TDR Targets

Basic information

Technical information

TDR Targets ID: 1324331
Name: 1-propyl-3-(1,3-thiazol-2-yl)urea
MW: 185.247 | Formula: C7H11N3OS
H donors: 2 H acceptors: 2 LogP: 1.19 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(=O)Nc1nccs1
InChi: 1S/C7H11N3OS/c1-2-3-8-6(11)10-7-9-4-5-12-7/h4-5H,2-3H2,1H3,(H2,8,9,10,11)
InChiKey: AYBSLNUHBOEHRE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-propyl-3-thiazol-2-yl-urea
1-propyl-3-(2-thiazolyl)urea
MLS000564155
SMR000151750
T0514-6838

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoic acid receptor RXR	0.0131	0.3208	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0063	0.0195	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0131	0.3208	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0062	0.016	0.0497
Schistosoma mansoni	nuclear receptor	0.0062	0.016	0.0497
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0195	0.0195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0131	0.3208	0.3208
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0195	0.5
Echinococcus granulosus	cathepsin l1	0.0063	0.0195	0.0036
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0131	0.3208	0.3098
Brugia malayi	hypothetical protein	0.0062	0.016	0.016
Onchocerca volvulus		0.0063	0.0195	0.0607
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0069	0.0486	0.1515
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0131	0.3208	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0131	0.3208	0.3098
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0131	0.3208	0.3098
Schistosoma mansoni	nuclear hormone receptor	0.0062	0.016	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Schistosoma mansoni	nuclear receptor nhr-48	0.0062	0.016	0.0497
Onchocerca volvulus	Cathepsin F homolog	0.0063	0.0195	0.0607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0131	0.3208	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0486	0.0332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0131	0.3208	0.3208
Brugia malayi	nuclear receptor NHR-67	0.0062	0.016	0.016
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0195	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0131	0.3208	0.3098
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0131	0.3208	0.3098
Onchocerca volvulus		0.0131	0.3208	1
Brugia malayi	tailless protein	0.0062	0.016	0.016
Echinococcus multilocularis	FTZ F1 alpha	0.0131	0.3208	0.3098
Loa Loa (eye worm)	steroid hormone receptor	0.0131	0.3208	0.3098
Plasmodium vivax	vivapain-2	0.0063	0.0195	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0131	0.3208	0.3098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0131	0.3208	0.3208
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0131	0.3208	1
Echinococcus multilocularis	cysteine protease	0.0063	0.0195	0.0036
Brugia malayi	Nuclear hormone receptor E75	0.0062	0.016	0.016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0131	0.3208	0.3098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Onchocerca volvulus		0.0063	0.0195	0.0607
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0131	0.3208	0.3098
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0062	0.016	0.0497
Brugia malayi	nuclear receptor NHR-88	0.0131	0.3208	0.3208
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Leishmania major	cysteine peptidase A (CPA)	0.0063	0.0195	0.5
Schistosoma mansoni	zinc finger protein	0.0062	0.016	0.0497
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0063	0.0195	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0069	0.0486	0.0486
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0069	0.0486	0.0332
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0131	0.3208	0.3098
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0131	0.3208	0.3208
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Onchocerca volvulus	Protein ultraspiracle homolog	0.0131	0.3208	1
Schistosoma mansoni	nuclear hormone receptor	0.0131	0.3208	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0131	0.3208	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Brugia malayi	Nuclear hormone receptor-like 1	0.0069	0.0486	0.0486
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Onchocerca volvulus		0.0063	0.0195	0.0607
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0131	0.3208	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0069	0.0486	0.0332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0131	0.3208	0.3098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0486	0.0332
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.0062	0.016	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0131	0.3208	0.3208
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0131	0.3208	0.3098
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Onchocerca volvulus		0.0063	0.0195	0.0607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0195	0.0195
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0069	0.0486	0.1515
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Loa Loa (eye worm)	ctsf protein	0.0063	0.0195	0.0036
Toxoplasma gondii	cathepsin CPL	0.0063	0.0195	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0131	0.3208	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0486	0.0332
Schistosoma mansoni	cathepsin F (C01 family)	0.0063	0.0195	0.0607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Onchocerca volvulus		0.0063	0.0195	0.0607
Onchocerca volvulus	Cathepsin L homolog	0.0063	0.0195	0.0607
Entamoeba histolytica	cysteine protease, putative	0.0063	0.0195	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0063	0.0195	0.0607
Brugia malayi	ecdysone receptor	0.0062	0.016	0.016
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0062	0.016	0.0497
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0131	0.3208	0.3098
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0131	0.3208	0.3208
Brugia malayi	Nuclear hormone receptor E75	0.0062	0.016	0.016
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0131	0.3208	1
Brugia malayi	Papain family cysteine protease containing protein	0.0063	0.0195	0.0195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0063	0.0195	0.5
Brugia malayi	nuclear hormone receptor	0.0062	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0486	0.0332
Schistosoma mansoni	coup transcription factor	0.0131	0.3208	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0131	0.3208	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0131	0.3208	0.3208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Onchocerca volvulus		0.0062	0.016	0.0497
Brugia malayi	nuclear hormone receptor	0.0131	0.3208	0.3208
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0069	0.0486	0.0332
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0131	0.3208	0.3098
Brugia malayi	conserved hypotetical protein	0.0062	0.016	0.016
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0195	0.0195
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0131	0.3208	0.3098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0131	0.3208	0.3208
Brugia malayi	nuclear receptor NHR-88	0.0062	0.016	0.016
Onchocerca volvulus		0.0062	0.016	0.0497
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.3208	1
Plasmodium vivax	vivapain-2	0.0063	0.0195	0.5
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0195	0.0195
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0131	0.3208	0.3208
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0131	0.3208	0.3208
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0063	0.0195	0.0036
Brugia malayi	ecdysteroid receptor	0.0131	0.3208	0.3208
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0195	0.5
Loa Loa (eye worm)	hypothetical protein	0.0286	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.3208	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0131	0.3208	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3208	0.3098
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0131	0.3208	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0131	0.3208	0.3098
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0062	0.016	0.016
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0195	0.0195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0063	0.0195	0.0036
Schistosoma mansoni	nuclear receptor	0.0062	0.016	0.0497
Brugia malayi	hypothetical protein	0.0069	0.0486	0.0486
Echinococcus multilocularis	cathepsin L cysteine protease	0.0063	0.0195	0.0036
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0131	0.3208	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0486	0.0332
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0131	0.3208	0.3098
Brugia malayi	hypothetical protein	0.0069	0.0486	0.0486
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0131	0.3208	0.3098
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0063	0.0195	0.5
Onchocerca volvulus		0.0063	0.0195	0.0607
Loa Loa (eye worm)	fibroinase	0.0063	0.0195	0.0036
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0063	0.0195	0.0036
Brugia malayi	hypothetical protein	0.0062	0.016	0.016
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0063	0.0195	0.0036
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0063	0.0195	0.0036
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0063	0.0195	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0195	0.5
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0062	0.016	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0131	0.3208	0.3208
Echinococcus multilocularis	ecdysone induced protein 78C	0.0131	0.3208	0.3098
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0131	0.3208	0.3098
Onchocerca volvulus	Bile acid receptor homolog	0.0131	0.3208	1
Brugia malayi	nuclear receptor RXR	0.0069	0.0486	0.0486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0131	0.3208	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0062	0.016	0.0497
Loa Loa (eye worm)	cysteine protease	0.0063	0.0195	0.0036
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0131	0.3208	0.3098
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0063	0.0195	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0131	0.3208	0.3098
Onchocerca volvulus		0.0063	0.0195	0.0607
Brugia malayi	nuclear receptor RXR	0.0062	0.016	0.016
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Echinococcus multilocularis	cysteine protease	0.0063	0.0195	0.0036
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0195	0.0195
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0063	0.0195	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0195	0.5
Echinococcus granulosus	survival motor neuron protein 1	0.0286	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0195	0.0036
Schistosoma mansoni	nuclear hormone receptor	0.0062	0.016	0.0497
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0131	0.3208	0.3208
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0131	0.3208	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0063	0.0195	0.0036
Onchocerca volvulus	Cathepsin L homolog	0.0063	0.0195	0.0607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0195	0.5
Leishmania major	cathepsin L-like protease	0.0063	0.0195	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0131	0.3208	0.3098
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0195	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0131	0.3208	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0062	0.016	0.016
Brugia malayi	steroid hormone receptor	0.0131	0.3208	0.3208

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.4147 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 1.5849 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1433068

Bibliographic References

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Detailed information for compound 1324331