Detailed information for compound 1324855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 505.541 | Formula: C23H27N3O8S
  • H donors: 1 H acceptors: 5 LogP: 1.59 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCS(=O)(=O)N1[C@@H](C[C@@]23C1=NC(=C([C@@H]2Nc1c3cccc1)C(=O)OC)C(=O)OC)C(=O)OC
  • InChi: 1S/C23H27N3O8S/c1-5-6-11-35(30,31)26-15(19(27)32-2)12-23-13-9-7-8-10-14(13)24-18(23)16(20(28)33-3)17(21(29)34-4)25-22(23)26/h7-10,15,18,24H,5-6,11-12H2,1-4H3/t15-,18-,23-/m0/s1
  • InChiKey: ZBWDOGDXKZMILP-WIRVKHDMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0127 0.051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0148 0.026 0.1394
Schistosoma mansoni hypothetical protein 0.0087 0.0141 0.1057
Mycobacterium tuberculosis Probable esterase LipL 0.0144 0.0253 0.0206
Loa Loa (eye worm) hypothetical protein 0.0153 0.027 0.1088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0048 0.1884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0063 0.0095 0.038
Mycobacterium leprae Probable lipase LipE 0.0144 0.0253 0.0229
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0037 0.0054
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.0288 0.1158
Onchocerca volvulus Protein ultraspiracle homolog 0.0063 0.0095 0.0387
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Mycobacterium tuberculosis Conserved protein 0.0144 0.0253 0.0206
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.003 0.0113
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0207 0.0835
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0467 0.2398
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0067 0.0267
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0072 0.0381
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0314 0.1571
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0962 0.185 0.2861
Leishmania major hypothetical protein, conserved 0.0024 0.0019 0.0689
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0054 0.3282
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0145
Schistosoma mansoni patched 1 0.009 0.0147 0.1106
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0063 0.0095 0.0387
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0169 0.6657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0063 0.0095 0.038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0138
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0067 0.035
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0089 0.0355
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0016 0.0061
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0067 0.0048
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0126 0.0107
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0057 0.0228
Loa Loa (eye worm) hypothetical protein 0.0091 0.0149 0.0598
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.003 0.0149
Loa Loa (eye worm) beta-lactamase 0.0144 0.0253 0.1019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0467 0.0882 0.3566
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0048 0.1829
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0063 0.0095 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0297 0.1477
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0048 0.1829
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0048 0.0132
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0023 0.0854
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0067 0.01
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Schistosoma mansoni lamin 0.0033 0.0035 0.0243
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0052 0.0072 0.0526
Brugia malayi tailless protein 0.003 0.003 0.0113
Echinococcus granulosus Protein patched homolog 1 0.009 0.0147 0.0787
Onchocerca volvulus 0.0153 0.027 0.1333
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.5137 1 1
Onchocerca volvulus 0.0186 0.0334 0.168
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0071 0.026
Brugia malayi glutaminase DH11.1 0.03 0.0556 0.2244
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.0288 0.0443
Brugia malayi Steroid receptor seven-up type 2 0.0063 0.0095 0.0377
Echinococcus multilocularis geminin 0.0684 0.1306 0.2019
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0072 0.0025
Loa Loa (eye worm) hypothetical protein 0.0319 0.0594 0.24
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.0169 0.0903
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0126 0.0191
Schistosoma mansoni nuclear receptor 0.003 0.003 0.0202
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Brugia malayi photoreceptor-specific nuclear receptor 0.0063 0.0095 0.0377
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0067 0.2639
Brugia malayi nuclear receptor NHR-88 0.0063 0.0095 0.0377
Brugia malayi beta-lactamase family protein 0.0144 0.0253 0.1016
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0005 0.0015
Schistosoma mansoni hypothetical protein 0.0319 0.0594 0.4534
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0087 0.0348
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0063 0.0095 0.0502
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Echinococcus multilocularis thyroid hormone receptor alpha 0.0063 0.0095 0.0144
Brugia malayi conserved hypotetical protein 0.003 0.003 0.0113
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0269 0.1447
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.003 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0297 0.1477
Brugia malayi ecdysteroid receptor 0.0063 0.0095 0.0377
Echinococcus granulosus lamin dm0 0.0033 0.0035 0.0178
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0089 0.0356
Echinococcus multilocularis ecdysone induced protein 78C 0.0063 0.0095 0.0144
Mycobacterium tuberculosis Conserved protein 0.0144 0.0253 0.0206
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.0253 0.124
Trypanosoma brucei polo-like protein kinase 0.0101 0.0169 0.6657
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.003 0.0149
Loa Loa (eye worm) hypothetical protein 0.021 0.0382 0.154
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0019 0.0751
Brugia malayi CHE-14 protein 0.009 0.0147 0.0589
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0037 0.0145
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0121 0.0644
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0069 0.0248
Echinococcus multilocularis lamin dm0 0.0033 0.0035 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0095 0.0377
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0147 0.0787
Brugia malayi Pre-SET motif family protein 0.0857 0.1644 0.6645
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0019 0.0689
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.1304 0.2016
Onchocerca volvulus 0.0144 0.0253 0.124
Echinococcus multilocularis lamin 0.0033 0.0035 0.0051
Plasmodium vivax SET domain protein, putative 0.0124 0.0213 0.8439
Schistosoma mansoni hypothetical protein 0.0684 0.1306 1
Echinococcus multilocularis Niemann Pick C1 protein 0.03 0.0558 0.086
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0067 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0297 0.1477
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0121 0.0184
Trichomonas vaginalis penicillin-binding protein, putative 0.0144 0.0253 0.124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0048 0.1829
Schistosoma mansoni hypothetical protein 0.0148 0.026 0.1967
Brugia malayi Nuclear hormone receptor E75 0.003 0.003 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0095 0.0703
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0126 0.0939
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.016 0.0284 0.0437
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0061 0.0321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0113 0.0603
Onchocerca volvulus 0.0063 0.0095 0.0387
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0095 0.0377
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0009 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0111 0.4334
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0111 0.4334
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.003 0.0043
Brugia malayi DnaJ domain containing protein 0.006 0.0089 0.0353
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0002 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0297 0.1477
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0067 0.259
Brugia malayi hypothetical protein 0.0024 0.0019 0.007
Brugia malayi hypothetical protein 0.003 0.003 0.0113
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.021 0.0382 1
Schistosoma mansoni retinoic acid receptor RXR 0.0063 0.0095 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0063 0.0095 0.038
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0127 0.0949
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0048 0.0189
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.003 0.0149
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.003 0.0116
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0063 0.0095 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0261 0.1976
Loa Loa (eye worm) hypothetical protein 0.0098 0.0163 0.0657
Loa Loa (eye worm) hypothetical protein 0.016 0.0284 0.1147
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0144 0.0253 0.0206
Echinococcus multilocularis expressed conserved protein 0.0197 0.0357 0.0549
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0071 0.2822
Schistosoma mansoni glutaminase 0.03 0.0556 0.4243
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0111 0.2438
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0148 0.026 0.0399
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0284 0.2158
Trichomonas vaginalis sucrase-isomaltase, putative 0.0071 0.0111 0.0472
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0095 0.0502
Brugia malayi hypothetical protein 0.0153 0.027 0.1085
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0126 0.4967
Loa Loa (eye worm) hypothetical protein 0.0082 0.0131 0.0527
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0048 0.2687
Schistosoma mansoni ap endonuclease 0.0039 0.0048 0.0341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.0095 0.0703
Schistosoma mansoni hypothetical protein 0.0044 0.0057 0.0415
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0144 0.0253 0.0206
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0063 0.0095 0.0703
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0052 0.0072 0.0108
Leishmania major alpha glucosidase II subunit, putative 0.0071 0.0111 0.4334
Trypanosoma brucei ISWI complex protein 0.0033 0.0035 0.1328
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Echinococcus multilocularis muscleblind protein 1 0.0446 0.0842 0.13
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0095 0.0377
Schistosoma mansoni zinc finger protein 0.0033 0.0035 0.0244
Echinococcus multilocularis protein patched 0.009 0.0147 0.0225
Mycobacterium tuberculosis Probable lipase LipD 0.0144 0.0253 0.0206
Echinococcus granulosus Niemann Pick C1 protein 0.03 0.0558 0.3007
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0111 0.2438
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0127 0.0507
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0144 0.0253 0.1019
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0002 0.0004
Brugia malayi steroid hormone receptor 0.0063 0.0095 0.0377
Echinococcus granulosus histone lysine methyltransferase setb 0.016 0.0284 0.1528
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0297 0.1477
Brugia malayi ecdysone receptor 0.003 0.003 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0019 0.0689
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0169 0.0787
Schistosoma mansoni hypothetical protein 0.0087 0.0141 0.1057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0067 0.259
Trypanosoma cruzi ISWI complex protein 0.0033 0.0035 0.1328
Trichomonas vaginalis set domain proteins, putative 0.0975 0.1875 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0111 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0063 0.0095 0.038
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0135 0.0234 0.0359
Mycobacterium tuberculosis Probable lipase LipE 0.0144 0.0253 0.0206
Schistosoma mansoni alpha-glucosidase 0.0277 0.0511 0.3899
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0147 0.0225
Loa Loa (eye worm) hypothetical protein 0.0144 0.0253 0.1019
Echinococcus multilocularis GPCR, family 2 0.0148 0.026 0.0399
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0145
Schistosoma mansoni hypothetical protein 0.0684 0.1306 1
Loa Loa (eye worm) DR-78 0.003 0.003 0.0116
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0071 0.026
Echinococcus multilocularis cpg binding protein 0.0067 0.0101 0.0154
Leishmania major hypothetical protein, conserved 0.0033 0.0035 0.1328
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0054 0.0523
Loa Loa (eye worm) hypothetical protein 0.0151 0.0266 0.1073
Schistosoma mansoni hypothetical protein 0.0087 0.0141 0.1057
Echinococcus multilocularis FTZ F1 alpha 0.0063 0.0095 0.0144
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.0133
Trypanosoma cruzi ISWI complex protein 0.0033 0.0035 0.1328
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.0827 0.1277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0261 0.14
Loa Loa (eye worm) hypothetical protein 0.0144 0.0253 0.1019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0095 0.0502
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0126 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0113 0.0172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0063 0.0095 0.0144
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0144 0.0253 0.0251
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0169 0.0787
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0095 0.0377
Entamoeba histolytica hypothetical protein 0.0073 0.0113 0.2517
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0063 0.0095 0.0502
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0061 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.0253 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0147 0.0593
Toxoplasma gondii pantoate-beta-alanine ligase 0.5137 1 1
Schistosoma mansoni coup transcription factor 0.0063 0.0095 0.0703
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0009 0.0037
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0126 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0111 0.0472
Brugia malayi Muscleblind-like protein 0.0446 0.0842 0.3398
Schistosoma mansoni zinc finger protein 0.0049 0.0067 0.0489
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.003 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.003 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0169 0.0787
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0071 0.0111 0.0444
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0127 0.4986
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0207 0.0835
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0145
Echinococcus multilocularis lysosomal alpha glucosidase 0.0321 0.0599 0.0924
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0019 0.0689
Mycobacterium tuberculosis Probable hydrolase 0.0144 0.0253 0.0206
Brugia malayi nuclear receptor RXR 0.0033 0.0037 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0261 0.0401
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0297 0.1477
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0067 0.4478
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0072 0.0048
Mycobacterium leprae conserved hypothetical protein 0.0144 0.0253 0.0229
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0048 0.0186
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0127 0.2895
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0016 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0284 0.2158
Trichomonas vaginalis maltase-glucoamylase, putative 0.0071 0.0111 0.0472
Brugia malayi Niemann-Pick C1 protein precursor 0.021 0.0382 0.1537
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.0288 0.2184
Onchocerca volvulus 0.0144 0.0253 0.124
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0067 0.259
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0024 0.0967
Echinococcus multilocularis protein dispatched 1 0.0103 0.0172 0.0264
Onchocerca volvulus Bile acid receptor homolog 0.0063 0.0095 0.0387
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.5137 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0213 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0063 0.0095 0.0377
Schistosoma mansoni nuclear hormone receptor 0.003 0.003 0.0202
Schistosoma mansoni zinc finger protein 0.003 0.003 0.0202
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0213 0.0327
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.003 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0261 0.14
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0067 0.01
Brugia malayi hypothetical protein 0.0033 0.0037 0.0141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0921 0.177 0.173
Brugia malayi Bromodomain containing protein 0.0167 0.0298 0.1199
Echinococcus multilocularis beta LACTamase domain containing family member 0.0144 0.0253 0.0388
Brugia malayi hypothetical protein 0.003 0.003 0.0113
Schistosoma mansoni nuclear receptor 0.003 0.003 0.0202
Loa Loa (eye worm) hypothetical protein 0.0446 0.0842 0.3401
Plasmodium vivax hypothetical protein, conserved 0.0144 0.0253 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.0467 0.1883
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0169 0.1271
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1282 0.2473 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0297 0.1477
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.0169 0.0258
Echinococcus granulosus geminin 0.0684 0.1306 0.7058
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0042 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.0261 0.1052
Schistosoma mansoni bromodomain containing protein 0.0142 0.0249 0.1887
Onchocerca volvulus 0.0033 0.0035 0.0063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0148 0.026 0.1047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0063 0.0095 0.0703
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.0253 0.124
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0069 0.0248
Onchocerca volvulus 0.0059 0.0087 0.0344
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0048 0.1829
Entamoeba histolytica hypothetical protein 0.0073 0.0113 0.2517
Toxoplasma gondii exonuclease III APE 0.0039 0.0048 0.0029
Schistosoma mansoni ap endonuclease 0.0039 0.0048 0.0341
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.0467 0.1886
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.003 0.0113
Brugia malayi Nuclear hormone receptor E75 0.003 0.003 0.0113
Toxoplasma gondii hypothetical protein 0.0027 0.0024 0.0005
Loa Loa (eye worm) hypothetical protein 0.0079 0.0126 0.0505
Schistosoma mansoni hypothetical protein 0.0073 0.0113 0.0845
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0072 0.0109
Mycobacterium ulcerans glutaminase 0.03 0.0556 0.0555
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0127 0.0193
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0297 0.1477
Loa Loa (eye worm) hypothetical protein 0.0148 0.026 0.1047
Loa Loa (eye worm) glutaminase 0.03 0.0556 0.2247
Echinococcus granulosus neutral alpha glucosidase AB 0.0071 0.0111 0.0587
Schistosoma mansoni alpha glucosidase 0.0071 0.0111 0.0823
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0035 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0063 0.0095 0.0377
Brugia malayi nuclear receptor RXR 0.003 0.003 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0063 0.0095 0.0703
Trichomonas vaginalis esterase, putative 0.0144 0.0253 0.124
Leishmania major hypothetical protein, conserved 0.0144 0.0253 1
Echinococcus granulosus FTZ F1 alpha 0.0063 0.0095 0.0502
Onchocerca volvulus 0.0975 0.1875 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0024 0.0511
Schistosoma mansoni hypothetical protein 0.0148 0.026 0.1967
Brugia malayi beta-lactamase 0.0144 0.0253 0.1016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0048 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0095 0.0703
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0169 0.0787
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.003 0.0043
Echinococcus granulosus muscleblind protein 0.0446 0.0842 0.4543
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0126 0.0669
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0067 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0063 0.0095 0.0377
Schistosoma mansoni hypothetical protein 0.0087 0.0141 0.1057
Brugia malayi nuclear hormone receptor 0.0063 0.0095 0.0377
Echinococcus multilocularis neutral alpha glucosidase AB 0.0071 0.0111 0.0168
Brugia malayi Glycosyl hydrolases family 31 protein 0.0071 0.0111 0.044
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.0253 0.124
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0048 0.2293
Echinococcus granulosus beta LACTamase domain containing family member 0.0144 0.0253 0.1357
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0857 0.1644 0.6646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0261 0.1976
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0063 0.0095 0.038
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.003 0.0202
Echinococcus granulosus intermediate filament protein 0.0033 0.0035 0.0178
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0063 0.0095 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0063 0.0095 0.0703
Echinococcus granulosus lamin 0.0033 0.0035 0.0178
Brugia malayi latrophilin 2 splice variant baaae 0.0319 0.0594 0.2397
Echinococcus granulosus fetal alzheimer antigen falz 0.0052 0.0072 0.0378
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0035 0.0138
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0213 0.0388 0.2952
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0127 0.4986
Loa Loa (eye worm) hypothetical protein 0.009 0.0147 0.0593
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.003 0.0043
Mycobacterium ulcerans hypothetical protein 0.0144 0.0253 0.0251
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0009 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0169 0.0787
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0054 0.086
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0126 1
Brugia malayi beta-lactamase family protein 0.0144 0.0253 0.1016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0063 0.0095 0.0502
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0023 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0111 0.0472
Schistosoma mansoni hypothetical protein 0.0148 0.026 0.1967
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0048 0.0247
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0126 0.0124
Schistosoma mansoni alpha-glucosidase 0.0277 0.0511 0.3899
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0126 1
Trypanosoma brucei hypothetical protein, conserved 0.0144 0.0253 1
Loa Loa (eye worm) steroid hormone receptor 0.0063 0.0095 0.038
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0126 0.0101
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.0261 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0095 0.0377
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0095 0.0377
Brugia malayi Probable ClpP-like protease 0.0079 0.0126 0.0501
Echinococcus granulosus zinc finger protein 0.0049 0.0067 0.0352
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0089 0.0135
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0095 0.0703
Onchocerca volvulus 0.0033 0.0035 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0144 0.0253 0.124
Onchocerca volvulus 0.0144 0.0253 0.124
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0127 0.4986
Brugia malayi isocitrate dehydrogenase 0.0049 0.0067 0.0263
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0009 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0063 0.0095 0.038
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.003 0.0116
Loa Loa (eye worm) glutaminase 2 0.03 0.0556 0.2247
Mycobacterium ulcerans esterase/lipase LipP 0.0144 0.0253 0.0251
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.0169 0.6657
Loa Loa (eye worm) hypothetical protein 0.1282 0.2473 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.0253 0.1019
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Echinococcus granulosus Niemann Pick C1 protein 0.021 0.0382 0.2054
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0111 0.0472
Schistosoma mansoni cpg binding protein 0.0067 0.0101 0.0754
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0095 0.0144
Schistosoma mansoni cpg binding protein 0.0059 0.0087 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0467 0.2398
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0016 0.0022
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0089 0.047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0261 0.0401
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0042 0.03
Loa Loa (eye worm) hypothetical protein 0.0446 0.0842 0.3401
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.0169 0.068
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0467 0.2398
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0005 0.0018
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0023 0.0854
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0127 0.0676
Schistosoma mansoni hypothetical protein 0.006 0.0089 0.0657
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0144 0.0253 0.1016
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0071 0.0111 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0213 0.1612
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0037 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0095 0.0377
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0321 0.0599 0.2419
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.0169 0.0676
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.0169 0.0787
Brugia malayi nuclear receptor NHR-88 0.003 0.003 0.0113
Mycobacterium ulcerans lipase LipD 0.0144 0.0253 0.0251
Brugia malayi MH2 domain containing protein 0.0121 0.0207 0.0832
Onchocerca volvulus 0.0124 0.0213 0.1027
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0035 0.0138
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0145
Trypanosoma brucei glucosidase, putative 0.0071 0.0111 0.4334
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0067 0.259
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0135 0.0234 0.1256
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.003 0.0149
Brugia malayi Glycosyl hydrolases family 31 protein 0.0321 0.0599 0.2416
Schistosoma mansoni kinase 0.0051 0.0072 0.0525
Trichomonas vaginalis glutaminase, putative 0.03 0.0556 0.2879
Entamoeba histolytica hypothetical protein 0.0073 0.0113 0.2517
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0144 0.0253 0.1915
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Entamoeba histolytica hypothetical protein 0.0073 0.0113 0.2517
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0042 0.0219
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0148 0.026 0.1044
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.003 0.0202
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0063 0.0095 0.0502
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0048 0.0132
Onchocerca volvulus 0.003 0.003 0.0035
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0071 0.0052
Brugia malayi nuclear receptor NHR-67 0.003 0.003 0.0113
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3325 0.6462 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0467 0.2398
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0037 0.0256
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Schistosoma mansoni hypothetical protein 0.0438 0.0827 0.6319
Echinococcus multilocularis zinc finger protein 0.0049 0.0067 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Brugia malayi PHD-finger family protein 0.006 0.0089 0.0354
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0111 0.0472
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0216 0.0198
Schistosoma mansoni nuclear hormone receptor 0.003 0.003 0.0202
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.003 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0063 0.0095 0.0377
Brugia malayi CXXC zinc finger family protein 0.0059 0.0087 0.0345
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0467 0.2398
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.003 0.0202
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0067 0.01
Brugia malayi hypothetical protein 0.0073 0.0113 0.0452
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0962 0.185 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0048 0.0071
Echinococcus multilocularis Niemann Pick C1 protein 0.021 0.0382 0.0588
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0023 0.0854
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0067 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.003 0.0149
Brugia malayi Calcitonin receptor-like protein seb-1 0.0467 0.0882 0.3564
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0467 0.2398
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0063 0.0095 0.0703
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0169 0.0787
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0126 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0071 0.0375
Loa Loa (eye worm) hypothetical protein 0.0144 0.0253 0.1019
Brugia malayi nuclear hormone receptor 0.003 0.003 0.0113
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0023 0.0087
Brugia malayi Pre-SET motif family protein 0.0124 0.0213 0.0856
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0067 0.0263
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0169 0.6657
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.1304 0.9983
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0037 0.0141
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0052 0.0209
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0067 0.0487
Echinococcus multilocularis musashi 0.0033 0.0035 0.0051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.001
Toxoplasma gondii ABC1 family protein 0.0144 0.0253 0.0234
Onchocerca volvulus 0.003 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0074
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Brugia malayi Bromodomain containing protein 0.0086 0.0138 0.0553
Schistosoma mansoni intermediate filament proteins 0.0033 0.0035 0.0243
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0145
Loa Loa (eye worm) hypothetical protein 0.0144 0.0253 0.1019
Brugia malayi Latrophilin receptor protein 2 0.0148 0.026 0.1044
Echinococcus granulosus microtubule associated protein 2 0.0683 0.1304 0.7047
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0071 0.0052
Brugia malayi hypothetical protein 0.0016 0.0002 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0113 0.0845
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0169 0.0787
Schistosoma mansoni hypothetical protein 0.0033 0.0035 0.0244
Schistosoma mansoni steroid hormone receptor ad4bp 0.0063 0.0095 0.0703
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.003 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0063 0.0095 0.038
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.003 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0213 0.1612
Brugia malayi intermediate filament protein 0.0033 0.0035 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0111 0.0472
Brugia malayi hypothetical protein 0.0033 0.0037 0.0141
Echinococcus granulosus expressed conserved protein 0.0197 0.0357 0.1919
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0095 0.0144
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0023 0.0854
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0063 0.0095 0.0377
Echinococcus granulosus cpg binding protein 0.0067 0.0101 0.0538
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0063 0.0095 0.0377
Loa Loa (eye worm) acetyltransferase 0.0162 0.0288 0.1161
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0126 0.0107
Schistosoma mansoni hypothetical protein 0.0148 0.026 0.1967
Echinococcus multilocularis lysosomal alpha glucosidase 0.0321 0.0599 0.0924
Loa Loa (eye worm) hypothetical protein 0.0144 0.0253 0.1019
Echinococcus granulosus lysosomal alpha glucosidase 0.0321 0.0599 0.3229
Mycobacterium tuberculosis Conserved protein 0.0144 0.0253 0.0206
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0144 0.0253 0.1915
Echinococcus granulosus dnaJ subfamily B 0.0438 0.0827 0.4463
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0063 0.0095 0.0377
Schistosoma mansoni cpg binding protein 0.0067 0.0101 0.0754
Loa Loa (eye worm) hypothetical protein 0.011 0.0187 0.0753
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0225 0.1704
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0169 0.4065
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0144 0.0253 0.0206
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0072 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0314 0.1571
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0202 0.1082
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0037 0.0141
Schistosoma mansoni lamin 0.0033 0.0035 0.0243
Echinococcus multilocularis muscleblind protein 0.0446 0.0842 0.13
Giardia lamblia Kinase, PLK 0.0101 0.0169 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0067 0.01
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0048 0.0683
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0126 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0147 0.0671
Mycobacterium ulcerans beta-lactamase 0.0144 0.0253 0.0251
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0127 0.4986
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0063 0.0095 0.0502
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0067 0.259
Echinococcus granulosus ecdysone induced protein 78C 0.0063 0.0095 0.0502
Loa Loa (eye worm) hypothetical protein 0.0063 0.0095 0.038
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0042 0.03
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0037 0.0256
Schistosoma mansoni RAR-like nuclear receptor 0.0063 0.0095 0.0703
Echinococcus granulosus GPCR family 2 0.0148 0.026 0.1394
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0261 0.1976
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0111 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.0253 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0316 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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