Detailed information for compound 1324892

Basic information

Technical information
  • TDR Targets ID: 1324892
  • Name: 2-(phenoxy)-N-pyridin-3-ylpropanamide
  • MW: 242.273 | Formula: C14H14N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.13 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(=O)Nc1cccnc1)Oc1ccccc1
  • InChi: 1S/C14H14N2O2/c1-11(18-13-7-3-2-4-8-13)14(17)16-12-6-5-9-15-10-12/h2-11H,1H3,(H,16,17)
  • InChiKey: QRNOGFVQLVSQRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(phenoxy)-N-(3-pyridyl)propanamide
  • 2-(phenoxy)-N-(3-pyridyl)propionamide
  • 2-(phenoxy)-N-pyridin-3-yl-propanamide
  • 2-Phenoxy-N-pyridin-3-yl-propionamide
  • BAS 03451274
  • AN-652/40797542
  • STK002138
  • Oprea1_412455
  • 2-phenoxy-N-3-pyridinylpropanamide
  • MLS000062146
  • SMR000070929

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Dopamine receptor 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0187 0.0324
Loa Loa (eye worm) melatonin receptor type 1A 0.0096 0.578 0.578
Schistosoma mansoni hypothetical protein 0.0096 0.578 1
Echinococcus multilocularis orexin receptor type 2 0.0096 0.578 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0096 0.578 0.578
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0096 0.578 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.578 1
Echinococcus multilocularis fmrfamide receptor 0.0096 0.578 1
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.578 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.578 1
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1741 0.1741
Brugia malayi Dopamine receptor protein 1 0.0096 0.578 0.5595
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0096 0.578 1
Echinococcus granulosus somatostatin receptor 0.0096 0.578 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1502 0.235
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni neuropeptide receptor 0.0096 0.578 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Schistosoma mansoni neuropeptide receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.578 1
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus 7TM GPCR rhodopsin 0.0096 0.578 1
Schistosoma mansoni biogenic amine receptor 0.0096 0.578 1
Brugia malayi sulfakinin receptor protein 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0096 0.578 1
Schistosoma mansoni hypothetical protein 0.0096 0.578 1
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0096 0.578 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0096 0.578 1
Echinococcus granulosus neuropeptide receptor 0.0096 0.578 1
Onchocerca volvulus Huntingtin homolog 0.0148 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus multilocularis serotonin receptor 0.0096 0.578 1
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.578 1
Schistosoma mansoni neuropeptide receptor 0.0096 0.578 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.3835 0.6521
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.578 0.578
Echinococcus multilocularis g protein coupled receptor 0.0096 0.578 1
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.578 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.578 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0096 0.578 0.5595
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.578 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0096 0.578 1
Brugia malayi G protein-coupled receptor 0.0096 0.578 0.5595
Brugia malayi putative neuropeptide receptor NPR1 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0049 0.1973 0.1973
Echinococcus multilocularis serotonin receptor 0.0096 0.578 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.578 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.578 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0096 0.578 1
Echinococcus granulosus serotonin receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni opsin-like receptor 0.0096 0.578 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.578 1
Brugia malayi AKH receptor 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni opsin-like receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Brugia malayi G-protein coupled receptor 0.0096 0.578 0.5595
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0096 0.578 1
Echinococcus multilocularis g-protein coupled receptor 0.0096 0.578 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0096 0.578 1
Brugia malayi ORL1-like opioid receptor 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.578 1
Brugia malayi Melatonin receptor type 1A 0.0096 0.578 0.5595
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.578 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.578 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.578 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.578 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0096 0.578 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.578 1
Echinococcus granulosus G protein coupled receptor 139 0.0096 0.578 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0096 0.578 0.5595
Schistosoma mansoni hypothetical protein 0.0096 0.578 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.578 1
Echinococcus granulosus orexin receptor type 2 0.0096 0.578 1
Schistosoma mansoni neuropeptide receptor 0.0096 0.578 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.3835 0.6521
Echinococcus granulosus neuropeptide receptor A26 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni amine GPCR 0.0096 0.578 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.578 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1502 0.235
Echinococcus granulosus fmrfamide receptor 0.0096 0.578 1
Brugia malayi Bromodomain containing protein 0.0091 0.5336 0.5132
Loa Loa (eye worm) hypothetical protein 0.0052 0.2161 0.2161
Echinococcus multilocularis dro:myosuppressin receptor 0.0096 0.578 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Schistosoma mansoni amine GPCR 0.0096 0.578 1
Echinococcus multilocularis fmrfamide receptor 0.0096 0.578 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0096 0.578 1
Echinococcus granulosus allatostatin A receptor 0.0096 0.578 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.578 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0096 0.578 1
Schistosoma mansoni amine GPCR 0.0096 0.578 1
Loa Loa (eye worm) TYRA-2 protein 0.0096 0.578 0.578
Echinococcus granulosus sex peptide receptor 0.0096 0.578 1
Echinococcus granulosus hypothetical protein 0.0096 0.578 1
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Brugia malayi RE15519p 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.578 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0096 0.578 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.578 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus peptide allatostatin:somatostatin 0.0096 0.578 1
Brugia malayi Serotonin receptor 0.0096 0.578 0.5595
Brugia malayi Serotonin receptor 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0085 0.4916 0.4916
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Schistosoma mansoni alpha-1 adrenergic receptor 0.0096 0.578 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0096 0.578 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0096 0.578 0.5595
Echinococcus granulosus g-protein coupled receptor 0.0096 0.578 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.578 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0096 0.578 0.5595
Echinococcus granulosus alpha 1A adrenergic receptor 0.0096 0.578 1
Echinococcus multilocularis somatostatin receptor 0.0096 0.578 1
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus multilocularis sex peptide receptor 0.0096 0.578 1
Echinococcus multilocularis neuropeptide s receptor 0.0096 0.578 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Brugia malayi GnHR receptor homolog 0.0096 0.578 0.5595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.578 1
Onchocerca volvulus Huntingtin homolog 0.0148 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0096 0.578 1
Brugia malayi follicle stimulating hormone receptor 0.0096 0.578 0.5595
Schistosoma mansoni bromodomain containing protein 0.0076 0.4186 0.7242
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0096 0.578 1
Brugia malayi Dopamine receptor protein 2 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus multilocularis g protein coupled receptor 0.0096 0.578 1
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.578 0.578
Brugia malayi neuropeptide F receptor 0.0096 0.578 0.5595
Brugia malayi G-protein coupled receptor 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Brugia malayi larval opioid receptor 0.0096 0.578 0.5595
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0096 0.578 0.5595
Echinococcus granulosus g protein coupled receptor 0.0096 0.578 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.578 1
Schistosoma mansoni myosin xvIII 0.0096 0.578 1
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.578 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0096 0.578 1
Schistosoma mansoni opsin-like receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus multilocularis neuropeptide FF receptor 2 0.0096 0.578 1
Echinococcus multilocularis neuropeptide receptor A26 0.0096 0.578 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni growth hormone secretagogue receptor 0.0096 0.578 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0096 0.578 1
Echinococcus multilocularis neuropeptide receptor 0.0096 0.578 1
Echinococcus granulosus dro:myosuppressin receptor 0.0096 0.578 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.578 1
Schistosoma mansoni hypothetical protein 0.0096 0.578 1
Echinococcus multilocularis allatostatin A receptor 0.0096 0.578 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Brugia malayi neuropeptide F receptor 0.0096 0.578 0.5595
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.578 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.578 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus neuropeptide s receptor 0.0096 0.578 1
Echinococcus granulosus g protein coupled receptor 0.0096 0.578 1
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Schistosoma mansoni amine GPCR 0.0096 0.578 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0096 0.578 0.5595
Echinococcus multilocularis neuropeptide receptor 0.0096 0.578 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus g protein coupled receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni histamine h1 receptor 0.0096 0.578 1
Schistosoma mansoni biogenic amine receptor 0.0096 0.578 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0096 0.578 1
Schistosoma mansoni amine GPCR 0.0096 0.578 1
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.578 0.578
Echinococcus multilocularis G protein coupled receptor 139 0.0096 0.578 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0096 0.578 1
Brugia malayi Bromodomain containing protein 0.0046 0.1734 0.1372
Echinococcus granulosus neuropeptide receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.578 0.578
Echinococcus multilocularis g protein coupled receptor 0.0096 0.578 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni adenoreceptor 0.0096 0.578 1
Brugia malayi hypothetical protein 0.0096 0.578 0.5595
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.578 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.578 0.578
Schistosoma mansoni biogenic amine receptor 0.0096 0.578 1
Brugia malayi putative neuropeptide receptor 0.0096 0.578 0.5595

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.7164 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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