Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0804 | 0.0804 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1492 | 0.2527 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0731 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.1492 | 0.147 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Schistosoma mansoni | slit | 0.005 | 0.0731 | 0.1239 |
Brugia malayi | Muscle positioning protein 4 | 0.005 | 0.0731 | 0.0731 |
Onchocerca volvulus | Dual oxidase homolog | 0.0237 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0154 | 0.5904 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Brugia malayi | Cadherin domain containing protein | 0.005 | 0.0731 | 0.0731 |
Onchocerca volvulus | Peroxidasin homolog | 0.0154 | 0.5904 | 0.5581 |
Echinococcus multilocularis | peroxidasin | 0.0154 | 0.5904 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0804 | 0.0804 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0154 | 0.5904 | 0.5581 |
Loa Loa (eye worm) | notch protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Brugia malayi | EGF-like domain containing protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0154 | 0.5904 | 0.5904 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0731 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | EGF-like domain containing protein | 0.005 | 0.0731 | 0.0731 |
Schistosoma mansoni | notch | 0.005 | 0.0731 | 0.1239 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0731 | 0.1239 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1492 | 0.2527 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0039 | 0.0185 | 0.5 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1492 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | Delta serrate ligand family protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1492 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Onchocerca volvulus | 0.0154 | 0.5904 | 0.5581 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1492 | 0.1492 |
Brugia malayi | Animal haem peroxidase family protein | 0.0154 | 0.5904 | 0.5904 |
Brugia malayi | Animal haem peroxidase family protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.8078 | 0.8078 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0804 | 0.0804 |
Brugia malayi | GCC2 and GCC3 family protein | 0.005 | 0.0731 | 0.0731 |
Schistosoma mansoni | septate junction protein | 0.005 | 0.0731 | 0.1239 |
Brugia malayi | notch-like transmembrane receptor | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Onchocerca volvulus | Peroxidasin homolog | 0.0154 | 0.5904 | 0.5581 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Echinococcus granulosus | peroxidasin | 0.0154 | 0.5904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1492 | 0.1492 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0731 | 0.1239 |
Leishmania major | ferric reductase, putative | 0.0039 | 0.0185 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0154 | 0.5904 | 0.5581 |
Schistosoma mansoni | cell polarity protein | 0.005 | 0.0731 | 0.1239 |
Brugia malayi | Animal haem peroxidase family protein | 0.0154 | 0.5904 | 0.5904 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1492 | 0.147 |
Onchocerca volvulus | Peroxidase homolog | 0.0154 | 0.5904 | 0.5581 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0154 | 0.5904 | 0.5904 |
Brugia malayi | EGF-like domain containing protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1492 | 0.1492 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0731 | 0.1239 |
Schistosoma mansoni | notch | 0.005 | 0.0731 | 0.1239 |
Schistosoma mansoni | laminin gamma-3 chain | 0.005 | 0.0731 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1492 | 0.2527 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Schistosoma mansoni | notch | 0.005 | 0.0731 | 0.1239 |
Toxoplasma gondii | EGF family domain-containing protein | 0.005 | 0.0731 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1492 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0731 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5904 | 0.5904 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.005 | 0.0731 | 0.1239 |
Schistosoma mansoni | notch | 0.005 | 0.0731 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Giardia lamblia | High cysteine protein | 0.005 | 0.0731 | 0.5 |
Onchocerca volvulus | 0.0154 | 0.5904 | 0.5581 | |
Brugia malayi | EGF-like domain containing protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | EGF-like domain containing protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | Peroxidasin | 0.0154 | 0.5904 | 0.5904 |
Schistosoma mansoni | notch | 0.005 | 0.0731 | 0.1239 |
Schistosoma mansoni | peroxidasin | 0.0154 | 0.5904 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.005 | 0.0731 | 0.0731 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0039 | 0.0185 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0154 | 0.5904 | 0.5904 |
Loa Loa (eye worm) | Notch2 | 0.005 | 0.0731 | 0.0731 |
Onchocerca volvulus | 0.0154 | 0.5904 | 0.5581 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0804 | 0.0804 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0731 | 0.1239 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.005 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0237 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.005 | 0.0731 | 0.0731 |
Brugia malayi | Animal haem peroxidase family protein | 0.0154 | 0.5904 | 0.5904 |
Brugia malayi | Cadherin domain containing protein | 0.005 | 0.0731 | 0.0731 |
Schistosoma mansoni | notch | 0.005 | 0.0731 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0039 | 0.0185 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1492 | 0.1492 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1492 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0731 | 0.0731 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | < 5 uM | Intracellular phosphorylation of the compound (100 microM) in uninfected CEM-SS cells was studied after 24 hrs of Incubation time; Value ranges from 3-5 | ChEMBL. | 10882371 |
IC50 (functional) | > 100 uM | Tested in vitro for cytotoxicity against murine L1210 leukemic cells | ChEMBL. | 10882371 |
IC50 (functional) | > 100 uM | Inhibition of KB cell growth was assessed | ChEMBL. | 10882371 |
IC50 (functional) | > 100 uM | Tested for visual cytotoxicity on uninfected HFF cells | ChEMBL. | 10882371 |
IC50 (functional) | > 100 uM | Tested for visual cytotoxicity on uninfected CEM-SS cells | ChEMBL. | 10882371 |
IC50 (binding) | > 100 uM | Antiviral activity was tested in cells acutely infected with HIV-1 RT (reverse transcriptase) | ChEMBL. | 10882371 |
IC50 (functional) | > 100 uM | Antiviral activity was tested using an enzyme-linked immunosorbent assay (ELISA) to detect HSV-1 (herpes simplex virus type 1) using BSC-1 cells | ChEMBL. | 10882371 |
IC50 (functional) | > 100 uM | HCMV plaque assay was performed using HFF cells and effect was calculated as a percentage of reduction in number of plaques | ChEMBL. | 10882371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.