Detailed information for compound 1324088

Basic information

Technical information
  • TDR Targets ID: 1324088
  • Name: 2-(1,3-dimethyl-6-oxo-4-phenylpyrazolo[5,4-b] pyridin-7-yl)-N-propan-2-ylacetamide
  • MW: 338.404 | Formula: C19H22N4O2
  • H donors: 1 H acceptors: 3 LogP: 1.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)Cn1c(=O)cc(c2c1n(C)nc2C)c1ccccc1)C
  • InChi: 1S/C19H22N4O2/c1-12(2)20-16(24)11-23-17(25)10-15(14-8-6-5-7-9-14)18-13(3)21-22(4)19(18)23/h5-10,12H,11H2,1-4H3,(H,20,24)
  • InChiKey: SQXRUAXUQYPPQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1,3-dimethyl-6-oxo-4-phenyl-pyrazolo[5,4-b]pyridin-7-yl)-N-isopropyl-acetamide
  • 2-(1,3-dimethyl-6-oxo-4-phenyl-7-pyrazolo[5,4-b]pyridinyl)-N-isopropylacetamide
  • N-isopropyl-2-(6-keto-1,3-dimethyl-4-phenyl-pyrazolo[5,4-b]pyridin-7-yl)acetamide
  • 2-(1,3-dimethyl-6-oxo-4-phenyl-pyrazolo[5,4-b]pyridin-7-yl)-N-propan-2-yl-ethanamide
  • NCGC00129572-01
  • G219-4470

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni egf-like domain protein 0.0015 0.0018 0.0026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0354 0.3518 0.3507
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0245 0.1456
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0023 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.2258 0.2244
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.0526
Schistosoma mansoni hypothetical protein 0.0023 0.0103 0.015
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0163 0.1549 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0071 0.0599 0.0873
Brugia malayi N-terminal motif family protein 0.0175 0.1673 0.1658
Schistosoma mansoni Smad4 0.003 0.0173 0.0252
Echinococcus multilocularis tumor protein p63 0.0328 0.325 0.4739
Echinococcus granulosus microtubule associated protein 2 0.0677 0.6858 1
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.4591 0.6695
Schistosoma mansoni hypothetical protein 0.0043 0.0313 0.0457
Schistosoma mansoni intermediate filament proteins 0.0033 0.0201 0.0293
Brugia malayi follicle stimulating hormone receptor 0.0232 0.2258 0.2244
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0201 0.0183
Echinococcus multilocularis mothers against decapentaplegic 5 0.0067 0.0555 0.0809
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.036 0.0525
Toxoplasma gondii cell division protein CDC48CY 0.0172 0.164 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0027 0.0039
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0245 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0027 0.0039
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0045 0.0027
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0061 0.009
Schistosoma mansoni tar DNA-binding protein 0.0314 0.3106 0.453
Onchocerca volvulus 0.0033 0.0201 0.1105
Schistosoma mansoni cpg binding protein 0.0036 0.0237 0.0346
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0167 0.0945
Loa Loa (eye worm) VCP protein 0.0071 0.0599 0.0582
Loa Loa (eye worm) TAR-binding protein 0.0314 0.3106 0.3094
Echinococcus multilocularis lamin dm0 0.0033 0.0201 0.0293
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.102 0.1488
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0068 0.0051
Schistosoma mansoni Smad4 0.003 0.0173 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.1714 0.2499
Schistosoma mansoni hypothetical protein 0.0047 0.0348 0.0507
Echinococcus granulosus Smad4 0.0067 0.0555 0.0809
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.1714 0.2499
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0167 0.0917
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0067 0.0555 0.0809
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0167 0.0945
Echinococcus multilocularis tar DNA binding protein 0.0314 0.3106 0.453
Schistosoma mansoni smad1 5 8 and 0.0067 0.0555 0.0809
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0167 0.0945
Brugia malayi hypothetical protein 0.0043 0.0313 0.0296
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0245 0.0357
Loa Loa (eye worm) hypothetical protein 0.0242 0.2362 0.2348
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0003
Schistosoma mansoni lamin 0.0033 0.0201 0.0293
Loa Loa (eye worm) MH2 domain-containing protein 0.0067 0.0555 0.0538
Onchocerca volvulus 0.0047 0.0348 0.1992
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0167 0.0945
Schistosoma mansoni cpg binding protein 0.0032 0.0196 0.0286
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0172 0.164 0.2392
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0439 0.067
Echinococcus multilocularis zinc finger protein 0.0024 0.0109 0.016
Plasmodium vivax cell division cycle ATPase, putative 0.0062 0.0507 0.3176
Loa Loa (eye worm) hypothetical protein 0.0086 0.0756 0.0739
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0167 0.0945
Trypanosoma brucei Valosin-containing protein 0.0163 0.1549 1
Mycobacterium tuberculosis Putative conserved ATPase 0.0103 0.0927 1
Onchocerca volvulus 0.0033 0.0201 0.1105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0354 0.3518 0.3507
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0439 0.2729
Loa Loa (eye worm) glutaminase 2 0.0317 0.3145 0.3132
Schistosoma mansoni Smad4 0.0067 0.0555 0.0809
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0071 0.0599 0.0873
Schistosoma mansoni hypothetical protein 0.0242 0.2362 0.3445
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0163 0.1549 1
Leishmania major hypothetical protein, conserved 0.0029 0.0167 0.0945
Schistosoma mansoni glutaminase 0.0317 0.3145 0.4586
Loa Loa (eye worm) hypothetical protein 0.0032 0.0195 0.0177
Trypanosoma cruzi ISWI complex protein 0.0017 0.0041 0.0121
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0023 0.0033
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.0526
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0167 0.0945
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.1714 0.2499
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0163 0.1549 0.2258
Schistosoma mansoni ap endonuclease 0.0037 0.0245 0.0357
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.04 0.0383
Echinococcus multilocularis lamin 0.0033 0.0201 0.0293
Loa Loa (eye worm) hypothetical protein 0.0112 0.102 0.1004
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0144 0.021
Echinococcus granulosus tumor protein p63 0.0328 0.325 0.4739
Mycobacterium ulcerans ATPase 0.0103 0.0927 0.2353
Brugia malayi intermediate filament protein 0.0033 0.0201 0.0183
Loa Loa (eye worm) MH2 domain-containing protein 0.0981 1 1
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0173 0.0252
Loa Loa (eye worm) hypothetical protein 0.0175 0.1673 0.1658
Brugia malayi MH2 domain containing protein 0.0067 0.0555 0.0538
Schistosoma mansoni hypothetical protein 0.0112 0.102 0.1488
Echinococcus multilocularis Tolloid protein 1 0.0015 0.0018 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.1714 0.2499
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.1673 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0245 0.1456
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0439 0.067
Loa Loa (eye worm) hypothetical protein 0.0079 0.0682 0.0665
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0173 0.0155
Echinococcus multilocularis smad 0.0067 0.0555 0.0809
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0173 0.0252
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0071 0.0599 0.0582
Echinococcus granulosus laminin 0.0015 0.0018 0.0026
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0103 0.0927 0.5604
Echinococcus granulosus mothers against decapentaplegic 5 0.0067 0.0555 0.0809
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0069 0.01
Echinococcus granulosus lamin 0.0033 0.0201 0.0293
Brugia malayi vesicle-fusing ATPase 0.0101 0.0906 0.0889
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.4597 0.6703
Brugia malayi Bromodomain containing protein 0.0043 0.0307 0.0289
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.0526
Loa Loa (eye worm) hypothetical protein 0.005 0.0376 0.0359
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0023 0.0028
Schistosoma mansoni cpg binding protein 0.0036 0.0237 0.0346
Toxoplasma gondii exonuclease III APE 0.0037 0.0245 0.1398
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0069 0.01
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.0149
Brugia malayi Bromodomain containing protein 0.0086 0.075 0.0733
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.102 0.1004
Trypanosoma cruzi Valosin-containing protein, putative 0.0163 0.1549 1
Brugia malayi hypothetical protein 0.0229 0.2234 0.222
Brugia malayi MH2 domain containing protein 0.003 0.0173 0.0155
Echinococcus granulosus dnaJ subfamily B 0.0457 0.4591 0.6695
Loa Loa (eye worm) hypothetical protein 0.0229 0.2234 0.222
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0033
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0245 0.1456
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0041 0.0284 0.0136
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0023 0.0033
Brugia malayi MH1 domain containing protein 0.0037 0.0246 0.0229
Echinococcus multilocularis cpg binding protein 0.0036 0.0237 0.0346
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0245 0.0227
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0163 0.1549 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0245 0.2456
Echinococcus multilocularis Smad4 0.0067 0.0555 0.0809
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0245 0.1456
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.6858 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0906 0.0889
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.102 0.1488
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0015 0.0018 0.0026
Echinococcus granulosus tar DNA binding protein 0.0314 0.3106 0.453
Brugia malayi MH1 domain containing protein 0.0067 0.0555 0.0538
Loa Loa (eye worm) RNA binding protein 0.0314 0.3106 0.3094
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0173 0.0252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0568 0.0829
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0144 0.021
Schistosoma mansoni tar DNA-binding protein 0.0314 0.3106 0.453
Schistosoma mansoni smad1 5 8 and 0.0067 0.0555 0.0809
Brugia malayi MH2 domain containing protein 0.0067 0.0555 0.0538
Brugia malayi Smad1 0.0067 0.0555 0.0538
Echinococcus granulosus Tolloid protein 1 0.0015 0.0018 0.0026
Echinococcus granulosus GPCR family 2 0.0112 0.102 0.1488
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0172 0.164 0.2392
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.102 0.1488
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0023 0.0033
Brugia malayi hypothetical protein 0.0086 0.0756 0.0739
Schistosoma mansoni smad 0.0067 0.0555 0.0809
Brugia malayi valosin containing protein 0.0101 0.0906 0.0889
Schistosoma mansoni survival motor neuron protein 0.0047 0.0348 0.0507
Loa Loa (eye worm) hypothetical protein 0.0043 0.0308 0.029
Schistosoma mansoni zinc finger protein 0.0017 0.0041 0.006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0313 0.0457
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0201 0.0183
Schistosoma mansoni hypothetical protein 0.0112 0.102 0.1488
Brugia malayi RNA binding protein 0.0314 0.3106 0.3094
Schistosoma mansoni hypothetical protein 0.0457 0.4591 0.6695
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0173 0.0155
Loa Loa (eye worm) glutaminase 0.0317 0.3145 0.3132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0313 0.0457
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.4597 0.6703
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.102 0.1488
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0155
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0439 0.0422
Schistosoma mansoni lamin 0.0033 0.0201 0.0293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.1714 0.2499
Echinococcus multilocularis musashi 0.0033 0.0201 0.0293
Loa Loa (eye worm) hypothetical protein 0.0354 0.3518 0.3507
Echinococcus granulosus cpg binding protein 0.0036 0.0237 0.0346
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0439 0.064
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0573 0.0836
Loa Loa (eye worm) nuclear factor I 0.0037 0.0246 0.0229
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.052 0.3098
Brugia malayi glutaminase DH11.1 0.0317 0.3145 0.3132
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0103 0.0085
Schistosoma mansoni zinc finger protein 0.0024 0.0109 0.016
Echinococcus granulosus intermediate filament protein 0.0033 0.0201 0.0293
Echinococcus granulosus smad 0.0067 0.0555 0.0809
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0061 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0981 1 1
Trichomonas vaginalis glutaminase, putative 0.0317 0.3145 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0183
Schistosoma mansoni smad1 5 8 and 0.0067 0.0555 0.0809
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0573 0.0836
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0067 0.0555 0.0809
Schistosoma mansoni tar DNA-binding protein 0.0314 0.3106 0.453
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0023 0.0028
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0144 0.021
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0173 0.0936
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0245 0.1456
Echinococcus granulosus TGF beta signal transducer SmadC 0.0067 0.0555 0.0809
Brugia malayi hypothetical protein 0.0019 0.006 0.0042
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0172 0.164 0.4811
Entamoeba histolytica cdc48-like protein, putative 0.0163 0.1549 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0439 0.064
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0245 0.0357
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0245 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0314 0.3106 0.3094
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.006
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0173 0.0252
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0314 0.3106 0.453
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0245 0.0227
Loa Loa (eye worm) Smad1 0.0067 0.0555 0.0538
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.0526
Brugia malayi Latrophilin receptor protein 2 0.0112 0.102 0.1004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0069 0.01
Brugia malayi MH1 domain containing protein 0.0037 0.0246 0.0229
Schistosoma mansoni hypothetical protein 0.0112 0.102 0.1488
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.4597 0.6703
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0172 0.164 0.9802
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0196 0.0179
Brugia malayi isocitrate dehydrogenase 0.0015 0.0023 0.0005
Brugia malayi TAR-binding protein 0.0314 0.3106 0.3094
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.028 0.0408
Trypanosoma brucei ISWI complex protein 0.0017 0.0041 0.0121
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2234 0.3257
Loa Loa (eye worm) MH1 domain-containing protein 0.0067 0.0555 0.0538
Brugia malayi CXXC zinc finger family protein 0.0032 0.0196 0.0179
Schistosoma mansoni smad 0.003 0.0173 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.1714 0.2499
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0354 0.3518 0.3507
Schistosoma mansoni ap endonuclease 0.0037 0.0245 0.0357
Loa Loa (eye worm) hypothetical protein 0.0086 0.0756 0.0739
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0439 0.4605
Onchocerca volvulus 0.0048 0.036 0.2066
Echinococcus granulosus zinc finger protein 0.0024 0.0109 0.016
Giardia lamblia AAA family ATPase 0.0103 0.0927 1
Echinococcus multilocularis fibrillin 1 0.0015 0.0018 0.0026
Onchocerca volvulus 0.0032 0.0196 0.1077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.028 0.0408
Mycobacterium ulcerans glutaminase 0.0317 0.3145 1
Echinococcus granulosus neuropeptide s receptor 0.0458 0.4597 0.6703
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0023 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0179 0.1714 0.1699
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0179 0.1714 0.1699
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0348 0.033
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0313 0.0457
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0003
Echinococcus granulosus lamin dm0 0.0033 0.0201 0.0293
Loa Loa (eye worm) vesicle-fusing ATPase 0.0101 0.0906 0.0889
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0314 0.3106 0.3094
Brugia malayi PHD-finger family protein 0.003 0.0171 0.0153
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0069 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.0242 0.2362 0.2348
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0439 0.064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0201 0.0183
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0046 0.0335 0.0318
Echinococcus multilocularis GPCR, family 2 0.0112 0.102 0.1488
Schistosoma mansoni bromodomain containing protein 0.0073 0.0615 0.0896
Loa Loa (eye worm) hypothetical protein 0.0048 0.036 0.0342
Schistosoma mansoni hypothetical protein 0.0112 0.102 0.1488
Loa Loa (eye worm) hypothetical protein 0.0037 0.0246 0.0229
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0172 0.164 0.2392
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0245 0.1456
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0041 0.0284 0.0136
Echinococcus multilocularis laminin 0.0015 0.0018 0.0026
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0061 0.009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.1714 0.2499
Brugia malayi MH1 domain containing protein 0.0067 0.0555 0.0538
Schistosoma mansoni tar DNA-binding protein 0.0314 0.3106 0.453
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0045 0.0027
Schistosoma mansoni eyes absent homolog 0.0086 0.0756 0.1102
Trypanosoma cruzi ISWI complex protein 0.0017 0.0041 0.0121
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2234 0.3257
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0163 0.1549 1
Leishmania major hypothetical protein, conserved 0.0017 0.0041 0.0121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.102 0.1004
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0173 0.0155
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.6858 1
Brugia malayi hypothetical protein 0.0029 0.0167 0.0149
Toxoplasma gondii cell division protein CDC48AP 0.0103 0.0927 0.5604

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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