Detailed information for compound 1324185

Basic information

Technical information
  • TDR Targets ID: 1324185
  • Name: 2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]deca n-3-yl)-N-(2-phenylphenyl)acetamide
  • MW: 391.463 | Formula: C23H25N3O3
  • H donors: 2 H acceptors: 3 LogP: 3.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCC2(CC1)NC(=O)N(C2=O)CC(=O)Nc1ccccc1c1ccccc1
  • InChi: 1S/C23H25N3O3/c1-16-11-13-23(14-12-16)21(28)26(22(29)25-23)15-20(27)24-19-10-6-5-9-18(19)17-7-3-2-4-8-17/h2-10,16H,11-15H2,1H3,(H,24,27)(H,25,29)
  • InChiKey: SKOHIRINWGGPIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,4-diketo-8-methyl-1,3-diazaspiro[4.5]decan-3-yl)-N-(2-phenylphenyl)acetamide
  • 2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-(2-phenylphenyl)ethanamide
  • MLS000516357
  • SMR000342563
  • ZINC03362569
  • T0519-3741

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutaminase 0.0268 0.145 0.5409
Brugia malayi RNA binding protein 0.0463 0.2592 0.9671
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0131 0.0131
Echinococcus granulosus Smad4 0.0033 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Echinococcus granulosus GPCR family 2 0.0128 0.0632 0.0632
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0138 0.0918
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0131 0.0131
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0017 0.0017
Echinococcus granulosus smad 0.0033 0.0075 0.0075
Mycobacterium tuberculosis Probable reductase 0.0105 0.0496 0.3292
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0516
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0128 0.0632 0.0632
Giardia lamblia Kinase, PLK 0.0092 0.042 1
Brugia malayi nuclear hormone receptor 0.0042 0.0131 0.049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1508 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0131 0.049
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.042 0.2156
Echinococcus granulosus tar DNA binding protein 0.0463 0.2592 0.2592
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0131 0.0131
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0131 0.0131
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0075 0.0279
Brugia malayi Smad1 0.0033 0.0075 0.0279
Leishmania major hypothetical protein, conserved 0.0043 0.0138 0.2251
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0478 0.2681 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0131 0.049
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0131 0.049
Toxoplasma gondii thioredoxin reductase 0.0046 0.0153 0.227
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0131 0.0131
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0159 0.2587
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0055
Mycobacterium ulcerans glutaminase 0.0268 0.145 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1038 0.1038
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0017 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.042 0.29
Leishmania major trypanothione reductase 0.0046 0.0153 0.2483
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0138 0.0918
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0075 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.042 0.29
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0131 0.0131
Echinococcus multilocularis GPCR, family 2 0.0128 0.0632 0.0632
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0138 0.2251
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.042 0.29
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0131 0.0671
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0001 0.0003
Onchocerca volvulus 0.0294 0.1606 0.8247
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0131 0.0131
Trypanosoma cruzi PAB1-binding protein , putative 0.0125 0.0615 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0496 0.3292
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0138 0.2251
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.042 0.042
Brugia malayi MH2 domain containing protein 0.0033 0.0075 0.0279
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0463 0.2592 0.2592
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.015 0.1032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0159 0.0593
Brugia malayi steroid hormone receptor 0.0042 0.0131 0.049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1038 0.1038
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0131 0.049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0055
Loa Loa (eye worm) hypothetical protein 0.0125 0.0615 0.2293
Brugia malayi ecdysone receptor 0.002 0.0001 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0138 0.2032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0404 0.2247 0.8384
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0001 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0125 0.0615 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0138 0.0955
Loa Loa (eye worm) hypothetical protein 0.0276 0.15 0.5594
Plasmodium falciparum ataxin-2 like protein, putative 0.0125 0.0615 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0138 0.2251
Mycobacterium tuberculosis Conserved protein 0.0043 0.0138 0.0918
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0001 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0463 0.2592 0.9671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1038 0.1038
Brugia malayi MH2 domain containing protein 0.0033 0.0075 0.0279
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0131 0.0131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0017
Schistosoma mansoni smad 0.0033 0.0075 0.0075
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.042 0.684
Brugia malayi beta-lactamase family protein 0.0043 0.0138 0.0516
Schistosoma mansoni hypothetical protein 0.0128 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Brugia malayi Pax transcription factor protein 2 0.0234 0.125 0.4665
Mycobacterium ulcerans hypothetical protein 0.0043 0.0138 0.0955
Toxoplasma gondii ABC1 family protein 0.0043 0.0138 0.2032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0131 0.049
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0056 0.0212 0.0212
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0015 0.0055
Schistosoma mansoni nuclear receptor 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0294 0.1606 0.599
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.0276
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0131 0.049
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0001 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Schistosoma mansoni hypothetical protein 0.0128 0.0632 0.0632
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0015 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0404 0.2247 0.8384
Brugia malayi nuclear receptor RXR 0.0022 0.0015 0.0055
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.042 0.042
Mycobacterium tuberculosis Conserved protein 0.0043 0.0138 0.0918
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0131 0.049
Loa Loa (eye worm) latrophilin receptor protein 2 0.0128 0.0632 0.2357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0131 0.049
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0131 0.0131
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0153 0.1012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0496 0.3292
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0075 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0131 0.049
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0001 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0153 0.2483
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.0276
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0128 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0015 0.0055
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0017 0.0063
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0131 0.0131
Schistosoma mansoni kinase 0.0047 0.0157 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0131 0.0131
Schistosoma mansoni Smad4 0.0033 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.173 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0015 0.0055
Onchocerca volvulus 0.0042 0.0131 0.0671
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0131 0.0131
Plasmodium falciparum glutathione reductase 0.0046 0.0153 0.227
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0404 0.2247 0.8384
Schistosoma mansoni nuclear hormone receptor 0.002 0.0001 0.0001
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0001 0.0003
Schistosoma mansoni glutaminase 0.0268 0.145 0.145
Brugia malayi MH1 domain containing protein 0.0033 0.0075 0.0279
Schistosoma mansoni smad1 5 8 and 0.0033 0.0075 0.0075
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0131 0.049
Brugia malayi beta-lactamase family protein 0.0043 0.0138 0.0516
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0138 0.0955
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0496 0.3292
Schistosoma mansoni tar DNA-binding protein 0.0463 0.2592 0.2592
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0128 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Loa Loa (eye worm) DR-78 0.002 0.0001 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0159 0.2376
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0131 0.0671
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0159 0.1054
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0001 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0017 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0131 0.0131
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0131 0.0131
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0131 0.0131
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0138 0.0918
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0017 0.5
Brugia malayi nuclear receptor NHR-88 0.002 0.0001 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0131 0.0131
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0015 0.0015
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0017
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0001 0.0001
Trypanosoma brucei trypanothione reductase 0.0046 0.0153 0.2483
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0565 0.3745
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0138 0.0955
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0117
Loa Loa (eye worm) glutaminase 2 0.0268 0.145 0.5409
Brugia malayi Latrophilin receptor protein 2 0.0128 0.0632 0.2357
Brugia malayi nuclear receptor RXR 0.002 0.0001 0.0003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0565 0.3745
Echinococcus multilocularis Smad4 0.0033 0.0075 0.0075
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0496 0.8398
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0153 0.0569
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0565 1
Brugia malayi RNA recognition motif domain containing protein 0.0463 0.2592 0.9671
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0138 0.0918
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0131 0.0131
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0017 0.0404
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0131 0.0131
Echinococcus multilocularis smad 0.0033 0.0075 0.0075
Brugia malayi hypothetical protein 0.002 0.0001 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.042 0.29
Trypanosoma cruzi PAB1-binding protein , putative 0.0125 0.0615 1
Brugia malayi latrophilin 2 splice variant baaae 0.0276 0.15 0.5594
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0125 0.0615 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1038 0.1038
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0138 0.0918
Brugia malayi beta-lactamase 0.0043 0.0138 0.0516
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0153 0.227
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0131 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0001 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0159 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0463 0.2592 0.2592
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.042 0.1568
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0565 0.3745
Brugia malayi glutathione reductase 0.0046 0.0153 0.0569
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0131 0.049
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0131 0.0131
Brugia malayi N-terminal motif family protein 0.0353 0.1947 0.7263
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0159 0.2587
Plasmodium falciparum ataxin-2 like protein, putative 0.0125 0.0615 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0138 0.0516
Brugia malayi hypothetical protein 0.0294 0.1606 0.599
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.1038 0.3871
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.125 0.4665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0159 0.0159
Trypanosoma brucei polo-like protein kinase 0.0092 0.042 0.684
Schistosoma mansoni nuclear hormone receptor 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0131 0.049
Schistosoma mansoni coup transcription factor 0.0042 0.0131 0.0131
Trichomonas vaginalis esterase, putative 0.0043 0.0138 0.0955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1038 0.1038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0138 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0131 0.049
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0131 0.0671
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.042 0.684
Brugia malayi isocitrate dehydrogenase 0.0047 0.0159 0.0593
Brugia malayi tailless protein 0.002 0.0001 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0159 0.2376
Loa Loa (eye worm) glutathione reductase 0.0046 0.0153 0.0569
Loa Loa (eye worm) hypothetical protein 0.0353 0.1947 0.7263
Brugia malayi hypothetical protein 0.0022 0.0015 0.0055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0128 0.0632 0.2357
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0159 0.2587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1038 0.1038
Onchocerca volvulus 0.0234 0.125 0.6422
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0496 0.3292
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.042 0.1568
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0159 0.2587
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0131 0.0131
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0075 0.0279
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0131 0.0131
Brugia malayi hypothetical protein 0.002 0.0001 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0017 0.0276
Brugia malayi nuclear receptor NHR-67 0.002 0.0001 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0131 0.049
Plasmodium falciparum thioredoxin reductase 0.0046 0.0153 0.227
Schistosoma mansoni smad1 5 8 and 0.0033 0.0075 0.0075
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0017 0.0063
Brugia malayi glutaminase DH11.1 0.0268 0.145 0.5409
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0017 0.0404
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0159 0.2587
Brugia malayi hypothetical protein 0.0125 0.0615 0.2293
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0516
Loa Loa (eye worm) MH2 domain-containing protein 0.0478 0.2681 1
Onchocerca volvulus 0.0043 0.0138 0.0707
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0131 0.049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0138 0.0138
Mycobacterium tuberculosis Conserved protein 0.0043 0.0138 0.0918
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Toxoplasma gondii LsmAD domain-containing protein 0.0125 0.0615 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0516
Schistosoma mansoni smad1 5 8 and 0.0033 0.0075 0.0075
Trichomonas vaginalis glutaminase, putative 0.0268 0.145 1
Brugia malayi TAR-binding protein 0.0463 0.2592 0.9671
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0138 0.0955
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0138 0.0918
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0153 0.0153
Brugia malayi hypothetical protein 0.0022 0.0015 0.0055
Loa Loa (eye worm) hypothetical protein 0.0128 0.0632 0.2357
Brugia malayi nuclear hormone receptor 0.002 0.0001 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.015 0.1032
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0001 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0463 0.2592 0.9671
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0001 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0131 0.0131
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0353 0.1947 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0138 0.0516
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Brugia malayi nuclear receptor NHR-88 0.0042 0.0131 0.049
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0131 0.049
Brugia malayi Thioredoxin reductase 0.0046 0.0153 0.0569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0131 0.049
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.049
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0131 0.0131
Plasmodium vivax glutathione reductase, putative 0.0046 0.0153 0.227
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.042 0.29
Echinococcus multilocularis geminin 0.173 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.042 0.684
Brugia malayi hypothetical protein 0.0081 0.0356 0.1327
Brugia malayi conserved hypotetical protein 0.002 0.0001 0.0003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0404 0.2247 0.8384
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0138 0.0955
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.173 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0159 0.0159
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.042 1
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0131 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.042 0.29
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0138 0.0955
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0017 0.0112
Schistosoma mansoni hypothetical protein 0.0128 0.0632 0.0632
Schistosoma mansoni hypothetical protein 0.0056 0.0212 0.0212
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.042 0.042
Schistosoma mansoni tar DNA-binding protein 0.0463 0.2592 0.2592
Loa Loa (eye worm) RNA binding protein 0.0463 0.2592 0.9671
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0131 0.049
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0001 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0128 0.0632 0.0632
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0131 0.0131
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0017 0.0117
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0496 0.3292
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0131 0.049
Brugia malayi MH1 domain containing protein 0.0033 0.0075 0.0279
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.1038 0.3871
Brugia malayi MH2 domain containing protein 0.0478 0.2681 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0138 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0131 0.049
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0159 0.2376
Mycobacterium ulcerans lipase LipD 0.0043 0.0138 0.0955
Schistosoma mansoni hypothetical protein 0.0276 0.15 0.15
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.042 0.29
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0138 0.0955
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0131 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0131 0.049
Loa Loa (eye worm) Smad1 0.0033 0.0075 0.0279
Brugia malayi ecdysteroid receptor 0.0042 0.0131 0.049
Onchocerca volvulus 0.0043 0.0138 0.0707
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0055
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0516
Brugia malayi Nuclear hormone receptor E75 0.002 0.0001 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0131 0.0131
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0056 0.0212 0.0212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0159 0.0159
Brugia malayi Nuclear hormone receptor E75 0.002 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0055
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0516
Schistosoma mansoni hypothetical protein 0.0128 0.0632 0.0632
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0138 0.0955
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0131 0.0131
Schistosoma mansoni zinc finger protein 0.002 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0131 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0131 0.049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0131 0.049
Echinococcus multilocularis tar DNA binding protein 0.0463 0.2592 0.2592
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0015 0.0015
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0001 0.0001
Schistosoma mansoni nuclear receptor 0.002 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0463 0.2592 0.2592
Trypanosoma brucei PAB1-binding protein , putative 0.0125 0.0615 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0131 0.0131
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0138 0.0918
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0159 0.2376
Onchocerca volvulus 0.0043 0.0138 0.0707
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0159 0.0593
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0138 0.0138

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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