Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.4504 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4504 | 0.5 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9646 | 0.9646 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.4504 | 0.4504 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.3875 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.4504 | 0.4504 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4504 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.4504 | 0.4504 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.4504 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.4504 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.4504 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1026 | 0.1026 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4504 | 0.4504 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.4504 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.3875 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.4504 | 0.4504 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 23.7558 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.