Detailed information for compound 1324355

Basic information

Technical information
  • TDR Targets ID: 1324355
  • Name: N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[(5-oxo-2 -propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7- yl)methylsulfanyl]acetamide
  • MW: 410.537 | Formula: C15H18N6O2S3
  • H donors: 1 H acceptors: 4 LogP: 2.02 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1sc2n(n1)c(=O)cc(n2)CSCC(=O)Nc1nnc(s1)CC
  • InChi: 1S/C15H18N6O2S3/c1-3-5-12-20-21-13(23)6-9(16-15(21)26-12)7-24-8-10(22)17-14-19-18-11(4-2)25-14/h6H,3-5,7-8H2,1-2H3,(H,17,19,22)
  • InChiKey: LJTMAQOGDPGMOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[(5-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methylthio]acetamide
  • N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[(5-keto-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methylthio]acetamide
  • N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[(5-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0249 0.027
Mycobacterium tuberculosis Probable reductase 0.0238 0.1155 0.1592
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0566 0.2797 0.2785
Schistosoma mansoni glutamate synthase 0.001 0.0016 0.0059
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0149 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0462 0.2277 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4942
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.003 0.0284
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.1288 0.1777
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0032 0.0341
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0176
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0099 0.0421
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.1949 0.2129
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0175 0.0188
Plasmodium vivax ferrodoxin reductase, putative 0.001 0.0016 0.0017
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0016 0.0627
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.001 0.0016 0.0017
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0462 0.2277 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0162 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0249 0.9555
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0327 0.1406
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0149 0.0133
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0175 0.0158
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.0496 0.2452
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0165 0.3151
Loa Loa (eye worm) hypothetical protein 0.0068 0.0311 0.1332
Echinococcus granulosus GPCR family 2 0.0018 0.0058 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0496 0.2168
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0462 0.2277 0.2488
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0017 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0496 0.2168
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.0341
Schistosoma mansoni hypothetical protein 0.0039 0.0162 0.0697
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0133
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0249 0.1084
Echinococcus multilocularis Smad4 0.0018 0.0058 0.006
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0249 0.1212
Leishmania major trypanothione reductase 0.0104 0.0489 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Echinococcus multilocularis smad 0.0018 0.0058 0.006
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.001 0.0016 0.0034
Plasmodium falciparum thioredoxin reductase 0.0104 0.0489 1
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0016 0.0059
Echinococcus granulosus tar DNA binding protein 0.0072 0.0327 0.1426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0016 0.0015
Trichomonas vaginalis rotamase, putative 0.004 0.017 0.6511
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0012 0.0013
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0149 0.0133
Brugia malayi MH2 domain containing protein 0.0018 0.0058 0.0249
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0175 0.0836
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0009 0.0006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0017 0.0063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0149 0.2803
Leishmania major DNA polymerase eta, putative 0.0068 0.0311 0.6228
Brugia malayi glutathione reductase 0.0104 0.0489 0.2417
Loa Loa (eye worm) hypothetical protein 0.0056 0.0249 0.1062
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.001 0.0016 0.0003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0249 0.1212
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0175 0.0158
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Leishmania major DNA damage repair protein, putative 0.0013 0.0032 0.0341
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.0496 0.2149
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Leishmania major DNA polymerase eta, putative 0.004 0.0168 0.322
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0281
Onchocerca volvulus 0.001 0.0017 0.0901
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1062
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0249 0.4934
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0058 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0017 0.0045
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0249 0.4934
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0149 0.0586
Echinococcus multilocularis glutamate synthase 0.001 0.0016 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0175 0.3349
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Schistosoma mansoni rotamase 0.004 0.017 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.004 0.017 0.6511
Schistosoma mansoni hypothetical protein 0.001 0.0016 0.0059
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0063
Schistosoma mansoni Smad4 0.0008 0.0009 0.0024
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0058 0.0242
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0259 0.5138
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0017 0.0063
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0064 0.2468
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0037
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0064 0.1018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0175 0.0754
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0175 0.0188
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0016 0.0059
Echinococcus granulosus dna polymerase eta 0.0068 0.0311 0.1353
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0063
Entamoeba histolytica thioredoxin reductase, putative 0.001 0.0016 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Trichomonas vaginalis C-MYB, putative 0.0058 0.026 0.9947
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0059 0.0261 0.0883
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0016
Echinococcus granulosus geminin 0.0373 0.1833 0.8049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0111 0.1995
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus multilocularis thioredoxin glutathione reductase 0.0104 0.0489 0.0532
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0238 0.1155 0.1592
Entamoeba histolytica recQ family DNA helicase 0.001 0.0017 0.0076
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.001 0.0016 0.0034
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0162 0.077
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0247
Mycobacterium ulcerans hypothetical protein 0.0013 0.0032 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0017 0.0063
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0249 0.4942
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0064 0.2468
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0032 0.0341
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0016
Leishmania major DNA polymerase kappa, putative 0.0013 0.0032 0.0341
Loa Loa (eye worm) hypothetical protein 0.0056 0.0249 0.1062
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0016 0.0059
Plasmodium falciparum glutathione reductase 0.0104 0.0489 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0017 0.0001
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0032 0.0341
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0251 0.122
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0311 0.152
Schistosoma mansoni DNA helicase recq1 0.0019 0.0064 0.027
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0039
Giardia lamblia DNA damage repair protein 0.0013 0.0032 0.0071
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0064 0.2468
Loa Loa (eye worm) nuclear factor I 0.001 0.0018 0.0042
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Schistosoma mansoni smad 0.0018 0.0058 0.0242
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0149 0.2803
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0175 0.6514
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0251 0.122
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0249 0.1212
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0249 0.1084
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.001 0.0016 0.0034
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trypanosoma cruzi trypanothione reductase, putative 0.0104 0.0489 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.0462 0.2277 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.003 0.0051
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0064 0.2003
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0016 0.0015
Echinococcus granulosus Smad4 0.0018 0.0058 0.0242
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0058 0.0241
Plasmodium vivax glutathione reductase, putative 0.0104 0.0489 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0149 0.0133
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.0016 0.004
Schistosoma mansoni coup transcription factor 0.001 0.0017 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0263 0.1145
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0149 0.0185
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0149 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0249 0.9555
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0238 0.1155 0.1592
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0009 0.0024
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0406 0.1996 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0011 0.0012
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0168 0.055
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0108 0.0437
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0032 0.0061
Leishmania major hypothetical protein, conserved 0.0058 0.0259 0.5138
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0032 0.0341
Loa Loa (eye worm) thioredoxin reductase 0.0104 0.0489 0.2118
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Onchocerca volvulus 0.001 0.0016 0.0793
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4942
Echinococcus granulosus smad 0.0018 0.0058 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0111 0.1995
Loa Loa (eye worm) glutathione reductase 0.0104 0.0489 0.2118
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0058 0.0248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0179 0.0772
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Echinococcus multilocularis cpg binding protein 0.0029 0.0115 0.0123
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.1288 0.1777
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0238 0.1155 0.1592
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0058 0.0218
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0016 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0249 0.1084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0232 0.0778
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0045
Trichomonas vaginalis apoptosis inducing factor, putative 0.001 0.0016 0.0627
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0017 0.0022
Brugia malayi Smad1 0.0018 0.0058 0.0249
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0149 0.57
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0175 0.0221
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0058 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0016 0.004
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0159
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.4934
Trichomonas vaginalis pc-MYB2, putative 0.0058 0.026 0.9947
Schistosoma mansoni sulfide quinone reductase 0.001 0.0016 0.0059
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0175 0.0754
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0175 0.3349
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1442 0.7172 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0063
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0179 0.0192
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0032 0.0341
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0063
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0016 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0045
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0566 0.2797 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0016 0.0003
Loa Loa (eye worm) RNA binding protein 0.0072 0.0327 0.1406
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0249 0.027
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0064 0.027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0496 0.0539
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0104 0.0489 0.066
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.003 0.0013
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0165 0.3151
Trypanosoma brucei unspecified product 0.0041 0.0175 0.3349
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0032 0.0341
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.1288 0.1777
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus granulosus dna polymerase kappa 0.0041 0.0175 0.0754
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0175 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0039
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0149 0.57
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0032 0.0341
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0058 0.006
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0238 0.1155 0.1592
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.001 0.0016 0.0017
Schistosoma mansoni smad1 5 8 and 0.0018 0.0058 0.0242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0249 0.1212
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0017 0.0045
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0064 0.0213
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0063
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0641
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.1282 0.5615
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0259 0.5138
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.001 0.0016 0.0003
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0045
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0016 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0496 0.2168
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Entamoeba histolytica disulphide oxidoreductase, putative 0.001 0.0016 0.0034
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0017 0.0063
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0064 0.0067
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1442 0.7172 1
Loa Loa (eye worm) PDE1B protein 0.0056 0.0249 0.1062
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1084
Brugia malayi ecdysteroid receptor 0.001 0.0017 0.0045
Brugia malayi MH1 domain containing protein 0.0018 0.0058 0.0249
Trichomonas vaginalis pc-MYB2, putative 0.0058 0.026 0.9947
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Schistosoma mansoni glutamate synthase 0.001 0.0016 0.0059
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0016 0.0015
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0101 0.0465
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0017 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0149 0.0479
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0249 0.1084
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.0341
Echinococcus multilocularis geminin 0.0373 0.1833 0.2002
Loa Loa (eye worm) programmed cell death 8 0.001 0.0016 0.0035
Brugia malayi MH2 domain containing protein 0.0018 0.0058 0.0249
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0063
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Schistosoma mansoni smad1 5 8 and 0.0018 0.0058 0.0242
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.1288 0.1777
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0009 0.0024
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0016 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0259 0.5147
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0249 0.1212
Brugia malayi TAR-binding protein 0.0072 0.0327 0.1604
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0149 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0249 0.9555
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1084
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0032 0.0341
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.001 0.0016 0.0627
Echinococcus granulosus expressed protein 0.004 0.017 0.0734
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0063
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0168 0.322
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Brugia malayi hypothetical protein 0.0058 0.0259 0.1261
Schistosoma mansoni Smad4 0.0008 0.0009 0.0024
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0149 0.2803
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0261 1
Leishmania major DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0039
Trypanosoma brucei unspecified product 0.0028 0.0111 0.1995
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.017 0.0813
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0406 0.1996 0.8761
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0099 0.0105
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0176
Echinococcus granulosus glutamate synthase 0.001 0.0016 0.0059
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0063
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0058 0.0242
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0175 0.0754
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0149 0.2803
Treponema pallidum NADH oxidase 0.0036 0.0149 0.0133
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0327 0.1406
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Brugia malayi MH1 domain containing protein 0.001 0.0018 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0111 0.1995
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0045
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0165 0.0538
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0058 0.006
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0016 0.0015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0175 0.3349
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.003 0.0284
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0462 0.2277 0.8131
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0259 0.5138
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Loa Loa (eye worm) hypothetical protein 0.0057 0.0251 0.1069
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0149 0.0133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0016
Echinococcus multilocularis dna polymerase eta 0.0068 0.0311 0.0337
Schistosoma mansoni hypothetical protein 0.0026 0.0099 0.0421
Trichomonas vaginalis MYB, putative 0.0059 0.0261 1
Echinococcus granulosus cpg binding protein 0.0029 0.0115 0.0494
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0045
Schistosoma mansoni glutamate synthase 0.001 0.0016 0.0059
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0149 0.2803
Giardia lamblia hypothetical protein 0.0056 0.0249 0.1031
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0175 0.6687
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0175 0.3349
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0017 0.0901
Giardia lamblia DINP protein human, muc B family 0.0041 0.0175 0.07
Echinococcus multilocularis expressed protein 0.004 0.017 0.0183
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0149 0.2803
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0064 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Brugia malayi MH2 domain containing protein 0.0263 0.1282 0.6409
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0064 0.1018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0641
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0058 0.0241
Trichomonas vaginalis MYB72, putative 0.0058 0.026 0.9947
Brugia malayi polk-prov protein 0.0013 0.0032 0.0121
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0462 0.2277 1
Loa Loa (eye worm) RecQ helicase 0.0019 0.0064 0.0247
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Plasmodium falciparum glutathione reductase 0.0036 0.0149 0.2803
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0101 0.0465
Schistosoma mansoni hypothetical protein 0.0373 0.1833 0.8049
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0259 0.0876
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0149 0.2816
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0149 0.2816
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4942
Schistosoma mansoni smad 0.0008 0.0009 0.0024
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.1018
Schistosoma mansoni DNA helicase recq5 0.0019 0.0064 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0016
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0016 0.0035
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0566 0.2797 0.3885
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0462 0.2277 0.2488
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0149 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0406 0.1996 0.8764
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0149 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0017 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0496 0.2168
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0032 0.0061
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0009 0.0006
Schistosoma mansoni cpg binding protein 0.0029 0.0115 0.0494
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0058 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Trichomonas vaginalis C-MYB, putative 0.0058 0.026 0.9947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0045
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1836 0.9143 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.1018
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0042 0.0179 0.0772
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0017 0.0063
Brugia malayi glutamate synthase 0.001 0.0016 0.004
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Toxoplasma gondii selenide, water dikinase 0.001 0.0016 0.0003
Echinococcus granulosus bloom syndrome protein 0.0019 0.0064 0.027
Giardia lamblia Myb 1-like protein 0.0059 0.0261 0.1082
Schistosoma mansoni cpg binding protein 0.0029 0.0115 0.0494
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0259 0.5138
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0016 0.004
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0327 0.1604
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0058 0.0248
Schistosoma mansoni sulfide quinone reductase 0.001 0.0016 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Loa Loa (eye worm) hypothetical protein 0.0056 0.0249 0.1062
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Loa Loa (eye worm) Smad1 0.0018 0.0058 0.0218
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Brugia malayi CXXC zinc finger family protein 0.0028 0.0108 0.0498
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0064 0.0247
Trichomonas vaginalis rotamase, putative 0.0039 0.0165 0.633
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0058 0.0218
Brugia malayi MH1 domain containing protein 0.001 0.0018 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0218
Schistosoma mansoni hypothetical protein 0.0396 0.1949 0.8557
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0032 0.0129
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0058 0.006
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0249 0.1084
Schistosoma mansoni cpg binding protein 0.0028 0.0108 0.046
Echinococcus granulosus dnaJ subfamily B 0.0396 0.1949 0.8557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0496 0.2168
Leishmania major hypothetical protein, conserved 0.0056 0.0249 0.4934
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Brugia malayi hypothetical protein 0.0042 0.0179 0.0856
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0165 0.6132
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0016 0.0034
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0032 0.0341
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0249 0.4934
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0249 0.4934
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0249 0.027
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0016 0.0034
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.017 0.0712
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0261 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0311 0.6228
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0462 0.2277 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1084
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0238 0.1155 0.1592
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.003 0.0284
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0016
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0016 0.0055
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0249 0.027
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0249 0.027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0009
Onchocerca volvulus 0.0028 0.0108 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0039
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0149 0.2803
Echinococcus granulosus thioredoxin glutathione reductase 0.0104 0.0489 0.2136
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0017 0.0901
Schistosoma mansoni smad1 5 8 and 0.0018 0.0058 0.0242
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0017 0.0063
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0175 0.6687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0496 0.0539
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0165 0.3151
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0016 0.0059
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0249 0.027
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0032 0.0341
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0311 0.6228
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0249 0.4934
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0165 0.3151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0016 0.0059
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0016 0.0627
Brugia malayi steroid hormone receptor 0.001 0.0017 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0251 0.1069
Brugia malayi Thioredoxin reductase 0.0104 0.0489 0.2417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0063
Schistosoma mansoni DNA polymerase eta 0.0068 0.0311 0.1353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0032 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Brugia malayi hypothetical protein 0.0038 0.0156 0.0743
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0149 0.0706
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0259 0.5138
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0149 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0017 0.0045
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.003 0.0284
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0064 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0045
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0016 0.0003
Schistosoma mansoni Smad4 0.0018 0.0058 0.0242
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0017 0.0022
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0406 0.1996 0.218
Toxoplasma gondii thioredoxin reductase 0.0104 0.0489 0.1702
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0175 0.0221
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0017 0.0063
Schistosoma mansoni hypothetical protein 0.0373 0.1833 0.8049
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0566 0.2797 0.2785
Mycobacterium tuberculosis Probable dehydrogenase 0.0238 0.1155 0.1592
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0016 0.0059
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0017 0.0039
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0249 0.4934
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Trypanosoma brucei unspecified product 0.0028 0.0111 0.1995
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0045
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0249 0.1084
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0249 0.4934
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Brugia malayi MH1 domain containing protein 0.0018 0.0058 0.0249
Brugia malayi RNA binding protein 0.0072 0.0327 0.1604
Echinococcus multilocularis GPCR, family 2 0.0018 0.0058 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0039
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.1282 0.5615
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Plasmodium falciparum thioredoxin reductase 0.0036 0.0149 0.2803
Loa Loa (eye worm) hypothetical protein 0.0058 0.0259 0.1105
Giardia lamblia Hypothetical protein 0.0056 0.0249 0.1031
Plasmodium vivax thioredoxin reductase, putative 0.0104 0.0489 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0045
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Trypanosoma brucei trypanothione reductase 0.0104 0.0489 1
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0064 0.0281
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0327 0.0355
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0016 0.0627
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Leishmania major hypothetical protein, conserved 0.0056 0.0249 0.4934
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0017 0.0901
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0035
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0281
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0064 0.027
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.001 0.0016 0.0627
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.1018
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0179 0.0772
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0249 0.1212
Trichomonas vaginalis MYB3r3, putative 0.0058 0.026 0.9947

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 8.1961 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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