Detailed information for compound 1324728

Basic information

Technical information
  • TDR Targets ID: 1324728
  • Name: 6-(1,3-benzodioxol-5-yl)-4-piperazin-1-ylquin azoline
  • MW: 334.372 | Formula: C19H18N4O2
  • H donors: 1 H acceptors: 2 LogP: 2.78 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N1CCN(CC1)c1ncnc2c1cc(cc2)c1ccc2c(c1)OCO2
  • InChi: 1S/C19H18N4O2/c1-3-16-15(19(22-11-21-16)23-7-5-20-6-8-23)9-13(1)14-2-4-17-18(10-14)25-12-24-17/h1-4,9-11,20H,5-8,12H2
  • InChiKey: WVUITNJNSZRMPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(1,3-benzodioxol-5-yl)-4-piperazin-1-yl-quinazoline
  • 6-(1,3-benzodioxol-5-yl)-4-(1-piperazinyl)quinazoline
  • NCGC00011686
  • PCOP-577382

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0074 0.0461 0.0478
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0225 0.0225
Plasmodium falciparum protein serine/threonine kinase-1 0.0074 0.0461 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.022 0.0536
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0225 0.0043
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0107 0.0734 0.1195
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0107 0.0734 0.197
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0745 0.0745
Trypanosoma brucei acetyl-CoA carboxylase 0.1243 1 1
Onchocerca volvulus 0.003 0.0105 0.0133
Onchocerca volvulus 0.0056 0.0321 0.0708
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0044 0.0216 0.0225
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0473 0.3723 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0087 0.009
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3891 0.3891
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0225 0.0043
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0473 0.3723 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0455 0.0455
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0083 0.0083
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0225 0.0225
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0225 0.0225
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0225 0.0225
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0168 0.1235 0.1235
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0189 0.0196
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.014
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0107 0.0734 0.1476
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.0745 0.3833
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0044 0.0216 0.0351
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0135 0.014
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0899 0.7198 1
Trichomonas vaginalis set domain proteins, putative 0.0484 0.381 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0057
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0074 0.0461 0.0461
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0168 0.1235 0.2011
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Plasmodium vivax serine/threonine kinase-1, putative 0.0074 0.0461 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0648 0.0648
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1243 1 1
Brugia malayi Protein kinase domain containing protein 0.0108 0.0745 0.0772
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0225 0.0366
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0107 0.0734 0.0734
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.034 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.0156
Plasmodium falciparum carbamoyl phosphate synthetase 0.0107 0.0734 0.095
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Echinococcus multilocularis chromobox protein 1 0.0068 0.0417 0.0417
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0473 0.3723 0.3723
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.022 0.0219
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0216 0.0224
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0225 0.0225
Echinococcus granulosus lamin dm0 0.0056 0.0321 0.0321
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0044 0.0216 0.0216
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0072 0.0452 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0044 0.0216 0.0216
Schistosoma mansoni zinc finger protein 0.0031 0.0116 0.0116
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0055 0.0055
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0044 0.0216 0.0216
Echinococcus granulosus dual specificity 0.0108 0.0745 0.0745
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0173 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.022 0.0536
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0145 0.0145
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0135 0.0135
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0044 0.0216 0.0351
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0212 0.159 1
Echinococcus granulosus lamin 0.0056 0.0321 0.0321
Leishmania major acetyl-CoA carboxylase, putative 0.1243 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0225 0.0366
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.034 0.034
Schistosoma mansoni lipoxygenase 0.01 0.0673 0.0673
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0044 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0225 0.0552
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0216
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0087 0.009
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0899 0.7198 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0147 0.0146
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0473 0.3723 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0225 0.0225
Schistosoma mansoni lamin 0.0056 0.0321 0.0321
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0168 0.1235 0.3316
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0725 0.0752
Echinococcus granulosus chromobox protein 1 0.0068 0.0417 0.0417
Echinococcus multilocularis lamin dm0 0.0056 0.0321 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0461 0.0461
Leishmania major carbamoyl-phosphate synthase, putative 0.0107 0.0734 0.0733
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0648 0.0648
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0055 0.0057
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0108 0.0112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0144 0.0149
Loa Loa (eye worm) hypothetical protein 0.0072 0.0452 0.0469
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0216 0.0578
Schistosoma mansoni chromobox protein 0.0068 0.0417 0.0417
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0168 0.1235 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0351
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0135 0.0135
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0473 0.3723 0.3723
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0044 0.0216 0.0216
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.022 0.022
Leishmania major carboxylase, putative 0.0473 0.3723 0.3723
Plasmodium vivax SET domain protein, putative 0.0062 0.0364 0.0432
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0168 0.1235 0.1235
Brugia malayi Bromodomain containing protein 0.0078 0.0499 0.0517
Echinococcus granulosus tumor protein p63 0.033 0.2556 0.2556
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0461 0.1174
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.1345 0.1394
Brugia malayi PHD-finger family protein 0.0053 0.0292 0.0303
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0087 0.009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0459 0.0459
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0044 0.0216 0.0216
Schistosoma mansoni chromobox protein 0.0068 0.0417 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0648 0.0648
Schistosoma mansoni aspartate carbamoyltransferase 0.0107 0.0734 0.0734
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0473 0.3723 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1023 0.1023
Leishmania major protein kinase, putative 0.0074 0.0461 0.0461
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1848 0.1916
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0044 0.0216 0.0216
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0364 0.0364
Echinococcus multilocularis lamin 0.0056 0.0321 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.022 0.0536
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0225 0.0552
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0745 0.1213
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0725 0.0752
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0725 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.0156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0135 0.014
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0461 0.0751
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.0745 0.0744
Echinococcus multilocularis RUN 0.0024 0.0055 0.0055
Treponema pallidum pyruvate carboxylase subunit B 0.0044 0.0216 0.5
Echinococcus multilocularis GPCR, family 2 0.0034 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0224
Schistosoma mansoni polycystin 1-related 0.0024 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0078
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0031 0.003
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0044 0.0216 0.0216
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0044 0.0216 0.0216
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0044 0.0216 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.015
Schistosoma mansoni zinc finger protein 0.0042 0.0203 0.0203
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0074 0.0461 0.0461
Onchocerca volvulus 0.0048 0.0256 0.0533
Brugia malayi hypothetical protein 0.0024 0.0055 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0102 0.0225
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0044 0.0216 0.0351
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0473 0.3723 0.6065
Brugia malayi CXXC zinc finger family protein 0.0035 0.0144 0.0149
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0168 0.1235 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.0745 0.0772
Brugia malayi hypothetical protein 0.0197 0.1469 0.1523
Echinococcus multilocularis tumor protein p63 0.033 0.2556 0.2556
Loa Loa (eye worm) hypothetical protein 0.0078 0.05 0.0518
Echinococcus multilocularis 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0107 0.0736 0.0763
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0197 0.1469 0.1523
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0044 0.0216 0.0579
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0168 0.1235 0.3316
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0417 0.0432
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0225 0.0225
Trypanosoma cruzi acetyl-CoA carboxylase 0.0769 0.6138 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0072 0.0452 0.0452
Toxoplasma gondii pyruvate carboxylase 0.0473 0.3723 0.3723
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0461 0.0461
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0168 0.1235 0.3316
Trypanosoma cruzi ISWI complex protein 0.0031 0.0116 0.0188
Onchocerca volvulus 0.0035 0.0144 0.0236
Schistosoma mansoni loxhd1 0.0024 0.0055 0.0055
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0135 0.0135
Onchocerca volvulus 0.0073 0.0455 0.1065
Brugia malayi Doublecortin family protein 0.0024 0.0055 0.0057
Chlamydia trachomatis biotin carboxylase 0.043 0.3368 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0173 0.0412
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0074 0.0461 0.0461
Echinococcus multilocularis cpg binding protein 0.0041 0.0192 0.0192
Echinococcus granulosus chromobox protein 1 0.0068 0.0417 0.0417
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0168 0.1235 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.015
Schistosoma mansoni acetyl-CoA carboxylase 0.1243 1 1
Brugia malayi Heterochromatin protein 1 0.0068 0.0417 0.0432
Loa Loa (eye worm) hypothetical protein 0.0055 0.0313 0.0324
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0044 0.0216 0.0579
Echinococcus multilocularis musashi 0.0056 0.0321 0.0321
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0473 0.3723 0.3723
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0107 0.0734 0.0733
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0056 0.0321 0.0333
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.022 0.0219
Echinococcus multilocularis chromobox protein 1 0.0068 0.0417 0.0417
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0252 0.0252
Brugia malayi cytochrome P450 0.0017 0.0001 0.0001
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0168 0.1235 0.1235
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.022 0.0357
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0044 0.0216 0.0579
Toxoplasma gondii histone lysine methyltransferase SET1 0.0073 0.0455 0.0454
Entamoeba histolytica hypothetical protein 0.0108 0.0745 0.3833
Brugia malayi intermediate filament protein 0.0056 0.0321 0.0333
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0452 0.0469
Trypanosoma brucei unspecified product 0.0311 0.24 0.24
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0107 0.0734 0.0734
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0225 0.0234
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0473 0.3723 0.3723
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0205 0.0212
Schistosoma mansoni hypothetical protein 0.0024 0.0055 0.0055
Leishmania major hypothetical protein, conserved 0.0031 0.0116 0.0115
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.022 0.022
Brugia malayi Pre-SET motif family protein 0.0062 0.0364 0.0378
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0168 0.1235 0.3316
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0225 0.0552
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0147 0.0146
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0225 0.0225
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0252 0.0252
Echinococcus multilocularis dual specificity protein kinase clk2 0.0074 0.0461 0.0461
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0147 0.0238
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0196 0.0475
Echinococcus granulosus dual specificity protein kinase clk2 0.0074 0.0461 0.0461
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0044 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Brugia malayi Cytochrome P450 family protein 0.0017 0.0001 0.0001
Mycobacterium ulcerans pyruvate carboxylase 0.0473 0.3723 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0135 0.0135
Brugia malayi Pre-SET motif family protein 0.0425 0.3331 0.3454
Echinococcus granulosus single minded 2 0.0043 0.0216 0.0216
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0044 0.0216 0.0224
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0044 0.0216 0.0216
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0252 0.0252
Brugia malayi Cytochrome P450 family protein 0.0028 0.0087 0.009
Entamoeba histolytica protein kinase, putative 0.0108 0.0745 0.3833
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0417 0.1056
Mycobacterium ulcerans hypothetical protein 0.0044 0.0216 0.0579
Echinococcus granulosus cpg binding protein 0.0041 0.0192 0.0192
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0461 0.0751
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0168 0.1235 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Brugia malayi chromobox protein homolog 3 0.0038 0.0173 0.0179
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.022 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0173 0.0412
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0044 0.0216 0.0216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0648 0.0648
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1243 1 1
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0044 0.0216 0.0224
Schistosoma mansoni cpg binding protein 0.0041 0.0192 0.0192
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0321 0.0333
Brugia malayi hypothetical protein 0.0024 0.0055 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0087 0.0141
Schistosoma mansoni rab6-interacting 0.0024 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0224
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0145 0.0145
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0196 0.0375
Schistosoma mansoni lipoxygenase 0.0142 0.1023 0.1023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0364 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0082 0.0173
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0461 0.0751
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0168 0.1235 0.3316
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0473 0.3723 0.3723
Schistosoma mansoni cpg binding protein 0.0041 0.0192 0.0192
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0168 0.1235 0.3316
Schistosoma mansoni hypothetical protein 0.0494 0.3891 0.3891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0108 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0082 0.0173
Loa Loa (eye worm) hypothetical protein 0.0096 0.0648 0.0672
Loa Loa (eye worm) hypothetical protein 0.0089 0.0587 0.0609
Echinococcus multilocularis Biotin lipoyl attachment 0.0044 0.0216 0.0216
Brugia malayi Cytochrome P450 family protein 0.004 0.0189 0.0196
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0044 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0044 0.0216 0.0216
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0083 0.0083
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0044 0.0216 0.0579
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.022 0.022
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.022 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0196 0.0475
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0168 0.1235 0.3233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0094 0.0205
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.0745 0.0744
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0087 0.0086
Schistosoma mansoni pyruvate carboxylase 0.0473 0.3723 0.3723
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0212 0.159 1
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.1235
Trypanosoma cruzi ISWI complex protein 0.0031 0.0116 0.0188
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.022 0.0228
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1023 0.1023
Schistosoma mansoni bromodomain containing protein 0.0131 0.093 0.093
Schistosoma mansoni cytochrome P450 0.0017 0.0001 0.0001
Giardia lamblia Kinase, CMGC CLK 0.0074 0.0461 0.1765
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0078
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0473 0.3723 1
Schistosoma mansoni intermediate filament proteins 0.0056 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0144 0.1038 0.1076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0256 0.0265
Schistosoma mansoni hypothetical protein 0.0042 0.0205 0.0205
Toxoplasma gondii carbamoylphosphate synthetase 0.0107 0.0734 0.0733
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0101
Loa Loa (eye worm) hypothetical protein 0.0045 0.0225 0.0234
Schistosoma mansoni cpg binding protein 0.0035 0.0144 0.0144
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0473 0.3723 1
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0044 0.0216 0.0225
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1199 0.9645 1
Echinococcus multilocularis dual specificity 0.0108 0.0745 0.0745
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0473 0.3723 0.3723
Onchocerca volvulus 0.0484 0.381 1
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0044 0.0216 0.0225
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0179
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0216
Onchocerca volvulus 0.0056 0.0321 0.0708
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0168 0.1235 0.3316
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0044 0.0216 0.0225
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0135 0.014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0871 0.0871
Schistosoma mansoni single-minded 0.0059 0.034 0.034
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0044 0.0216 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Loa Loa (eye worm) hypothetical protein 0.0083 0.0539 0.0559
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.3331 0.3454
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1848 0.1916
Echinococcus granulosus zinc finger protein 0.0042 0.0203 0.0203
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0461 0.0751
Entamoeba histolytica protein kinase, putative 0.0108 0.0745 0.3833
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0044 0.0216 0.0579
Echinococcus multilocularis zinc finger protein 0.0042 0.0203 0.0203
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0044 0.0216 0.0224
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0044 0.0216 0.0216
Trypanosoma brucei ISWI complex protein 0.0031 0.0116 0.0115
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0417 0.1056
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1243 1 1
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0044 0.0216 0.0216
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0225 0.0225
Brugia malayi Protein kinase domain containing protein 0.0074 0.0461 0.0478
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0128 0.0127
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0044 0.0216 0.0216
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3891 0.3891
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0087 0.0141
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0459 0.0459
Brugia malayi hypoxia-induced factor 1 0.0182 0.1345 0.1394
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0351
Loa Loa (eye worm) hypothetical protein 0.0106 0.0725 0.0752
Echinococcus granulosus RUN 0.0024 0.0055 0.0055
Echinococcus granulosus Biotin lipoyl attachment 0.0044 0.0216 0.0216
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.022 0.0228
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0155 0.0161
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0044 0.0216 0.0216
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0321 0.0333
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.001 0.0009
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0107 0.0734 0.1195
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.022 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0101
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0168 0.1235 0.3316
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0107 0.0734 0.095
Echinococcus granulosus intermediate filament protein 0.0056 0.0321 0.0321
Leishmania major protein kinase, putative 0.0074 0.0461 0.0461
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0087 0.0232
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0044 0.0216 0.0579
Leishmania major cytochrome p450-like protein 0.0028 0.0087 0.0086
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0871 0.0871
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0044 0.0216 0.0351
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.2011
Echinococcus granulosus hypothetical protein 0.0072 0.0452 0.0452
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0473 0.3723 0.3723
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0745 0.1213
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0216 0.0216
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0044 0.0216 0.0216
Schistosoma mansoni rab6-interacting 0.0024 0.0055 0.0055
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0044 0.0216 0.0579
Brugia malayi MH2 domain containing protein 0.0244 0.1848 0.1916
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0167 0.0398
Onchocerca volvulus 0.0043 0.0216 0.0427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0364 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0101
Loa Loa (eye worm) hypothetical protein 0.0107 0.0736 0.0763
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0224
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0168 0.1235 0.2905
Loa Loa (eye worm) cytochrome P450 0.0017 0.0001 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0321 0.0333
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0168 0.1235 0.3316
Schistosoma mansoni hypothetical protein 0.0031 0.0116 0.0116
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0473 0.3723 0.6065
Brugia malayi PAS domain containing protein 0.0059 0.034 0.0353
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0473 0.3723 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.2011
Brugia malayi Bromodomain containing protein 0.0155 0.1125 0.1167
Echinococcus multilocularis 0.0072 0.0452 0.0452
Echinococcus granulosus GPCR family 2 0.0034 0.0135 0.0135
Brugia malayi Carboxyl transferase domain containing protein 0.1199 0.9645 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0087 0.009
Schistosoma mansoni lamin 0.0056 0.0321 0.0321

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.995262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.511886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.5825 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay): SAR round 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1770, AID1983, AID1997, AID2710, AID488872, AID488883, AID488887, AID504421, AID504424, AID504427, AID504428, AID504429, AID504430] ChEMBL. No reference
Potency (ADMET) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 5.1912 uM PUBCHEM_BIOASSAY: Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay): round 2 SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1770, AID1970, AID2705, AID488872] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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