Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0217 | 1 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0175 | 0.7722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0217 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0217 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.0175 | 0.5 | |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0052 | 0.1007 | 0.2238 |
Echinococcus multilocularis | acetylcholinesterase | 0.0217 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.0175 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0037 | 0.0175 | 0.0655 |
Echinococcus granulosus | acetylcholinesterase | 0.0217 | 1 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0059 | 0.14 | 0.3111 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0083 | 0.2678 | 0.5951 |
Onchocerca volvulus | 0.0037 | 0.0175 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0.0175 | 0.0655 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0217 | 1 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0175 | 0.7722 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0037 | 0.0175 | 0.039 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0.0175 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0217 | 1 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0083 | 0.2678 | 0.5951 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0059 | 0.14 | 0.3111 |
Onchocerca volvulus | 0.0037 | 0.0175 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0.0175 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0217 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0217 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0217 | 1 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0083 | 0.2678 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0059 | 0.14 | 0.5229 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0116 | 0.45 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0175 | 0.7722 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k obs / 1 (functional) | = 7100 M-1 s-1 | Inactivation of porcine pancreatic elastase (PPE) expressed as rate constant. | ChEMBL. | 1552505 |
k obs / 1 (functional) | = 7100 M-1 s-1 | Inactivation of porcine pancreatic elastase (PPE) expressed as rate constant. | ChEMBL. | 1552505 |
[I] (functional) | = 8.3 uM | Inactivation of porcine pancreatic elastase (PPE) expressed as rate constant [I]. | ChEMBL. | 1552505 |
[I] (functional) | = 8.3 uM | Inactivation of porcine pancreatic elastase (PPE) expressed as rate constant [I]. | ChEMBL. | 1552505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.