Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0138 | 0.142 | 0.142 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0378 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0378 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0962 | 0.0962 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0378 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0023 | 0.0023 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0378 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0378 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.814 | 0.814 |
Loa Loa (eye worm) | FKBP5 protein | 0.0378 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0378 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0378 | 1 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0378 | 1 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0125 | 0.0962 | 0.0962 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0125 | 0.0962 | 0.0962 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0378 | 1 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0378 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0125 | 0.0962 | 0.0962 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0378 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0326 | 0.814 | 0.814 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0378 | 1 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0378 | 1 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0378 | 1 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0378 | 1 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0125 | 0.0962 | 0.0962 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0378 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.0125 | 0.0962 | 0.0962 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0378 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0378 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0326 | 0.814 | 0.814 |
Onchocerca volvulus | 0.0138 | 0.142 | 1 | |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0138 | 0.142 | 0.142 |
Trichomonas vaginalis | immunophilin, putative | 0.0378 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.0962 | 0.0962 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0378 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0125 | 0.0962 | 0.0962 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0378 | 1 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0378 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0138 | 0.142 | 0.142 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0962 | 0.0962 |
Brugia malayi | Cell death protein 3 precursor | 0.0125 | 0.0962 | 0.0962 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0378 | 1 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0378 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0378 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0378 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0378 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0326 | 0.814 | 0.814 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0378 | 1 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0378 | 1 | 1 |
Loa Loa (eye worm) | lipase | 0.0138 | 0.142 | 0.142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K | = 1.1 | Compound was evaluated for the partition coefficient in octanol/water | ChEMBL. | 3023612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.