0.3297 | 0.2243 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0845 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0161 | 0.1358 | 0.1358 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1088 | 0.1065 |
Echinococcus multilocularis | protein dispatched 1 | 0.0057 | 0.0053 | 0.0027 |
Mycobacterium ulcerans | hypothetical protein | 0.0163 | 0.1393 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0139 | 0.1088 | 0.1065 |
Leishmania major | 0.0845 | 1 | 1 | |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0845 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0057 | 0.0053 | 0.0027 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0065 | 0.0154 | 0.0774 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0057 | 0.0053 | 0.0027 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0845 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0139 | 0.1088 | 0.1065 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0845 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0845 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0845 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0845 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0057 | 0.0053 | 0.0027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.