Detailed information for compound 1324785

Basic information

Technical information
  • TDR Targets ID: 1324785
  • Name: N-(5-methylpyridin-2-yl)-4-[(2-oxo-1,3-dihydr obenzimidazol-5-yl)sulfonylamino]benzamide
  • MW: 423.445 | Formula: C20H17N5O4S
  • H donors: 4 H acceptors: 6 LogP: 2.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(nc1)NC(=O)c1ccc(cc1)NS(=O)(=O)c1ccc2c(c1)nc([nH]2)O
  • InChi: 1S/C20H17N5O4S/c1-12-2-9-18(21-11-12)24-19(26)13-3-5-14(6-4-13)25-30(28,29)15-7-8-16-17(10-15)23-20(27)22-16/h2-11,25H,1H3,(H,21,24,26)(H2,22,23,27)
  • InChiKey: PXDIAJMBDCLSOD-UHFFFAOYSA-N  


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Synonyms

  • N-(5-methyl-2-pyridyl)-4-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)sulfonylamino]benzamide
  • 4-[(2-keto-1,3-dihydrobenzimidazol-5-yl)sulfonylamino]-N-(5-methyl-2-pyridyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0033 0.014 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0267
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0031 0.0124 0.0276
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0189 0.1154 0.569
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0022 0.0067 0.0046
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0067 0.0229
Mycobacterium tuberculosis Possible oxidoreductase 0.0104 0.0604 0.0598
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0237 0.147 0.1452
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1542 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0105 0.0608 0.2872
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0104 0.0604 0.0604
Entamoeba histolytica hypothetical protein 0.004 0.0186 0.0805
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0032
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0104 0.0604 0.1182
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0598
Toxoplasma gondii hypothetical protein 0.0052 0.0259 0.0238
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0104 0.0604 0.293
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0598
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0147 0.0634
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.026 0.1168
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.0784 0.139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1367 0.3404
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0237 0.147 0.7276
Brugia malayi Pre-SET motif family protein 0.0221 0.1367 0.3387
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0055 0.0284 0.0825
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0255 0.0471
Loa Loa (eye worm) TK/INSR protein kinase 0.0417 0.2646 0.6624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0161 0.0153
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0153 0.0924 0.2274
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0114 0.0669 0.2808
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.0911 0.447
Schistosoma mansoni hypothetical protein 0.037 0.2337 0.4668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0079 0.044 0.2047
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0124 0.0103
Loa Loa (eye worm) hypothetical protein 0.016 0.0968 0.2401
Plasmodium vivax glutathione reductase, putative 0.01 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0404
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0227 0.1406 0.1399
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0165 0.0268
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.026 0.1199
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0376 0.065
Loa Loa (eye worm) intermediate filament protein 0.003 0.012 0.0267
Loa Loa (eye worm) hypothetical protein 0.0104 0.0604 0.1486
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0104 0.0604 0.0585
Onchocerca volvulus 0.016 0.0968 0.6129
Schistosoma mansoni tyrosine kinase 0.019 0.1161 0.2298
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0189 0.1154 0.554
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0186 0.0305
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0124 0.0103
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0121 0.0269
Loa Loa (eye worm) hypothetical protein 0.0052 0.026 0.0619
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0124 0.0207
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0205 0.0481
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0623 0.3994 0.8008
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0203 0.0336
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0147 0.0147
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0104 0.0604 0.1468
Plasmodium falciparum enoyl-acyl carrier reductase 0.1542 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0227 0.1406 0.1399
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0532 0.1285
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0104 0.0604 0.293
Treponema pallidum cell division protein FtsZ 0.0318 0.1998 0.9659
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0031 0.0124 0.0258
Brugia malayi PHD-finger family protein 0.0016 0.0026 0.0013
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0417 0.2646 0.5294
Loa Loa (eye worm) hypothetical protein 0.0093 0.0532 0.1303
Chlamydia trachomatis oxoacy-ACP reductase 0.0104 0.0604 0.0516
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0093 0.0072
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0147 0.0126
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0227 0.1406 0.1388
Loa Loa (eye worm) oxidoreductase 0.0104 0.0604 0.1486
Trypanosoma brucei oxidoreductase-like protein 0.0104 0.0604 0.293
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0121 0.0209
Echinococcus granulosus microtubule associated protein 2 0.0775 0.4983 1
Brugia malayi Protein kinase domain containing protein 0.0417 0.2646 0.6608
Brugia malayi Cell division protein ftsZ 0.0157 0.0947 0.233
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0073 0.0398 0.0967
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1542 1 1
Entamoeba histolytica hypothetical protein 0.004 0.0186 0.0805
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0079 0.044 0.2047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0133 0.0225
Echinococcus granulosus dnaJ subfamily B 0.0433 0.2753 0.5509
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0434 0.0755
Brugia malayi jmjC domain containing protein 0.0043 0.0205 0.0462
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0163 0.0985 0.0966
Schistosoma mansoni zinc finger protein 0.0044 0.0212 0.0385
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.012 0.0267
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.026 0.0239
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0022 0.0067 0.0229
Echinococcus granulosus lamin dm0 0.003 0.012 0.0206
Trichomonas vaginalis rotamase, putative 0.0073 0.0398 0.0378
Brugia malayi AMP-binding enzyme family protein 0.0052 0.026 0.0601
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0572 0.0565
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.044 0.1054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0174 0.0154
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.026 0.0253
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0026 0.0017
Brugia malayi hypothetical protein 0.016 0.0968 0.2383
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0153 0.0924 0.1827
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0093 0.0363
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0124 0.0103
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0104 0.0604 0.0585
Echinococcus granulosus geminin 0.037 0.2337 0.4672
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.026 0.1168
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0093 0.0093
Plasmodium falciparum glutathione reductase 0.0035 0.0147 0.0147
Brugia malayi intermediate filament protein 0.003 0.012 0.0248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0133 0.0225
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0104 0.0604 0.0585
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.2753 0.4958
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0021 0.0007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0147 0.0634
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0237 0.147 0.7086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.026 0.0253
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.023 0.1424 0.6862
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0147 0.014
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.0969 0.095
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0072 0.0394 0.1872
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0031 0.0124 0.0124
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0031 0.0124 0.0501
Schistosoma mansoni cpg binding protein 0.003 0.0121 0.0201
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0255 0.043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0604 0.0598
Brugia malayi STAT protein, DNA binding domain containing protein 0.0159 0.096 0.2362
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0104 0.0604 0.0598
Onchocerca volvulus 0.003 0.012 0.0638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0021 0.0021
Echinococcus multilocularis zinc finger protein 0.0044 0.0212 0.0353
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0376 0.0722
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0532 0.1029
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0598
Schistosoma mansoni lamin 0.003 0.012 0.0199
Toxoplasma gondii peptidylprolyl isomerase 0.0071 0.0387 0.0366
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0104 0.0604 0.1468
Echinococcus multilocularis insulin receptor 0.0417 0.2646 0.4765
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0147 0.0634
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0088 0.0167
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0093 0.0072
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0147 0.0126
Onchocerca volvulus 0.0252 0.1566 1
Plasmodium falciparum thioredoxin reductase 0.01 0.0572 0.0572
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0124 0.0514
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0104 0.0604 0.2853
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0859 0.5534 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0227 0.1406 0.1399
Schistosoma mansoni tyrosine kinase 0.019 0.1161 0.2298
Echinococcus granulosus expressed protein 0.0073 0.0398 0.0767
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0404
Trypanosoma brucei ISWI complex protein 0.0033 0.014 0.0597
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0104 0.0604 0.0604
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0026 0.0015
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0318 0.1998 0.1944
Plasmodium falciparum glutathione reductase 0.01 0.0572 0.0572
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0147 0.0236
Loa Loa (eye worm) hypothetical protein 0.0154 0.093 0.2306
Leishmania major mitochondrial DNA polymerase beta 0.032 0.2012 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0071 0.0387 0.1837
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0161 0.0153
Echinococcus multilocularis musashi 0.003 0.012 0.0185
Loa Loa (eye worm) glutathione reductase 0.01 0.0572 0.1406
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0166 0.027
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0104 0.0604 0.293
Schistosoma mansoni cpg binding protein 0.0036 0.0159 0.0278
Schistosoma mansoni tyrosine kinase 0.0417 0.2646 0.5291
Echinococcus multilocularis 0.0054 0.0278 0.0472
Loa Loa (eye worm) retinol dehydrogenase 12 0.0104 0.0604 0.1486
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0572 0.2769
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0147 0.0147
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0021 0.0014
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0124 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.026 0.1199
Brugia malayi Pre-SET motif family protein 0.0032 0.0133 0.0281
Echinococcus granulosus epidermal growth factor receptor 0.019 0.1161 0.2304
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0088 0.0167
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0147 0.0634
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0079 0.044 0.2102
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0147 0.0634
Brugia malayi CXXC zinc finger family protein 0.003 0.0121 0.0251
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0104 0.0604 0.293
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0623 0.3994 0.7208
Loa Loa (eye worm) hypothetical protein 0.0188 0.1148 0.2854
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0404
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0576 0.1125
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0104 0.0604 0.0585
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.2012 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.026 0.0239
Leishmania major pteridine reductase 1 0.0104 0.0604 0.293
Brugia malayi PHD-finger family protein 0.0056 0.0288 0.0673
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0093 0.0086
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0021 0.0019
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0067 0.0229
Mycobacterium tuberculosis Probable oxidoreductase 0.0252 0.1571 0.1565
Trichomonas vaginalis hypothetical protein 0.1542 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0124 0.0206
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0083 0.0157
Schistosoma mansoni hypothetical protein 0.0433 0.2753 0.5506
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0147 0.0634
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0104 0.0604 0.0585
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0124 0.0514
Schistosoma mansoni tyrosine kinase 0.0186 0.1139 0.2253
Brugia malayi Furin-like cysteine rich region family protein 0.019 0.1161 0.287
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0009
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0174 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.0072 0.0394 0.0956
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0031 0.0124 0.0103
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.0067 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0398 0.0378
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0104 0.0604 0.0585
Giardia lamblia Fructose-bisphosphate aldolase 0.0328 0.2065 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0147 0.0634
Brugia malayi AMP-binding enzyme family protein 0.0052 0.026 0.0601
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0028 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0189 0.1154 0.2868
Loa Loa (eye worm) hypothetical protein 0.0095 0.0541 0.1327
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0124 0.0514
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0328 0.2065 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0104 0.0604 0.1486
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0093 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.026 0.1199
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0071 0.0387 0.1789
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0237 0.147 0.2633
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0186 0.0332
Onchocerca volvulus 0.0104 0.0604 0.3777
Echinococcus granulosus intermediate filament protein 0.003 0.012 0.0206
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0021 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0093 0.0363
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0104 0.0604 0.0598
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0019
Mycobacterium tuberculosis Probable reductase 0.0227 0.1406 0.1399
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0014
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0071 0.0387 0.1837
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0031 0.0124 0.0214
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0147 0.0254
Entamoeba histolytica hypothetical protein 0.004 0.0186 0.0805
Schistosoma mansoni hypothetical protein 0.037 0.2337 0.4668
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0911 0.447
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0147 0.0122
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.026 0.0239
Onchocerca volvulus 0.0032 0.0133 0.0723
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0186 0.0339
Mycobacterium leprae cell division protein FtsZ 0.0318 0.1998 0.1981
Schistosoma mansoni intermediate filament proteins 0.003 0.012 0.0199
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0031 0.0124 0.0501
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0124 0.0103
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1542 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0576 0.1013
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0147 0.0147
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.019 0.1161 0.2304
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0216 0.0509
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0079 0.044 0.0844
Loa Loa (eye worm) TK/EGFR protein kinase 0.019 0.1161 0.2887
Trichomonas vaginalis rotamase, putative 0.0071 0.0387 0.0366
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0021 0.0014
Loa Loa (eye worm) hypothetical protein 0.0069 0.0376 0.0911
Entamoeba histolytica hypothetical protein 0.0189 0.1154 0.554
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0237 0.147 0.292
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0147 0.0147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0252 0.1571 0.1565
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0147 0.0126
Plasmodium falciparum phd finger protein, putative 0.0031 0.0124 0.0124
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1023 0.1016
Brugia malayi AMP-binding enzyme family protein 0.0052 0.026 0.0601
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0434 0.0839
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0237 0.147 0.3646
Schistosoma mansoni hypothetical protein 0.0033 0.014 0.024
Treponema pallidum fructose-bisphosphate aldolase 0.0328 0.2065 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.026 0.1168
Loa Loa (eye worm) hypothetical protein 0.0052 0.026 0.0619
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0104 0.0604 0.293
Schistosoma mansoni protein kinase 0.0623 0.3994 0.8007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0376 0.0715
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0252 0.1571 0.1553
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0124 0.0277
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0028 0.0017
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.0784 0.1544
Trypanosoma brucei pteridine reductase 1 0.0104 0.0604 0.293
Schistosoma mansoni microtubule-associated protein tau 0.0775 0.4983 1
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0104 0.0604 0.1064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1542 1 1
Loa Loa (eye worm) hypothetical protein 0.0622 0.3988 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0583 0.1139
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0021 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0165 0.029
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0255 0.0478
Leishmania major trypanothione reductase 0.01 0.0572 0.2769
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0207
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0147 0.0054
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0604 0.0585
Echinococcus multilocularis peregrin 0.0036 0.0157 0.0254
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0604 0.0585
Echinococcus multilocularis geminin 0.037 0.2337 0.4205
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0165 0.029
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0071 0.0387 0.1837
Leishmania major oxidoreductase-like protein 0.0104 0.0604 0.293
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.012 0.0248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0376 0.0715
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0351 0.0665
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0161 0.0153
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0216 0.0978
Schistosoma mansoni zinc finger protein 0.0033 0.014 0.024
Schistosoma mansoni cpg binding protein 0.0036 0.0159 0.0278
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0073 0.0398 0.0949
Schistosoma mansoni tyrosine kinase 0.019 0.1161 0.2298
Mycobacterium tuberculosis Cell division protein FtsZ 0.0318 0.1998 0.1992
Toxoplasma gondii thioredoxin reductase 0.01 0.0572 0.0552
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0124 0.0124
Echinococcus granulosus insulin receptor 0.0417 0.2646 0.5294
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Entamoeba histolytica hypothetical protein 0.004 0.0186 0.0805
Brugia malayi Bromodomain containing protein 0.0165 0.1002 0.247
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0079 0.044 0.0419
Brugia malayi Bromodomain containing protein 0.0036 0.0157 0.0343
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0911 0.447
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0216 0.0978
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0161 0.0153
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0147 0.0126
Loa Loa (eye worm) oxidoreductase 0.0015 0.0021 0.0019
Brugia malayi Bromodomain containing protein 0.0084 0.0468 0.1124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Loa Loa (eye worm) hypothetical protein 0.0084 0.0469 0.1145
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.2012 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0153 0.0924 0.1644
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0174 0.0174
Onchocerca volvulus Alhambra homolog 0.0031 0.0124 0.0664
Treponema pallidum NADH oxidase 0.0035 0.0147 0.0273
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.0969 0.095
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0339 0.0817
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0205 0.0377
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0093 0.0072
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0021 0.0021
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0203 0.0373
Onchocerca volvulus 0.0093 0.0532 0.3305
Mycobacterium tuberculosis Possible oxidoreductase 0.0104 0.0604 0.0598
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0328 0.2065 1
Onchocerca volvulus 0.0104 0.0604 0.3777
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0147 0.0318
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0031 0.0124 0.0206
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0079 0.044 0.0419
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0604 0.0585
Onchocerca volvulus 0.003 0.012 0.0638
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0572 0.1406
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0237 0.147 0.2925
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0205 0.037
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0021 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0147 0.0081
Schistosoma mansoni jumonji domain containing protein 0.008 0.0447 0.0858
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0147 0.0126
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0104 0.0604 0.0541
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0104 0.0604 0.0585
Loa Loa (eye worm) STAT protein 0.0159 0.096 0.238
Mycobacterium ulcerans hypothetical protein 0.0052 0.026 0.0239
Echinococcus granulosus peregrin 0.0036 0.0157 0.0282
Echinococcus multilocularis lamin dm0 0.003 0.012 0.0185
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0404
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0174 0.0403
Echinococcus multilocularis epidermal growth factor receptor 0.019 0.1161 0.2073
Brugia malayi Protein kinase domain containing protein 0.0231 0.1429 0.3544
Echinococcus granulosus zinc finger protein 0.0044 0.0212 0.0393
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0079 0.044 0.2102
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0021 0.0019
Schistosoma mansoni tyrosine kinase 0.0186 0.1139 0.2253
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.026 0.0239
Schistosoma mansoni lamin 0.003 0.012 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Brugia malayi hypothetical protein 0.004 0.0186 0.0414
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0237 0.147 0.1452
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.026 0.0239
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0031 0.0124 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.026 0.0239
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.026 0.0239
Loa Loa (eye worm) hypothetical protein 0.0153 0.0924 0.2292
Schistosoma mansoni tyrosine kinase 0.0417 0.2646 0.5291
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0093 0.0027
Echinococcus granulosus lamin 0.003 0.012 0.0206
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0163 0.0985 0.0966
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0124 0.0193
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0604 0.0585
Brugia malayi Neuronal symmetry protein 1 0.0623 0.3994 1
Schistosoma mansoni dihydropteridine reductase 0.0104 0.0604 0.1176
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0532 0.1036
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0174 0.0167
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0071 0.0387 0.1837
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.028 0.1301
Plasmodium vivax SET domain protein, putative 0.0032 0.0133 0.0133
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0604 0.0585
Trypanosoma cruzi ISWI complex protein 0.0033 0.014 0.0597
Brugia malayi Thioredoxin reductase 0.01 0.0572 0.1388
Schistosoma mansoni hypothetical protein 0.0045 0.0216 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0083 0.0467 0.1141
Echinococcus granulosus cpg binding protein 0.0036 0.0159 0.0286
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0021 0.0014
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0147 0.0634
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0417 0.2646 0.4765
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0079 0.044 0.0419
Schistosoma mansoni protein kinase 0.0623 0.3994 0.8007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0216 0.0978
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0227 0.1406 0.1399
Echinococcus multilocularis cpg binding protein 0.0036 0.0159 0.0257
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0237 0.147 0.1452
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0147 0.0126
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.2012 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0133 0.0112
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0104 0.0604 0.0585
Brugia malayi jmjC domain containing protein 0.0101 0.0583 0.1414
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0045 0.0048
Mycobacterium ulcerans oxidoreductase 0.0104 0.0604 0.0585
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1542 1 1
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0572 0.0572
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0252 0.1571 0.1565
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0093 0.0072
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0583 0.1025
Echinococcus multilocularis epidermal growth factor receptor 0.019 0.1161 0.2073
Echinococcus multilocularis lamin 0.003 0.012 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0257
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0147 0.0634
Trypanosoma cruzi ISWI complex protein 0.0033 0.014 0.0597
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0124 0.0214
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0124 0.0514
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0093 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0014
Mycobacterium ulcerans cell division protein FtsZ 0.0318 0.1998 0.1981
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0104 0.0604 0.0598
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0031 0.0124 0.0192
Trichomonas vaginalis set domain proteins, putative 0.0252 0.1566 0.1548
Echinococcus multilocularis Zinc finger, PHD finger 0.0031 0.0124 0.0192
Schistosoma mansoni bromodomain containing protein 0.014 0.0835 0.1641
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0277
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0227 0.1406 0.1399
Onchocerca volvulus 0.0052 0.026 0.1546
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0021 0.0014
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.0969 0.0962
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0124 0.0514
Schistosoma mansoni rotamase 0.0073 0.0398 0.076
Loa Loa (eye worm) hypothetical protein 0.0052 0.026 0.0619
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0124 0.0103
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0147 0.0126
Echinococcus granulosus epidermal growth factor receptor 0.019 0.1161 0.2304
Brugia malayi Cell division protein ftsZ 0.0152 0.0918 0.2258
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0147 0.0081
Mycobacterium ulcerans hypothetical protein 0.0169 0.1023 0.1004
Brugia malayi glutathione reductase 0.01 0.0572 0.1388
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0104 0.0604 0.0585
Schistosoma mansoni tyrosine kinase 0.0186 0.1139 0.2253
Trypanosoma brucei trypanothione reductase 0.01 0.0572 0.2769
Schistosoma mansoni hypothetical protein 0.004 0.0186 0.0332
Brugia malayi PHD-finger family protein 0.0031 0.0124 0.0258
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0031 0.0124 0.0214
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0216 0.0978
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0104 0.0604 0.293
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.026 0.0239
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.026 0.0239
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0604 0.0585
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1542 1 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0165 0.0297
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0189 0.1154 0.569
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0404
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0104 0.0604 0.1176
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0604 0.0585
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0021 0.0014
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0104 0.0604 0.293
Onchocerca volvulus 0.003 0.0121 0.0644
Entamoeba histolytica hypothetical protein 0.0026 0.0093 0.0353
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0205 0.037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.034 0.0319
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0133 0.0209
Loa Loa (eye worm) hypothetical protein 0.0053 0.0268 0.0639
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Echinococcus multilocularis microtubule associated protein 2 0.0775 0.4983 0.9
Loa Loa (eye worm) hypothetical protein 0.0227 0.1407 0.3506
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0189 0.1154 0.2869
Plasmodium falciparum thioredoxin reductase 0.0035 0.0147 0.0147
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0147 0.0634
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0237 0.147 0.7276
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.2065 0.2049
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0532 0.0932
Echinococcus multilocularis expressed protein 0.0073 0.0398 0.069
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0147 0.0262
Loa Loa (eye worm) hypothetical protein 0.0089 0.0503 0.123

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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