Detailed information for compound 1325065

Basic information

Technical information
  • TDR Targets ID: 1325065
  • Name: N-methyl-N-(2-oxo-2-pyrrolidin-1-ylethyl)naph thalene-2-sulfonamide
  • MW: 332.417 | Formula: C17H20N2O3S
  • H donors: 0 H acceptors: 3 LogP: 2.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC1)CN(S(=O)(=O)c1ccc2c(c1)cccc2)C
  • InChi: 1S/C17H20N2O3S/c1-18(13-17(20)19-10-4-5-11-19)23(21,22)16-9-8-14-6-2-3-7-15(14)12-16/h2-3,6-9,12H,4-5,10-11,13H2,1H3
  • InChiKey: ULFJKHKKWOCUDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-methyl-N-(2-oxo-2-pyrrolidin-1-yl-ethyl)naphthalene-2-sulfonamide
  • N-methyl-N-(2-oxo-2-1-pyrrolidinylethyl)-2-naphthalenesulfonamide
  • N-(2-keto-2-pyrrolidin-1-yl-ethyl)-N-methyl-naphthalene-2-sulfonamide
  • ST066233
  • ZINC00609748
  • MLS000716184
  • SMR000277701
  • BAS 09096981
  • Naphthalene-2-sulfonic acid methyl-(2-oxo-2-pyrrolidin-1-yl-ethyl)-amide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0254 1 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0073 0.152 0.0006
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1515 0.1477
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0045 0.0045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0045 0.0045
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Giardia lamblia Aldose reductase 0.0254 1 0.5
Trypanosoma brucei prostaglandin f synthase 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni amine GPCR 0.0042 0.0045 0.0045
Toxoplasma gondii aldose reductase, putative 0.0254 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0045 0.0045
Brugia malayi Serotonin receptor 0.0042 0.0045 0.0045
Schistosoma mansoni opsin-like receptor 0.0042 0.0045 0.0045
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0045 0.0045
Schistosoma mansoni histamine h1 receptor 0.0042 0.0045 0.0045
Brugia malayi putative neuropeptide receptor 0.0042 0.0045 0.0045
Echinococcus multilocularis voltage gated potassium channel subunit 0.0073 0.152 0.1482
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0045 0.0045
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0254 1 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.152 0.0006
Echinococcus multilocularis aldo keto reductase 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus granulosus hypothetical protein 0.0254 1 1
Echinococcus multilocularis aldehyde reductase 0.018 0.6542 0.6527
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Leishmania major prostaglandin f synthase, putative 0.0254 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0254 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Brugia malayi G protein-coupled receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0045 0.0045
Toxoplasma gondii aldo-keto reductase 0.0073 0.152 0.0006
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Mycobacterium leprae Conserved hypothetical protein 0.018 0.6542 0.5922
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Echinococcus granulosus aldehyde reductase 0.018 0.6542 0.6527
Schistosoma mansoni biogenic amine receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0045 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1515 0.1477
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi neuropeptide F receptor 0.0042 0.0045 0.0045
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0045 0.0045
Trypanosoma cruzi aldo/keto reductase, putative 0.0254 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0045 0.0045
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0045 0.0045
Entamoeba histolytica aldose reductase, putative 0.0254 1 1
Schistosoma mansoni biogenic amine receptor 0.0042 0.0045 0.0045
Brugia malayi GnHR receptor homolog 0.0042 0.0045 0.0045
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi ORL1-like opioid receptor 0.0042 0.0045 0.0045
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0042 0.0045 0.0045
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0254 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0042 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0897 0.0897
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0897 0.0897
Onchocerca volvulus 0.0254 1 1
Schistosoma mansoni pol-related 0.0254 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1515 0.1515
Loa Loa (eye worm) oxidoreductase 0.0254 1 1
Brugia malayi Dopamine receptor 0.0042 0.0045 0.0045
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni neuropeptide receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Giardia lamblia Aldose reductase 0.0254 1 0.5
Brugia malayi larval opioid receptor 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) oxidoreductase 0.0254 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0254 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0254 1 1
Echinococcus granulosus aldo keto reductase 0.0254 1 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0073 0.152 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0297 0.0297
Brugia malayi G-protein coupled receptor 0.0042 0.0045 0.0045
Brugia malayi NADH-dependent xylose reductase 0.0073 0.152 0.152
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus multilocularis aldo keto reductase 0.0254 1 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0073 0.152 0.152
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Brugia malayi sulfakinin receptor protein 0.0042 0.0045 0.0045
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0073 0.152 0.152
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0073 0.152 0.1482
Entamoeba histolytica aldose reductase, putative 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus multilocularis aldo keto reductase 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Schistosoma mansoni biogenic amine receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Brugia malayi Melatonin receptor type 1A 0.0042 0.0045 0.0045
Onchocerca volvulus 0.0254 1 1
Plasmodium falciparum aldo-keto reductase, putative 0.0073 0.152 0.5
Echinococcus granulosus aldo keto reductase 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0897 0.0897
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo/keto reductase, putative 0.0254 1 1
Loa Loa (eye worm) oxidoreductase 0.0254 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) oxidoreductase 0.0254 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0045 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1515 0.1515
Schistosoma mansoni neuropeptide receptor 0.0042 0.0045 0.0045
Schistosoma mansoni neuropeptide receptor 0.0042 0.0045 0.0045
Trypanosoma cruzi aldo-keto reductase 0.0254 1 1
Entamoeba histolytica aldose reductase, putative 0.0254 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Brugia malayi AKH receptor 0.0042 0.0045 0.0045
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0254 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Schistosoma mansoni neuropeptide receptor 0.0042 0.0045 0.0045
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0073 0.152 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0254 1 1
Mycobacterium ulcerans hypothetical protein 0.0073 0.152 0.0006
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Echinococcus granulosus aldo keto reductase 0.0254 1 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0073 0.152 0.0006
Schistosoma mansoni potassium channel beta 0.0073 0.152 0.152
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus multilocularis aldo keto reductase 0.0254 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0254 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0897 0.0897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Brugia malayi Dopamine receptor protein 2 0.0042 0.0045 0.0045
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0045 0.0045
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0045 0.0045
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0045 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni myosin xvIII 0.0042 0.0045 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0045 0.0045
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0045 0.0045
Schistosoma mansoni aldo-keto reductase 0.0254 1 1
Brugia malayi neuropeptide F receptor 0.0042 0.0045 0.0045
Mycobacterium ulcerans oxidoreductase 0.0254 1 1
Brugia malayi G-protein coupled receptor 0.0042 0.0045 0.0045
Plasmodium vivax aldehyde reductase, putative 0.0073 0.152 0.5
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni opsin-like receptor 0.0042 0.0045 0.0045
Schistosoma mansoni opsin-like receptor 0.0042 0.0045 0.0045
Trypanosoma brucei aldo-keto reductase, putative 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Onchocerca volvulus 0.0254 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0073 0.152 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Brugia malayi Serotonin receptor 0.0042 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0042 0.0045 0.0045
Schistosoma mansoni adenoreceptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Echinococcus granulosus voltage gated potassium channel subunit 0.0073 0.152 0.1482
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0045 0.0045
Trichomonas vaginalis aldo/keto reductase, putative 0.0254 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0254 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0045 0.0045
Onchocerca volvulus 0.0254 1 1
Brugia malayi RE15519p 0.0042 0.0045 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Leishmania major aldo-keto reductase-like protein 0.0254 1 1
Schistosoma mansoni aldo-keto reductase 0.0254 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Onchocerca volvulus 0.0254 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi hypothetical protein 0.0042 0.0045 0.0045
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0045 0.0045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0254 1 1
Onchocerca volvulus 0.0073 0.152 0.1482
Brugia malayi Dopamine receptor protein 1 0.0042 0.0045 0.0045
Brugia malayi Cytochrome P450 family protein 0.0047 0.0297 0.0297

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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