Detailed information for compound 1324344

Basic information

Technical information
  • TDR Targets ID: 1324344
  • Name: 8-nitroquinolin-6-ol
  • MW: 190.156 | Formula: C9H6N2O3
  • H donors: 1 H acceptors: 4 LogP: 1.66 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc2cccnc2c(c1)[N+](=O)[O-]
  • InChi: 1S/C9H6N2O3/c12-7-4-6-2-1-3-10-9(6)8(5-7)11(13)14/h1-5,12H
  • InChiKey: AZDVQVFOHUFHOP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-Nitro-6-quinolinol
  • 5437-99-0
  • NSC16523
  • 6-Hydroxy-8-nitroquinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 90, putative heat shock protein 90kDa alpha (cytosolic), class B member 1 724 aa 725 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine proteinase, putative 0.0462 0.5018 0.4976
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0082 0.0082
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0462 0.5018 0.4929
Entamoeba histolytica cysteine proteinase, putative 0.0462 0.5018 0.4929
Loa Loa (eye worm) hypothetical protein 0.06 0.6603 0.6543
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0165 0.162 0.1472
Plasmodium falciparum serine repeat antigen 2 0.0165 0.162 0.162
Loa Loa (eye worm) cathepsin B 0.0165 0.162 0.1472
Brugia malayi Papain family cysteine protease containing protein 0.0165 0.162 0.1472
Giardia lamblia Cathepsin L-like protease 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Plasmodium falciparum serine repeat antigen 3 0.0165 0.162 0.162
Toxoplasma gondii cathepsin CPC2 0.0165 0.162 0.1472
Leishmania major cathepsin L-like protease 0.0896 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.5018 0.4929
Brugia malayi Cathepsin L-like precursor 0.0896 1 1
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Onchocerca volvulus Cathepsin L homolog 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0165 0.162 0.1472
Brugia malayi fibroinase precursor 0.0165 0.162 0.1472
Schistosoma mansoni cathepsin F (C01 family) 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.5018 0.5018
Echinococcus multilocularis cysteine protease 0.0896 1 1
Brugia malayi cathepsin L-like precursor 0.06 0.6603 0.6543
Echinococcus granulosus cathepsin l cysteine peptidase 0.0896 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0462 0.5018 0.4929
Giardia lamblia Cathepsin L precursor 0.0165 0.162 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0462 0.5018 0.4929
Entamoeba histolytica cysteine protease, putative 0.0165 0.162 0.1472
Echinococcus multilocularis cathepsin L 0.0165 0.162 0.1551
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0082 0.0082
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Plasmodium falciparum heat shock protein 90 0.0039 0.0174 0.0174
Entamoeba histolytica cysteine protease, putative 0.0896 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0462 0.5018 0.4929
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0896 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0896 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.162 0.1472
Trypanosoma cruzi cruzipain precursor, putative 0.0296 0.3121 0.3064
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.162 0.162
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0896 1 1
Giardia lamblia Cathepsin L precursor 0.0165 0.162 1
Giardia lamblia Cathepsin L precursor 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0165 0.162 0.1472
Schistosoma mansoni cathepsin s 0.0296 0.3121 0.2999
Echinococcus multilocularis cathepsin b 0.0165 0.162 0.1551
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0165 0.162 0.1472
Trypanosoma cruzi cysteine peptidase, putative 0.0896 1 1
Onchocerca volvulus 0.0896 1 1
Brugia malayi Cathepsin L-like precursor 0.0296 0.3121 0.2999
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Plasmodium vivax vivapain-3 0.0462 0.5018 0.4929
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0896 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0165 0.162 0.162
Echinococcus multilocularis cathepsin L 0.0462 0.5018 0.4976
Echinococcus granulosus cathepsin b 0.0165 0.162 0.1551
Giardia lamblia Cathepsin L precursor 0.0165 0.162 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0165 0.162 0.1472
Entamoeba histolytica hypothetical protein 0.0165 0.162 0.1472
Schistosoma mansoni cathepsin F (C01 family) 0.06 0.6603 0.6543
Echinococcus granulosus cysteine protease 0.0462 0.5018 0.4976
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0462 0.5018 0.4976
Onchocerca volvulus 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0174 0.0092
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Brugia malayi Cathepsin L-like precursor 0.0896 1 1
Leishmania major cathepsin L-like protease 0.0896 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0462 0.5018 0.4976
Loa Loa (eye worm) hypothetical protein 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Entamoeba histolytica cysteine protease, putative 0.0165 0.162 0.1472
Loa Loa (eye worm) ctsf protein 0.0896 1 1
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0165 0.162 0.162
Loa Loa (eye worm) hypothetical protein 0.06 0.6603 0.6543
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.06 0.6603 0.6575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.162 0.162
Trypanosoma cruzi cysteine peptidase, putative 0.0896 1 1
Entamoeba histolytica cysteine proteinase 2 0.0462 0.5018 0.4929
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Giardia lamblia Hypothetical protein 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Trypanosoma cruzi cruzipain precursor, putative 0.0896 1 1
Loa Loa (eye worm) fibroinase 0.0896 1 1
Entamoeba histolytica cysteine proteinase, putative 0.06 0.6603 0.6543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6603 0.6603
Plasmodium vivax vivapain-1 0.0462 0.5018 0.4929
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0165 0.162 0.1472
Plasmodium falciparum serine repeat antigen 4 0.0165 0.162 0.162
Trypanosoma cruzi cysteine protease, putative 0.0462 0.5018 0.4976
Echinococcus multilocularis cathepsin b 0.0165 0.162 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.162 0.162
Plasmodium vivax serine-repeat antigen (SERA) 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.162 0.162
Trypanosoma cruzi cysteine peptidase, putative 0.0296 0.3121 0.3064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.162 0.162
Trypanosoma cruzi cysteine peptidase, putative 0.0896 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0165 0.162 0.1472
Brugia malayi Papain family cysteine protease containing protein 0.0462 0.5018 0.4929
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0165 0.162 0.162
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Onchocerca volvulus 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.162 0.162
Loa Loa (eye worm) hypothetical protein 0.0165 0.162 0.1472
Echinococcus granulosus cathepsin L cysteine proteinase 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0174 0.0092
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0165 0.162 0.1472
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0165 0.162 0.1472
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0082 0.5
Trypanosoma cruzi major cysteine proteinase, putative 0.0165 0.162 0.1551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Giardia lamblia Encystation-specific protease 0.0165 0.162 1
Echinococcus granulosus heat shock protein 90 0.0039 0.0174 0.0092
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Loa Loa (eye worm) hypothetical protein 0.0296 0.3121 0.2999
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0462 0.5018 0.4929
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0165 0.162 0.1551
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0174 0.0174
Plasmodium vivax unspecified product 0.0296 0.3121 0.2999
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0165 0.162 0.1472
Giardia lamblia Hypothetical protein 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.162 0.162
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0165 0.162 0.1472
Brugia malayi cathepsin B-like cysteine proteinase 0.0165 0.162 0.1472
Onchocerca volvulus 0.06 0.6603 0.5946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0296 0.3121 0.2999
Plasmodium vivax unspecified product 0.0462 0.5018 0.4929
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.162 0.162
Echinococcus granulosus cathepsin l1 0.0896 1 1
Giardia lamblia Cysteine protease 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Giardia lamblia Cysteine protease 0.0165 0.162 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0165 0.162 0.1472
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0082 0.0082
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Toxoplasma gondii cathepsin B 0.0165 0.162 0.1472
Leishmania major cysteine peptidase A (CPA) 0.0896 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0462 0.5018 0.5018
Echinococcus multilocularis cathepsin L cysteine protease 0.0896 1 1
Echinococcus granulosus cathepsin L 0.0165 0.162 0.1551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.162 0.162
Plasmodium vivax vivapain-2 0.0896 1 1
Echinococcus granulosus cathepsin L 0.0462 0.5018 0.4976
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Entamoeba histolytica cysteine protease, putative 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0296 0.3121 0.2999
Brugia malayi cathepsin L-like cysteine proteinase 0.0165 0.162 0.1472
Plasmodium falciparum serine repeat antigen 6 0.0165 0.162 0.162
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Plasmodium falciparum serine repeat antigen 1 0.0165 0.162 0.162
Brugia malayi Cathepsin L-like precursor 0.0896 1 1
Leishmania major cathepsin L-like protease 0.0896 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0165 0.162 0.1551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0165 0.162 0.1472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Echinococcus granulosus cathepsin l1 0.06 0.6603 0.6575
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0082 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0165 0.162 1
Plasmodium falciparum serine repeat antigen 8 0.0165 0.162 0.162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Plasmodium falciparum serine repeat antigen 7 0.0165 0.162 0.162
Brugia malayi cathepsin L precursor 0.0165 0.162 0.1472
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0165 0.162 0.1551
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6603 0.6603
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0165 0.162 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Plasmodium falciparum serine repeat antigen 9 0.0165 0.162 0.162
Loa Loa (eye worm) hypothetical protein 0.0165 0.162 0.1472
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Brugia malayi Cathepsin L-like precursor 0.0896 1 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.3121 0.2999
Onchocerca volvulus 0.0896 1 1
Onchocerca volvulus Cathepsin L homolog 0.0896 1 1
Giardia lamblia Cathepsin L-like protease 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0174 0.0092
Onchocerca volvulus 0.0896 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.162 0.1472
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0165 0.162 0.1472
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0165 0.162 0.162
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Entamoeba histolytica cysteine protease, putative 0.0165 0.162 0.1472
Leishmania major cathepsin L-like protease 0.0896 1 1
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Leishmania major cathepsin L-like protease 0.0896 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0165 0.162 0.1472
Entamoeba histolytica cysteine proteinase, putative 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0165 0.162 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.3121 0.2999
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0896 1 1
Leishmania major cathepsin L-like protease 0.0896 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0165 0.162 0.1472
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0462 0.5018 0.4976
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.162 0.162
Brugia malayi Cathepsin L-like cysteine proteinase 0.06 0.6603 0.6543
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0896 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0165 0.162 0.1472
Brugia malayi Cathepsin L-like precursor 0.06 0.6603 0.6543
Loa Loa (eye worm) hypothetical protein 0.0165 0.162 0.1472
Schistosoma mansoni cathepsin B (C01 family) 0.0165 0.162 0.1472
Giardia lamblia Cathepsin L precursor 0.0165 0.162 1
Echinococcus multilocularis cysteine protease 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0165 0.162 0.162
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.162 0.1472
Entamoeba histolytica cysteine proteinase, putative 0.0896 1 1
Toxoplasma gondii cathepsin CPL 0.0896 1 1
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0082 0.5
Plasmodium vivax unspecified product 0.0165 0.162 0.1472
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Brugia malayi cathepsin F-like cysteine proteinase 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.162 0.162
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.5018 0.4929
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.162 0.162
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 1 1
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0165 0.162 0.162
Echinococcus multilocularis heat shock protein 0.0039 0.0174 0.0092
Entamoeba histolytica cysteine protease, putative 0.0165 0.162 0.1472
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Treponema pallidum heat shock protein 90 0.0031 0.0082 0.5
Echinococcus multilocularis heat shock protein 90 0.0039 0.0174 0.0092
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0165 0.162 0.1472
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0462 0.5018 0.5018
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0165 0.162 0.1472
Brugia malayi Papain family cysteine protease containing protein 0.0165 0.162 0.1472
Echinococcus multilocularis cathepsin L cysteine protease 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0165 0.162 0.162
Giardia lamblia Cysteine protease 0.0165 0.162 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0165 0.162 0.162
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Loa Loa (eye worm) hypothetical protein 0.06 0.6603 0.6543
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0896 1 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0174 0.0092
Giardia lamblia Cysteine protease 0.0165 0.162 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0165 0.162 0.1472
Plasmodium vivax serine-repeat antigen (SERA) 0.0165 0.162 0.1472
Schistosoma mansoni cathepsin C 0.0165 0.162 0.1472
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0082 0.5
Plasmodium vivax vivapain-2 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.162 0.162
Brugia malayi Papain family cysteine protease containing protein 0.0462 0.5018 0.4929
Echinococcus granulosus heat shock protein 0.0039 0.0174 0.0092
Brugia malayi Papain family cysteine protease containing protein 0.0896 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0296 0.3121 0.2999
Loa Loa (eye worm) hypothetical protein 0.0165 0.162 0.1472
Plasmodium falciparum cysteine proteinase falcipain 3 0.0896 1 1
Brugia malayi Cathepsin L-like precursor 0.0896 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Brugia malayi Cathepsin L-like precursor 0.06 0.6603 0.6543
Onchocerca volvulus Cathepsin F homolog 0.0896 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0174 0.0596
Brugia malayi cathepsin Z-like cysteine proteinase 0.0165 0.162 0.1472
Giardia lamblia Cathepsin L precursor 0.0165 0.162 1
Plasmodium falciparum serine repeat antigen 5 0.0165 0.162 0.162
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0165 0.162 0.162
Onchocerca volvulus 0.0896 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.162 0.1472
Loa Loa (eye worm) cysteine protease 0.0896 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.5018 0.4976
Leishmania major cathepsin L-like protease 0.0896 1 1
Onchocerca volvulus 0.0896 1 1
Giardia lamblia Cathepsin B precursor 0.0165 0.162 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0896 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0462 0.5018 0.4929
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0165 0.162 1
Leishmania major cathepsin L-like protease 0.0896 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0174 0.0092
Toxoplasma gondii cathepsin CPC1 0.0165 0.162 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0165 0.162 0.162
Echinococcus granulosus cathepsin b 0.0165 0.162 0.1551
Brugia malayi Papain family cysteine protease containing protein 0.0165 0.162 0.1472
Entamoeba histolytica cysteine protease, putative 0.0165 0.162 0.1472
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0165 0.162 0.1551
Leishmania major heat shock protein 83-1 0.0039 0.0174 0.0092
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0462 0.5018 0.4929
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0165 0.162 0.1472
Entamoeba histolytica cysteine protease, putative 0.0462 0.5018 0.4929
Trypanosoma cruzi cysteine peptidase, putative 0.0896 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0896 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.56 um PUBCHEM_BIOASSAY: Tumor Hsp90 Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 429 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
IC50 (functional) > 10 um PUBCHEM_BIOASSAY: Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2. (Class of assay: confirmatory) [Related pubchem assays: 429 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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