Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0071 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 ug ml-1 | Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 h to 50% of control growth | ChEMBL. | 2391684 |
IC50 (functional) | > 20 ug ml-1 | Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 h to 50% of control growth | ChEMBL. | 2391684 |
Inhibition (functional) | = 2 % | Antitumor activity in vivo against the 6C3HED lymphosarcoma, dosed for 10 days at 300 mg/kg | ChEMBL. | 2391684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.