Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.034 | 0.4128 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4158 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.034 | 0.4128 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.034 | 0.4128 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4158 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.034 | 0.4128 | 0.4128 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4158 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.034 | 0.4128 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4158 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.034 | 0.4128 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.034 | 0.4128 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.034 | 0.4128 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.034 | 0.4128 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Trypanosoma brucei | RNA helicase, putative | 0.0639 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.4158 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.034 | 0.4128 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.31 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Mycobacterium avium (Ma) | ChEMBL. | 11754594 |
IC50 (binding) | = 0.31 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Mycobacterium avium (Ma) | ChEMBL. | 11754594 |
IC50 (binding) | = 6.5 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg) | ChEMBL. | 11754594 |
IC50 (binding) | = 6.5 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg) | ChEMBL. | 11754594 |
IC50 (binding) | = 19 uM | In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. | ChEMBL. | 11754594 |
IC50 (binding) | = 19 uM | In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. | ChEMBL. | 11754594 |
IC50 (binding) | = 44 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 11754594 |
IC50 (binding) | = 44 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 11754594 |
SI (binding) | = 2.3 | Selective index against dihydrofolate reductase of Rat liver and dihydrofolate reductase of P. carinii | ChEMBL. | 11754594 |
SI (binding) | = 6.8 | Selective index against dihydrofolate reductase of Rat liver and T. gondii | ChEMBL. | 11754594 |
SI (binding) | = 140 | Selective index for rat liver and M. avium dihydrofolate reductase | ChEMBL. | 11754594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.